AutismKB 2.0

Annotation Detail for PSMB4


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Basic Information Top
Gene Symbol:PSMB4 ( HN3,HsN3,PROS-26,PROS26 )
Gene Full Name: proteasome (prosome, macropain) subunit, beta type, 4
Band: 1q21.3
Quick LinksEntrez ID:5692; OMIM: 602177; Uniprot ID:PSB4_HUMAN; ENSEMBL ID: ENSG00000159377; HGNC ID: 9541
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa03050Proteasome
Pathway IDPathway Name
Signaling by Wnt
Cell Cycle, Mitotic
DNA Replication
Apoptosis
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
HIV Infection
Cell Cycle Checkpoints
Regulation of activated PAK-2p34 by proteasome mediated degradation
Metabolism of amino acids and derivatives
No data
No data
Pathway IDPathway Name
500401Autodegradation of Cdh1 by Cdh1:APC/C
500372SCF(Skp2)-mediated degradation of p27/p21
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C049325 1,2-dithiol-3-thione 1,2-dithiol-3-thione results in increased expression of PSMB4 mRNAincreases expression 15375163
C019499 2-nitrofluorene 2-nitrofluorene results in increased expression of PSMB4 mRNAincreases expression 15890375
C016583 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of PSMB4 mRNAincreases expression 15890375
D000082 Acetaminophen Acetaminophen affects the expression of PSMB4 mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 results in increased expression of PSMB4 mRNAincreases expression 15890375
D000643 Ammonium Chloride Ammonium Chloride affects the expression of PSMB4 mRNAaffects expression 16483693
C006632 arsenic trioxide arsenic trioxide results in increased expression of PSMB4 mRNAincreases expression 20458559
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of PSMB4 proteinincreases expression 20097212
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of PSMB4 mRNAdecreases expression 20018196
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of PSMB4 mRNAincreases expression 19150397
D002509 Cephaloridine Cephaloridine results in increased expression of PSMB4 mRNAincreases expression 18172885
D002713 Chlorine Chlorine results in increased expression of PSMB4 mRNAincreases expression 18636392
D002713 Chlorine [Ozone co-treated with Chlorine] affects the expression of PSMB4 mRNAaffects cotreatment|affects expression 18636392
D002994 Clofibrate PPARA protein affects the reaction [Clofibrate results in increased expression of PSMB4 mRNA]affects reaction|increases expression 17585979
C014347 decitabine decitabine results in decreased expression of PSMB4 proteindecreases expression 19294695
C014347 decitabine [trichostatin A co-treated with decitabine] results in decreased expression of PSMB4 proteinaffects cotreatment|decreases expression 19294695
D016190 Carboplatin Carboplatin results in decreased expression of PSMB4 mRNAdecreases expression 18172885
D002945 Cisplatin Cisplatin affects the expression of PSMB4 mRNAaffects expression 18172885
D004008 Diclofenac Diclofenac results in decreased expression of PSMB4 mRNAdecreases expression 18172885
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of PSMB4 mRNAincreases expression 15890375
D004128 Dimethylnitrosamine Dimethylnitrosamine results in increased expression of PSMB4 mRNAincreases expression 15890375
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of PSMB4 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of PSMB4 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PSMB4 mRNAaffects cotreatment|increases expression 17942748
D005419 Flavonoids Flavonoids results in decreased expression of PSMB4 mRNAdecreases expression 18035473
D005839 Gentamicins Gentamicins results in decreased expression of PSMB4 mRNAdecreases expression 18172885
D007657 Ketone Bodies Ketone Bodies results in increased expression of PSMB4 mRNAincreases expression 16807920
D008095 Lithocholic Acid Lithocholic Acid affects the expression of PSMB4 mRNAaffects expression 18246545
D008095 Lithocholic Acid Lithocholic Acid results in decreased expression of PSMB4 mRNAdecreases expression 18246545
D008701 Methapyrilene Methapyrilene results in increased expression of PSMB4 mRNAincreases expression 15890375
D009151 Mustard Gas Mustard Gas affects the expression of PSMB4 mRNAaffects expression 15651846
D010126 Ozone [Ozone co-treated with Chlorine] affects the expression of PSMB4 mRNAaffects cotreatment|affects expression 18636392
C023036 perfluorooctanoic acid perfluorooctanoic acid results in increased expression of PSMB4 mRNAincreases expression 18467677
