AutismKB 2.0

Annotation Detail for NRIP3


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Basic Information Top
Gene Symbol:NRIP3 ( C11orf14,NY-SAR-105 )
Gene Full Name: nuclear receptor interacting protein 3
Band: 11p15.4
Quick LinksEntrez ID:56675; OMIM: 613125; Uniprot ID:NRIP3_HUMAN; ENSEMBL ID: ENSG00000175352; HGNC ID: 1167
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C068073 Am 580 Am 580 results in increased expression of NRIP3 mRNAincreases expression 16982809
D001151 Arsenic Arsenic affects the expression of NRIP3 mRNAaffects expression 18414638
C006632 arsenic trioxide arsenic trioxide results in increased expression of NRIP3 mRNAincreases expression 20458559
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NRIP3 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NRIP3 mRNAaffects cotreatment|increases expression 17942748
D019772 Topotecan NRIP3 protein affects the susceptibility to Topotecanaffects response to substance 16217747
D014635 Valproic Acid Valproic Acid results in increased expression of NRIP3 mRNAincreases expression 19101580
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 9.6614514962 15322242 11752688
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 9.668875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.2119490988
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.3817505938
MESH:D000230 Adenocarcinoma arsenic trioxide 4.4811798837 19825857
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.4814692618
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.7716835633
MESH:D018246 Adrenocortical Adenoma Arsenic 5.6617306315
MESH:D000550 Amblyopia Valproic Acid 5.6817688650
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2111748828
MESH:D001008 Anxiety Disorders Valproic Acid 3.7917497229
MESH:D020261 Arsenic Poisoning Arsenic 2.9316835338 12569548 18414634 16251483
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.8211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8215885639
MESH:D050197 Atherosclerosis Arsenic 3.4012928151 19371607
MESH:D001321 Autistic Disorder Valproic Acid 1.9917507914 18940202 15238991 18396377 20603192 19460635 18316065 18177632 18985861 16609825 18558336 17688650 18775368 17157402 19232924
MESH:D001714 Bipolar Disorder Valproic Acid 3.2020046352 17594078
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 9.9216206674
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.9212125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.2315340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 8.5715746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 8.578888407
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.6820435547
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.6311589617
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.0216835633
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.7315504454 17687452
MESH:D006528 Carcinoma, Hepatocellular Arsenic 3.3316507464 17306315
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 3.3314691202 11135700 15073043 15553829 16217749
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.3219014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.3812490120
MESH:D002294 Carcinoma, Squamous Cell Arsenic 2.7517687452 15504454 18922899
MESH:D002295 Carcinoma, Transitional Cell Arsenic 4.3418640142
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5016120746 18850075 18670907
MESH:D002318 Cardiovascular Diseases Arsenic 3.6319152805 15738583 17938729
MESH:D002340 Carotid Artery Diseases Arsenic 4.5618022660 16973168
MESH:D002386 Cataract Am 580 4.4917460283
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7920734317
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4116835633
MESH:D002779 Cholestasis Ethinyl Estradiol 3.0717681005 11677210 16919318 17333356 16105132 15861022 17110522
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2015340226 15668235 8697196 12621046 16354765
MESH:D003092 Colitis Am 580 5.3217035595
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3117141729 14669216
MESH:D023903 Coronary Restenosis arsenic trioxide 4.5112609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 3.9010525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.9010048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Valproic Acid 3.908888407 17688650 16575769
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.4015213294
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7217107852
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.9920420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 3.9919641884 1733752
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9611462148
MESH:D004421 Dystonia Valproic Acid 4.351851702
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.6512711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.3516714409 15322242 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.5212538720
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.2910568697 9294722
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.5117275665 3659116
MESH:D004828 Epilepsies, Partial Valproic Acid 4.3616628512 3922381
MESH:D004827 Epilepsy Valproic Acid 3.0618234410 20417680
MESH:D004832 Epilepsy, Absence Valproic Acid 3.846426943 6254150 7562514
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.667750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.463659116
MESH:D004938 Esophageal Neoplasms arsenic trioxide 2.3612903497
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2111564622
MESH:D005234 Fatty Liver arsenic trioxide 14.8315073043
MESH:D005234 Fatty Liver Ethinyl Estradiol 14.8315345470
MESH:D005234 Fatty Liver Valproic Acid 14.8319224547 14986274
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.8111858732
MESH:D005315 Fetal Diseases Valproic Acid 5.3316575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.468888407 18558336
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.3120067830
MESH:D005534 Foot Diseases Arsenic 6.006392382
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.5916904648
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.0410696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4610048152 11294989
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.6211000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.2515340226 16120746 12621046
