AutismKB 2.0

Annotation Detail for BBX


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Basic Information Top
Gene Symbol:BBX ( HBP2,HSPC339,MDS001 )
Gene Full Name: bobby sox homolog (Drosophila)
Band: 3q13.12
Quick LinksEntrez ID:56987; OMIM: NA; Uniprot ID:BBX_HUMAN; ENSEMBL ID: ENSG00000114439; HGNC ID: 14422
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
No data
Desease Name
CHEMDEPENDENCY
smoking behavior
Desease Name
Smoking behavior
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of BBX mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of BBX mRNAincreases expression 18648102
C035207 4-amino-2,6-dinitrotoluene 4-amino-2,6-dinitrotoluene affects the expression of BBX mRNAaffects expression 21346803
D006710 Homocysteine Homocysteine results in decreased expression of BBX mRNAdecreases expression 17326132
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of BBX mRNAdecreases expression 20064835
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of BBX mRNAdecreases expression 20018196
D005472 Fluorouracil BBX protein affects the susceptibility to Fluorouracilaffects response to substance 16217747
C020771 methylmercury hydroxide methylmercury hydroxide results in increased expression of BBX mRNAincreases expression 20493249
D008942 Mitoxantrone BBX protein affects the susceptibility to Mitoxantroneaffects response to substance 16217747
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of BBX mRNAaffects binding|increases activity|increases expression 19710929
D012643 Selenium [Selenium co-treated with Vitamin E] results in decreased expression of BBX mRNAaffects cotreatment|decreases expression 19244175
D012643 Selenium Selenium results in decreased expression of BBX mRNAdecreases expression 19244175
C004648 testosterone enanthate testosterone enanthate affects the expression of BBX mRNAaffects expression 17440010
D014635 Valproic Acid Valproic Acid results in increased expression of BBX mRNAincreases expression 19101580
D014810 Vitamin E [Selenium co-treated with Vitamin E] results in decreased expression of BBX mRNAaffects cotreatment|decreases expression 19244175
D014810 Vitamin E Vitamin E results in decreased expression of BBX mRNAdecreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced 4-amino-2,6-dinitrotoluene 8.997525203
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 8.998875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.9819490988
MESH:D055371 Acute Lung Injury pirinixic acid 3.1718653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.4520127859 20464547
MESH:D000230 Adenocarcinoma Fluorouracil 4.4517638652
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 6.703712494
MESH:D000236 Adenoma Benzo(a)pyrene 6.706695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.5616434500
MESH:D000550 Amblyopia Valproic Acid 5.3317688650
MESH:D000740 Anemia Fluorouracil 3.7616511603 17963324 15504547
MESH:D001008 Anxiety Disorders Valproic Acid 3.6217497229
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.1519183758
MESH:D001321 Autistic Disorder Homocysteine 2.4516297937 20468076
MESH:D001321 Autistic Disorder Valproic Acid 2.4518775368 18985861 18396377 18558336 16609825 15238991 19232924 20603192 19460635 17507914 18940202 18316065 17688650 17157402 18177632
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.1211289319 1440618
MESH:D001714 Bipolar Disorder Valproic Acid 3.1017594078 20046352
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.2019483382
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.438888407
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.1720146248 17474063
MESH:D001943 Breast Neoplasms Fluorouracil 2.1715136595 16595493 19217205 18357371 18608205 16110121 16557594
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.0016050911
MESH:D002276 Carcinoid Tumor Fluorouracil 4.7616051944
MESH:D002277 Carcinoma Fluorouracil 3.6117121937
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 4.6516705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 4.657296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 4.6516799960 16332177 17045692 17088986 17971768 18930000
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 6.577296757
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 6.5718695887
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.6920419170
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 4.6916757204 16280240 17066447 18986760
MESH:D002386 Cataract 4-amino-2,6-dinitrotoluene 3.6614694615
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 6.767505956
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 6.7620889678
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7220734317
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 7.9819486331 9022650
MESH:D002779 Cholestasis pirinixic acid 7.9819176532
MESH:D003092 Colitis Selenium 3.8517936198
