AutismKB 2.0

Annotation Detail for C21orf7


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Basic Information Top
Gene Symbol:C21orf7 ( HC21ORF7,TAK1L,TAKL,TAKL-1,TAKL-2,TAKL-4 )
Gene Full Name: chromosome 21 open reading frame 7
Band: 21q22.3
Quick LinksEntrez ID:56911; OMIM: 611110; Uniprot ID:TAK1L_HUMAN; ENSEMBL ID: ENSG00000156265; HGNC ID:
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D016572 Cyclosporine Cyclosporine results in decreased expression of C21ORF7 mRNAdecreases expression 20106945
D004958 Estradiol [Progesterone co-treated with Estradiol] results in decreased expression of C21ORF7 mRNAaffects cotreatment|decreases expression 17404688
D011374 Progesterone [Progesterone co-treated with Estradiol] results in decreased expression of C21ORF7 mRNAaffects cotreatment|decreases expression 17404688
D011374 Progesterone Progesterone results in decreased expression of C21ORF7 mRNAdecreases expression 17404688
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of C21ORF7 mRNAdecreases expression 20106945
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.4715322242 14514962 11752688
MESH:D000230 Adenocarcinoma Estradiol 2.1711473722
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 4.0116835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.3411748828
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.4712125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.5115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 3.0015746008
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 6.0617868700
MESH:D001930 Brain Injuries Progesterone 4.8215845082 15665606 15380490
MESH:D001943 Breast Neoplasms Estradiol 1.8416675129 12948864 14630087 18497071 17261762 19861407 17018787 17289903
MESH:D001943 Breast Neoplasms Progesterone 1.8416175315 17614352 15562024
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8420435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 5.0916111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.1216835633
MESH:D006528 Carcinoma, Hepatocellular Estradiol 1.7916924424
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5618850075 18670907 16120746
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 7.4612371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 7.4618566989
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.5316835633
MESH:D002779 Cholestasis Cyclosporine 3.2119486331
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2412621046 8697196 15340226 16354765 15668235
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.4314669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2715322242 20055451 10048152
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7417107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.7819279558
MESH:D003929 Diabetic Neuropathies Progesterone 5.0517187935
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.6220420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 3.0511462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.8011000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.6216714409 15322242 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 4.2817692515
MESH:D016889 Endometrial Neoplasms Estradiol 3.2219148513 11473722 18566989
MESH:D004715 Endometriosis Progesterone 10.2716134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 10.279294722 10568697
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.3111564622
MESH:D005234 Fatty Liver Cyclosporine 3.2819224547
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 4.0211858732
MESH:D005355 Fibrosis Cyclosporine 10.4212168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 10.4220067830
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.858708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.3210696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.5111294989 10048152
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 5.0515720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.7611000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.4512621046 16120746 15340226
MESH:D006558 Herpes Genitalis Estradiol 5.7615709030
MESH:D019584 Hot Flashes Estradiol 4.4717088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.7716959395 18606429 16354765 15340226 8697196
MESH:D006973 Hypertension Cyclosporine 5.3510903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.3518670907 18850075
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.9615869954
MESH:D007249 Inflammation Progesterone 5.5815869954
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.5812200463 12878042
MESH:D007333 Insulin Resistance Estradiol 3.2116627594 16393666
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.7616580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 5.1615604871
MESH:D007674 Kidney Diseases Cyclosporine 6.6218776723 10903974 8314463
MESH:D007674 Kidney Diseases Estradiol 6.6215618244
MESH:D007680 Kidney Neoplasms Cyclosporine 8.4412371664
MESH:D007680 Kidney Neoplasms Estradiol 8.4415610895
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 2.3514659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.3512878042
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 1.8316984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.3312151625
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 1.2411884234 19555203
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 6.8611807958 17203775 16891317 11408345
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 6.8617203775 11408345
MESH:D020149 Manganese Poisoning Estradiol 5.2119453300
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.5116801185
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.3412213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.5916810080
MESH:D009389 Neovascularization, Pathologic Estradiol 4.3617289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 5.1617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.6518481113 19348381
MESH:D009421 Nervous System Malformations Estradiol 11.2016427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 11.2014600291
MESH:D010051 Ovarian Neoplasms Estradiol 5.2019401270
MESH:D010051 Ovarian Neoplasms Progesterone 5.2016525653 17393432
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.9712520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 4.0718163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.5912371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.8211896295 11222880 11118676 11399792
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.3120887781
MESH:D011471 Prostatic Neoplasms Estradiol 3.0216740699
MESH:D011565 Psoriasis Cyclosporine 2.3316882103
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.3518990726
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.9618045962
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.2016192470
MESH:D013119 Spinal Cord Injuries Progesterone 4.9115862959 16503802
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.6212697716
MESH:D013978 Tibial Fractures Estradiol 5.4119048282
MESH:D014605 Uveitis Cyclosporine 4.711336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.3212125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.9715886252
MESH:D014985 Xerophthalmia Cyclosporine 5.1617120751
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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