C023036 perfluorooctanoic acid PPARA protein promotes the reaction [perfluorooctanoic acid results in increased expression of PSMB4 mRNA]increases expression|increases reaction 18467677
D010882 Piperonyl Butoxide Piperonyl Butoxide results in increased expression of PSMB4 mRNAincreases expression 15890375
C006253 pirinixic acid pirinixic acid results in increased expression of PSMB4 mRNAincreases expression 18301758
15375163
18467677
C006253 pirinixic acid PPARA protein promotes the reaction [pirinixic acid results in increased expression of PSMB4 mRNA]increases expression|increases reaction 18467677
C006253 pirinixic acid pirinixic acid results in increased expression of PSMB4 mRNAincreases expression 15890375
C443641 poly(propyleneimine) poly(propyleneimine) analog results in decreased expression of PSMB4 mRNAdecreases expression 16308212
C031280 pyrazole pyrazole results in increased expression of PSMB4 mRNAincreases expression 17945193
D012643 Selenium Selenium results in increased expression of PSMB4 mRNAincreases expression 19244175
D013629 Tamoxifen Tamoxifen affects the expression of PSMB4 mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PSMB4 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of PSMB4 mRNAincreases expression 18796159
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of PSMB4 mRNAincreases expression 18796159
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of PSMB4 proteinincreases expression 19201780
C012589 trichostatin A [trichostatin A co-treated with decitabine] results in decreased expression of PSMB4 proteinaffects cotreatment|decreases expression 19294695
D014303 Trinitrotoluene Trinitrotoluene affects the expression of PSMB4 mRNAaffects expression 21346803
D014810 Vitamin E Vitamin E results in increased expression of PSMB4 mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.1614745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 7.3115322242 14514962 11752688
MESH:D000014 Abnormalities, Drug-Induced Trinitrotoluene 7.317525203
MESH:D000138 Acidosis Ammonium Chloride 3.1818287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.5517505938
MESH:D058186 Acute Kidney Injury Cisplatin 12.7915814532 12690470 17670903
MESH:D058186 Acute Kidney Injury Diclofenac 12.797897758
MESH:D058186 Acute Kidney Injury Gentamicins 12.7911274264
MESH:D055371 Acute Lung Injury Chlorine 7.9920601635
MESH:D055371 Acute Lung Injury pirinixic acid 7.9918653653
MESH:D000230 Adenocarcinoma arsenic trioxide 12.3919825857 11798837
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 12.3920127859 20464547
MESH:D000230 Adenocarcinoma Cisplatin 12.3917638652 11798837
MESH:D000230 Adenocarcinoma Dimethylnitrosamine 12.3916033868
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 12.3914692618
MESH:D000236 Adenoma 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 10.0616176798
MESH:D000236 Adenoma Benzo(a)pyrene 10.066695378
MESH:D000236 Adenoma Dimethylnitrosamine 10.0619555203
MESH:D018248 Adenoma, Liver Cell pirinixic acid 8.6316434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 8.6316835633
MESH:D000544 Alzheimer Disease Ozone 2.3515513908
MESH:D000686 Amyloidosis Diethylstilbestrol 4.1215469931
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.6211748828
MESH:D000799 Angioedema Acetaminophen 3.4610982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.7019183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.0911256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.4315885639
MESH:D001172 Arthritis, Rheumatoid Ozone 2.4615570426
MESH:D001249 Asthma Mustard Gas 4.6610378619
MESH:D001249 Asthma Ozone 4.6616373670 17854713
MESH:D001321 Autistic Disorder Acetaminophen 1.4618445737
MESH:D001768 Blister Mustard Gas 4.7819167455
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 19.1816206674
MESH:D001778 Blood Coagulation Disorders Clofibrate 19.1819483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 19.1819483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 19.1812125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.4015340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.5215746008
MESH:D019046 Bone Marrow Neoplasms Cisplatin 4.5014601052
MESH:D001943 Breast Neoplasms 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 3.4920146248
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 3.4920146248 17474063
MESH:D001943 Breast Neoplasms Cisplatin 3.4919526202 18382427
