AutismKB 2.0

Annotation Detail for NPDC1


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Basic Information Top
Gene Symbol:NPDC1 ( CAB,CAB-,CAB-1,CAB1,DKFZp586J0523 )
Gene Full Name: neural proliferation, differentiation and control, 1
Band: 9q34.3
Quick LinksEntrez ID:56654; OMIM: 605798; Uniprot ID:NPDC1_HUMAN; ENSEMBL ID: ENSG00000107281; HGNC ID: 7899
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1712Yersinia infection
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of NPDC1 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of NPDC1 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of NPDC1 mRNAaffects expression 17562736
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of NPDC1 mRNAaffects cotreatment|increases expression 18164116
D004041 Dietary Fats Dietary Fats results in decreased expression of NPDC1 mRNAdecreases expression 18042831
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of NPDC1 mRNAaffects cotreatment|increases expression 18164116
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of NPDC1 mRNAincreases expression 19638242
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of NPDC1 mRNAincreases expression 17557909
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of NPDC1 mRNAaffects cotreatment|increases expression 17183730
C041786 palm oil palm oil results in decreased expression of NPDC1 mRNAdecreases expression 18042831
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in increased expression of NPDC1 mRNA]affects reaction|increases expression 19482888
D010634 Phenobarbital Phenobarbital results in increased expression of NPDC1 mRNAincreases expression 19482888
C006253 pirinixic acid pirinixic acid results in decreased expression of NPDC1 mRNAdecreases expression 17426115
D012402 Rotenone Rotenone results in decreased expression of NPDC1 mRNAdecreases expression 19013527
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of NPDC1 mRNAaffects cotreatment|increases expression 17183730
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 8.926195326
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 8.928875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.0119490988
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.0817505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.2018653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8314692618
MESH:D000236 Adenoma beta-Naphthoflavone 7.0319389873
MESH:D000236 Adenoma Diethylnitrosamine 7.036695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 18.0717162532 19052882 18056438 16434500 19061943 17620307
MESH:D018248 Adenoma, Liver Cell Phenobarbital 18.0717620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 18.0716434500
MESH:D000550 Amblyopia Valproic Acid 5.3717688650
MESH:D000799 Angioedema Acetaminophen 3.9810982225
MESH:D001008 Anxiety Disorders Valproic Acid 3.6417497229
MESH:D001161 Arteriosclerosis Dietary Fats 10.2615238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 10.2611256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7115885639
MESH:D001321 Autistic Disorder Acetaminophen 1.8518445737
MESH:D001321 Autistic Disorder Valproic Acid 1.8517688650 15238991 18316065 19460635 18558336 19232924 17507914 18177632 18985861 18775368 20603192 16609825 18940202 17157402 18396377
MESH:D001714 Bipolar Disorder Valproic Acid 3.1120046352 17594078
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.2319483382
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.458888407
MESH:D001943 Breast Neoplasms Dietary Fats 2.1720435547
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.1717474063
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 8.9916705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 8.9916705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 8.993084413
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 8.9919822196 18210153 18691550 19539802 18971187 16569478 19335982 17055752 16681979 17978847 19383236 19052882 17428255 20514400 11831363 20727157 21159647 17173139 18494052 16288022 16779866 16830150 3581430 16502159 18785209 19701751 18506893 20214788 20084675 16935385 17162532 3084413 19519916 18393292 20935162 19919837 20101231 16540662 19418558 10672840 10737359 18788625 20432363 19208518 18978308 16878318 17761372 16698587 18056438 16328049 20007298 17138121 20524982 19171122 16807293 19394651 18665156 20512989 19107877
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 8.9917173139 20007298 6705139 1701930 20935162
MESH:D002386 Cataract Acetaminophen 2.6310977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 6.886135515
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 6.8821159647 17174075 7505956 2727394
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.364080065
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7320734317
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.7619052882
MESH:D002779 Cholestasis Ethinyl Estradiol 7.9411677210 17110522 17333356 17681005 16105132 16919318 15861022
MESH:D002779 Cholestasis pirinixic acid 7.9419176532
MESH:D019465 Craniofacial Abnormalities Valproic Acid 1.908888407 17688650 16575769