MESH:D006849 Hydrocephalus Valproic Acid 5.2617688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.4915340226 16959395 16354765 18606429 8697196
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.7217050553
MESH:D006973 Hypertension Arsenic 5.5216076760 11953799 9931084
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.5218850075 18670907
MESH:D006987 Hypesthesia Arsenic 6.0016093927
MESH:D007021 Hypospadias Ethinyl Estradiol 4.1716945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.7712013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6617937319
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9812878042 12200463
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.6216580747
MESH:D007642 Keratosis Arsenic 5.3916930632 12749816
MESH:D007938 Leukemia arsenic trioxide 2.9515070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 4.0817077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.7016972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.6314633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 4.0419077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 4.0416467208 16968895 20471514 19850784 17050201
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 4.0417596541 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 8.3517339181
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 8.3516823087 12018890 16891316 17869043 15213294 16331271 16966277 11468182 19225113 11161223 17712046 16330433 19642359 16112521 17649720 15336539 17107899 17217047 19075265 12679006 12712474 15622746 19035177 15748426 9834237
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.6816882451
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2412878042
MESH:D008107 Liver Diseases Arsenic 2.5911134558
MESH:D008113 Liver Neoplasms Arsenic 7.9916368122
MESH:D008113 Liver Neoplasms arsenic trioxide 7.9914682389
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.9916984957
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 6.3420377131
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.3412151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.5615213294
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.7017228818
MESH:D008175 Lung Neoplasms Arsenic 3.5819168569 17306315 17976673
MESH:D008175 Lung Neoplasms arsenic trioxide 3.5819825857 11798837
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.5811884234 19555203
MESH:D008881 Migraine Disorders Valproic Acid 3.3818803445 18765137
MESH:D009101 Multiple Myeloma arsenic trioxide 3.2919549372 19417148 11468182 14977855 15949261
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.318888407
MESH:D009182 Mycosis Fungoides arsenic trioxide 5.1218349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 7.8916882451 16105982
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 7.8917596541
MESH:D017202 Myocardial Ischemia Arsenic 9.7515371236
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 9.7512213967
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.2916624393
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.5414600291
MESH:D009436 Neural Tube Defects Arsenic 13.2116620997
MESH:D009436 Neural Tube Defects arsenic trioxide 13.2110525206
MESH:D009436 Neural Tube Defects Valproic Acid 13.2116359493 8888407
MESH:D009447 Neuroblastoma Topotecan 3.9715176712
MESH:D020078 Neurogenic Inflammation Arsenic 4.6817056641
MESH:D010051 Ovarian Neoplasms Arsenic 5.2617306315
MESH:D010051 Ovarian Neoplasms arsenic trioxide 5.2612452020 19769630 16624393
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 2.6015580305
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9911578682
MESH:D010235 Paraganglioma arsenic trioxide 4.4719927285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.6912520081
MESH:D010523 Peripheral Nervous System Diseases Arsenic 4.5116093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 5.3915371236 6392382 16905509
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8918163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 10.8211118676 11222880 11896295 11399792
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 10.8220603192
MESH:D011471 Prostatic Neoplasms Arsenic 3.3516140617
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.3519131511
MESH:D011507 Proteinuria Arsenic 4.3121343184
MESH:D011537 Pruritus Ethinyl Estradiol 3.7116919318 15861022
MESH:D019310 Pseudolymphoma Valproic Acid 4.9811422049 12752131
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.1718990726
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.4819155313
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.2916646077
MESH:D012559 Schizophrenia Valproic Acid 2.0919110320 15737665
MESH:D012640 Seizures Valproic Acid 2.913137016 1511512 16876388 11738929 11044598 15475178 14763951 17978042
MESH:D012871 Skin Diseases Arsenic 2.8017938729 18709164 17050553 16353154 15952646 17548696 17453740 16759981 16702368 6392382 19834688
MESH:D012878 Skin Neoplasms Arsenic 6.0919538983 16251483 15504454 17050553 17029826 17976673
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 6.0916192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.3816709447
MESH:D016135 Spinal Dysraphism Valproic Acid 3.9919490988
MESH:D013226 Status Epilepticus Valproic Acid 4.9812833885
MESH:D013274 Stomach Neoplasms arsenic trioxide 1.8617007042
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.9211994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.4015669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.3512697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 3.2919014326
MESH:D016171 Torsades de Pointes arsenic trioxide 4.3615213294
MESH:D014178 Translocation, Genetic Valproic Acid 5.6817262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.923119515
MESH:D001749 Urinary Bladder Neoplasms Arsenic 5.5819322015 17306315 19429237 15987713 11144890 18640142 17976673
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 5.5820435036 12845720 12973940 11780464
MESH:D014564 Urogenital Abnormalities Valproic Acid 5.008888407
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.6314692618
MESH:D014652 Vascular Diseases Arsenic 5.1317056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.0412125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.8214671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.6915886252
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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