MESH:D001943 Breast Neoplasms decitabine 3.4919208741 18320071
MESH:D001943 Breast Neoplasms Diethylstilbestrol 3.4917129689 15324884
MESH:D001943 Breast Neoplasms Tamoxifen 3.4917261762 17893378 17440819 19189210 16818667 19142967 20390343 20135344 20065188 18815881 20859285 20005174 19288272 19189212 16873071 19115204 18997820 11161223 19011961 18984771 19487384 20544844 16273361 19103187 19200415 19289846 18821012 18351453 18425577 19221464 17049068 16202921 21152245 15565566 17242785 19155303 21138602 18629630 19059307 18855134 19084267 19066611 19410462 15668708 19244106
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 3.4920435547
MESH:D016535 Bronchial Hyperreactivity Ozone 3.3818315731 17626835 18417511 19059883 15516495 16777450 14754758
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 4.7815286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 4.5917687719 10378619
MESH:D002051 Burkitt Lymphoma arsenic trioxide 3.9811589617
MESH:D002100 Cachexia Ozone 4.3616183385
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 3.5616050911
MESH:D002277 Carcinoma Dimethylnitrosamine 7.3619555203
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.3616835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.1319066611
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 10.453084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 10.4521507988 12907637 12619106
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 10.4515073043 16217749 14691202 11135700 15553829
MESH:D006528 Carcinoma, Hepatocellular Cisplatin 10.4517982673
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 10.4515948411 16924424
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 10.4516924424
MESH:D002289 Carcinoma, Non-Small-Cell Lung Carboplatin 5.6716685392
MESH:D002289 Carcinoma, Non-Small-Cell Lung Cisplatin 5.6716685392 12023789
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.4919014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 3.7912490120
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 9.8320419170
MESH:D002294 Carcinoma, Squamous Cell Cisplatin 9.836189445 17066447 18337622
MESH:D002294 Carcinoma, Squamous Cell decitabine 9.8319215824
MESH:D002294 Carcinoma, Squamous Cell Dimethylnitrosamine 9.8316033868
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.2917572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.1518850075 18670907 16120746
MESH:D002386 Cataract Acetaminophen 6.7510977129
MESH:D002386 Cataract Trinitrotoluene 6.7515817613 14694615
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 6.0520889678
MESH:D002471 Cell Transformation, Neoplastic Clofibrate 6.051399818
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.8416835633
MESH:D002779 Cholestasis Ethinyl Estradiol 12.0216105132 17110522 11677210 17333356 17681005 16919318 15861022
MESH:D002779 Cholestasis Lithocholic Acid 12.0219965603
MESH:D002779 Cholestasis pirinixic acid 12.0219176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 1.9416354765 15340226 15668235 12621046 8697196
MESH:D003092 Colitis Selenium 3.4117936198
MESH:D003110 Colonic Neoplasms decitabine 2.2717616700
MESH:D015179 Colorectal Neoplasms arsenic trioxide 3.2920501625
MESH:D015179 Colorectal Neoplasms Cisplatin 3.2915273666
MESH:D015179 Colorectal Neoplasms decitabine 3.2918981723
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 8.2114669216 17141729
MESH:D000013 Congenital Abnormalities Trinitrotoluene 8.2115095906
MESH:D023903 Coronary Restenosis arsenic trioxide 3.8212609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 3.5010525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.5010048152 15322242 20055451
MESH:D019465 Craniofacial Abnormalities Vitamin E 3.5019769572
MESH:D003456 Cryptorchidism Diethylstilbestrol 4.1912952375 16002989
MESH:D003490 Cyanosis Trinitrotoluene 4.5518551238
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 3.7415213294
MESH:D003711 Demyelinating Diseases Tamoxifen 3.9919031437
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.2418249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.5717107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.1619279558
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 13.6311743745 16781746 19420014 16227642 10663392 14725611 14550746 11834606 2444490 16081117 19164858 12392966 11529661 19085960 19739265 16485898 19923254 12705907 12540782 11421492 12153990 17522070 18713872 16393943 11461765 15968718 15619225 16109766 19416960 17562736 12594235 11287661 11739529 10774834 12958197 16177239 10915739 14986274 18071297 17906064 19370779
