AutismKB 2.0

Annotation Detail for SLC2A9


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Basic Information Top
Gene Symbol:SLC2A9 ( GLUT9,GLUTX,UAQTL2,URATv1 )
Gene Full Name: solute carrier family 2 (facilitated glucose transporter), member 9
Band: 4p16.1
Quick LinksEntrez ID:56606; OMIM: 606142; Uniprot ID:GTR9_HUMAN; ENSEMBL ID: ENSG00000109667; HGNC ID: 13446
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Transmembrane transport of small molecules
No data
No data
Pathway IDPathway Name
500350Class II GLUTs
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1876Gouts
1918Atherosclerosis
2113Degenerative disc disease
Desease Name
Biochemical measures
serum uric acid
METABOLIC
serum urate
Desease Name
Serum uric acid
Biochemical measures
Serum urate
Desease Name
Uric acid concentration, serum, QTL 2
Hypouricemia, renal, 2
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of SLC2A9 mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of SLC2A9 proteinaffects expression 20106945
D001553 Benzbromarone Benzbromarone inhibits the reaction [SLC2A9 protein alternative form results in increased transport of Uric Acid]decreases reaction|increases transport 18842065
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of SLC2A9 mRNAdecreases expression 20106945
20064835
D002945 Cisplatin Cisplatin results in increased expression of SLC2A9 mRNAincreases expression 18656965
D005632 Fructose Fructose promotes the reaction [SLC2A9 protein alternative form results in increased transport of Uric Acid]increases reaction|increases transport 18842065
D005632 Fructose SLC2A9 protein results in increased transport of Fructoseincreases transport 17710649
D005839 Gentamicins Gentamicins results in increased expression of SLC2A9 mRNAincreases expression 18656965
D005947 Glucose Glucose promotes the reaction [SLC2A9 protein alternative form results in increased transport of Uric Acid]increases reaction|increases transport 18842065
D005947 Glucose SLC2A9 protein results in increased transport of Glucoseincreases transport 17710649
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of SLC2A9 mRNAaffects cotreatment|increases expression 17183730
D014527 Uric Acid SLC2A9 protein results in increased transport of Uric Acidincreases transport 18989453
D014527 Uric Acid Benzbromarone inhibits the reaction [SLC2A9 protein alternative form results in increased transport of Uric Acid]decreases reaction|increases transport 18842065
D014527 Uric Acid Fructose promotes the reaction [SLC2A9 protein alternative form results in increased transport of Uric Acid]increases reaction|increases transport 18842065
D014527 Uric Acid Glucose promotes the reaction [SLC2A9 protein alternative form results in increased transport of Uric Acid]increases reaction|increases transport 18842065
D014527 Uric Acid SLC2A9 gene polymorphism affects the abundance of Uric Acidaffects abundance 18327257
D014527 Uric Acid SLC2A9 intron SNP affects the abundance of Uric Acidaffects abundance 18327256
D014527 Uric Acid SLC2A9 protein affects the transport of Uric Acidaffects transport 18327257
D014527 Uric Acid SLC2A9 protein alternative form results in increased transport of Uric Acidincreases transport 18842065
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of SLC2A9 mRNAaffects cotreatment|increases expression 17183730
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 3.688875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.0719490988
MESH:D058186 Acute Kidney Injury Cisplatin 9.6117670903 15814532 12690470
MESH:D058186 Acute Kidney Injury Gentamicins 9.6111274264
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.6320127859 20464547
MESH:D000230 Adenocarcinoma Cisplatin 4.6317638652 11798837
MESH:D000236 Adenoma Benzo(a)pyrene 2.736695378
MESH:D000550 Amblyopia Valproic Acid 5.4517688650
MESH:D000799 Angioedema Acetaminophen 4.0610982225
MESH:D001008 Anxiety Disorders Valproic Acid 3.6817497229
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2519183758
MESH:D015210 Arthritis, Gouty Uric Acid 6.9619655406
MESH:D001321 Autistic Disorder Acetaminophen 1.8618445737
MESH:D001321 Autistic Disorder Valproic Acid 1.8618316065 18775368 17507914 16609825 19232924 19460635 17157402 18985861 18558336 15238991 18940202 20603192 18396377 17688650 18177632
MESH:D001714 Bipolar Disorder Valproic Acid 3.1417594078 20046352
MESH:D001778 Blood Coagulation Disorders Benzbromarone 4.5419483382
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.498888407
MESH:D019046 Bone Marrow Neoplasms Cisplatin 5.1014601052
