AutismKB 2.0

Annotation Detail for PANX2


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Basic Information Top
Gene Symbol:PANX2 ( MGC119432,PX2,hPANX2 )
Gene Full Name: pannexin 2
Band: 22q13.33
Quick LinksEntrez ID:56666; OMIM: 608421; Uniprot ID:PANX2_HUMAN; ENSEMBL ID: ENSG00000073150; HGNC ID: 8600
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
Synaptic Transmission
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Related Diseases/Disorders Top
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Desease IDDesease Name
1860Brain tumor
2069Schizophrenia
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of PANX2 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of PANX2 mRNAaffects expression 21346803
C035208 2-amino-4,6-dinitrotoluene 2-amino-4,6-dinitrotoluene affects the expression of PANX2 mRNAaffects expression 21346803
C035207 4-amino-2,6-dinitrotoluene 4-amino-2,6-dinitrotoluene affects the expression of PANX2 mRNAaffects expression 21346803
C006632 arsenic trioxide arsenic trioxide results in decreased expression of PANX2 mRNAdecreases expression 20458559
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of PANX2 mRNAaffects cotreatment|increases expression 18164116
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of PANX2 mRNAaffects cotreatment|increases expression 18164116
D014303 Trinitrotoluene Trinitrotoluene affects the expression of PANX2 mRNAaffects expression 21346803
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced 2-amino-4,6-dinitrotoluene 16.727525203
MESH:D000014 Abnormalities, Drug-Induced 4-amino-2,6-dinitrotoluene 16.727525203
MESH:D000014 Abnormalities, Drug-Induced Trinitrotoluene 16.727525203
MESH:D000230 Adenocarcinoma arsenic trioxide 2.3319825857 11798837
MESH:D000236 Adenoma beta-Naphthoflavone 7.3119389873
MESH:D000236 Adenoma Diethylnitrosamine 7.3110737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 4.2416434500 17620307 19061943 19052882 18056438 17162532
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 3.9116206674
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.2017474063
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.5911589617
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 6.8416705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 6.8416705839
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 6.8411135700 15553829 16217749 15073043 14691202
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 6.8419383236 17173139 20101231 16288022 18978308 19519916 16935385 18788625 16830150 19052882 18056438 19701751 19107877 19919837 20432363 20084675 18971187 18393292 18494052 18506893 17055752 18210153 20214788 3581430 18665156 3084413 20524982 16328049 16681979 16807293 16569478 16502159 16540662 19335982 16698587 19539802 16779866 17978847 20512989 20514400 21159647 17761372 19822196 19171122 19418558 17138121 10737359 20727157 11831363 18785209 17162532 16878318 20007298 19394651 17428255 10672840 18691550 20935162 19208518
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.2519014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.3512490120
MESH:D002386 Cataract 4-amino-2,6-dinitrotoluene 8.3314694615
MESH:D002386 Cataract Trinitrotoluene 8.3314694615 15817613
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 7.236135515
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 7.232727394 17174075 21159647 7505956
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.9019052882
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D000013 Congenital Abnormalities 2-amino-4,6-dinitrotoluene 17.1815095906
MESH:D000013 Congenital Abnormalities 4-amino-2,6-dinitrotoluene 17.1815095906
MESH:D000013 Congenital Abnormalities Trinitrotoluene 17.1815095906
MESH:D023903 Coronary Restenosis arsenic trioxide 4.4712609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 1.8910525206
MESH:D003490 Cyanosis 2,4-dinitrotoluene 20.6918551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 20.6918551238
MESH:D003490 Cyanosis Trinitrotoluene 20.6918551238
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.3615213294
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.2320387270
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 16.1118551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 16.1121346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2-amino-4,6-dinitrotoluene 16.1121346803
MESH:D056486 Drug-Induced Liver Injury 4-amino-2,6-dinitrotoluene 16.1121346803
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 16.1119107877
MESH:D056486 Drug-Induced Liver Injury Trinitrotoluene 16.1118551238 21346803
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.4916302075
MESH:D004938 Esophageal Neoplasms arsenic trioxide 2.3612903497
MESH:D005234 Fatty Liver arsenic trioxide 8.6915073043
MESH:D005234 Fatty Liver Diethylnitrosamine 8.6920387270 21071580
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.5416904648
MESH:D006529 Hepatomegaly Trinitrotoluene 4.5415817613
MESH:D007248 Infertility, Male Trinitrotoluene 3.8312150543