MESH:D003110 Colonic Neoplasms Fluorouracil 2.2418772588 15001691 17018589 17725105 17169374 16510598 17016597 17287894 16340194 17172411
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.0017594712 18448328 15289873 16282729 17016601 16524972 16391804 14970324 18949393 15148649 18288408 16331619 20501625 17401013 16303861 17695437 17454858 17255274 18509181 17094418 18383874 18802399
MESH:D000013 Congenital Abnormalities 4-amino-2,6-dinitrotoluene 4.2115095906
MESH:D003324 Coronary Artery Disease Homocysteine 3.7716379339
MESH:D019465 Craniofacial Abnormalities Valproic Acid 2.738888407 17688650 16575769
MESH:D019465 Craniofacial Abnormalities Vitamin E 2.7319769572
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.0918551238
MESH:D007644 Darier Disease Fluorouracil 4.8716733453
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.8711298694 14531868 8970840 11906362 8156756 2524372 12868966 18759878
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4518249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.552952479 3621924
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 12.2018551238 21346803
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 12.201440618 6482804 9328219 7440962 18692083 9653073 18289764 6679447 8291058 16192314 9022650 18648102 11289319
MESH:D056486 Drug-Induced Liver Injury 4-amino-2,6-dinitrotoluene 12.2021346803
MESH:D056486 Drug-Induced Liver Injury Selenium 12.2015131321
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 12.201733752 19641884
MESH:D004421 Dystonia Valproic Acid 4.111851702
MESH:C538011 Eales disease Vitamin E 4.809068938
MESH:D004487 Edema pirinixic acid 2.5312083418
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.233659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 4.0116628512 3922381
MESH:D004827 Epilepsy Valproic Acid 2.9620417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.636254150 7562514 6426943
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.377750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.153659116
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 10.503581430
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 10.5020426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 10.5016530937
MESH:D004938 Esophageal Neoplasms Fluorouracil 10.5016337965 16481741 17638652 15173087 16785472
MESH:D017889 Exfoliation Syndrome Homocysteine 5.7816504073
MESH:D005234 Fatty Liver pirinixic acid 7.9119236843 20131406
MESH:D005234 Fatty Liver Valproic Acid 7.9114986274 19224547
MESH:D005315 Fetal Diseases Valproic Acid 4.9816575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.198888407 18558336
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.126705139
MESH:D005901 Glaucoma Homocysteine 5.3516504073
MESH:D005910 Glioma Fluorouracil 2.8916145905
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.107505956
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.4215162350 15102660 18337622
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 11.4920471113
MESH:D006330 Heart Defects, Congenital Homocysteine 11.4919638421
MESH:D006330 Heart Defects, Congenital Vitamin E 11.4916080930
MESH:D006331 Heart Diseases Mitoxantrone 4.1916019553
MESH:D006333 Heart Failure pirinixic acid 7.0620558911
MESH:D006333 Heart Failure Selenium 7.0617162251
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.586705139
MESH:D006529 Hepatomegaly pirinixic acid 3.0719772884 18467677 16221962 19176532
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7216490937 16863852
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 5.8417440010
MESH:D019584 Hot Flashes Vitamin E 4.0714716179
MESH:D006849 Hydrocephalus Valproic Acid 4.9517688650
MESH:D006943 Hyperglycemia pirinixic acid 3.2320558911
MESH:D020138 Hyperhomocysteinemia Homocysteine 4.7517369066 18234410 17292331
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.0115034207
MESH:D007251 Influenza, Human Selenium 11.2916624496
MESH:D007251 Influenza, Human Vitamin E 11.2916624496
MESH:D007333 Insulin Resistance pirinixic acid 2.6616306350
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.128074119 9022650
MESH:D007674 Kidney Diseases Vitamin E 2.8312488133
MESH:D007676 Kidney Failure, Chronic Selenium 3.9416518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 12.7116705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 12.716582329
MESH:D007680 Kidney Neoplasms Fluorouracil 12.7116985049
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Mitoxantrone 3.8118172266
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1617596541 16294345
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.2315034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.3915474484
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 2.3916169303
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 7.5320195826 21137059