MESH:D003490 Cyanosis 2,4-dinitrotoluene 11.2518551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 11.2518551238
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4618249437
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.2120387270
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 12.2618551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 12.2618551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 12.2619370779 18071297 19164858 11421492 12153990 11834606 19923254 16109766 17906064 16081117 11529661 15968718 19420014 16781746 14550746 12392966 18713872 17522070 17562736 16227642 2444490 12958197 16485898 16177239 10663392 11287661 16393943 12705907 12540782 19085960 11739529 15619225 12594235 10915739 11743745 11461765 19416960 14986274 14725611 19739265 10774834
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 12.2619107877
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 12.261733752 19641884
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.2319426721
MESH:D050171 Dyslipidemias Dietary Fats 3.5118367378
MESH:D004421 Dystonia Phenobarbital 10.731851702
MESH:D004421 Dystonia Valproic Acid 10.731851702
MESH:D004487 Edema pirinixic acid 2.5612083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.2812538720
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 11.153659116
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 11.1517275665 3659116
MESH:D004828 Epilepsies, Partial Phenobarbital 10.433922381 11558140
MESH:D004828 Epilepsies, Partial Valproic Acid 10.433922381 16628512
MESH:D004827 Epilepsy Phenobarbital 6.8020417680
MESH:D004827 Epilepsy Valproic Acid 6.8018234410 20417680
MESH:D004832 Epilepsy, Absence Phenobarbital 9.106401628
MESH:D004832 Epilepsy, Absence Valproic Acid 9.106426943 7562514 6254150
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 11.657750514
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 11.657750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 10.883659116
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 10.883659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.2516302075
MESH:D005234 Fatty Liver Dietary Fats 25.5819551842 17967931 19004024 18296743
MESH:D005234 Fatty Liver Diethylnitrosamine 25.5820387270 21071580
MESH:D005234 Fatty Liver Ethinyl Estradiol 25.5815345470
MESH:D005234 Fatty Liver pirinixic acid 25.5819236843 20131406
MESH:D005234 Fatty Liver Valproic Acid 25.5814986274 19224547
MESH:D005315 Fetal Diseases Valproic Acid 5.0216575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.238888407 18558336
MESH:D005355 Fibrosis Dietary Fats 3.6318296743
MESH:D005756 Gastritis Acetaminophen 3.8116983495
MESH:D006333 Heart Failure pirinixic acid 2.5820558911
MESH:D006529 Hepatomegaly Phenobarbital 8.8316109766
MESH:D006529 Hepatomegaly pirinixic acid 8.8319772884 18467677 16221962 19176532
MESH:D006849 Hydrocephalus Valproic Acid 4.9817688650
MESH:D006930 Hyperalgesia Acetaminophen 2.7616870215
MESH:D006937 Hypercholesterolemia Dietary Fats 3.6721332399
MESH:D006943 Hyperglycemia pirinixic acid 3.2620558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.7021332399
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 4.7316612254
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9116945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.5512013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5417937319
MESH:D007249 Inflammation Dietary Fats 5.2420412841
MESH:D007249 Inflammation Diethylnitrosamine 5.2418785209
MESH:D007333 Insulin Resistance Dietary Fats 7.4218457598 11836018
MESH:D007333 Insulin Resistance pirinixic acid 7.4216306350
MESH:D007674 Kidney Diseases Acetaminophen 2.2415629191 12587719
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 7.5916705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 7.5916705839
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1617596541 16294345
MESH:D008103 Liver Cirrhosis Dietary Fats 11.2818296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 11.2819638242 18407596 20032147 18665156 18522880
MESH:D008103 Liver Cirrhosis Phenobarbital 11.2821047994
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3415474484
MESH:D008107 Liver Diseases Acetaminophen 6.6016610002 12969438 16611625 19460945 12587719 19014921 11587558 19784758
MESH:D008107 Liver Diseases Diethylnitrosamine 6.6017034775
MESH:D008107 Liver Diseases Phenobarbital 6.6019363144
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3116871587 17185352
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 14.567678174
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 14.5621295105 19389873
MESH:D008113 Liver Neoplasms Diethylnitrosamine 14.5620434301 20101389 19833225 20137499 20492335 19254457 19638242 18754104 19256749 18648771 9163691 19294768 15885732 12112319 20452335 19642983 21278145 12771043 19850985 19996281 21047994 18644402 19812893 15175105 20501860 19426721 2422723 19255062 21167192 19690152 20405173 20583210 19090486 18977376 21071580 18978307 16942905 19551842 2862719 19499222 20118626 10737359 19427195 19073162
