AutismKB 2.0

Annotation Detail for CYP26B1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:CYP26B1 ( CYP26A2,DKFZp686G0638,MGC129613,P450RAI-2 )
Gene Full Name: cytochrome P450, family 26, subfamily B, polypeptide 1
Band: 2p13.2
Quick LinksEntrez ID:56603; OMIM: 605207; Uniprot ID:CP26B_HUMAN; ENSEMBL ID: ENSG00000003137; HGNC ID: 20581
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa00830Retinol metabolism
Pathway IDPathway Name
Biological oxidations
No data
No data
Pathway IDPathway Name
500202Vitamins
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C055506 4-(diethylamino)benzaldehyde 4-(diethylamino)benzaldehyde inhibits the reaction [R 115866 results in decreased activity of CYP26B1 protein]decreases activity|decreases reaction 17164423
C019429 4-hydroxyretinoic acid 4-hydroxyretinoic acid affects the expression of CYP26B1 mRNAaffects expression 16054125
C002202 4-oxoretinoic acid 4-oxoretinoic acid affects the expression of CYP26B1 mRNAaffects expression 16054125
D000082 Acetaminophen Acetaminophen affects the expression of CYP26B1 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of CYP26B1 mRNAaffects expression 16483693
D001151 Arsenic Arsenic results in increased expression of CYP26B1 mRNAincreases expression 19654921
C095105 bexarotene bexarotene results in increased expression of CYP26B1 mRNAincreases expression 17849452
D002117 Calcitriol Calcitriol results in increased expression of CYP26B1 mRNAincreases expression 16002434
D004958 Estradiol [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of CYP26B1 mRNAaffects cotreatment|decreases expression 19619570
D004958 Estradiol Estradiol results in decreased expression of CYP26B1 mRNAdecreases expression 19619570
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of CYP26B1 mRNAdecreases expression 17557909
C011890 kojic acid kojic acid results in increased expression of CYP26B1 mRNAincreases expression 16595896
D008070 Lipopolysaccharides Lipopolysaccharides inhibits the reaction [Tretinoin results in increased expression of CYP26B1 mRNA]decreases reaction|increases expression 17185629
C007350 nitrofen nitrofen results in decreased expression of CYP26B1 mRNAdecreases expression 17203325
D010656 Phenylephrine Phenylephrine results in increased expression of CYP26B1 mRNAincreases expression 18158353
C406527 R 115866 4-(diethylamino)benzaldehyde inhibits the reaction [R 115866 results in decreased activity of CYP26B1 protein]decreases activity|decreases reaction 17164423
C406527 R 115866 R 115866 results in decreased activity of CYP26B1 proteindecreases activity 17164423
C406527 R 115866 [R 115866 co-treated with Vitamin A] results in increased expression of CYP26B1 mRNAaffects cotreatment|increases expression 17510468
C406527 R 115866 [R 115866 results in decreased activity of CYP26B1 protein] which results in increased abundance of Tretinoindecreases activity|increases abundance 17510468
C406527 R 115866 R 115866 results in increased expression of CYP26B1 mRNAincreases expression 17510468
C450682 R116010 R116010 promotes the reaction [Isotretinoin results in increased expression of CYP26B1 mRNA]increases expression|increases reaction 17486130
C450682 R116010 R116010 promotes the reaction [Tretinoin results in increased expression of CYP26B1 mRNA]increases expression|increases reaction 17486130
D020849 Raloxifene [Raloxifene co-treated with ESR2 protein] results in decreased expression of CYP26B1 mRNAaffects cotreatment|decreases expression 19059307
D015474 Isotretinoin Isotretinoin results in increased expression of CYP26B1 mRNAincreases expression 17486130
D015474 Isotretinoin R116010 promotes the reaction [Isotretinoin results in increased expression of CYP26B1 mRNA]increases expression|increases reaction 17486130
D013629 Tamoxifen [Tamoxifen co-treated with ESR2 protein] results in decreased expression of CYP26B1 mRNAaffects cotreatment|decreases expression 19059307
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of CYP26B1 mRNAdecreases expression 16443690
D013749 Tetrachlorodibenzodioxin [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of CYP26B1 mRNAaffects cotreatment|decreases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of CYP26B1 mRNAdecreases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of CYP26B1 mRNAincreases expression 19490992