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.2820146248 17474063
MESH:D001943 Breast Neoplasms Cisplatin 2.2818382427 19526202
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.803084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 6.8021507988 12619106 12907637
MESH:D006528 Carcinoma, Hepatocellular Benzbromarone 6.801701930
MESH:D006528 Carcinoma, Hepatocellular Cisplatin 6.8017982673
MESH:D002289 Carcinoma, Non-Small-Cell Lung Cisplatin 3.0812023789 16685392
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.8820419170
MESH:D002294 Carcinoma, Squamous Cell Cisplatin 4.886189445 17066447 18337622
MESH:D002386 Cataract Acetaminophen 2.6610977129
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7520734317
MESH:D015179 Colorectal Neoplasms Cisplatin 2.3315273666
MESH:D003327 Coronary Disease Fructose 4.5618504504
MESH:D019465 Craniofacial Abnormalities Valproic Acid 1.9016575769 17688650 8888407
MESH:D003921 Diabetes Mellitus, Experimental Fructose 4.6118603373
MESH:D003922 Diabetes Mellitus, Type 1 Uric Acid 4.6616506275
MESH:D003924 Diabetes Mellitus, Type 2 Fructose 3.4118603373
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.9116393943 17906064 16485898 11461765 17562736 12392966 19370779 10774834 16109766 14550746 16081117 18071297 19923254 11739529 19739265 15619225 19085960 18713872 15968718 12153990 2444490 12705907 14986274 11743745 16177239 14725611 12594235 11529661 11421492 12540782 17522070 16781746 19164858 19416960 11287661 19420014 11834606 10663392 16227642 12958197 10915739
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 3.9119641884 1733752
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3219426721
MESH:D004362 Drug Toxicity Cisplatin 9.1419839026 15033597 12231392 12649298
MESH:D004362 Drug Toxicity Gentamicins 9.1411033412 15033597
MESH:D004421 Dystonia Valproic Acid 4.201851702
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.333659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 4.1316628512 3922381
MESH:D004827 Epilepsy Valproic Acid 3.0018234410 20417680
MESH:D004832 Epilepsy, Absence Valproic Acid 3.717562514 6426943 6254150
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.477750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.263659116
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.7116530937
MESH:D004938 Esophageal Neoplasms Cisplatin 4.7117638652 15464296 16785472 16481741 15173087
MESH:D005234 Fatty Liver Fructose 8.7819196556 18395287 18641190
MESH:D005234 Fatty Liver Valproic Acid 8.7819224547 14986274
MESH:D005315 Fetal Diseases Valproic Acid 5.1016575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.2918558336 8888407
MESH:D005355 Fibrosis Fructose 4.8318504504
MESH:D005756 Gastritis Acetaminophen 3.8916983495
MESH:D018149 Glucose Intolerance Fructose 5.4719165636
MESH:D006073 Gout marker/mechanism 18327256 18327257
MESH:D006258 Head and Neck Neoplasms Cisplatin 3.8015102660 15464296
MESH:D034381 Hearing Loss Cisplatin 10.7119898482
MESH:D034381 Hearing Loss Gentamicins 10.7119130971 18024279 17868369 15968427
MESH:D006319 Hearing Loss, Sensorineural Cisplatin 4.5415464296
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.7220471113
MESH:D006689 Hodgkin Disease Cisplatin 3.7216200630 16170182
MESH:D006849 Hydrocephalus Valproic Acid 5.0617688650
MESH:D006930 Hyperalgesia Acetaminophen 2.8116870215
MESH:D053565 Hypercalciuria Gentamicins 5.9017652376
MESH:D006946 Hyperinsulinism Fructose 5.0119008412 18360027 18563319 15752949 14757778
MESH:D006949 Hyperlipidemias Fructose 4.9015752949
MESH:D006973 Hypertension Fructose 3.6614573337 16843071 14568997 14633139 19008412
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 4.8016612254
MESH:D015228 Hypertriglyceridemia Fructose 5.2119799862 19342510
MESH:D033461 Hyperuricemia marker/mechanism 18989453
OMIM:220150 HYPOURICEMIA, RENAL, 1 marker/mechanism 18989453
OMIM:612076 HYPOURICEMIA, RENAL, 2 marker/mechanism
MESH:D007333 Insulin Resistance Fructose 4.3314573337 17133782 14633139 19008412 19586609 19342510 18563319 14757778 18057795 18981581 19799862
MESH:D007673 Kidney Cortex Necrosis Cisplatin 14.0615464296
MESH:D007673 Kidney Cortex Necrosis Gentamicins 14.0618842672
MESH:D007674 Kidney Diseases Acetaminophen 10.7115629191 12587719
MESH:D007674 Kidney Diseases Cisplatin 10.7118289764 15190930 12649298 19839026 12231392
MESH:D007674 Kidney Diseases Gentamicins 10.7117934191 19349640 18289764
MESH:D007683 Kidney Tubular Necrosis, Acute Cisplatin 12.7511231351
MESH:D007683 Kidney Tubular Necrosis, Acute Gentamicins 12.7511231351
MESH:D016773 Leishmaniasis, Cutaneous Gentamicins 4.5810219319
