AutismKB 2.0

Annotation Detail for MRPS22


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Basic Information Top
Gene Symbol:MRPS22 ( C3orf5,COXPD5,GIBT,MRP-S22,RPMS22 )
Gene Full Name: mitochondrial ribosomal protein S22
Band: 3q23
Quick LinksEntrez ID:56945; OMIM: 605810; Uniprot ID:RT22_HUMAN; ENSEMBL ID: ENSG00000175110; HGNC ID: 14508
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
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Desease Name
Combined oxidative phosphorylation deficiency 5
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C075773 4-phenylbutyric acid 4-phenylbutyric acid results in decreased expression of MRPS22 mRNAdecreases expression 14583596
D000082 Acetaminophen Acetaminophen affects the expression of MRPS22 mRNAaffects expression 17562736
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of MRPS22 mRNAaffects expression 17484886
C006253 pirinixic acid pirinixic acid results in decreased expression of MRPS22 mRNAdecreases expression 18445702
D011794 Quercetin Quercetin affects the expression of MRPS22 proteinaffects expression 15221776
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.5218653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 4.0216434500
MESH:D000743 Anemia, Hemolytic Quercetin 4.6117084956
MESH:D000799 Angioedema Acetaminophen 4.4510982225
MESH:D001260 Ataxia Telangiectasia Quercetin 5.5215336622
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001327 Autoimmune Diseases Quercetin 4.8919761891
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.5219483382
MESH:D001943 Breast Neoplasms Quercetin 2.6218628248
MESH:D002105 Cadmium Poisoning Quercetin 6.1616962696
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 4.2618705752 15673190 16192424 15721981 3786805 16227642 16050911 15700767 16097048 10355542 16011737 16124888
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.843084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 4.8418788625
MESH:D006528 Carcinoma, Hepatocellular Quercetin 4.8412508355 19519916
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 5.4417234771
MESH:D006332 Cardiomegaly Quercetin 3.4919794523
MESH:D002386 Cataract Acetaminophen 2.7710977129
MESH:D002779 Cholestasis pirinixic acid 3.0819176532
MESH:D003110 Colonic Neoplasms Quercetin 2.4619056647 17148506 15741050 11134977 16640504 19440933 17191121
MESH:D015179 Colorectal Neoplasms Quercetin 2.1918095365 18852136
OMIM:611719 COMBINED OXIDATIVE PHOSPHORYLATION DEFICIENCY 5 marker/mechanism
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5618249437
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 4.0419496084
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 4.0210774834 14725611 19164858 19416960 11739529 18071297 12392966 11461765 16393943 14550746 12594235 16081117 16485898 16109766 15968718 12540782 19420014 14986274 15619225 17906064 19923254 19739265 11529661 12958197 2444490 19085960 18713872 12153990 19370779 12705907 17562736 16177239 11743745 16227642 10663392 10915739 11421492 11287661 17522070 11834606 16781746
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 4.022869522 6623471 7179309 7440962 11566570 9327722 19336974 15998439 10092053 7120509 6884620 17522070 3732212 16227642 15027814 4309450 21278145 19085960 15968718 3786805 16177239 10915739
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.7119426721
MESH:D004487 Edema pirinixic acid 2.8512083418
MESH:D005234 Fatty Liver Carbon Tetrachloride 8.9416045604 15959796 61145 12795759 12631006 17595544 19224547 16239168
MESH:D005234 Fatty Liver pirinixic acid 8.9420131406 19236843
MESH:D005355 Fibrosis Carbon Tetrachloride 10.6118705752
MESH:D005355 Fibrosis Quercetin 10.6119474275
MESH:D005756 Gastritis Acetaminophen 4.2916983495
MESH:D005909 Glioblastoma Quercetin 3.6119804834
MESH:D005910 Glioma Quercetin 3.1717643826
MESH:D006333 Heart Failure pirinixic acid 2.7320558911
MESH:D006505 Hepatitis Carbon Tetrachloride 4.0319110552 19900420
MESH:D006529 Hepatomegaly pirinixic acid 3.4819772884 19176532 18467677 16221962