D014050 Toluene Toluene affects the expression of CYP26B1 mRNAaffects expression 18653662
D014212 Tretinoin Tretinoin affects the expression of CYP26B1 mRNAaffects expression 16054125
D014212 Tretinoin Tretinoin affects the expression of CYP26B1 mRNAaffects expression 17164423
D014212 Tretinoin Tretinoin results in increased expression of CYP26B1 mRNAincreases expression 18230668
D014212 Tretinoin CYP26B1 protein affects the degradation of Tretinoinaffects degradation 16574820
D014212 Tretinoin CYP26B1 protein results in increased metabolism of Tretinoinincreases metabolic processing 17486130
D014212 Tretinoin R116010 promotes the reaction [Tretinoin results in increased expression of CYP26B1 mRNA]increases expression|increases reaction 17486130
D014212 Tretinoin Tretinoin results in increased expression of CYP26B1 mRNAincreases expression 17431108
17486130
D014212 Tretinoin Tretinoin results in increased expression of CYP26B1 mRNAincreases expression 16688765
D014212 Tretinoin Lipopolysaccharides inhibits the reaction [Tretinoin results in increased expression of CYP26B1 mRNA]decreases reaction|increases expression 17185629
D014212 Tretinoin [R 115866 results in decreased activity of CYP26B1 protein] which results in increased abundance of Tretinoindecreases activity|increases abundance 17510468
D014212 Tretinoin Tretinoin results in increased expression of CYP26B1 mRNAincreases expression 17185629
17510468
D014212 Tretinoin CYP26B1 protein results in increased degradation of Tretinoinincreases degradation 17510468
D014212 Tretinoin CYP26B1 protein results in increased metabolism of and results in decreased activity of Tretinoindecreases activity|increases metabolic processing 16933217
C017963 vinyl carbamate vinyl carbamate results in decreased expression of CYP26B1 mRNAdecreases expression 17849452
D014801 Vitamin A [R 115866 co-treated with Vitamin A] results in increased expression of CYP26B1 mRNAaffects cotreatment|increases expression 17510468
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.3814745880
MESH:D000014 Abnormalities, Drug-Induced Isotretinoin 8.1218769834
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.1211752688 15322242 14514962
MESH:D000015 Abnormalities, Multiple Isotretinoin 10.2418769834
MESH:D000015 Abnormalities, Multiple Vitamin A 10.2410992263
MESH:D000138 Acidosis Ammonium Chloride 3.3918287403
MESH:D017486 Acneiform Eruptions Isotretinoin 6.1116232082
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 11.4217505938
MESH:D000152 Acne Vulgaris Isotretinoin 11.4218769834 16185265
MESH:D055371 Acute Lung Injury Lipopolysaccharides 3.8718653653 11850527
MESH:D000230 Adenocarcinoma Estradiol 7.0011473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 7.0014692618
MESH:D000230 Adenocarcinoma vinyl carbamate 7.0016247444 17363558
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.1116835633
MESH:D018248 Adenoma, Liver Cell vinyl carbamate 10.1112371669
MESH:D018246 Adrenocortical Adenoma Arsenic 5.0417306315
MESH:D000419 Albuminuria Raloxifene 4.4317308373 17451421
MESH:D000505 Alopecia Tretinoin 3.4815955085
MESH:D000544 Alzheimer Disease Raloxifene 2.5015800139
MESH:D000740 Anemia Tetrachlorodibenzodioxin 8.4811748828
MESH:D000740 Anemia Vitamin A 8.4816960172
MESH:D018798 Anemia, Iron-Deficiency Vitamin A 4.6516960172
MESH:D000799 Angioedema Acetaminophen 3.6710982225
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 3.9617460149
MESH:D020261 Arsenic Poisoning Arsenic 2.8212569548 18414634 16251483 16835338
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.2911256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 6.8615885639
MESH:D001169 Arthritis, Experimental Tretinoin 6.8616412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2316292516
MESH:D001249 Asthma Tretinoin 5.0416456186
MESH:D001249 Asthma Vitamin A 5.0416732791
MESH:D050197 Atherosclerosis Arsenic 3.1512928151 19371607
MESH:D001321 Autistic Disorder Acetaminophen 1.4318445737
MESH:D001471 Barrett Esophagus Tretinoin 4.2416935849
