AutismKB 2.0

Annotation Detail for RGMA


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Basic Information Top
Gene Symbol:RGMA ( RGM )
Gene Full Name: RGM domain family, member A
Band: 15q26.1
Quick LinksEntrez ID:56963; OMIM: 607362; Uniprot ID:RGMA_HUMAN; ENSEMBL ID: ENSG00000182175; HGNC ID: 30308
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of RGMA mRNAaffects expression 17484886
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of RGMA mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RGMA mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of RGMA mRNAdecreases expression 18495758
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RGMA mRNAaffects cotreatment|increases expression 17942748
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.5911752688 14514962 15322242
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.8117505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8914692618
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 4.1216835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.3911748828
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 4.1211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.9115885639
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.5312125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.6615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 3.0215746008
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.6620435547
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 4.4315700767 16011737 15721981 16192424 15673190 10355542 18705752 16124888 16097048 16050911 16227642 3786805
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.1616835633
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 1.8618788625
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5818850075 18670907 16120746
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.5816835633
MESH:D002779 Cholestasis Ethinyl Estradiol 3.2017110522 17333356 15861022 16919318 11677210 16105132 17681005
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.258697196 15668235 15340226 12621046 16354765
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.4814669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2720055451 15322242 10048152
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7417107852
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 4.0610915739 11566570 4309450 3786805 16227642 19085960 2869522 15998439 9327722 15968718 6884620 7440962 21278145 7120509 7179309 19336974 10092053 17522070 3732212 16177239 15027814 6623471
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 4.0620420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 3.0911462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.8512711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.7715322242 16714409 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.7712538720
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.479294722 10568697
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.3411564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 9.3416045604 19224547 12795759 15959796 12631006 16239168 61145 17595544
MESH:D005234 Fatty Liver Ethinyl Estradiol 9.3415345470
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 4.1111858732
MESH:D005355 Fibrosis Carbon Tetrachloride 10.8618705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 10.8620067830
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.4610696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.5311294989 10048152
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.8211000095
MESH:D006505 Hepatitis Carbon Tetrachloride 4.1819110552 19900420
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.5415340226 12621046 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.9116354765 18606429 8697196 16959395 15340226
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 5.2716899240
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 2.0318670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.7415338365
MESH:D007021 Hypospadias Ethinyl Estradiol 4.4616569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.9912013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.7617937319
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 2.0412878042 12200463
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.8216580747
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 3.0217174718 11903743 16221502 16943688 17334410 11408273 17157831 21278145 16239168
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 2.3812958196 15876570 17766677 18156304 15052691 12667390 16116963 18429990 18263696 17714472 16192424 12649538 17565644 16015684 18166357 16027843 12666154 13678700 18277467 18279442 16097048 15730626 18481824 12445418 17976157 18472094 15893842 18376398 18705752 17557913 16011737 18251166 18395095 15338365 15123356 18412020 14716833 15931870 20821823 15925388 14748882 12898905 12741479 16248980 17944888 14620537 18339082 12389079 16033810 18395914 15362042 17698563 17823541 12445421 18317297 18054572 12632512 17640975 15057751 16638106 18472332 12632514 18420326 17805973 14724832 15673190 15959796 16136751 18187930 15370692 14716496 17481882 12609069 14512876 15996030 18006644 12586293 17525996 15650968 17761835 17631135 18205269 17900296 15818738 11481614 12546737 17721639 17869086 18210741 18418968 10355542 17922224 17708605
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.3812878042
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.1617285989 16246199 15830285 16964402 15720792
MESH:D017093 Liver Failure Carbon Tetrachloride 4.8215123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 4.1416899240 14706259
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 4.8419294768
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.8416984957
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 6.6112014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.6112151625
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 1.2411884234 19555203
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.3812213967
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.8014600291
MESH:D016584 Panic Disorder Ethinyl Estradiol 4.2211578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 5.1212520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 4.1418163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.9311222880 11896295 11399792 11118676
MESH:D011537 Pruritus Ethinyl Estradiol 4.0515861022 16919318
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.4218990726
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.2116192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.8116709447
MESH:D019851 Thrombophilia Ethinyl Estradiol 4.1511994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.5715669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.7712697716
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.8814692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.4612125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 4.0214671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 5.1215886252
Pathway ID Pathway Name
REACT:18266 Axon guidance
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA128394693
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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