Annotation Detail for SHD
Basic Information
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| Chemical ID |
Chemical Name |
Interaction |
Interaction Action |
Publication |
|---|
| C006253 |
pirinixic acid |
[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of SHD mRNA | affects binding|decreases expression|increases activity | 19710929
|
| D014635 |
Valproic Acid |
Valproic Acid results in decreased expression of SHD mRNA | decreases expression | 19101580
|
| Disease ID |
Disease Name |
Direct Evidence |
Inference Chemical Name |
Inference Score |
Publication |
|---|
| MESH:D000014 |
Abnormalities, Drug-Induced |
|
Valproic Acid |
4.37 | 8875741 |
| MESH:D000015 |
Abnormalities, Multiple |
|
Valproic Acid |
4.48 | 19490988 |
| MESH:D055371 |
Acute Lung Injury |
|
pirinixic acid |
3.72 | 18653653 |
| MESH:D018248 |
Adenoma, Liver Cell |
|
pirinixic acid |
4.37 | 16434500 |
| MESH:D000550 |
Amblyopia |
|
Valproic Acid |
6.30 | 17688650 |
| MESH:D001008 |
Anxiety Disorders |
|
Valproic Acid |
3.98 | 17497229 |
| MESH:D001321 |
Autistic Disorder |
|
Valproic Acid |
1.98 | 18396377 17688650 19460635 18316065 20603192 16609825 18558336 17157402 15238991 18177632 19232924 17507914 18985861 18775368 18940202 |
| MESH:D001714 |
Bipolar Disorder |
|
Valproic Acid |
3.28 | 20046352 17594078 |
| MESH:D001778 |
Blood Coagulation Disorders |
|
pirinixic acid |
3.70 | 19483382 |
| MESH:D001848 |
Bone Diseases, Developmental |
|
Valproic Acid |
3.69 | 8888407 |
| MESH:D002659 |
Child Development Disorders, Pervasive |
|
Valproic Acid |
2.84 | 20734317 |
| MESH:D002779 |
Cholestasis |
|
pirinixic acid |
3.19 | 19176532 |
| MESH:D019465 |
Craniofacial Abnormalities |
|
Valproic Acid |
1.91 | 8888407 16575769 17688650 |
| MESH:D003876 |
Dermatitis, Atopic |
|
pirinixic acid |
2.61 | 18249437 |
| MESH:D056486 |
Drug-Induced Liver Injury |
|
Valproic Acid |
2.27 | 19641884 1733752 |
| MESH:D004421 |
Dystonia |
|
Valproic Acid |
4.66 | 1851702 |
| MESH:D004487 |
Edema |
|
pirinixic acid |
3.02 | 12083418 |
| MESH:D004831 |
Epilepsies, Myoclonic |
|
Valproic Acid |
4.92 | 3659116 17275665 |
| MESH:D004828 |
Epilepsies, Partial |
|
Valproic Acid |
4.98 | 16628512 3922381 |
| MESH:D004827 |
Epilepsy |
|
Valproic Acid |
3.14 | 18234410 20417680 |
| MESH:D004832 |
Epilepsy, Absence |
|
Valproic Acid |
4.06 | 7562514 6254150 6426943 |
| MESH:D017029 |
Epilepsy, Complex Partial |
|
Valproic Acid |
5.06 | 7750514 |
| MESH:D004830 |
Epilepsy, Tonic-Clonic |
|
Valproic Acid |
4.95 | 3659116 |
| MESH:D005234 |
Fatty Liver |
|
pirinixic acid |
9.61 | 20131406 19236843 |
| MESH:D005234 |
Fatty Liver |
|
Valproic Acid |
9.61 | 14986274 19224547 |
| MESH:D005315 |
Fetal Diseases |
|
Valproic Acid |
5.96 | 16575769 |
| MESH:D005317 |
Fetal Growth Retardation |
|
Valproic Acid |
4.81 | 8888407 18558336 |
| MESH:D006333 |
Heart Failure |
|
pirinixic acid |
2.81 | 20558911 |
| MESH:D006529 |
Hepatomegaly |
|
pirinixic acid |
3.76 | 16221962 19176532 18467677 19772884 |
| MESH:D006849 |
Hydrocephalus |
|
Valproic Acid |
5.75 | 17688650 |
| MESH:D006943 |
Hyperglycemia |
|
pirinixic acid |
3.69 | 20558911 |
| MESH:D007333 |
Insulin Resistance |
|
pirinixic acid |
2.93 | 16306350 |
| MESH:D015470 |
Leukemia, Myeloid, Acute |
|
Valproic Acid |
2.21 | 16294345 17596541 |
| MESH:D008106 |
Liver Cirrhosis, Experimental |
|
pirinixic acid |
1.35 | 15474484 |
| MESH:D008113 |
Liver Neoplasms |
|
pirinixic acid |
1.95 | 20007298 15890375 16377806 |
| MESH:D017563 |
Lung Diseases, Interstitial |
|
Valproic Acid |
5.33 | 17228818 |
| MESH:D008881 |
Migraine Disorders |
|
Valproic Acid |
3.53 | 18803445 18765137 |
| MESH:D009135 |
Muscular Diseases |
|
pirinixic acid |
4.27 | 16239165 |
| MESH:D009139 |
Musculoskeletal Abnormalities |
|
Valproic Acid |
4.58 | 8888407 |
| MESH:D009190 |
Myelodysplastic Syndromes |
|
Valproic Acid |
3.40 | 17596541 |
| MESH:D009203 |
Myocardial Infarction |
|
pirinixic acid |
2.30 | 19151258 |
| MESH:D015428 |
Myocardial Reperfusion Injury |
|
pirinixic acid |
3.33 | 16411023 |
| MESH:D009369 |
Neoplasms |
|
pirinixic acid |
2.14 | 17405874 |
| MESH:D009436 |
Neural Tube Defects |
|
Valproic Acid |
3.42 | 8888407 16359493 |
| MESH:D009765 |
Obesity |
|
pirinixic acid |
1.90 | 20558911 |
| MESH:D011297 |
Prenatal Exposure Delayed Effects |
|
Valproic Acid |
4.71 | 20603192 |
| MESH:D019310 |
Pseudolymphoma |
|
Valproic Acid |
5.61 | 12752131 11422049 |
| MESH:D015427 |
Reperfusion Injury |
|
pirinixic acid |
2.58 | 19058328 |
| MESH:D012208 |
Rhabdomyosarcoma |
|
Valproic Acid |
4.78 | 19155313 |
| MESH:D012559 |
Schizophrenia |
|
Valproic Acid |
2.11 | 15737665 19110320 |
| MESH:D012640 |
Seizures |
|
Valproic Acid |
3.05 | 11044598 11738929 14763951 17978042 3137016 15475178 1511512 16876388 |
| MESH:D016135 |
Spinal Dysraphism |
|
Valproic Acid |
4.17 | 19490988 |
| MESH:D013226 |
Status Epilepticus |
|
Valproic Acid |
5.61 | 12833885 |
| MESH:D014178 |
Translocation, Genetic |
|
Valproic Acid |
6.30 | 17262798 |
| MESH:D020194 |
Unverricht-Lundborg Syndrome |
|
Valproic Acid |
5.41 | 3119515 |
| MESH:D014564 |
Urogenital Abnormalities |
|
Valproic Acid |
5.41 | 8888407 |
| Pathway ID |
Pathway Name |
|---|
| KEGG:00981 |
Insect hormone biosynthesis |
Related Pathway Information