MESH:D056486 Drug-Induced Liver Injury Dimethylnitrosamine 13.638172417
MESH:D056486 Drug-Induced Liver Injury pyrazole 13.6312499123
MESH:D056486 Drug-Induced Liver Injury Selenium 13.6315131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 13.6320420201
MESH:D056486 Drug-Induced Liver Injury Trinitrotoluene 13.6321346803 18551238
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.7119426721
MESH:D004362 Drug Toxicity Cisplatin 12.2519839026 12649298 15033597 12231392
MESH:D004362 Drug Toxicity Gentamicins 12.2515033597 11033412
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 12.2511462148
MESH:D050171 Dyslipidemias Clofibrate 3.7916707586
MESH:D004417 Dyspnea Chlorine 4.2420016425
MESH:C538011 Eales disease Vitamin E 4.329068938
MESH:D004487 Edema Diclofenac 18.0916273134
MESH:D004487 Edema Mustard Gas 18.099260866 11428647 11402378 11428631
MESH:D004487 Edema perfluorooctanoic acid 18.0912083418 17259670
MESH:D004487 Edema pirinixic acid 18.0912083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 18.0912711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.5115322242 16714409 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 7.7512538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 7.7519031437
MESH:D004701 Endocrine Gland Neoplasms decitabine 12.7319294695
MESH:D004701 Endocrine Gland Neoplasms trichostatin A 12.7319294695
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 4.3116402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 6.7316804899 15700306
MESH:D016889 Endometrial Neoplasms Tamoxifen 6.7319155303 17893378 16202921 20544844
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.6910568697 9294722
MESH:D004890 Erythema Mustard Gas 4.789357497
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 12.6520426865
MESH:D004938 Esophageal Neoplasms arsenic trioxide 12.6512903497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 12.6516530937
MESH:D004938 Esophageal Neoplasms Cisplatin 12.6516785472 15464296 17638652 15173087 16481741
MESH:D004938 Esophageal Neoplasms Dimethylnitrosamine 12.6517016578
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.7311564622
MESH:D005234 Fatty Liver arsenic trioxide 21.0515073043
MESH:D005234 Fatty Liver Clofibrate 21.0519224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 21.0515345470
MESH:D005234 Fatty Liver pirinixic acid 21.0519236843 20131406
MESH:D005234 Fatty Liver Tamoxifen 21.0519224547 14986274
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 7.4316513791 16534752 16611131 15751030 16002989
MESH:D052776 Female Urogenital Diseases Tamoxifen 7.4316709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.0811858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.1514745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 3.8019069698
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 2.5820067830
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 3.9016904648
MESH:D005739 Gas Poisoning Chlorine 4.6220016425
MESH:D005756 Gastritis Acetaminophen 3.2916983495
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 4.5716452187
MESH:D005909 Glioblastoma trichostatin A 3.5818801729
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.2110696789
MESH:D006258 Head and Neck Neoplasms Cisplatin 7.1715464296 15102660
MESH:D006258 Head and Neck Neoplasms decitabine 7.1719215824
MESH:D034381 Hearing Loss Cisplatin 9.2319898482
MESH:D034381 Hearing Loss Gentamicins 9.2315968427 19130971 17868369 18024279
MESH:D006319 Hearing Loss, Sensorineural Cisplatin 4.1115464296
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 9.9020471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 9.9011294989 10048152
MESH:D006330 Heart Defects, Congenital Vitamin E 9.9016080930
MESH:D006333 Heart Failure pirinixic acid 6.1620558911
MESH:D006333 Heart Failure Selenium 6.1617162251
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.0011000095
MESH:D006521 Hepatitis, Chronic Diclofenac 5.2914986274
MESH:D006529 Hepatomegaly perfluorooctanoic acid 17.673609246
MESH:D006529 Hepatomegaly pirinixic acid 17.6716221962 18467677 19772884 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 17.6716120746 15340226 12621046
MESH:D006529 Hepatomegaly Trinitrotoluene 17.6715817613
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.5616490937 16863852
