AutismKB 2.0

Annotation Detail for PRSS8


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Basic Information Top
Gene Symbol:PRSS8 ( CAP1,PROSTASIN )
Gene Full Name: protease, serine, 8
Band: 16p11.2
Quick LinksEntrez ID:5652; OMIM: 600823; Uniprot ID:PRSS8_HUMAN; ENSEMBL ID: ENSG00000052344; HGNC ID: 9491
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C028474 1,4-bis(2-(3,5-dichloropyridyloxy))benzene 1,4-bis(2-(3,5-dichloropyridyloxy))benzene affects the expression of PRSS8 mRNAaffects expression 18281256
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of PRSS8 mRNAaffects expression 21346803
C040534 alpha-hexachlorocyclohexane alpha-hexachlorocyclohexane results in increased expression of PRSS8 mRNAincreases expression 17785943
D000643 Ammonium Chloride Ammonium Chloride affects the expression of PRSS8 mRNAaffects expression 16483693
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of PRSS8 mRNAaffects cotreatment|increases expression 18164116
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of PRSS8 mRNAaffects cotreatment|increases expression 18164116
D000431 Ethanol [Fish Oils co-treated with Ethanol] results in increased expression of PRSS8 mRNAaffects cotreatment|increases expression 17347304
D005395 Fish Oils [Fish Oils co-treated with Ethanol] results in increased expression of PRSS8 mRNAaffects cotreatment|increases expression 17347304
D005419 Flavonoids Flavonoids results in increased expression of PRSS8 mRNAincreases expression 18035473
C533894 LG 100815 LG 100815 results in increased expression of PRSS8 mRNAincreases expression 16951191
C062198 octa-2,4,6-trienoic acid octa-2,4,6-trienoic acid results in increased expression of PRSS8 mRNAincreases expression 16951191
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in increased expression of PRSS8 mRNA]affects reaction|increases expression 19482888
D010634 Phenobarbital Phenobarbital affects the expression of PRSS8 mRNAaffects expression 19136022
D010634 Phenobarbital Phenobarbital results in increased expression of PRSS8 mRNAincreases expression 19482888
19270015
C006253 pirinixic acid pirinixic acid affects the expression of PRSS8 mRNAaffects expression 19136022
D012643 Selenium Selenium results in increased expression of PRSS8 mRNAincreases expression 19244175
C017947 sodium arsenite sodium arsenite results in decreased expression of PRSS8 mRNAdecreases expression 12634122
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Ethanol 8.8617676605 18926900
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 8.866195326
MESH:D000138 Acidosis Ammonium Chloride 10.6418287403
MESH:D000138 Acidosis Ethanol 10.6411192467
MESH:D055371 Acute Lung Injury pirinixic acid 3.1518653653
MESH:D000236 Adenoma beta-Naphthoflavone 6.9319389873
MESH:D000236 Adenoma Diethylnitrosamine 6.936695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 17.6719061943 17620307 16434500 17162532 18056438 19052882
MESH:D018248 Adenoma, Liver Cell Phenobarbital 17.6717620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 17.6716434500
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.7615276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.9617306315 16712894
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 5.3815451040 15451039
MESH:D000853 Anophthalmos Ethanol 4.8615513904
MESH:D001008 Anxiety Disorders Ethanol 4.0311141031
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.1719483382
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.2317474063
MESH:D002056 Burns Ethanol 4.6916374292
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 8.9316705839
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 8.9321159647 17978847 16681979 19539802 20101231 18788625 16779866 19335982 19383236 16328049 11831363 18785209 18665156 18506893 10672840 19701751 18494052 19394651 19208518 17761372 20524982 3084413 18056438 18393292 19822196 16878318 20512989 17428255 18978308 16502159 19418558 20514400 17055752 3581430 16830150 19519916 19107877 20727157 20214788 16288022 16569478 17173139 16698587 19919837 10737359 19052882 16935385 16807293 16540662 18210153 18691550 17138121 17162532 20084675 18971187 19171122 20007298 20935162 20432363
MESH:D006528 Carcinoma, Hepatocellular Ethanol 8.9318788625 15289165 15763234
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 8.9320935162 1701930 17173139 20007298 6705139
