AutismKB 2.0

Annotation Detail for PSMA3


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Basic Information Top
Gene Symbol:PSMA3 ( HC8,MGC12306,MGC32631,PSC3 )
Gene Full Name: proteasome (prosome, macropain) subunit, alpha type, 3
Band: 14q23.1
Quick LinksEntrez ID:5684; OMIM: 176843; Uniprot ID:PSA3_HUMAN; ENSEMBL ID: ENSG00000100567; HGNC ID: 9532
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa03050Proteasome
Pathway IDPathway Name
Signaling by Wnt
Cell Cycle, Mitotic
DNA Replication
Apoptosis
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
HIV Infection
Cell Cycle Checkpoints
Regulation of activated PAK-2p34 by proteasome mediated degradation
Metabolism of amino acids and derivatives
Pathway IDPathway Name
200010Aurora B signaling
Pathway IDPathway Name
P00049Parkinson disease
Pathway IDPathway Name
500401Autodegradation of Cdh1 by Cdh1:APC/C
500372SCF(Skp2)-mediated degradation of p27/p21
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of PSMA3 mRNAdecreases expression 18648102
D000082 Acetaminophen Acetaminophen results in increased expression of PSMA3 proteinincreases expression 16538041
D000643 Ammonium Chloride Ammonium Chloride affects the expression of PSMA3 mRNAaffects expression 16483693
C072553 benzyloxycarbonylleucyl-leucyl-leucine aldehyde benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of PSMA3 mRNAincreases expression 15525353
C032036 bromobenzene bromobenzene results in increased expression of PSMA3 mRNAincreases expression 12628495
D002994 Clofibrate PPARA protein affects the reaction [Clofibrate results in increased expression of PSMA3 mRNA]affects reaction|increases expression 17585979
D016572 Cyclosporine Cyclosporine results in increased expression of PSMA3 mRNAincreases expression 20106945
C472511 dimethylarsinous acid dimethylarsinous acid results in decreased expression of PSMA3 mRNAdecreases expression 16507463
D004317 Doxorubicin Doxorubicin results in increased metabolism of PSMA3 proteinincreases metabolic processing 17346995
D009151 Mustard Gas Mustard Gas affects the expression of PSMA3 mRNAaffects expression 15651846
C017557 nickel subsulfide nickel subsulfide results in increased expression of PSMA3 mRNAincreases expression 12760830
D010852 Picrotoxin Picrotoxin results in decreased expression of PSMA3 mRNAdecreases expression 15170462
C006253 pirinixic acid pirinixic acid results in increased expression of PSMA3 mRNAincreases expression 15375163
C037219 quinoline quinoline analog results in decreased expression of PSMA3 proteindecreases expression 18645022
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.6418287403
MESH:D055371 Acute Lung Injury pirinixic acid 3.1718653653
MESH:D000230 Adenocarcinoma Doxorubicin 2.5817418594
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.783712494
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.5616434500
MESH:D000419 Albuminuria Doxorubicin 4.6121441931
MESH:D000799 Angioedema Acetaminophen 3.9410982225
MESH:D001249 Asthma Mustard Gas 2.7210378619
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.121440618 11289319
MESH:D001768 Blister Mustard Gas 5.2419167455
MESH:D001778 Blood Coagulation Disorders Clofibrate 9.3919483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.3919483382
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 4.8014601052
MESH:D001932 Brain Neoplasms Doxorubicin 3.8617150277
MESH:D001943 Breast Neoplasms Doxorubicin 2.6115939500 17983394 18695136 17369602 16096432 16935488 17426702 15993339 18628466 15994142 16264153 18234424 18382427 11325840 15567936 16322301 15136595 15634643 15668708 19526202 16115903 16595493 16826403 15692762
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 5.2415286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 5.0717687719 10378619
MESH:D002276 Carcinoid Tumor Doxorubicin 4.9116051944
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 6.717296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.713084413
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 6.7118059187 16023760 16234567 17876044
MESH:D006528 Carcinoma, Hepatocellular quinoline 6.71598648
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 6.637296757
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 6.631485588 16201981
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 2.656189445
MESH:D009202 Cardiomyopathies Doxorubicin 3.5617974986 16612575 17519947 15792986 15476868 16242529 17924179 17928571 17329180 16364871 16109756 16455267 16651473 17007740 17351982 16278810 17308081 17131338 17382496 15811867 15505089 16952015 16731534 18627295 16269455
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.9617334414 16243910
MESH:D002386 Cataract Acetaminophen 2.6110977129
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 11.467505956