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.4212125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 8.4216206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.6215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6515746008
MESH:D001919 Bradycardia Phenylephrine 4.3715306635
MESH:D001930 Brain Injuries Raloxifene 4.3016580743
MESH:D001943 Breast Neoplasms bexarotene 3.6616344269 16818667
MESH:D001943 Breast Neoplasms Calcitriol 3.6611237771
MESH:D001943 Breast Neoplasms Estradiol 3.6612948864 16675129 17289903 17261762 18497071 14630087 19861407 17018787
MESH:D001943 Breast Neoplasms Raloxifene 3.6617440819 17893378 16837676 15775269 17595753 15572757 17049068 15758505 17952589 16912660 17261762 17242785
MESH:D001943 Breast Neoplasms Tamoxifen 3.6616273361 20135344 16818667 15565566 17049068 19142967 19103187 19221464 18855134 18629630 16873071 19155303 19410462 20544844 20859285 19189210 18997820 19189212 18984771 16202921 18351453 19115204 20005174 11161223 19289846 17893378 19059307 18815881 18821012 19084267 21138602 21152245 19066611 19011961 17440819 19288272 17242785 17261762 20065188 20390343 18425577 15668708 19487384 19200415 19244106
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 3.6620435547
MESH:D001943 Breast Neoplasms Tretinoin 3.6616873071 16443354 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 12.4416813970
MESH:D001997 Bronchopulmonary Dysplasia Vitamin A 12.4417377406 17426644
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.2916111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.6616835633
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.5015504454 17687452
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.3419066611
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.9916168501
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 11.033084413
MESH:D006528 Carcinoma, Hepatocellular Arsenic 11.0317306315 16507464
MESH:D006528 Carcinoma, Hepatocellular Estradiol 11.0316924424
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 11.0316924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 11.031917145
MESH:D006528 Carcinoma, Hepatocellular vinyl carbamate 11.0312371669
MESH:D002289 Carcinoma, Non-Small-Cell Lung bexarotene 6.1016247446
MESH:D002289 Carcinoma, Non-Small-Cell Lung vinyl carbamate 6.1016247446
MESH:D002294 Carcinoma, Squamous Cell Arsenic 10.4718922899 17687452 15504454
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 10.4711237771
MESH:D002294 Carcinoma, Squamous Cell Isotretinoin 10.4711237771
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 10.4716096774 16051514
MESH:D002295 Carcinoma, Transitional Cell Arsenic 15.0518640142
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 15.0517572228
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 15.0517572228
MESH:D006332 Cardiomegaly Phenylephrine 6.5717124262 11179087 11754973 17287366 15728586 16170337
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.5718850075 16120746 18670907
MESH:D002318 Cardiovascular Diseases Arsenic 7.1617938729 15738583 19152805
MESH:D002318 Cardiovascular Diseases Raloxifene 7.1615775269
MESH:D002340 Carotid Artery Diseases Arsenic 4.1618022660 16973168
MESH:D002386 Cataract Acetaminophen 6.8910977129
MESH:D002386 Cataract Tretinoin 6.8917460283
MESH:D002471 Cell Transformation, Neoplastic Estradiol 2.6618566989
MESH:D002547 Cerebral Palsy Toluene 5.689294310
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.4216129372
MESH:D015362 Child Nutrition Disorders Vitamin A 5.3016153327
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.0216835633
MESH:D002779 Cholestasis Ethinyl Estradiol 7.8617681005 15861022 16919318 17333356 11677210 17110522 16105132
MESH:D002779 Cholestasis Vitamin A 7.8616175620
MESH:D002822 Choriocarcinoma Tretinoin 4.9916461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 9.508697196 15668235 12621046 16354765 15340226
MESH:D002972 Cleft Palate Tretinoin 9.509407595
MESH:D002972 Cleft Palate Vitamin A 9.5016054864
MESH:D003072 Cognition Disorders Raloxifene 4.4515800139
MESH:D003092 Colitis Tretinoin 3.5317035595
MESH:D003110 Colonic Neoplasms Vitamin A 3.0116267017 17219422
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9117141729 14669216