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 8.9316507464 15276417 17306315
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 2.3918572023
MESH:D006332 Cardiomegaly Ethanol 3.4519332462
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 6.8417174075 21159647 7505956 2727394
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 6.8419524636 20056578
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.294080065
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.7119052882
MESH:D002779 Cholestasis pirinixic acid 2.8519176532
MESH:D002971 Cleft Lip Ethanol 3.6015513904
MESH:D002972 Cleft Palate Ethanol 3.1815513904
MESH:D003092 Colitis Selenium 3.8217936198
MESH:D019465 Craniofacial Abnormalities Ethanol 2.3311198716 11873399 15451039 10194807 19302082 15513904 15451040
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.0618551238
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4418249437
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.2020387270
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 9.0921346803 18551238
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 9.0919107877
MESH:D056486 Drug-Induced Liver Injury Ethanol 9.0911566570
MESH:D056486 Drug-Induced Liver Injury Selenium 9.0915131321
MESH:D004421 Dystonia Phenobarbital 4.041851702
MESH:D004487 Edema pirinixic acid 2.5112083418
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.153659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.933922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.9020417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.576401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.297750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.073659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.1816302075
MESH:D004938 Esophageal Neoplasms Ethanol 2.7616704527
MESH:D005234 Fatty Liver Diethylnitrosamine 19.1120387270 21071580
MESH:D005234 Fatty Liver Ethanol 19.1116409862 19236843 18620774
MESH:D005234 Fatty Liver Fish Oils 19.1118620774
MESH:D005234 Fatty Liver pirinixic acid 19.1120131406 19236843
MESH:D005235 Fatty Liver, Alcoholic Ethanol 5.7317920746
MESH:D005310 Fetal Alcohol Syndrome Ethanol 5.3516946407 15451040 10194807 15513904
MESH:D005756 Gastritis Ethanol 4.7615046732
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.7316452187
MESH:D006333 Heart Failure pirinixic acid 7.0120558911
MESH:D006333 Heart Failure Selenium 7.0117162251
MESH:D006529 Hepatomegaly 1,4-bis(2-(3,5-dichloropyridyloxy))benzene 14.8916109766
MESH:D006529 Hepatomegaly Phenobarbital 14.8916109766
MESH:D006529 Hepatomegaly pirinixic acid 14.8919772884 19176532 18467677 16221962
MESH:D006689 Hodgkin Disease sodium arsenite 3.1812676792
MESH:D006930 Hyperalgesia Ethanol 3.7418783367
MESH:D006943 Hyperglycemia pirinixic acid 3.2120558911
MESH:D006949 Hyperlipidemias Fish Oils 4.7915752949
MESH:D006968 Hypersensitivity, Delayed Fish Oils 5.5711484837
MESH:D007248 Infertility, Male sodium arsenite 3.0112646999 15346721
MESH:D007249 Inflammation Diethylnitrosamine 5.2318785209
MESH:D007249 Inflammation Flavonoids 5.2317296493
MESH:D007251 Influenza, Human Selenium 4.2616624496
MESH:D007333 Insulin Resistance pirinixic acid 2.6516306350
MESH:D007569 Jaw Abnormalities Ethanol 4.4315513904
MESH:D007674 Kidney Diseases sodium arsenite 2.8120008137
MESH:D007676 Kidney Failure, Chronic Selenium 3.9116518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 3.0016705839
MESH:D007859 Learning Disorders Ethanol 4.2515451040
MESH:D017880 Limb Deformities, Congenital Ethanol 3.8317676605
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 11.1818665156 18407596 20032147 19638242 18522880
MESH:D008103 Liver Cirrhosis Ethanol 11.1815289165
MESH:D008103 Liver Cirrhosis Phenobarbital 11.1821047994
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 5.1518295389
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 2.5418166357
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.5415474484
MESH:D008107 Liver Diseases Diethylnitrosamine 4.1317034775
MESH:D008107 Liver Diseases Phenobarbital 4.1319363144
MESH:D008108 Liver Diseases, Alcoholic Ethanol 4.6917207112 17347304
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 14.3621295105 19389873
