AutismKB 2.0

Annotation Detail for UBQLN4


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Basic Information Top
Gene Symbol:UBQLN4 ( A1U,C1orf6,CIP75,UBIN )
Gene Full Name: ubiquilin 4
Band: 1q22
Quick LinksEntrez ID:56893; OMIM: 605440; Uniprot ID:UBQL4_HUMAN; ENSEMBL ID: ENSG00000160803; HGNC ID: 1237
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04141Protein processing in endoplasmic reticulum
No data
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No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of UBQLN4 mRNAaffects expression 21346803
C035207 4-amino-2,6-dinitrotoluene 4-amino-2,6-dinitrotoluene affects the expression of UBQLN4 mRNAaffects expression 21346803
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of UBQLN4 mRNAaffects expression 17555576
C006253 pirinixic acid pirinixic acid results in increased expression of UBQLN4 mRNAincreases expression 18301758
D013629 Tamoxifen Tamoxifen affects the expression of UBQLN4 mRNAaffects expression 17555576
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 5.1614745880
MESH:D000014 Abnormalities, Drug-Induced 4-amino-2,6-dinitrotoluene 4.497525203
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.5517505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.5218653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8814692618
MESH:D018248 Adenoma, Liver Cell pirinixic acid 4.0216434500
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.9511256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8615885639
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.5219483382
MESH:D001943 Breast Neoplasms Tamoxifen 2.1715565566 19288272 19189212 19059307 19189210 18821012 20544844 20135344 19200415 19289846 16873071 19066611 19115204 19244106 19011961 18351453 19084267 19142967 17440819 18855134 18815881 19155303 17893378 19221464 21152245 16273361 15668708 18629630 17049068 18425577 20859285 19410462 16818667 19487384 20390343 20065188 11161223 17261762 17242785 20005174 21138602 18984771 19103187 18997820 16202921
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.9919066611
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 3.1116705839
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 3.1116924424
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.9617572228
MESH:D002386 Cataract 4-amino-2,6-dinitrotoluene 3.8114694615
MESH:D002779 Cholestasis Ethinyl Estradiol 8.6216105132 17110522 17681005 15861022 16919318 17333356 11677210
MESH:D002779 Cholestasis pirinixic acid 8.6219176532
MESH:D000013 Congenital Abnormalities 4-amino-2,6-dinitrotoluene 4.4915095906
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.5018551238
MESH:D003711 Demyelinating Diseases Tamoxifen 4.8519031437
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5618249437
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.8019279558
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 4.3818551238 21346803
MESH:D056486 Drug-Induced Liver Injury 4-amino-2,6-dinitrotoluene 4.3821346803
MESH:D004487 Edema pirinixic acid 2.8512083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 10.4512538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 10.4519031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.2619155303 16202921 20544844 17893378
MESH:D005234 Fatty Liver Ethinyl Estradiol 15.3115345470
MESH:D005234 Fatty Liver pirinixic acid 15.3119236843 20131406
MESH:D005234 Fatty Liver Tamoxifen 15.3114986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.4316709447
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 5.0714745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.7219069698
MESH:D006333 Heart Failure pirinixic acid 2.7320558911
MESH:D006529 Hepatomegaly pirinixic acid 3.4819176532 16221962 18467677 19772884
MESH:D006943 Hyperglycemia pirinixic acid 3.5320558911
MESH:D007021 Hypospadias Ethinyl Estradiol 4.2916569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.8712013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.7117937319
MESH:D007249 Inflammation Tamoxifen 2.5119457130
MESH:D007333 Insulin Resistance pirinixic acid 2.8516306350
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 8.4116705839
MESH:D007680 Kidney Neoplasms Tamoxifen 8.4118625569
MESH:D008064 Lipidoses Tamoxifen 3.4017567588 15342952
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.4015474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 2.4018564211
MESH:D008113 Liver Neoplasms pirinixic acid 4.8020007298 16377806 15890375
MESH:D008113 Liver Neoplasms Tamoxifen 4.8016684651
MESH:D008175 Lung Neoplasms Tamoxifen 1.7418625569
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.3019428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.8314580682 19196722 11731420 16827153 19196723
MESH:D020149 Manganese Poisoning Tamoxifen 5.1619453300
MESH:D008545 Melanoma Tamoxifen 1.9212393984 19393235
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.7215990972
MESH:D009135 Muscular Diseases pirinixic acid 3.9916239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2619151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.2216411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.4018551238
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.6619393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.6019410462
MESH:D009369 Neoplasms pirinixic acid 2.0917405874
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.6119196722 19189210 19200415
MESH:D009765 Obesity pirinixic acid 1.8820558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 10.3116049721 12819281
MESH:D009784 Occupational Diseases 4-amino-2,6-dinitrotoluene 10.3114694615
MESH:D016584 Panic Disorder Ethinyl Estradiol 4.0911578682
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.0915067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.8515861022 16919318
MESH:D015427 Reperfusion Injury pirinixic acid 2.5319058328
MESH:D012640 Seizures 2,4-dinitrotoluene 2.7618551238
MESH:D013088 Spermatocele Ethinyl Estradiol 13.6916709447
MESH:D013088 Spermatocele Tamoxifen 13.6916709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.5819457130
MESH:D019851 Thrombophilia Ethinyl Estradiol 4.0211994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.4815669648
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.4216049721
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 5.4216712894 17572228 8653321
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.8610091137
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.7414692618
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.9115869587 14671159
Pathway ID Pathway Name
KEGG:04141 Protein processing in endoplasmic reticulum
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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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