MESH:D008113 Liver Neoplasms Fluorouracil 7.5316603448 15113037 17045692 18383874
MESH:D008113 Liver Neoplasms pirinixic acid 7.5315890375 16377806 20007298
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 2.56598648 1399818 6587162 3712494
MESH:D008171 Lung Diseases Vitamin E 3.2116863852
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.3617228818
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.506695378 17053015 18569708 20064080 20135361 18520028 20464547 20869020 18816296
MESH:D008175 Lung Neoplasms Fluorouracil 3.5015246190
MESH:D008175 Lung Neoplasms Vitamin E 3.5011062179
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.8715086387
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.7915318939
MESH:D008591 Meningomyelocele Homocysteine 5.6116602021
MESH:D008654 Mesothelioma Selenium 2.8115107826
MESH:D008881 Migraine Disorders Valproic Acid 3.2318765137 18803445
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 8.6716381670
MESH:D009062 Mouth Neoplasms Fluorouracil 8.6716757204 18986760
MESH:D009135 Muscular Diseases pirinixic acid 3.5816239165
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.088888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.1817596541
MESH:D009203 Myocardial Infarction Homocysteine 6.0617412321
MESH:D009203 Myocardial Infarction pirinixic acid 6.0619151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.9916411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 3.9418551238
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.493581430
MESH:D009369 Neoplasms Benzo(a)pyrene 12.1211141357
MESH:D009369 Neoplasms Fluorouracil 12.1216928823 18600527 18239605
MESH:D009369 Neoplasms Mitoxantrone 12.1216640825
MESH:D009369 Neoplasms pirinixic acid 12.1217405874
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 7.376679447
MESH:D009436 Neural Tube Defects Valproic Acid 7.3716359493 8888407
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.4716436463
MESH:D009765 Obesity pirinixic acid 1.8220558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 15.4616049721 12819281
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 15.464026338 6482804
MESH:D009784 Occupational Diseases 4-amino-2,6-dinitrotoluene 15.4614694615
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.123988306
MESH:D010190 Pancreatic Neoplasms Fluorouracil 2.6819003803 16929163 16500647 15113037
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.557296757
MESH:D010300 Parkinson Disease Homocysteine 3.5916275827
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.576228378
MESH:D010954 Plasmacytoma Selenium 4.9915087411
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 3.9120603192
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.5617292933
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.5619082440 18626508
MESH:D011471 Prostatic Neoplasms Vitamin E 2.5615084515
MESH:D019310 Pseudolymphoma Valproic Acid 4.6412752131 11422049
MESH:D012004 Rectal Neoplasms Fluorouracil 4.0618286688 15538739 18722050 16160472
MESH:D015427 Reperfusion Injury pirinixic acid 2.4119058328
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.413692021
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.2319155313
MESH:D012559 Schizophrenia Homocysteine 3.9916641680
MESH:D012559 Schizophrenia Valproic Acid 3.9919110320 15737665
MESH:D012640 Seizures 2,4-dinitrotoluene 6.0618551238
MESH:D012640 Seizures Valproic Acid 6.0611044598 3137016 1511512 15475178 14763951 11738929 16876388 17978042
MESH:D012871 Skin Diseases Vitamin E 2.4518709164
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.3910029692 19755658
MESH:D016135 Spinal Dysraphism Valproic Acid 3.8219490988
MESH:D013226 Status Epilepticus Valproic Acid 4.6412833885
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.432093021 20155912
MESH:D013274 Stomach Neoplasms Fluorouracil 2.4316951190 17498489 15786421 17522103 18567086 16424979 19084572 18396642 17172411 19015929
MESH:D020521 Stroke Vitamin E 3.5616517955
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 2.921399818 6582329 3712494 7505956 6587162
MESH:D014062 Tongue Neoplasms Fluorouracil 4.0416280240
MESH:D014178 Translocation, Genetic Valproic Acid 5.3317262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.603119515
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 8.3816049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 8.388074119
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 8.3817053015
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.718888407
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.4010091137
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 3.9316803524
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA25280
    • No data
    Releated disease ID Related disease Name
    PA445876Tobacco Use Disorder
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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