AutismKB 2.0

Annotation Detail for WRNIP1


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Basic Information Top
Gene Symbol:WRNIP1 ( FLJ22526,RP11-420G6.2,WHIP,bA420G6.2 )
Gene Full Name: Werner helicase interacting protein 1
Band: 6p25.2
Quick LinksEntrez ID:56897; OMIM: 608196; Uniprot ID:WRIP1_HUMAN; ENSEMBL ID: ENSG00000124535; HGNC ID: 20876
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of WRNIP1 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of WRNIP1 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of WRNIP1 mRNAaffects expression 16483693
C055494 caffeic acid phenethyl ester [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of WRNIP1 mRNAaffects cotreatment|decreases expression 20360939
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of WRNIP1 mRNAaffects cotreatment|decreases expression 20360939
D026023 Permethrin Permethrin results in increased expression of WRNIP1 mRNAincreases expression 19017407
C006253 pirinixic acid pirinixic acid results in increased expression of WRNIP1 mRNAincreases expression 18301758
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.9518287403
MESH:D055371 Acute Lung Injury pirinixic acid 3.4218653653
MESH:D000236 Adenoma Diethylnitrosamine 2.996695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 11.4517162532 19052882 18056438 19061943 17620307 16434500
MESH:D018248 Adenoma, Liver Cell pirinixic acid 11.4516434500
MESH:D000799 Angioedema Acetaminophen 4.2910982225
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.4319483382
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.2017474063
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 4.7216705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.723084413
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 4.7219418558 17055752 19539802 16569478 17428255 20514400 3084413 16878318 19519916 16935385 17173139 20214788 16807293 18494052 16779866 20101231 16288022 20512989 18785209 19107877 18210153 19383236 18056438 18788625 19335982 10672840 19394651 16540662 3581430 16830150 10737359 19208518 17138121 20727157 21159647 17162532 19701751 16698587 19171122 19919837 19822196 17978847 18971187 18978308 18691550 16681979 20524982 16502159 20084675 11831363 16328049 20007298 18665156 20432363 19052882 18393292 17761372 20935162 18506893
MESH:D002386 Cataract Acetaminophen 2.7310977129
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 3.0421159647 2727394 17174075 7505956
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.9319052882
MESH:D002779 Cholestasis pirinixic acid 3.0319176532
MESH:D019465 Craniofacial Abnormalities Permethrin 3.1919861644
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.3718551238
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5318249437
MESH:D003877 Dermatitis, Contact Permethrin 5.2914617103
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.2420387270
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 6.5921346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.5916485898 14550746 19420014 11529661 16227642 12153990 14725611 12540782 2444490 18713872 16781746 17906064 16109766 11739529 10663392 11743745 17562736 18071297 17522070 12705907 15619225 19164858 14986274 16081117 19739265 19370779 11287661 15968718 19085960 19923254 12392966 16177239 16393943 19416960 11834606 11421492 12594235 10774834 12958197 10915739 11461765
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 6.5919107877
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.5419426721
MESH:D004487 Edema pirinixic acid 2.7612083418
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.5616302075
MESH:D005234 Fatty Liver Diethylnitrosamine 8.6320387270 21071580
MESH:D005234 Fatty Liver pirinixic acid 8.6319236843 20131406
MESH:D005756 Gastritis Acetaminophen 4.1216983495
MESH:D006333 Heart Failure pirinixic acid 2.6920558911
MESH:D006529 Hepatomegaly pirinixic acid 3.3519176532 19772884 16221962 18467677
MESH:D006930 Hyperalgesia Acetaminophen 2.9216870215
MESH:D006943 Hyperglycemia pirinixic acid 3.4520558911
MESH:D007249 Inflammation Diethylnitrosamine 2.5018785209
MESH:D007299 Insect Bites and Stings Permethrin 6.2712971516 15189238 12749493
MESH:D007333 Insulin Resistance pirinixic acid 2.8016306350
MESH:D007414 Intestinal Neoplasms caffeic acid phenethyl ester 4.8510783313
MESH:D007674 Kidney Diseases Acetaminophen 6.7215629191 12587719
MESH:D007674 Kidney Diseases caffeic acid phenethyl ester 6.7215369732
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 3.2116705839
MESH:D007938 Leukemia Permethrin 4.2512937054
MESH:D015473 Leukemia, Promyelocytic, Acute caffeic acid phenethyl ester 4.1616766008
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.9618665156 19638242 20032147 18522880 18407596
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3515474484
MESH:D008107 Liver Diseases Acetaminophen 4.1011587558 19014921 12587719 19460945 19784758 12969438 16610002 16611625
MESH:D008107 Liver Diseases Diethylnitrosamine 4.1017034775
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5016871587 17185352
MESH:D008113 Liver Neoplasms Diethylnitrosamine 4.7315175105 19833225 19255062 9163691 15885732 2862719 19996281 12771043 19294768 19073162 20434301 20405173 18977376 19499222 19254457 21071580 19850985 21167192 20583210 20501860 12112319 19812893 10737359 19426721 21047994 18648771 19642983 2422723 21278145 20452335 18644402 16942905 18754104 20101389 19427195 20137499 19090486 19551842 19690152 20492335 19638242 19256749 20118626 18978307
MESH:D008113 Liver Neoplasms pirinixic acid 4.7316377806 15890375 20007298
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 2.7916267830 17174075 18282651 18775883 17854601 18079962 21159647 18308698 19009564 3124819 19539802 17942915 18253720 16842330 19126423 19004024 2563599 18164116 18093689 9362446 19519916 18544905
MESH:D008175 Lung Neoplasms Diethylnitrosamine 1.766695378 20970405 21163286 20512841
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9319513568
MESH:D009135 Muscular Diseases pirinixic acid 3.8616239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2419151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1616411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.2518551238
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.669029167 3581430
MESH:D009369 Neoplasms pirinixic acid 2.0617405874
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.9718514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 8.9720387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.5620387270
MESH:D009765 Obesity pirinixic acid 1.8620558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.6912819281 16049721
MESH:D010146 Pain Acetaminophen 2.6216870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.5016540662
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.802563599
MESH:D015427 Reperfusion Injury pirinixic acid 2.5019058328
MESH:D012640 Seizures 2,4-dinitrotoluene 2.7118551238
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7618456281
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 3.197505956
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 2.3716049721
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.7110091137
MESH:D014581 Urticaria Acetaminophen 3.2810982225
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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