MESH:D019465 Craniofacial Abnormalities Isotretinoin 9.2518769834 9879862
MESH:D019465 Craniofacial Abnormalities nitrofen 9.2511405365
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 9.2510048152 15322242 20055451
MESH:D019465 Craniofacial Abnormalities Toluene 9.259294310
MESH:D019465 Craniofacial Abnormalities Tretinoin 9.259142499 10589399 9211117 8800419 16925845 17551590 9224671 9125849 14991402 9664655
MESH:D019465 Craniofacial Abnormalities Vitamin A 9.2510992263
MESH:D003643 Death Toluene 5.496431079
MESH:D003711 Demyelinating Diseases Tamoxifen 4.1919031437
MESH:D003865 Depressive Disorder, Major Raloxifene 4.0217474826
MESH:D003922 Diabetes Mellitus, Type 1 Vitamin A 3.4616506275
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6317107852
MESH:D003928 Diabetic Nephropathies Estradiol 14.1819279558
MESH:D003928 Diabetic Nephropathies Raloxifene 14.1817308373 17451421 15920148
MESH:D003928 Diabetic Nephropathies Tamoxifen 14.1819279558
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.3910774834 19416960 15619225 11834606 19164858 16227642 12594235 16109766 19923254 14986274 18713872 10915739 11743745 12705907 19420014 12958197 12392966 17522070 16485898 11421492 2444490 11461765 17562736 18071297 16393943 17906064 11739529 11287661 16177239 10663392 19085960 14550746 19370779 11529661 15968718 16781746 16081117 19739265 12540782 14725611 12153990
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.3920420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.9319426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.6311462148
MESH:D015352 Dry Eye Syndromes Vitamin A 5.6316146918
MESH:C538011 Eales disease Vitamin A 5.459068938
MESH:D004480 Ectromelia Vitamin A 5.6516054864
MESH:D004487 Edema Raloxifene 6.3415860553
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.3412711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 11.3715322242 18230668 16714409
MESH:D004489 Edema, Cardiac Tretinoin 11.3718230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 20.5715138306
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 20.5712538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 20.5715845917
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 20.5719031437
MESH:D016889 Endometrial Neoplasms Estradiol 11.7819148513 11473722 18566989
MESH:D016889 Endometrial Neoplasms Tamoxifen 11.7816202921 19155303 17893378 20544844
MESH:D016889 Endometrial Neoplasms Tretinoin 11.7816569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.879294722 10568697
MESH:D019446 Endotoxemia Lipopolysaccharides 4.2217637181 15821434 15328337
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.4111564622
MESH:D005124 Eye Abnormalities Tretinoin 8.4116938888 9664655
MESH:D005234 Fatty Liver Ethinyl Estradiol 12.2515345470
MESH:D005234 Fatty Liver Raloxifene 12.2517473493
MESH:D005234 Fatty Liver Tamoxifen 12.2514986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.1316709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2911858732
MESH:D005327 Fetal Resorption Vitamin A 5.1916054864
MESH:D005334 Fever Lipopolysaccharides 3.8611852909 9205823
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.3514745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.0119069698
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.0520067830
MESH:D005355 Fibrosis Tretinoin 8.0517994277
MESH:D005534 Foot Diseases Arsenic 5.396392382
MESH:D005756 Gastritis Acetaminophen 3.5016983495
MESH:D005909 Glioblastoma Tretinoin 2.9017312396
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.4210696789
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.0716096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.9916084493
MESH:D006330 Heart Defects, Congenital nitrofen 15.3516080930
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 15.3510048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 15.3514991402 9664655
MESH:D006330 Heart Defects, Congenital Vitamin A 15.3510992263 16080930
MESH:D006331 Heart Diseases Raloxifene 3.4211110106
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 4.2316366002