MESH:D008113 Liver Neoplasms Phenobarbital 14.5619073162 19812893 15975961 19482888 21047994 8742319
MESH:D008113 Liver Neoplasms pirinixic acid 14.5615890375 20007298 16377806
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 14.572876786 2876784 6135515
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 14.5718164116
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 14.5717942915 19009564 17174075 19519916 18079962 18282651 17854601 18308698 18164116 16267830 16842330 19539802 3124819 19126423 9362446 18253720 18544905 18093689 18775883 2563599 21159647 19004024
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 14.5718308698 6150874 1399818 17172636 2563599
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.4017228818
MESH:D008175 Lung Neoplasms Diethylnitrosamine 1.7620970405 21163286 20512841 6695378
MESH:D008546 Melanoma, Experimental Acetaminophen 3.6719513568
MESH:D008881 Migraine Disorders Valproic Acid 3.2518765137 18803445
MESH:D009135 Muscular Diseases pirinixic acid 3.6116239165
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.118888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.2017596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.1719151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0116411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.5917484760
MESH:D009336 Necrosis 2,4-dinitrotoluene 10.7418551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 10.7418551238 7678174
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.599029167 3581430
MESH:D009369 Neoplasms pirinixic acid 1.9817405874
MESH:D009410 Nerve Degeneration Rotenone 3.9418619942 15790535 17356569
MESH:D009436 Neural Tube Defects Valproic Acid 3.188888407 16359493
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.4118514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 8.4120387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.2520387270
MESH:D009765 Obesity Dietary Fats 4.4917217161 18674790 21332399 20132043 18457598 19632207 20518802 16723640 11836018
MESH:D009765 Obesity pirinixic acid 4.4920558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.1412819281 16049721
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.1416049721
MESH:D010018 Osteomalacia Phenobarbital 4.4817016548
MESH:D010146 Pain Acetaminophen 2.4616870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 5.3516540662
MESH:D010190 Pancreatic Neoplasms Phenobarbital 5.3516965848
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.7711578682
MESH:D010300 Parkinson Disease Rotenone 3.0019114014 11535288 15451049 18619942 18191903 11445065 16140633 16412576 19232380
MESH:D020734 Parkinsonian Disorders Rotenone 4.1515795934 15574749 15927086 18197244
MESH:D011230 Precancerous Conditions Diethylnitrosamine 9.332563599
MESH:D011230 Precancerous Conditions Phenobarbital 9.332563599
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 3.9520603192
MESH:D011537 Pruritus Ethinyl Estradiol 3.4315861022 16919318
MESH:D019310 Pseudolymphoma Phenobarbital 12.6412752131
MESH:D019310 Pseudolymphoma Valproic Acid 12.6412752131 11422049
MESH:D015427 Reperfusion Injury pirinixic acid 2.4219058328
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.2619155313
MESH:D012559 Schizophrenia Valproic Acid 2.0815737665 19110320
MESH:D012640 Seizures 2,4-dinitrotoluene 14.5418551238
MESH:D012640 Seizures 2,6-dinitrotoluene 14.5418551238
MESH:D012640 Seizures Phenobarbital 14.543137016 11442880 4039156 16876388
MESH:D012640 Seizures Valproic Acid 14.5411044598 17978042 3137016 15475178 1511512 11738929 14763951 16876388
MESH:D003294 Seizures, Febrile Phenobarbital 4.946407741
MESH:D013088 Spermatocele Ethinyl Estradiol 4.0816709447
MESH:D016135 Spinal Dysraphism Valproic Acid 3.8419490988
MESH:D013226 Status Epilepticus Valproic Acid 4.6712833885
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7618456281
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7111994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2215669648
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 7.397505956
MESH:D013964 Thyroid Neoplasms Phenobarbital 7.391399818
MESH:D014178 Translocation, Genetic Valproic Acid 5.3717262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.643119515
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.1116049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.1116049721
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.758888407
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 12.3910091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 12.3910091137
MESH:D014581 Urticaria Acetaminophen 3.0610982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.3914692618
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6215869587 14671159
MESH:D015430 Weight Gain Dietary Fats 3.8116723640
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA31701
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top

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      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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