AutismKB 2.0

Annotation Detail for RAD18


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Basic Information Top
Gene Symbol:RAD18 ( RNF73 )
Gene Full Name: RAD18 homolog (S. cerevisiae)
Band: 3p25.3
Quick LinksEntrez ID:56852; OMIM: 605256; Uniprot ID:RAD18_HUMAN; ENSEMBL ID: ENSG00000070950; HGNC ID: 18278
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
2053Colon cancer
Desease Name
CHEMDEPENDENCY
smoking cessation
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of RAD18 mRNAaffects expression 17562736
C015001 arsenite arsenite results in decreased expression of RAD18 mRNAdecreases expression 18929588
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of RAD18 mRNAdecreases expression 20064835
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of RAD18 mRNAincreases expression 20713471
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of RAD18 mRNAdecreases expression 20382639
19150397
C006253 pirinixic acid pirinixic acid results in increased expression of RAD18 mRNAincreases expression 18301758
C031280 pyrazole pyrazole results in increased expression of RAD18 mRNAincreases expression 17945193
D012402 Rotenone Rotenone results in increased expression of RAD18 mRNAincreases expression 18191903
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.4218653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0420127859 20464547
MESH:D000236 Adenoma Benzo(a)pyrene 2.806695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.8816434500
MESH:D000799 Angioedema Acetaminophen 4.2910982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.4319183758
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.4319483382
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.0020146248 17474063
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 1.403084413
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1120419170
MESH:D002386 Cataract Acetaminophen 2.7310977129
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.9020889678
MESH:D002779 Cholestasis pirinixic acid 3.0319176532
MESH:D003110 Colonic Neoplasms arsenite 2.6215037631
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5318249437
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 4.3219164858 17522070 14725611 18071297 19739265 16177239 11739529 11461765 14550746 14986274 16781746 17906064 15619225 12594235 12153990 10915739 11529661 12392966 18713872 16109766 11743745 16227642 19923254 19416960 12540782 11834606 19420014 17562736 10663392 19085960 2444490 12705907 19370779 15968718 11287661 12958197 10774834 16081117 16393943 16485898 11421492
MESH:D056486 Drug-Induced Liver Injury pyrazole 4.3212499123
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.5419426721
MESH:D004487 Edema pirinixic acid 2.7612083418
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.5420426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.5416530937
MESH:D005234 Fatty Liver arsenite 8.8518296743
MESH:D005234 Fatty Liver pirinixic acid 8.8519236843 20131406
MESH:D005355 Fibrosis arsenite 4.4218296743
MESH:D005756 Gastritis Acetaminophen 4.1216983495
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.7820471113
MESH:D006333 Heart Failure pirinixic acid 2.6920558911
MESH:D006529 Hepatomegaly pirinixic acid 3.3519176532 18467677 19772884 16221962
MESH:D006930 Hyperalgesia Acetaminophen 2.9216870215
MESH:D006943 Hyperglycemia pirinixic acid 3.4520558911
MESH:D007333 Insulin Resistance pirinixic acid 2.8016306350
MESH:D007674 Kidney Diseases Acetaminophen 2.3415629191 12587719
MESH:D008103 Liver Cirrhosis arsenite 3.5518296743
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3515474484
MESH:D008107 Liver Diseases Acetaminophen 1.6812587719 19784758 11587558 12969438 16610002 19014921 19460945 16611625
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5016871587 17185352
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 4.6621137059 20195826
MESH:D008113 Liver Neoplasms pirinixic acid 4.6620007298 15890375 16377806
MESH:D008175 Lung Neoplasms arsenite 2.6616809336
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.666695378 20464547 20064080 18816296 20869020 18569708 17053015 18520028 20135361
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9319513568
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.4016381670
MESH:D009135 Muscular Diseases pirinixic acid 3.8616239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2419151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1616411023
MESH:D009369 Neoplasms Benzo(a)pyrene 5.2211141357
MESH:D009369 Neoplasms pirinixic acid 5.2217405874
MESH:D009389 Neovascularization, Pathologic arsenite 4.8115738583
MESH:D009410 Nerve Degeneration Rotenone 4.0918619942 17356569 15790535
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1018514411
MESH:D009765 Obesity pirinixic acid 1.8620558911
MESH:D010146 Pain Acetaminophen 2.6216870215
MESH:D010300 Parkinson Disease Rotenone 3.0611445065 19114014 16412576 18191903 19232380 15451049 18619942 11535288 16140633
MESH:D020734 Parkinsonian Disorders Rotenone 4.3415927086 18197244 15795934 15574749
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.9317292933
MESH:D015427 Reperfusion Injury pirinixic acid 2.5019058328
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.4810029692 19755658
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.5620155912 2093021
MESH:D013733 Testicular Diseases pyrazole 5.216499806
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.2617053015
MESH:D014581 Urticaria Acetaminophen 3.2810982225
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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