MESH:D002471 Cell Transformation, Neoplastic Clofibrate 11.461399818
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 11.4612371664
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 13.6219486331 9022650
MESH:D002779 Cholestasis Cyclosporine 13.6219486331
MESH:D002779 Cholestasis pirinixic acid 13.6219176532
MESH:D015179 Colorectal Neoplasms Doxorubicin 2.1418259882 18802399
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.878970840 11906362 11298694 14531868 12868966 2524372 18759878 8156756
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4518249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.552952479 3621924
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 9.1718289764 9328219 18692083 6482804 9022650 11289319 18648102 16192314 8291058 9653073 7440962 6679447 1440618
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 9.1711834606 10915739 10774834 11461765 14986274 11287661 15619225 19739265 14550746 16081117 10663392 18713872 19420014 16781746 12540782 14725611 16177239 16109766 19370779 11421492 16393943 18071297 12958197 17906064 12392966 12705907 19164858 15968718 11529661 11739529 17562736 19416960 19923254 17522070 16227642 11743745 12594235 12153990 2444490 19085960 16485898
MESH:D056486 Drug-Induced Liver Injury bromobenzene 9.1712628495 10092053
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 9.1717416283
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1919426721
MESH:D004362 Drug Toxicity Doxorubicin 3.7118602426
MESH:D050171 Dyslipidemias Clofibrate 4.1016707586
MESH:D004487 Edema Mustard Gas 7.0611428647 9260866 11402378 11428631
MESH:D004487 Edema pirinixic acid 7.0612083418
MESH:D016889 Endometrial Neoplasms Doxorubicin 3.4817359293
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 5.2518037988
MESH:D004890 Erythema Mustard Gas 5.249357497
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.123581430
MESH:D005234 Fatty Liver Clofibrate 13.4619224547
MESH:D005234 Fatty Liver Cyclosporine 13.4619224547
MESH:D005234 Fatty Liver pirinixic acid 13.4619236843 20131406
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.126705139
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 4.6719069698
MESH:D005355 Fibrosis Cyclosporine 3.2112168785 12639820
MESH:D005756 Gastritis Acetaminophen 3.7716983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.308708960
MESH:D005909 Glioblastoma Doxorubicin 3.3817150277
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.107505956
MESH:D006258 Head and Neck Neoplasms Doxorubicin 3.5615692506
MESH:D006331 Heart Diseases Doxorubicin 3.5217875725 16144979 16495754 18674790 16879835 16330681 18006777 12587719 16244372 14766674 16244371 17888722 16707910
MESH:D006333 Heart Failure Doxorubicin 7.1617481944
MESH:D006333 Heart Failure pirinixic acid 7.1620558911
MESH:D006390 Hemangioendothelioma quinoline 6.00598648
MESH:D006394 Hemangiosarcoma Doxorubicin 9.8115692506
MESH:D006394 Hemangiosarcoma quinoline 9.81598648
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.5015720958
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.586705139
MESH:D006529 Hepatomegaly pirinixic acid 3.0716221962 19772884 19176532 18467677
MESH:D006689 Hodgkin Disease Doxorubicin 3.4518501091 17606976 15147373
MESH:D006930 Hyperalgesia Acetaminophen 2.7416870215
MESH:D006943 Hyperglycemia pirinixic acid 3.2320558911
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.0115034207
MESH:D006973 Hypertension Cyclosporine 2.1210903974
MESH:D007249 Inflammation Mustard Gas 2.819260866 16001271 11428631 11428647 11428620 9357497 8975870 17524151 11402378
MESH:D007333 Insulin Resistance pirinixic acid 2.6616306350
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.128074119 9022650
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.5415604871
MESH:D007674 Kidney Diseases Acetaminophen 10.2115629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 10.2110903974 18776723 8314463
MESH:D007674 Kidney Diseases Doxorubicin 10.2115369732 16775033 15699352
MESH:D007676 Kidney Failure, Chronic Doxorubicin 4.2116707910
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 7.426582329
MESH:D007680 Kidney Neoplasms Cyclosporine 7.4212371664
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 5.2516085563
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.239327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 2.4816439617 16595196
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.4815474484
MESH:D008107 Liver Diseases Acetaminophen 1.6416611625 12587719 12969438 11587558 16610002 19784758 19460945 19014921
MESH:D017114 Liver Failure, Acute Acetaminophen 3.2916871587 17185352
MESH:D008113 Liver Neoplasms pirinixic acid 1.8420007298 16377806 15890375
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 6.17598648 1399818 3712494 6587162
