AutismKB 2.0

Annotation Detail for PRSS3


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Basic Information Top
Gene Symbol:PRSS3 ( MTG,PRSS4,T9,TRY3,TRY4 )
Gene Full Name: protease, serine, 3
Band: 9p13.3
Quick LinksEntrez ID:5646; OMIM: 613578; Uniprot ID:TRY3_HUMAN; ENSEMBL ID: ENSG00000010438; HGNC ID: 9486
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04080Neuroactive ligand-receptor interaction
hsa04972Pancreatic secretion
hsa04974Protein digestion and absorption
No data
No data
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D001151 Arsenic Arsenic results in increased methylation of PRSS3 promoterincreases methylation 15987713
C055494 caffeic acid phenethyl ester [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of PRSS3 mRNAaffects cotreatment|decreases expression 20360939
D003520 Cyclophosphamide PRSS3 protein affects the susceptibility to Cyclophosphamideaffects response to substance 16217747
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of PRSS3 mRNAaffects cotreatment|decreases expression 20360939
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of PRSS3 mRNAaffects binding|decreases expression|increases activity 19710929
C079198 S 1 (combination) PRSS3 protein results in increased susceptibility to S 1 (combination)increases response to substance 16734730
D014302 Trinitrobenzenesulfonic Acid Trinitrobenzenesulfonic Acid results in increased expression of PRSS3 mRNAincreases expression 17982090
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.4218653653
MESH:D000236 Adenoma Diethylnitrosamine 2.9910737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 11.4517162532 19061943 18056438 19052882 16434500 17620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 11.4516434500
MESH:D018246 Adrenocortical Adenoma Arsenic 5.6617306315
MESH:D020261 Arsenic Poisoning Arsenic 2.9318414634 12569548 16251483 16835338
MESH:D001161 Arteriosclerosis Cyclophosphamide 4.9615014928
MESH:D050197 Atherosclerosis Arsenic 3.4019371607 12928151
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.4319483382
MESH:D001943 Breast Neoplasms Cyclophosphamide 2.4112006526 18323546 15136595 11325840 16978400 18234424 15093573 17388661 17020986
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.4117474063
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.7317687452 15504454
MESH:D006528 Carcinoma, Hepatocellular Arsenic 4.9616507464 17306315
MESH:D006528 Carcinoma, Hepatocellular Cyclophosphamide 4.9619701751
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 4.9616328049 16698587 19418558 21159647 18971187 17428255 17055752 20524982 19052882 20084675 20727157 19701751 17978847 19519916 16569478 18785209 18506893 18056438 16935385 3581430 18665156 16779866 16288022 18393292 20214788 19539802 19107877 20007298 17761372 16830150 19208518 16540662 16878318 20935162 20432363 19394651 10737359 11831363 17173139 16807293 18494052 18978308 20514400 19822196 3084413 19335982 17162532 16681979 10672840 20101231 19383236 19919837 20512989 18788625 19171122 16502159 18691550 18210153 17138121
MESH:D018827 Carcinoma, Lewis Lung Cyclophosphamide 5.2816152834
MESH:D002289 Carcinoma, Non-Small-Cell Lung S 1 (combination) 4.1518212800 18347146
MESH:D002292 Carcinoma, Renal Cell Cyclophosphamide 3.6516201981
MESH:D002294 Carcinoma, Squamous Cell Arsenic 5.6015504454 17687452 18922899
MESH:D002294 Carcinoma, Squamous Cell S 1 (combination) 5.6015984520
MESH:D002295 Carcinoma, Transitional Cell Arsenic 4.3418640142
MESH:D002318 Cardiovascular Diseases Arsenic 3.6315738583 17938729 19152805
MESH:D002340 Carotid Artery Diseases Arsenic 4.5616973168 18022660
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 3.047505956 21159647 2727394 17174075
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.9319052882
MESH:D002779 Cholestasis pirinixic acid 3.0319176532
MESH:D003092 Colitis Trinitrobenzenesulfonic Acid 4.9018200517 16782535 16867261 16804969 17936198 11698051 17991707 16474422 18023891