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1811000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.7215340226 16120746 12621046
MESH:D006548 Hernia, Diaphragmatic nitrofen 6.4315707848 9859898 15088113 7520565 11685700 11409163 12194112 16720372 15136996 11584395 17270546 9698600 7760232 17618886 10370017 15756563 17245593 12759764 9575882 11051153 16490937 18280292 10898222 18958481 8863223 10370016 11076806 10541330 15793718 12904592 12505043 11329586 18280291 15578192 9476886 10693666 10359170 11057544 10646786 12407540 7576705 10898224 15764645 12021965 16863852 15185205 16292651 16473863 16080930 11588001 12547725 9473106 12746050
MESH:D006548 Hernia, Diaphragmatic Vitamin A 6.4315707848 17436238 16877224 16490937 16863852 16292552
MESH:D006558 Herpes Genitalis Estradiol 4.8615709030
MESH:D015658 HIV Infections Vitamin A 3.7316960176
MESH:D006679 HIV Seropositivity Vitamin A 5.4317209195
MESH:D019584 Hot Flashes Estradiol 3.5817088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.8715340226 18606429 16354765 16959395 8697196
MESH:D006930 Hyperalgesia Acetaminophen 7.1716870215
MESH:D006930 Hyperalgesia Tretinoin 7.1716870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.4016778211
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.3017050553
MESH:D006973 Hypertension Arsenic 11.8916076760 11953799 9931084
MESH:D006973 Hypertension Phenylephrine 11.8912717712 8949925
MESH:D006973 Hypertension Raloxifene 11.8917577099 15787275
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 11.8918670907 18850075
MESH:D006984 Hypertrophy Phenylephrine 4.4012791704 18502941
MESH:D006986 Hypervitaminosis A Vitamin A 6.0016054864
MESH:D006987 Hypesthesia Arsenic 5.3916093927
MESH:D007021 Hypospadias Ethinyl Estradiol 3.6416569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.3012013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.3717937319
MESH:D007249 Inflammation Lipopolysaccharides 7.8217963957 9205823 17255318 12878042 17237260
MESH:D007249 Inflammation Tamoxifen 7.8219457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 7.8212200463 12878042
MESH:D007333 Insulin Resistance Estradiol 2.8616627594 16393666
MESH:D007410 Intestinal Diseases Tretinoin 3.6017994277
MESH:D019586 Intracranial Hypertension Vitamin A 5.6515955940
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 4.4717255318
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.4116580747
MESH:D007569 Jaw Abnormalities Tretinoin 9.4115992940 17551590
MESH:D007642 Keratosis Arsenic 4.8212749816 16930632
MESH:D007674 Kidney Diseases Acetaminophen 5.5615629191 12587719
MESH:D007674 Kidney Diseases Estradiol 5.5615618244
MESH:D007680 Kidney Neoplasms Estradiol 6.9215610895
MESH:D007680 Kidney Neoplasms Tamoxifen 6.9218625569
MESH:D007889 Leiomyoma Raloxifene 4.3316973256
MESH:D007938 Leukemia Tretinoin 2.6917143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.5416932348 19285840 16482212
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.0519850784 16294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 7.3917339181
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 7.399834237 17506722 17107899 16140955 17294898 17368321 17339181 19225113 16823087 19035177 16788101 17301526 17649720 19642359 17712046 16935935 17361223 16331271 12679006 17217047 19075265 19029980 16891316 16766008 15748426
MESH:D007970 Leukopenia Lipopolysaccharides 4.5315821434
MESH:D017880 Limb Deformities, Congenital Tretinoin 8.109224671
MESH:D017880 Limb Deformities, Congenital Vitamin A 8.1016054864
MESH:D008064 Lipidoses Tamoxifen 3.0315342952 17567588
MESH:D008103 Liver Cirrhosis Vitamin A 3.7816256175
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 8.4614659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 8.4612878042
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 8.4618564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 8.4612878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 8.4618397230 16248980
MESH:D008106 Liver Cirrhosis, Experimental Vitamin A 8.4616248980
MESH:D008107 Liver Diseases Acetaminophen 6.4112969438 11587558 19014921 12587719 19784758 16610002 19460945 16611625
MESH:D008107 Liver Diseases Arsenic 6.4111134558
MESH:D008107 Liver Diseases Vitamin A 6.4116175620