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 6.1716842330 17085340
MESH:D008171 Lung Diseases Mustard Gas 3.4818702808 18161513
MESH:D008175 Lung Neoplasms Doxorubicin 2.7517418594 6189445
MESH:D008175 Lung Neoplasms Mustard Gas 2.758781369 3148597
MESH:D008223 Lymphoma Doxorubicin 3.5016098063
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 3.8317654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.6415621674
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 3.0615458769
MESH:D008545 Melanoma Doxorubicin 2.2916827129
MESH:D008546 Melanoma, Experimental Acetaminophen 3.6419513568
MESH:D008654 Mesothelioma Doxorubicin 3.0817638057
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.8816801185
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.5515792986
MESH:D052016 Mucositis Doxorubicin 4.8717415656
MESH:D009135 Muscular Diseases pirinixic acid 3.5816239165
MESH:D009203 Myocardial Infarction Doxorubicin 5.7815857846 19429709
MESH:D009203 Myocardial Infarction pirinixic acid 5.7819151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.9916411023
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 9.833581430
MESH:D009362 Neoplasm Metastasis Doxorubicin 9.8318259882
MESH:D009362 Neoplasm Metastasis quinoline 9.83598648
MESH:D009369 Neoplasms pirinixic acid 1.9717405874
MESH:D009401 Nephrosis Doxorubicin 4.8416636307 16899518
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.5417954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 9.4618481113 19348381
MESH:D009404 Nephrotic Syndrome Doxorubicin 9.4615640375 16889571
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 2.956679447
MESH:D009447 Neuroblastoma Doxorubicin 3.2915555623
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9118514411
MESH:D009503 Neutropenia Mustard Gas 4.0316761898 7688884
MESH:D052556 Niemann-Pick Disease, Type C Clofibrate 5.019802331
MESH:D009765 Obesity pirinixic acid 1.8220558911
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.476482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.123988306
MESH:D012516 Osteosarcoma Doxorubicin 4.1615930896
MESH:D010146 Pain Acetaminophen 2.4316870215
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.557296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.576228378
MESH:D003557 Phyllodes Tumor Doxorubicin 5.2517983394
MESH:D010997 Pleural Neoplasms Doxorubicin 5.2517638057
MESH:D011041 Poisoning Mustard Gas 3.8515727166
MESH:D011230 Precancerous Conditions Cyclosporine 3.2712371664
MESH:D011471 Prostatic Neoplasms Doxorubicin 3.5515897917 15749863 16868541 16888761 18437689 16729912
MESH:D011537 Pruritus Mustard Gas 4.1718058305
MESH:D011565 Psoriasis Cyclosporine 2.2416882103
MESH:D011658 Pulmonary Fibrosis Mustard Gas 2.9417620002 17894541 10334151 17720292 17266442
MESH:D051437 Renal Insufficiency Doxorubicin 4.2917922066
MESH:D015427 Reperfusion Injury pirinixic acid 2.4119058328
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.413692021
MESH:D012509 Sarcoma Doxorubicin 4.0416767912 15625365 18313854 17710206 15675481 17203757
MESH:D012512 Sarcoma, Ewing's Doxorubicin 4.3114601052 16326096
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.8717846226
MESH:D012640 Seizures Picrotoxin 4.038635557 8954991
MESH:D012871 Skin Diseases Mustard Gas 2.7316961503 12880345 15451306
MESH:D012878 Skin Neoplasms Doxorubicin 2.9715692506
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.6415625365 17203757 16767912
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 7.401399818 7505956 6587162 6582329 3712494
MESH:D013964 Thyroid Neoplasms Doxorubicin 7.4017909728 16010429
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.258074119
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 5.2517653716
MESH:D014581 Urticaria Acetaminophen 3.0310982225
MESH:D014605 Uveitis Cyclosporine 4.081336536
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 4.2917334414 17638931 17678736 16364871
MESH:D014985 Xerophthalmia Cyclosporine 4.5417120751
Pathway ID Pathway Name
REACT:578 Apoptosis
REACT:6850 Cdc20:Phospho-APC/C mediated degradation of Cyclin A
REACT:1538 Cell Cycle Checkpoints
REACT:152 Cell Cycle, Mitotic
REACT:383 DNA Replication
REACT:6185 HIV Infection
REACT:13 Metabolism of amino acids and derivatives
REACT:21257 Metabolism of RNA
KEGG:03050 Proteasome
REACT:13505 Proteasome mediated degradation of PAK-2p34
REACT:11045 Signaling by Wnt
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA33877
    • No data
    No data
    Releated drug ID Related drug Name
    PA164743471adenosine triphosphate
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB07475 - N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE
    DB08515 - (3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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