MESH:D006689 Hodgkin Disease Cisplatin 3.2916170182 16200630
MESH:D019584 Hot Flashes Vitamin E 3.5914716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.6616354765 15340226 18606429 16959395 8697196
MESH:D006930 Hyperalgesia Acetaminophen 6.8716870215
MESH:D006930 Hyperalgesia perfluorooctanoic acid 6.8712083418
MESH:D053565 Hypercalciuria Gentamicins 5.3217652376
MESH:D006943 Hyperglycemia pirinixic acid 2.8520558911
MESH:D006965 Hyperplasia Diethylstilbestrol 4.0614722030 12960047
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.7618670907 18850075
MESH:D007021 Hypospadias Diethylstilbestrol 10.0016002989
MESH:D007021 Hypospadias Ethinyl Estradiol 10.0016945680 16569931
MESH:D007246 Infertility Diethylstilbestrol 3.9915036965
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.1112013081
MESH:D007248 Infertility, Male decitabine 9.8417581917
MESH:D007248 Infertility, Male Ethinyl Estradiol 9.8417937319
MESH:D007248 Infertility, Male Trinitrotoluene 9.8412150543
MESH:D007249 Inflammation Diclofenac 17.3116273134
MESH:D007249 Inflammation Flavonoids 17.3117296493
MESH:D007249 Inflammation Mustard Gas 17.3111428620 11428631 9260866 11402378 17524151 9357497 8975870 16001271 11428647
MESH:D007249 Inflammation perfluorooctanoic acid 17.3112083418
MESH:D007249 Inflammation Tamoxifen 17.3119457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 17.3112878042 12200463
MESH:D007251 Influenza, Human Selenium 9.6716624496
MESH:D007251 Influenza, Human Vitamin E 9.6716624496
MESH:D007333 Insulin Resistance pirinixic acid 2.3816306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.0016580747
MESH:D007673 Kidney Cortex Necrosis Cisplatin 12.0315464296
MESH:D007673 Kidney Cortex Necrosis Gentamicins 12.0318842672
MESH:D007674 Kidney Diseases Acetaminophen 12.6712587719 15629191
MESH:D007674 Kidney Diseases Cisplatin 12.6719839026 15190930 18289764 12231392 12649298
MESH:D007674 Kidney Diseases Gentamicins 12.6717934191 18289764 19349640
MESH:D007674 Kidney Diseases Vitamin E 12.6712488133
MESH:D007676 Kidney Failure, Chronic Selenium 3.5516518626
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 6.5515003126 16762066 14681315
MESH:D007680 Kidney Neoplasms Tamoxifen 6.5518625569
MESH:D007683 Kidney Tubular Necrosis, Acute Cisplatin 10.7211231351
MESH:D007683 Kidney Tubular Necrosis, Acute Gentamicins 10.7211231351
MESH:D007859 Learning Disorders Diethylstilbestrol 3.6917184923
MESH:D016773 Leishmaniasis, Cutaneous Gentamicins 4.1610219319
MESH:D007938 Leukemia arsenic trioxide 5.8015070760
MESH:D007938 Leukemia decitabine 5.8018980019 19235587
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.4612560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 3.9316972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.1514633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 8.4619077051
MESH:D007951 Leukemia, Myeloid decitabine 8.4619117987 18454857 17236224
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 5.7816968895 16467208 19850784 17050201 20471514
MESH:D015470 Leukemia, Myeloid, Acute decitabine 5.7819010910 18206229 18460780 19387464 18704418 17679729
MESH:D015470 Leukemia, Myeloid, Acute trichostatin A 5.7818206229
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.0718055864
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 2.9619642359 17869043 16331271 16891316 9834237 15622746 19035177 11161223 16330433 16966277 16112521 12018890 11468182 19225113 15748426 12679006 17107899 17217047 17649720 15213294 12712474 17712046 15336539 19075265 16823087
MESH:D015458 Leukemia, T-Cell arsenic trioxide 3.9916882451
MESH:D007984 Leydig Cell Tumor perfluorooctanoic acid 4.858812269
MESH:D008064 Lipidoses Tamoxifen 2.8815342952 17567588
MESH:D008106 Liver Cirrhosis, Experimental Dimethylnitrosamine 6.1516042886 15798949 16270385 15161499 17036385 15571005 15081153 17534399 15864749 15744066 15492853 18210741 17719030 14659978 15339415 12925901 15479170 17881167 14568256 16603200 12918455 18629640 18237412 16570917 15942678 17203207 18371158 16009107 17666798 18239293 17465448 16627068 15383259 15138612 17196135 15793283 15067225 17198567 18364076 18567088 15842777 14643895 17432682 15504291 14709902 16544323 15086199 18637143 17640959 16169303 18095165 17724770 17201889 15723089 17348192 15591649 14726149 15577212 15366600 15298665 15099470 15733078 15369754 15763062 18672772
