AutismKB 2.0

Annotation Detail for PAK6


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Basic Information Top
Gene Symbol:PAK6 ( PAK5 )
Gene Full Name: p21 protein (Cdc42/Rac)-activated kinase 6
Band: 15q15.1
Quick LinksEntrez ID:56924; OMIM: 608110; Uniprot ID:PAK6_HUMAN; ENSEMBL ID: ENSG00000137843; HGNC ID: 16061
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04012ErbB signaling pathway
hsa04360Axon guidance
hsa05211Renal cell carcinoma
hsa04810Regulation of actin cytoskeleton
hsa04510Focal adhesion
hsa04660T cell receptor signaling pathway
Pathway IDPathway Name
Axon guidance
No data
Pathway IDPathway Name
P00016Cytoskeletal regulation by Rho GTPase
P00031Inflammation mediated by chemokine and cytokine signaling pathway
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1831Prostate cancer
1730Disseminated cancer
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of PAK6 mRNAaffects expression 17562736
D002117 Calcitriol Calcitriol results in decreased expression of PAK6 mRNAdecreases expression 16002434
D010634 Phenobarbital Phenobarbital affects the expression of PAK6 mRNAaffects expression 19136022
C006253 pirinixic acid pirinixic acid affects the expression of PAK6 mRNAaffects expression 19136022
C034028 vanadyl sulfate vanadyl sulfate results in decreased expression of PAK6 mRNAdecreases expression 16330358
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 3.986195326
MESH:D055371 Acute Lung Injury pirinixic acid 3.5218653653
MESH:D018248 Adenoma, Liver Cell Phenobarbital 11.9817620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 11.9816434500
MESH:D000799 Angioedema Acetaminophen 4.4510982225
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.5219483382
MESH:D001943 Breast Neoplasms Calcitriol 2.5711237771
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 3.013084413
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 3.0120007298 17173139 1701930 6705139 20935162
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 2.7011237771
MESH:D002386 Cataract Acetaminophen 2.7710977129
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.744080065
MESH:D002779 Cholestasis pirinixic acid 3.0819176532
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5618249437
MESH:D003921 Diabetes Mellitus, Experimental vanadyl sulfate 4.6816684804
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 1.6610915739 19164858 11743745 16081117 19739265 12392966 19085960 19370779 17522070 16393943 14725611 15619225 11287661 12153990 12958197 2444490 14986274 10663392 19416960 10774834 16227642 17562736 11739529 16109766 11529661 19923254 15968718 19420014 11421492 18713872 18071297 16485898 11461765 12594235 16781746 14550746 17906064 12705907 12540782 11834606 16177239
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.7119426721
MESH:D004421 Dystonia Phenobarbital 4.411851702
MESH:D004487 Edema pirinixic acid 2.8512083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 4.3715138306
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.593659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.483922381 11558140
MESH:D004827 Epilepsy Phenobarbital 3.0420417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.876401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.747750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.563659116
MESH:D005234 Fatty Liver pirinixic acid 3.1420131406 19236843
MESH:D005756 Gastritis Acetaminophen 4.2916983495
MESH:D006333 Heart Failure pirinixic acid 2.7320558911
MESH:D006529 Hepatomegaly Phenobarbital 10.1416109766
MESH:D006529 Hepatomegaly pirinixic acid 10.1419176532 19772884 18467677 16221962
MESH:D006930 Hyperalgesia Acetaminophen 2.9916870215
MESH:D006943 Hyperglycemia pirinixic acid 3.5320558911
MESH:D007333 Insulin Resistance pirinixic acid 2.8516306350
MESH:D007674 Kidney Diseases Acetaminophen 2.3812587719 15629191
MESH:D008103 Liver Cirrhosis Phenobarbital 3.0721047994
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3515474484
MESH:D008107 Liver Diseases Acetaminophen 4.1716611625 19784758 16610002 19014921 12587719 12969438 11587558 19460945
MESH:D008107 Liver Diseases Phenobarbital 4.1719363144
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5816871587 17185352
MESH:D008113 Liver Neoplasms Phenobarbital 4.8321047994 19812893 19482888 15975961 19073162 8742319
MESH:D008113 Liver Neoplasms pirinixic acid 4.8316377806 15890375 20007298
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 2.9017172636 18308698 1399818 2563599 6150874
MESH:D008546 Melanoma, Experimental Acetaminophen 4.0519513568
MESH:D009135 Muscular Diseases pirinixic acid 3.9916239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2619151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.2216411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 5.0217484760
MESH:D009369 Neoplasms pirinixic acid 2.0917405874
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1818514411
MESH:D009765 Obesity pirinixic acid 1.8820558911
MESH:D010018 Osteomalacia Phenobarbital 4.9017016548
MESH:D010146 Pain Acetaminophen 2.6916870215
MESH:D010190 Pancreatic Neoplasms Phenobarbital 2.5916965848
MESH:D011230 Precancerous Conditions Phenobarbital 3.952563599
MESH:D011470 Prostatic Hyperplasia Calcitriol 5.3215572423
MESH:D011471 Prostatic Neoplasms marker/mechanism 18642328
MESH:D011471 Prostatic Neoplasms Calcitriol 3.4916644109 15754350 16289102 12479363 18247401
MESH:D019310 Pseudolymphoma Phenobarbital 5.1112752131
MESH:D015427 Reperfusion Injury pirinixic acid 2.5319058328
MESH:D012640 Seizures Phenobarbital 2.924039156 11442880 16876388 3137016
MESH:D003294 Seizures, Febrile Phenobarbital 5.366407741
MESH:D013964 Thyroid Neoplasms Phenobarbital 3.321399818
MESH:D014581 Urticaria Acetaminophen 3.3810982225
Pathway ID Pathway Name
KEGG:04360 Axon guidance
REACT:18266 Axon guidance
KEGG:04012 ErbB signaling pathway
KEGG:04510 Focal adhesion
KEGG:04810 Regulation of actin cytoskeleton
KEGG:05211 Renal cell carcinoma
KEGG:04660 T cell receptor signaling pathway
Pharmacogenomics Knowledge Base Top
Drug Bank Top

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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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