MESH:D003093 Colitis, Ulcerative Trinitrobenzenesulfonic Acid 3.5217276891
MESH:D003556 Cystitis Cyclophosphamide 5.4318093676 17979934 10498854 18483878 18433785 18372110 12913760 16413132 18295254 16989017 16614059 12388444 15643279 18710439 15276878 11948286 17010015 10700343 16651033 12161096
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5318249437
MESH:D003921 Diabetes Mellitus, Experimental Cyclophosphamide 4.3015331540 11751995 10990075
MESH:D003922 Diabetes Mellitus, Type 1 Cyclophosphamide 3.2918772604
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.2420387270
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 2.1219107877
MESH:D004487 Edema pirinixic acid 2.7612083418
MESH:D004802 Eosinophilia Cyclophosphamide 4.5711006010
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.5616302075
MESH:D005234 Fatty Liver Diethylnitrosamine 8.6320387270 21071580
MESH:D005234 Fatty Liver pirinixic acid 8.6320131406 19236843
MESH:D005355 Fibrosis Trinitrobenzenesulfonic Acid 4.7117994277
MESH:D005534 Foot Diseases Arsenic 6.006392382
MESH:D005706 Gallbladder Neoplasms S 1 (combination) 6.0919093184
MESH:D018316 Gliosarcoma Cyclophosphamide 5.9111389073
MESH:D006086 Graft vs Host Disease Cyclophosphamide 5.3916376943 11014644 15172196
MESH:D006258 Head and Neck Neoplasms S 1 (combination) 4.9215984520 18607998
MESH:D006333 Heart Failure pirinixic acid 2.6920558911
MESH:D006467 Hemophilia A Cyclophosphamide 5.6511918545
MESH:D006504 Hepatic Veno-Occlusive Disease Cyclophosphamide 5.9814986274
MESH:D006529 Hepatomegaly pirinixic acid 3.3516221962 19176532 18467677 19772884
MESH:D006689 Hodgkin Disease Cyclophosphamide 4.0317606976 16135485
MESH:D006943 Hyperglycemia pirinixic acid 3.4520558911
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.7217050553
MESH:D006973 Hypertension Arsenic 2.959931084 11953799 16076760
MESH:D006987 Hypesthesia Arsenic 6.0016093927
MESH:D007154 Immune System Diseases Cyclophosphamide 5.7716076520
MESH:D007248 Infertility, Male Cyclophosphamide 3.797193160 16517039
MESH:D007249 Inflammation Diethylnitrosamine 2.5018785209
MESH:D015212 Inflammatory Bowel Diseases Trinitrobenzenesulfonic Acid 3.6718200517
MESH:D007333 Insulin Resistance pirinixic acid 2.8016306350
MESH:D007410 Intestinal Diseases Trinitrobenzenesulfonic Acid 4.9617994277
MESH:D007414 Intestinal Neoplasms caffeic acid phenethyl ester 4.8510783313
MESH:D007642 Keratosis Arsenic 5.3916930632 12749816
MESH:D007674 Kidney Diseases caffeic acid phenethyl ester 3.6915369732
MESH:D007938 Leukemia Cyclophosphamide 3.6110602166
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Cyclophosphamide 3.5917008537 17296974 17658394 18587576 18172266 17802794
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Cyclophosphamide 4.2910373061
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 8.6417339181
MESH:D015473 Leukemia, Promyelocytic, Acute caffeic acid phenethyl ester 8.6416766008
MESH:D007970 Leukopenia Cyclophosphamide 5.3610052129 11830472
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.9618665156 19638242 18522880 18407596 20032147
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3515474484
MESH:D008107 Liver Diseases Arsenic 4.4411134558
MESH:D008107 Liver Diseases Diethylnitrosamine 4.4417034775
MESH:D008113 Liver Neoplasms Arsenic 7.9916368122
MESH:D008113 Liver Neoplasms Diethylnitrosamine 7.9920101389 19427195 18754104 2862719 18977376 19690152 19638242 20492335 19551842 19255062 15885732 19833225 12112319 21047994 20118626 10737359 19294768 21167192 19812893 19426721 18644402 19996281 19090486 19256749 20137499 20583210 12771043 19073162 19254457 21071580 20434301 19642983 21278145 9163691 15175105 20405173 20452335 16942905 18978307 2422723 19499222 18648771 19850985 20501860
MESH:D008113 Liver Neoplasms pirinixic acid 7.9915890375 20007298 16377806
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 2.792563599 18164116 21159647 19126423 19009564 18282651 17854601 9362446 18544905 19519916 18775883 16842330 18079962 17942915 17174075 18253720 19539802 18093689 16267830 18308698 19004024 3124819