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 6.1515474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 6.1518564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.1512878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 6.1516169303
MESH:D008107 Liver Diseases Acetaminophen 4.1119460945 11587558 12969438 19014921 19784758 16610002 16611625 12587719
MESH:D008107 Liver Diseases Diclofenac 4.1114566034 16867024
MESH:D017114 Liver Failure, Acute Acetaminophen 8.5817185352 16871587
MESH:D017114 Liver Failure, Acute Dimethylnitrosamine 8.5817457977
MESH:D008113 Liver Neoplasms 2-nitrofluorene 43.6915890375
MESH:D008113 Liver Neoplasms 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 43.6915890375
MESH:D008113 Liver Neoplasms Aflatoxin B1 43.699163691 15890375 2125692 18177683
MESH:D008113 Liver Neoplasms arsenic trioxide 43.6914682389
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 43.6921137059 20195826
MESH:D008113 Liver Neoplasms Diethylstilbestrol 43.6915890375 16712894
MESH:D008113 Liver Neoplasms Dimethylnitrosamine 43.6915890375 3113478
MESH:D008113 Liver Neoplasms Methapyrilene 43.6915890375
MESH:D008113 Liver Neoplasms perfluorooctanoic acid 43.6918709148 14757943
MESH:D008113 Liver Neoplasms Piperonyl Butoxide 43.6918648771 19690152 20101389 15890375
MESH:D008113 Liver Neoplasms pirinixic acid 43.6920007298 16377806 15890375
MESH:D008113 Liver Neoplasms Tamoxifen 43.6916684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 43.6916984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 12.178603461
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 12.1720377131
MESH:D008114 Liver Neoplasms, Experimental Dimethylnitrosamine 12.171848544 6150874 15603536
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 12.1712151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.0615213294
MESH:D008171 Lung Diseases Mustard Gas 10.9118161513 18702808
MESH:D008171 Lung Diseases Ozone 10.9119066396 8266340
MESH:D008171 Lung Diseases Vitamin E 10.9116863852
MESH:D055370 Lung Injury Ozone 3.4820417186
MESH:D008175 Lung Neoplasms 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 19.2419931552 12438228 9255578 15172992 16061637 17139156 14755239 18508827 18813816 15893417 16401635
MESH:D008175 Lung Neoplasms Aflatoxin B1 19.2414755239
MESH:D008175 Lung Neoplasms arsenic trioxide 19.2419825857 11798837
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 19.2418569708 17053015 20464547 6695378 18816296 20869020 20135361 20064080 18520028
MESH:D008175 Lung Neoplasms Cisplatin 19.2417225452 6189445 11798837
MESH:D008175 Lung Neoplasms Dimethylnitrosamine 19.2416061637 19555203 11884234
MESH:D008175 Lung Neoplasms Mustard Gas 19.248781369 3148597
MESH:D008175 Lung Neoplasms Ozone 19.248597069 7614698
MESH:D008175 Lung Neoplasms Tamoxifen 19.2418625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 19.2411884234 19555203
MESH:D008175 Lung Neoplasms Vitamin E 19.2411062179
MESH:D008181 Lupus Nephritis Diethylstilbestrol 4.7715166399
MESH:D008223 Lymphoma decitabine 6.8319470736
MESH:D008223 Lymphoma Diethylstilbestrol 6.8315700306
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.1316002989
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.3819428831
MESH:D008325 Mammary Neoplasms, Experimental Selenium 5.2315318939
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 5.2319196723 19196722 14580682 16827153 11731420
MESH:D020149 Manganese Poisoning Tamoxifen 4.1619453300
MESH:D008545 Melanoma Carboplatin 8.9912040289 11712820 16225601 16342250
MESH:D008545 Melanoma Cisplatin 8.9918332650 12374674 16248763 18176117 12883367 16432458 15577323 18505091 16809738 12393984 17023156 11135225 17761969
MESH:D008545 Melanoma decitabine 8.9917785578 16505122
MESH:D008545 Melanoma Tamoxifen 8.9919393235 12393984
MESH:D008545 Melanoma trichostatin A 8.9916505122
MESH:D018328 Melanoma, Amelanotic Cisplatin 10.2415990972
MESH:D018328 Melanoma, Amelanotic Tamoxifen 10.2415990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.2019513568
MESH:D008654 Mesothelioma Cisplatin 5.8217638057
MESH:D008654 Mesothelioma Selenium 5.8215107826
MESH:D008679 Metaplasia Ozone 4.7210496685
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 2.9016381670
MESH:D009101 Multiple Myeloma arsenic trioxide 10.6619417148 15949261 11468182 19549372 14977855
MESH:D009101 Multiple Myeloma decitabine 10.6618172295
MESH:D009101 Multiple Myeloma trichostatin A 10.6618172295
MESH:D009135 Muscular Diseases pirinixic acid 3.1416239165
MESH:D009137 Muscular Dystrophy, Animal Gentamicins 5.8918694830