MESH:D008113 Liver Neoplasms Diethylnitrosamine 14.3619294768 19996281 9163691 21071580 18644402 15885732 19426721 20118626 21278145 19850985 19833225 15175105 18754104 20434301 19499222 2862719 20452335 20101389 20405173 20583210 10737359 21167192 19638242 19642983 20492335 18648771 19812893 19255062 12771043 19073162 20137499 18977376 21047994 19551842 19256749 19254457 19690152 18978307 12112319 2422723 19427195 20501860 16942905 19090486
MESH:D008113 Liver Neoplasms Phenobarbital 14.3615975961 21047994 19073162 8742319 19812893 19482888
MESH:D008113 Liver Neoplasms pirinixic acid 14.3616377806 15890375 20007298
MESH:D008113 Liver Neoplasms sodium arsenite 14.3615276417 16712894
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 10.0418164116
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 10.0418308698 16267830 18164116 19009564 18253720 17942915 18282651 18775883 17174075 18079962 16842330 19539802 21159647 3124819 18093689 18544905 9362446 2563599 19004024 17854601 19126423 19519916
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 10.042563599 1399818 18308698 6150874 17172636
MESH:D008171 Lung Diseases sodium arsenite 3.1919095001
MESH:D008175 Lung Neoplasms Diethylnitrosamine 2.5021163286 6695378 20512841 20970405
MESH:D008175 Lung Neoplasms sodium arsenite 2.5017306315 19931552 16712894 17077188 15276417
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.7815318939
MESH:D008545 Melanoma sodium arsenite 2.0316487513 19082730
MESH:D008569 Memory Disorders Ethanol 4.2218411066 15451040
MESH:D008654 Mesothelioma Selenium 2.8015107826
MESH:D009135 Muscular Diseases pirinixic acid 3.5516239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1519151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.9716411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.5317484760
MESH:D009336 Necrosis 2,4-dinitrotoluene 3.9118551238
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.583581430 9029167
MESH:D009369 Neoplasms pirinixic acid 4.9817405874
MESH:D009369 Neoplasms sodium arsenite 4.9811559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.7120056578
MESH:D009436 Neural Tube Defects sodium arsenite 3.1612854658
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.3620387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.1820387270
MESH:D009765 Obesity pirinixic acid 1.8220558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.4512819281 16049721
MESH:D010018 Osteomalacia Phenobarbital 4.4117016548
MESH:D010051 Ovarian Neoplasms sodium arsenite 2.4417306315 15276417
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 8.7316540662
MESH:D010190 Pancreatic Neoplasms Ethanol 8.7312384795
MESH:D010190 Pancreatic Neoplasms Phenobarbital 8.7316965848
MESH:D010954 Plasmacytoma Selenium 4.9515087411
MESH:D011230 Precancerous Conditions Diethylnitrosamine 9.172563599
MESH:D011230 Precancerous Conditions Phenobarbital 9.172563599
MESH:D011471 Prostatic Neoplasms marker/mechanism 16541421
MESH:D011471 Prostatic Neoplasms sodium arsenite 3.3016039940
MESH:D019310 Pseudolymphoma Phenobarbital 4.5612752131
MESH:D015427 Reperfusion Injury pirinixic acid 2.4019058328
MESH:D012640 Seizures 2,4-dinitrotoluene 10.0118551238
MESH:D012640 Seizures Ethanol 10.019754883
MESH:D012640 Seizures Phenobarbital 10.0116876388 11442880 4039156 3137016
MESH:D003294 Seizures, Febrile Phenobarbital 4.876407741
MESH:D012878 Skin Neoplasms sodium arsenite 2.7118572023 19524636
MESH:D016135 Spinal Dysraphism sodium arsenite 3.8212854658
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 2.6118456281
MESH:D013274 Stomach Neoplasms Ethanol 2.6118456281
MESH:D013276 Stomach Ulcer Ethanol 3.5617189318 11906479 9562338 17918041 9211565 16755016
MESH:D013375 Substance Withdrawal Syndrome Ethanol 4.289754883
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 7.257505956
MESH:D013964 Thyroid Neoplasms Phenobarbital 7.251399818
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.1316049721
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 5.1316452187 11723127 16712894 17306315
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.3710091137
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 3.7911813266
MESH:D014652 Vascular Diseases sodium arsenite 4.4717056641
No data
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB06900 - 1-[4-(hydroxymethyl)phenyl]guanidine
No data
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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