MESH:D008175 Lung Neoplasms Arsenic 2.6717976673 17306315 19168569
MESH:D008175 Lung Neoplasms Diethylnitrosamine 2.6720512841 20970405 21163286 6695378
MESH:D008223 Lymphoma Cyclophosphamide 4.0312854902
MESH:D016393 Lymphoma, B-Cell Cyclophosphamide 4.9016675587
MESH:D008228 Lymphoma, Non-Hodgkin Cyclophosphamide 4.4011911406
MESH:D008546 Melanoma, Experimental Cyclophosphamide 5.1616388313
MESH:D009135 Muscular Diseases pirinixic acid 3.8616239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2419151258
MESH:D017202 Myocardial Ischemia Arsenic 4.2115371236
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1616411023
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.663581430 9029167
MESH:D009369 Neoplasms Cyclophosphamide 5.5818854779
MESH:D009369 Neoplasms pirinixic acid 5.5817405874
MESH:D009436 Neural Tube Defects Arsenic 3.6216620997
MESH:D009447 Neuroblastoma Cyclophosphamide 3.7616115947 15176712 8761367
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.5720387270
MESH:D017599 Neuroectodermal Tumors Cyclophosphamide 5.288761367 12837982
MESH:D020078 Neurogenic Inflammation Arsenic 4.6817056641
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.5620387270
MESH:D009503 Neutropenia Cyclophosphamide 4.638291058
MESH:D009765 Obesity pirinixic acid 1.8620558911
MESH:D009845 Oligospermia Cyclophosphamide 5.1116517039
MESH:D010051 Ovarian Neoplasms Arsenic 2.8117306315
MESH:D010146 Pain Cyclophosphamide 3.8512161096 18093676
MESH:D010190 Pancreatic Neoplasms Cyclophosphamide 5.7911332152
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 5.7916540662
MESH:D010195 Pancreatitis Trinitrobenzenesulfonic Acid 4.5017698068
MESH:D010523 Peripheral Nervous System Diseases Arsenic 4.5116093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 5.396392382 15371236 16905509
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.802563599
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Cyclophosphamide 3.9421297632
MESH:D011471 Prostatic Neoplasms Arsenic 3.5916140617
MESH:D011471 Prostatic Neoplasms Cyclophosphamide 3.5917136230
MESH:D011507 Proteinuria Arsenic 4.3121343184
MESH:D011658 Pulmonary Fibrosis Cyclophosphamide 3.3716636934
MESH:D015427 Reperfusion Injury pirinixic acid 2.5019058328
MESH:D012595 Scleroderma, Systemic Cyclophosphamide 5.1316636934
MESH:D012871 Skin Diseases Arsenic 2.8018709164 16759981 19834688 17548696 17938729 15952646 6392382 17453740 17050553 16353154 16702368
MESH:D012878 Skin Neoplasms Arsenic 3.1217976673 15504454 17050553 19538983 16251483 17029826
OMIM:102530 SPERMATOGENIC FAILURE 6 Cyclophosphamide 5.9116517039
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 3.0518456281
MESH:D013274 Stomach Neoplasms S 1 (combination) 3.0518506536 16557585 18553229
MESH:D015173 Supratentorial Neoplasms Cyclophosphamide 5.4512837982
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 3.197505956
MESH:D001749 Urinary Bladder Neoplasms marker/mechanism 15987713
MESH:D001749 Urinary Bladder Neoplasms Arsenic 5.8319429237 17976673 15987713 11144890 18640142 19322015 17306315
MESH:D001749 Urinary Bladder Neoplasms Cyclophosphamide 5.8314692829
MESH:D014652 Vascular Diseases Arsenic 5.1317056641
Pathway ID Pathway Name
KEGG:04080 Neuroactive ligand-receptor interaction
KEGG:04972 Pancreatic secretion
KEGG:04974 Protein digestion and absorption
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB02308 - 4-(1,3,2-Dioxaborolan-2-Yloxy)Butan-1-Aminium
DB02541 - 4-Hydroxybutan-1-Aminium
DB02585 - 4-(Hydroxymethyl)Benzamidine
DB03127 - Benzamidine Serine Proteinase Inhibitors
DB03129 - [3-(1,3,2-Dioxaborolan-2-Yloxy)Propyl]Guanidine
DB03637 - Guanidine-3-Propanol
DB03965 - Fucose
DB04109 - [4-(1,3,2-Dioxaborolan-2-Yloxy)Methyl]Benzamidine
DB04184 - Acetate Ion Indicators and Reagents
DB04369 - 1,3,2-Dioxaborolan-2-Ol
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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