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.2818349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 6.7616882451 16105982
MESH:D009190 Myelodysplastic Syndromes decitabine 6.7619010910 16882708 19157545 18608210
MESH:D009203 Myocardial Infarction pirinixic acid 1.9819151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.7212213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.6616411023
MESH:D009336 Necrosis Trinitrotoluene 4.3918551238
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.6016624393
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.3919393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.3919410462
MESH:D009369 Neoplasms Benzo(a)pyrene 17.2511141357
MESH:D009369 Neoplasms Carboplatin 17.2518854779 17925555
MESH:D009369 Neoplasms Cisplatin 17.2516773208
MESH:D009369 Neoplasms decitabine 17.2517925555 19116145 19470736
MESH:D009369 Neoplasms Diethylstilbestrol 17.2515313581
MESH:D009369 Neoplasms pirinixic acid 17.2517405874
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.6119189210 19200415 19196722
MESH:D009395 Nephritis, Interstitial Cisplatin 4.1115464296
MESH:D009421 Nervous System Malformations Diethylstilbestrol 8.4411399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 8.4414600291
MESH:D009436 Neural Tube Defects arsenic trioxide 2.8710525206
MESH:D009447 Neuroblastoma Cisplatin 3.258761367
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.5618514411
MESH:D017599 Neuroectodermal Tumors Carboplatin 10.5312837982
MESH:D017599 Neuroectodermal Tumors Cisplatin 10.538761367
MESH:D009503 Neutropenia Mustard Gas 3.6216761898 7688884
MESH:D052556 Niemann-Pick Disease, Type C Clofibrate 10.829802331
MESH:D052556 Niemann-Pick Disease, Type C perfluorooctanoic acid 10.829802331
MESH:D009765 Obesity pirinixic acid 1.7220558911
MESH:D009784 Occupational Diseases Trinitrotoluene 4.0112819281 14694615 17852074
MESH:D010003 Osteoarthritis Diclofenac 4.3618287210
MESH:D010051 Ovarian Neoplasms arsenic trioxide 10.2819769630 12452020 16624393
MESH:D010051 Ovarian Neoplasms Cisplatin 10.2815464296 6897625 17225452 19769630
MESH:D010051 Ovarian Neoplasms decitabine 10.2819259094 19331143
MESH:D010051 Ovarian Neoplasms trichostatin A 10.2819331143
MESH:D010146 Pain Acetaminophen 6.1316870215
MESH:D010146 Pain Diclofenac 6.1313679232
MESH:D010190 Pancreatic Neoplasms 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 14.7812384795
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 14.7815580305
MESH:D010190 Pancreatic Neoplasms Cisplatin 14.7819003803
MESH:D010190 Pancreatic Neoplasms decitabine 14.7819294695
MESH:D010190 Pancreatic Neoplasms trichostatin A 14.7819294695
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.3411578682
MESH:D010235 Paraganglioma arsenic trioxide 3.8119927285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.8612520081
MESH:D010523 Peripheral Nervous System Diseases Cisplatin 3.9515464296
MESH:D010538 Peritonitis Ozone 3.7616369182
MESH:D010900 Pituitary Diseases Diethylstilbestrol 4.7814722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.3016977796 15687265
MESH:D010954 Plasmacytoma Selenium 4.5015087411
MESH:D010997 Pleural Neoplasms Cisplatin 4.9517638057
MESH:D011014 Pneumonia Ozone 4.0118929643 18007984 18381685
MESH:D011041 Poisoning Mustard Gas 3.4515727166
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.2018163543
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 14.1317184923
MESH:D011297 Prenatal Exposure Delayed Effects perfluorooctanoic acid 14.1317132714
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 14.1311399792 11118676 11896295 11222880
MESH:D055728 Primary Myelofibrosis decitabine 11.1917616702
MESH:D055728 Primary Myelofibrosis trichostatin A 11.1917616702
MESH:D011471 Prostatic Neoplasms arsenic trioxide 1.8719131511
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 1.8717292933
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 1.8717136230 15846301 15046698
MESH:D011471 Prostatic Neoplasms Tamoxifen 1.8715067354
MESH:D011471 Prostatic Neoplasms trichostatin A 1.8719789329 18798265
MESH:D011471 Prostatic Neoplasms Vitamin E 1.8715084515
MESH:D011507 Proteinuria Gentamicins 4.3715033597
MESH:D011537 Pruritus Ethinyl Estradiol 8.2615861022 16919318
MESH:D011537 Pruritus Mustard Gas 8.2618058305
MESH:D011658 Pulmonary Fibrosis Mustard Gas 2.7817720292 17266442 10334151 17894541 17620002
MESH:D051437 Renal Insufficiency Cisplatin 9.4315464296