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1717596541 16294345
MESH:D008107 Liver Diseases Acetaminophen 1.6611587558 12969438 19784758 16611625 12587719 19460945 16610002 19014921
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3716871587 17185352
MESH:D008113 Liver Neoplasms Aflatoxin B1 4.7215890375 18177683 9163691 2125692
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 4.7221137059 20195826
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 2.828603461
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.4817228818
MESH:D008175 Lung Neoplasms Aflatoxin B1 3.5814755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.5820869020 20464547 20064080 18520028 6695378 17053015 18569708 20135361 18816296
MESH:D008175 Lung Neoplasms Cisplatin 3.5817225452 11798837 6189445
MESH:D008545 Melanoma Cisplatin 3.9916809738 18176117 18505091 12393984 16248763 12883367 17761969 11135225 17023156 18332650 15577323 16432458 12374674
MESH:D008545 Melanoma Glucose 3.9914993021
MESH:D018328 Melanoma, Amelanotic Cisplatin 4.9715990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7419513568
MESH:D008654 Mesothelioma Cisplatin 3.2917638057
MESH:D024821 Metabolic Syndrome X Fructose 4.9318497449 17261469 17098227 19165636 16815490
MESH:D008881 Migraine Disorders Valproic Acid 3.2918803445 18765137
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3016381670
MESH:D009137 Muscular Dystrophy, Animal Gentamicins 6.4918694830
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.178888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.2317596541
MESH:D009369 Neoplasms Benzo(a)pyrene 5.4011141357
MESH:D009369 Neoplasms Cisplatin 5.4016773208
MESH:D009395 Nephritis, Interstitial Cisplatin 4.7115464296
MESH:D009436 Neural Tube Defects Valproic Acid 3.218888407 16359493
MESH:D009447 Neuroblastoma Cisplatin 3.518761367
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9918514411
MESH:D017599 Neuroectodermal Tumors Cisplatin 4.898761367
MESH:D009765 Obesity Fructose 3.4518585860 17707055
MESH:D010051 Ovarian Neoplasms Cisplatin 2.9117225452 19769630 6897625 15464296
MESH:D010146 Pain Acetaminophen 2.5016870215
MESH:D010190 Pancreatic Neoplasms Cisplatin 3.0419003803
MESH:D010523 Peripheral Nervous System Diseases Cisplatin 4.4715464296
MESH:D010997 Pleural Neoplasms Cisplatin 5.5617638057
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 4.0220603192
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.9517292933
MESH:D011507 Proteinuria Gentamicins 4.8715033597
MESH:D019310 Pseudolymphoma Valproic Acid 4.7611422049 12752131
MESH:D051437 Renal Insufficiency Cisplatin 11.2615464296
MESH:D051437 Renal Insufficiency Gentamicins 11.2617132701 15728788
MESH:D012173 Retinitis Gentamicins 6.4918644591
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.3219155313
MESH:D012512 Sarcoma, Ewing's Cisplatin 4.5914601052
MESH:D012559 Schizophrenia Valproic Acid 2.0819110320 15737665
MESH:D012640 Seizures Valproic Acid 2.833137016 14763951 1511512 11738929 15475178 16876388 17978042 11044598
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 6.3010029692 19755658
MESH:D012878 Skin Neoplasms Glucose 6.3014993021
MESH:D055752 Small Cell Lung Carcinoma Cisplatin 5.5615464296
MESH:D016135 Spinal Dysraphism Valproic Acid 3.8919490988
MESH:D013226 Status Epilepticus Valproic Acid 4.7612833885
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.572093021 20155912
MESH:D013274 Stomach Neoplasms Cisplatin 2.5718396642 15958060 17522103
MESH:D013736 Testicular Neoplasms Cisplatin 4.7815464296 17225452
MESH:D014178 Translocation, Genetic Valproic Acid 5.4517262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.713119515
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.3817053015
MESH:D001749 Urinary Bladder Neoplasms Cisplatin 5.3812973940 17225452 15464296
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.828888407
MESH:D014581 Urticaria Acetaminophen 3.1210982225
MESH:D002583 Uterine Cervical Neoplasms Cisplatin 4.3416803524
MESH:D014625 Vaginal Neoplasms Cisplatin 4.7815577323
MESH:D015837 Vestibular Diseases Gentamicins 5.6818776599
MESH:D014839 Vomiting Cisplatin 4.9311897121
Pathway ID Pathway Name
REACT:15518 Transmembrane transport of small molecules
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA37771
    • No data
    Releated disease ID Related disease Name
    PA162370425Hypouricemia
    PA443635Cardiovascular Diseases
    PA443797Coronary Disease
    PA444318Gout
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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