MESH:D006930 Hyperalgesia Acetaminophen 2.9916870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 5.0716899240
MESH:D006943 Hyperglycemia pirinixic acid 10.4220558911
MESH:D006943 Hyperglycemia Quercetin 10.4218262572 11834736
MESH:D006973 Hypertension Quercetin 2.9618356687
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.5715338365
MESH:D007251 Influenza, Human Quercetin 5.1216624496
MESH:D007333 Insulin Resistance pirinixic acid 2.8516306350
MESH:D007627 Keloid Quercetin 5.4417086741
MESH:D007674 Kidney Diseases Acetaminophen 6.6912587719 15629191
MESH:D007674 Kidney Diseases Quercetin 6.6916962696
MESH:D007938 Leukemia Quercetin 3.3117468513
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.9811408273 17334410 16221502 17174718 16943688 21278145 16239168 17157831 11903743
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 3.6918420326 18210741 13678700 17823541 14716833 17869086 18187930 12445418 11481614 15925388 12741479 12546737 12958196 17557913 12445421 15338365 16027843 15931870 17640975 12898905 15057751 15818738 18705752 18395914 15876570 18412020 16011737 14716496 18166357 12632514 18418968 17708605 12632512 18317297 12667390 18472094 15996030 12389079 17976157 16638106 17525996 14748882 18429990 17481882 18376398 15730626 18156304 18054572 18481824 12666154 15959796 17698563 17944888 18006644 12586293 17805973 15123356 14620537 18339082 16248980 15362042 12649538 17721639 15650968 14724832 17565644 16033810 17922224 10355542 14512876 17766677 15370692 18263696 17761835 18279442 16015684 17900296 15893842 16097048 18472332 17631135 18277467 18395095 16116963 12609069 16136751 18251166 15673190 20821823 15052691 16192424 17714472 18205269
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.6915474484
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 3.6912741479
MESH:D008107 Liver Diseases Acetaminophen 4.1416610002 19014921 16611625 12969438 11587558 19460945 12587719 19784758
MESH:D008107 Liver Diseases Carbon Tetrachloride 4.1416246199 16964402 17285989 15720792 15830285
MESH:D017093 Liver Failure Carbon Tetrachloride 4.6515123358
MESH:D017114 Liver Failure, Acute Acetaminophen 10.5917185352 16871587
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 10.5914706259 16899240
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 8.1219294768
MESH:D008113 Liver Neoplasms pirinixic acid 8.1215890375 20007298 16377806
MESH:D008113 Liver Neoplasms Quercetin 8.1218980244
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 6.8012014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Quercetin 6.8019519916
MESH:D008175 Lung Neoplasms Quercetin 2.1916280456
MESH:D008546 Melanoma, Experimental Acetaminophen 4.0519513568
MESH:D009135 Muscular Diseases pirinixic acid 3.9916239165
MESH:D009203 Myocardial Infarction pirinixic acid 6.1319151258
MESH:D009203 Myocardial Infarction Quercetin 6.1319595682
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 9.3616411023
MESH:D015428 Myocardial Reperfusion Injury Quercetin 9.3619207477
MESH:D009369 Neoplasms 4-phenylbutyric acid 9.3619116145
MESH:D009369 Neoplasms pirinixic acid 9.3617405874
MESH:D009369 Neoplasms Quercetin 9.3615185748
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1818514411
MESH:D020078 Neurogenic Inflammation Quercetin 4.7717929310
MESH:D009765 Obesity pirinixic acid 1.8820558911
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 4.6219495926
MESH:D010051 Ovarian Neoplasms Quercetin 2.8219005980
MESH:D010146 Pain Acetaminophen 2.6916870215
MESH:D010190 Pancreatic Neoplasms Quercetin 2.9516965848
MESH:D011230 Precancerous Conditions Quercetin 4.3119056647
MESH:D011471 Prostatic Neoplasms Quercetin 3.5414715546 17292933
MESH:D015427 Reperfusion Injury pirinixic acid 2.5319058328
MESH:D012554 Schistosomiasis japonica Quercetin 6.1616862918
MESH:D001749 Urinary Bladder Neoplasms Quercetin 2.9116720314
MESH:D014581 Urticaria Acetaminophen 3.3810982225
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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