AutismKB 2.0

Annotation Detail for MMP26


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Basic Information Top
Gene Symbol:MMP26 ( MGC126590,MGC126592 )
Gene Full Name: matrix metallopeptidase 26
Band: 11p15.4
Quick LinksEntrez ID:56547; OMIM: 605470; Uniprot ID:MMP26_HUMAN; ENSEMBL ID: ENSG00000167346; HGNC ID: 14249
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of MMP26 mRNAdecreases expression 20106945
D014212 Tretinoin Tretinoin results in decreased expression of MMP26 mRNAdecreases expression 16984259
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0720464547 20127859
MESH:D000236 Adenoma Benzo(a)pyrene 2.906695378
MESH:D000505 Alopecia Tretinoin 4.0215955085
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.8419183758
MESH:D001169 Arthritis, Experimental Tretinoin 3.3516412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.3416292516
MESH:D001249 Asthma Tretinoin 2.4516456186
MESH:D001471 Barrett Esophagus Tretinoin 5.0816935849
MESH:D001778 Blood Coagulation Disorders Tretinoin 4.1616197459 16206674
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.0620146248 17474063
MESH:D001943 Breast Neoplasms Tretinoin 2.0616873071 16443354 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 5.4816813970
MESH:D018236 Carcinoma, Embryonal Tretinoin 6.2316168501
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 1.921917145
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.9320419170
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 4.9316096774 16051514
MESH:D002386 Cataract Tretinoin 3.3417460283
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 5.4816129372
MESH:D002822 Choriocarcinoma Tretinoin 6.2316461808
MESH:D002972 Cleft Palate Tretinoin 2.839407595
MESH:D003092 Colitis Tretinoin 4.4717035595
MESH:D019465 Craniofacial Abnormalities Tretinoin 1.838800419 17551590 9664655 10589399 9125849 16925845 9142499 9211117 14991402 9224671
MESH:D004489 Edema, Cardiac Tretinoin 5.5418230668
MESH:D016889 Endometrial Neoplasms Tretinoin 3.4016569247
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0916530937
MESH:D005124 Eye Abnormalities Tretinoin 3.949664655 16938888
MESH:D005355 Fibrosis Tretinoin 4.2717994277
MESH:D005909 Glioblastoma Tretinoin 3.3017312396
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.4916096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 6.2316084493
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 7.3920471113
MESH:D006330 Heart Defects, Congenital Tretinoin 7.3914991402 9664655
MESH:D006930 Hyperalgesia Tretinoin 3.6216870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 5.3316778211
MESH:D007410 Intestinal Diseases Tretinoin 4.5317994277
MESH:D007569 Jaw Abnormalities Tretinoin 4.4517551590 15992940
MESH:D007938 Leukemia Tretinoin 2.9717143497
MESH:D007951 Leukemia, Myeloid Tretinoin 4.2516482212 16932348 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.1316294345 17596541 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.4517368321 19642359 17107899 19075265 16935935 17339181 16140955 9834237 17301526 16788101 17217047 12679006 16331271 16823087 15748426 17649720 16766008 17361223 19029980 17294898 19225113 16891316 17506722 19035177 17712046
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.659224671
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 1.8118397230 16248980
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 2.1820195826 21137059
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 1.5720064080 18816296 17053015 18569708 6695378 20464547 20135361 20869020 18520028
MESH:D008527 Medulloblastoma Tretinoin 2.9317453147
MESH:D008545 Melanoma Tretinoin 1.9916752155
MESH:D008591 Meningomyelocele Tretinoin 5.1916940565
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.5716381670
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.3217596541
MESH:D009369 Neoplasms Benzo(a)pyrene 5.6711141357
MESH:D009369 Neoplasms Tretinoin 5.6716594593 16946489
MESH:D009421 Nervous System Malformations Tretinoin 4.459125849
MESH:D009436 Neural Tube Defects Tretinoin 3.359142499
MESH:D010051 Ovarian Neoplasms Tretinoin 2.4616936753
MESH:D010146 Pain Tretinoin 3.3316870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.5915976015
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.9017292933
MESH:D011507 Proteinuria Tretinoin 4.2116636307
MESH:D011625 Pterygium Tretinoin 5.6816723453
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.7116283617 16116481
MESH:D012871 Skin Diseases marker/mechanism 16984259
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 6.3219755658 10029692
MESH:D012878 Skin Neoplasms Tretinoin 6.3216467112
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.4320155912 2093021
MESH:D013274 Stomach Neoplasms Tretinoin 2.4317261132
MESH:D013964 Thyroid Neoplasms Tretinoin 3.4017045167 16026305
MESH:D014062 Tongue Neoplasms Tretinoin 4.2916051514
MESH:D014376 Tuberculosis Tretinoin 3.5016040207
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.3217053015
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 4.1816129372
MESH:D014604 Uveal Neoplasms Tretinoin 5.6816752155
MESH:D014820 Vitiligo Tretinoin 4.7316761959
MESH:D009396 Wilms Tumor Tretinoin 4.4416287080
No data
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB00786 antagonist Marimastat Antineoplastic Agents;Enzyme Inhibitors
No data
No data
No data

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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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