MESH:D007249 Inflammation Diethylnitrosamine 2.4818785209
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 8.0416705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 8.0416705839
MESH:D007938 Leukemia arsenic trioxide 2.9315070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 4.0412560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.6416972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.6014633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 4.0019077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1717050201 19850784 16467208 16968895 20471514
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.3616891316 15622746 17107899 17869043 16823087 17217047 16112521 15748426 19075265 16966277 11468182 12018890 19642359 15336539 19035177 9834237 15213294 16330433 17649720 17712046 12679006 19225113 16331271 11161223 12712474
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.6316882451
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.9418407596 20032147 18522880 18665156 19638242
MESH:D008107 Liver Diseases Diethylnitrosamine 2.1517034775
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 11.407678174
MESH:D008113 Liver Neoplasms arsenic trioxide 11.4014682389
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 11.4021295105 19389873
MESH:D008113 Liver Neoplasms Diethylnitrosamine 11.4021278145 19256749 21047994 19427195 20452335 20101389 19638242 20118626 19499222 2422723 18754104 19551842 10737359 15175105 18644402 19073162 19426721 19642983 20405173 20583210 20492335 9163691 12112319 16942905 19690152 19090486 19294768 19255062 20137499 18648771 12771043 18978307 19812893 2862719 20501860 19850985 21167192 18977376 19833225 21071580 20434301 19254457 19996281 15885732
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 15.356135515 2876786 2876784
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 15.3520377131
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 15.3518164116
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 15.352563599 19009564 18308698 19539802 18164116 18079962 19004024 16267830 9362446 18093689 18253720 17942915 19126423 18775883 21159647 3124819 17174075 18544905 18282651 19519916 17854601 16842330
MESH:D008133 Long QT Syndrome arsenic trioxide 3.5315213294
MESH:D008175 Lung Neoplasms arsenic trioxide 2.5411798837 19825857
MESH:D008175 Lung Neoplasms Diethylnitrosamine 2.546695378 20970405 20512841 21163286
MESH:D009101 Multiple Myeloma arsenic trioxide 3.2719549372 19417148 11468182 15949261 14977855
MESH:D009182 Mycosis Fungoides arsenic trioxide 5.0518349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.2616882451 16105982
MESH:D009336 Necrosis 2,4-dinitrotoluene 19.8718551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 19.877678174 18551238
MESH:D009336 Necrosis Trinitrotoluene 19.8718551238
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.2416624393
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.653581430 9029167
MESH:D009436 Neural Tube Defects arsenic trioxide 3.2610525206
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.5420387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.4920387270
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 23.6112819281 16049721
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 23.6116049721
MESH:D009784 Occupational Diseases 4-amino-2,6-dinitrotoluene 23.6114694615
MESH:D009784 Occupational Diseases Trinitrotoluene 23.6112819281 17852074 14694615
MESH:D010051 Ovarian Neoplasms arsenic trioxide 2.4719769630 12452020 16624393
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 5.5215580305
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 5.5216540662
MESH:D010235 Paraganglioma arsenic trioxide 4.4219927285
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.772563599
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.2319131511
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.2416646077
MESH:D012640 Seizures 2,4-dinitrotoluene 10.8518551238
MESH:D012640 Seizures 2,6-dinitrotoluene 10.8518551238
MESH:D012640 Seizures Trinitrotoluene 10.8518551238
MESH:D013163 Splenomegaly Trinitrotoluene 5.5115817613
MESH:D013274 Stomach Neoplasms arsenic trioxide 2.4917007042
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 2.4918456281
MESH:D013964 Thyroid Neoplasms arsenic trioxide 7.8119014326
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 7.817505956
MESH:D016171 Torsades de Pointes arsenic trioxide 4.3015213294
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 8.7816049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.7816049721
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 8.7812845720 20435036 12973940 11780464
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 13.1410091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 13.1410091137
Pathway ID Pathway Name
REACT:13685 Synaptic Transmission
Pharmacogenomics Knowledge Base Top
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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