MESH:D008108 Liver Diseases, Alcoholic Vitamin A 4.9816762690
MESH:D017114 Liver Failure, Acute Acetaminophen 3.0816871587 17185352
MESH:D008113 Liver Neoplasms Arsenic 7.0716368122
MESH:D008113 Liver Neoplasms Tamoxifen 7.0716684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.0716984957
MESH:D008114 Liver Neoplasms, Experimental kojic acid 9.4218544905
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 9.4212151625
MESH:D008114 Liver Neoplasms, Experimental Vitamin A 9.4217113696
MESH:D008171 Lung Diseases nitrofen 7.8517245593 16863852 9614859 9859898
MESH:D008171 Lung Diseases Vitamin A 7.8516863852
MESH:D055370 Lung Injury Lipopolysaccharides 3.8421114838
MESH:D008175 Lung Neoplasms Arsenic 8.3017306315 17976673 19168569
MESH:D008175 Lung Neoplasms bexarotene 8.3017849452
MESH:D008175 Lung Neoplasms Isotretinoin 8.3015899809
MESH:D008175 Lung Neoplasms Tamoxifen 8.3018625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 8.3019555203 11884234
MESH:D008175 Lung Neoplasms vinyl carbamate 8.3012438228 17163412 11134547 12117777 15172992 15824018 17361011 17363558 16247444 12765245 11195469 14755239 16885199
MESH:D016410 Lymphoma, T-Cell, Cutaneous bexarotene 4.9811161223
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.5919428831
MESH:D008325 Mammary Neoplasms, Experimental bexarotene 9.4119196723 15591091 19196722
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 9.4117203775 11807958 11408345 16891317
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 9.4114580682 19196723 11731420 19196722 16827153
MESH:D020149 Manganese Poisoning Estradiol 12.0719453300
MESH:D020149 Manganese Poisoning Tamoxifen 12.0719453300
MESH:D008527 Medulloblastoma Tretinoin 2.7217453147
MESH:D008545 Melanoma Isotretinoin 5.0517237267
MESH:D008545 Melanoma Tamoxifen 5.0519393235 12393984
MESH:D008545 Melanoma Tretinoin 5.0516752155
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.0115990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.4019513568
MESH:D008591 Meningomyelocele Tretinoin 4.2516940565
MESH:D008607 Mental Retardation Toluene 3.599294310
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.3815863610
MESH:D019957 Motor Skills Disorders Toluene 5.079294310
MESH:D009101 Multiple Myeloma Raloxifene 7.3616497877
MESH:D009101 Multiple Myeloma Vitamin A 7.3616374440
MESH:D009190 Myelodysplastic Syndromes Tretinoin 2.9817596541
MESH:D017202 Myocardial Ischemia Arsenic 8.5515371236
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 8.5512213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.1516810080
MESH:D009232 Myxoma Raloxifene 5.3816343187
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.4819393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4619410462
MESH:D009369 Neoplasms Tretinoin 2.3316594593 16946489
MESH:D009376 Neoplasms, Hormone-Dependent bexarotene 10.3619196722
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 10.3619189210 19196722 19200415
MESH:D009389 Neovascularization, Pathologic Estradiol 3.5617289903
MESH:D009421 Nervous System Malformations Estradiol 15.3711399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 15.3714600291
MESH:D009421 Nervous System Malformations Tretinoin 15.379125849
MESH:D009436 Neural Tube Defects Arsenic 11.6816620997
MESH:D009436 Neural Tube Defects Tretinoin 11.689142499
MESH:D009436 Neural Tube Defects Vitamin A 11.6817400914
MESH:D009447 Neuroblastoma Isotretinoin 3.9617368321
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.7318514411
MESH:D020078 Neurogenic Inflammation Arsenic 4.2117056641
MESH:D010024 Osteoporosis Raloxifene 3.2917882678 19059307 15775268
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 4.0715579764 15758505 17823083 17893378
MESH:D010051 Ovarian Neoplasms Arsenic 7.6017306315
MESH:D010051 Ovarian Neoplasms Estradiol 7.6019401270
MESH:D010051 Ovarian Neoplasms Tretinoin 7.6016936753
MESH:D010146 Pain Acetaminophen 6.1316870215
MESH:D010146 Pain Tretinoin 6.1316870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.4015976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.5311578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.0812520081