MESH:D051437 Renal Insufficiency Gentamicins 9.4315728788 17132701
MESH:D015427 Reperfusion Injury pirinixic acid 2.2019058328
MESH:D012120 Respiration Disorders Chlorine 4.8218579056
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.4718990726
MESH:D012173 Retinitis Gentamicins 5.8918644591
MESH:D012208 Rhabdomyosarcoma decitabine 4.0519155313
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 9.1416646077
MESH:D012512 Sarcoma, Ewing's Cisplatin 9.1414601052
MESH:D012640 Seizures Trinitrotoluene 3.1918551238
MESH:D012871 Skin Diseases Mustard Gas 4.6616961503 12880345 15451306
MESH:D012871 Skin Diseases Vitamin E 4.6618709164
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 4.8519755658 10029692
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 4.8516192470
MESH:D055752 Small Cell Lung Carcinoma Cisplatin 4.9515464296
MESH:D013088 Spermatocele Diethylstilbestrol 17.8816002989 16709447
MESH:D013088 Spermatocele Ethinyl Estradiol 17.8816709447
MESH:D013088 Spermatocele Tamoxifen 17.8816709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.6619457130
MESH:D013158 Splenic Diseases Dimethylnitrosamine 4.8812587719
MESH:D013163 Splenomegaly Trinitrotoluene 4.8315817613
MESH:D013274 Stomach Neoplasms arsenic trioxide 5.9317007042
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 5.932093021 20155912
MESH:D013274 Stomach Neoplasms Cisplatin 5.9317522103 18396642 15958060
MESH:D013274 Stomach Neoplasms decitabine 5.9319037991
MESH:D013274 Stomach Neoplasms Dimethylnitrosamine 5.9316033868
MESH:D020521 Stroke Vitamin E 3.2216517955
MESH:D015173 Supratentorial Neoplasms Carboplatin 5.4312837982
MESH:D013733 Testicular Diseases pyrazole 4.446499806
MESH:D013736 Testicular Neoplasms Cisplatin 4.2815464296 17225452
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.2711994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.8315669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.5112697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 6.3719014326
MESH:D013964 Thyroid Neoplasms decitabine 6.3717967635
MESH:D016171 Torsades de Pointes arsenic trioxide 3.5815213294
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 17.8120435036 11780464 12845720 12973940
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 17.8117053015
MESH:D001749 Urinary Bladder Neoplasms Cisplatin 17.8117225452 15464296 12973940
MESH:D001749 Urinary Bladder Neoplasms decitabine 17.8117616700 19087683
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 17.8116452187 16712894 17306315
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 17.8117572228 8653321 16712894
MESH:D014581 Urticaria Acetaminophen 2.6310982225
MESH:D002583 Uterine Cervical Neoplasms Cisplatin 8.6116803524
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 8.6116175088
MESH:D014591 Uterine Diseases Diethylstilbestrol 4.7814652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 8.2716690809 15809267
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 8.2714692618
MESH:D014604 Uveal Neoplasms decitabine 4.5217785578
MESH:D014625 Vaginal Neoplasms Cisplatin 9.8415577323
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 9.8416513791 16002989
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.2112125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.2014671159 15869587
MESH:D015837 Vestibular Diseases Gentamicins 5.1618776599
MESH:D014839 Vomiting Cisplatin 4.3311897121
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.8615886252
Pathway ID Pathway Name
REACT:578 Apoptosis
REACT:6850 Cdc20:Phospho-APC/C mediated degradation of Cyclin A
REACT:1538 Cell Cycle Checkpoints
REACT:152 Cell Cycle, Mitotic
REACT:383 DNA Replication
REACT:6185 HIV Infection
REACT:13 Metabolism of amino acids and derivatives
REACT:21257 Metabolism of RNA
KEGG:03050 Proteasome
REACT:13505 Proteasome mediated degradation of PAK-2p34
REACT:11045 Signaling by Wnt
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA33886
    • No data
    Releated disease ID Related disease Name
    PA447278Depression
    PA447321Depressive Disorder, Major
    Releated drug ID Related drug Name
    PA164743471adenosine triphosphate
    PA449233desipramine
    PA449673fluoxetine
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB07475 - N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE
    DB08515 - (3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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