MESH:D010523 Peripheral Nervous System Diseases Arsenic 4.0116093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 4.826392382 16905509 15371236
MESH:D011014 Pneumonia Lipopolysaccharides 4.3811605937 12224865
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3918163543
MESH:D011297 Prenatal Exposure Delayed Effects Isotretinoin 9.2818769834
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.2811896295 11222880 11118676 11399792
MESH:D011470 Prostatic Hyperplasia Calcitriol 4.6115572423
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.7320887781
MESH:D011471 Prostatic Neoplasms Arsenic 1.8816140617
MESH:D011471 Prostatic Neoplasms Calcitriol 1.8815754350 18247401 16289102 12479363 16644109
MESH:D011471 Prostatic Neoplasms Estradiol 1.8816740699
MESH:D011471 Prostatic Neoplasms Raloxifene 1.8816536755 15731164 16220300
MESH:D011471 Prostatic Neoplasms Tamoxifen 1.8815067354
MESH:D011507 Proteinuria Arsenic 8.7421343184
MESH:D011507 Proteinuria Tretinoin 8.7416636307
MESH:D011537 Pruritus Ethinyl Estradiol 3.1415861022 16919318
MESH:D011596 Psychomotor Disorders Isotretinoin 5.7518769834
MESH:D011625 Pterygium Tretinoin 4.6216723453
MESH:D011693 Purpura Raloxifene 5.3815770314
MESH:D012127 Respiratory Distress Syndrome, Newborn Vitamin A 5.6316877224
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.6210835634
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6718990726
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.9416116481 16283617
MESH:D012640 Seizures Toluene 3.616431079 9294310
MESH:D012852 Sinusitis Phenylephrine 4.537327846
MESH:D012871 Skin Diseases Arsenic 5.2316759981 17453740 6392382 17548696 19834688 16353154 16702368 15952646 17050553 18709164 17938729
MESH:D012871 Skin Diseases Vitamin A 5.2318709164
MESH:D012878 Skin Neoplasms Arsenic 9.0117050553 17976673 16251483 19538983 17029826 15504454
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 9.0116192470
MESH:D012878 Skin Neoplasms Tretinoin 9.0116467112
MESH:D013088 Spermatocele Ethinyl Estradiol 10.9816709447
MESH:D013088 Spermatocele Tamoxifen 10.9816709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.8719457130
MESH:D013274 Stomach Neoplasms Tretinoin 1.7917261132
MESH:D020521 Stroke Raloxifene 3.6916837676
MESH:D013733 Testicular Diseases Toluene 4.7810514026 10048760
MESH:D013921 Thrombocytopenia Lipopolysaccharides 4.0115821434
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.4611994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.0115669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.7312697716
MESH:D013964 Thyroid Neoplasms Tretinoin 2.9016026305 17045167
MESH:D013978 Tibial Fractures Estradiol 13.1419048282
MESH:D013978 Tibial Fractures Raloxifene 13.1419048282
MESH:D014062 Tongue Neoplasms Tretinoin 3.6416051514
MESH:D014376 Tuberculosis Tretinoin 3.1216040207
MESH:D001749 Urinary Bladder Neoplasms Arsenic 8.0417306315 18640142 19322015 17976673 11144890 19429237 15987713
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 8.0417572228
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 8.048653321 16712894 17572228
MESH:D014581 Urticaria Acetaminophen 2.8210982225
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.5316129372
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.1314692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.4416752155
MESH:D014652 Vascular Diseases Arsenic 4.5617056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.4212125929
MESH:D054556 Venous Thromboembolism Raloxifene 5.0416837676
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.3814671159 15869587
MESH:D014802 Vitamin A Deficiency Vitamin A 5.1216960172 16146918 16175781
MESH:D014820 Vitiligo Tretinoin 3.8916761959
MESH:D014846 Vulvar Neoplasms Raloxifene 5.3816343187
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.0815886252
MESH:D009396 Wilms Tumor Tretinoin 3.8216287080
Pathway ID Pathway Name
REACT:13433 Biological oxidations
KEGG:00830 Retinol metabolism
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA134879191
    • No data
    No data
    Releated drug ID Related drug Name
    PA448717calcitriol
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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