AutismKB 2.0

Annotation Detail for TULP4


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Basic Information Top
Gene Symbol:TULP4 ( KIAA1397,TUSP )
Gene Full Name: tubby like protein 4
Band: 6q25.3
Quick LinksEntrez ID:56995; OMIM: NA; Uniprot ID:TULP4_HUMAN; ENSEMBL ID: ENSG00000130338; HGNC ID: 15530
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of TULP4 mRNAdecreases expression 20064835
20106945
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of TULP4 mRNAdecreases expression 20018196
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of TULP4 mRNAaffects expression 17484886
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of TULP4 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of TULP4 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TULP4 mRNAaffects cotreatment|increases expression 17942748
D013629 Tamoxifen Tamoxifen affects the expression of TULP4 mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TULP4 mRNAaffects cotreatment|increases expression 17942748
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 5.0714745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.3115322242 14514962 11752688
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.4617505938
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.3920127859 20464547
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.3914692618
MESH:D000236 Adenoma Benzo(a)pyrene 2.826695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.8416835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2511748828
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.4919183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.8811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8415885639
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.3712125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.3115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9515746008
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.7917474063 20146248
MESH:D001943 Breast Neoplasms Tamoxifen 1.7919084267 16202921 21138602 15668708 17440819 18815881 17049068 20135344 20859285 17893378 20390343 19059307 19410462 20065188 19487384 18997820 16873071 19189210 19288272 17242785 19200415 18629630 19011961 18855134 21152245 19155303 17261762 19221464 20544844 18984771 16273361 18821012 18351453 16818667 19115204 19103187 19244106 11161223 19189212 19066611 20005174 19142967 18425577 15565566 19289846
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.7920435547
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 4.2015673190 16097048 16192424 18705752 15700767 16011737 16227642 16124888 16050911 10355542 15721981 3786805
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.0516835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.9219066611
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 3.1318788625
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 3.1316924424
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1220419170
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.9217572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5218850075 16120746 18670907
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.9320889678
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4516835633
MESH:D002779 Cholestasis Ethinyl Estradiol 3.1011677210 17681005 16105132 17333356 16919318 15861022 17110522
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2116354765 12621046 8697196 15668235 15340226
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3414669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2615322242 20055451 10048152
MESH:D003711 Demyelinating Diseases Tamoxifen 4.7819031437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7217107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.7619279558
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 3.979327722 10092053 19336974 2869522 3786805 15027814 4309450 10915739 11566570 21278145 15968718 16227642 6623471 6884620 15998439 19085960 3732212 7179309 17522070 16177239 7120509 7440962
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.9720420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9911462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.7011000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.4216714409 18230668 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 10.2412538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 10.2419031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.2419155303 20544844 16202921 17893378
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.3310568697 9294722
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.5720426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.5716530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2411564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 15.0615959796 61145 17595544 12631006 16239168 12795759 19224547 16045604
MESH:D005234 Fatty Liver Ethinyl Estradiol 15.0615345470
MESH:D005234 Fatty Liver Tamoxifen 15.0619224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.4116709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.8711858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.9914745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.6419069698
MESH:D005355 Fibrosis Carbon Tetrachloride 10.0218705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 10.0220067830
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.1210696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.9320471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.9310048152 11294989
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.6611000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.9719110552 19900420
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.3116120746 12621046 15340226
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.5715340226 18606429 16354765 16959395 8697196
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.9916899240
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 2.0018850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.5015338365
MESH:D007021 Hypospadias Ethinyl Estradiol 4.2316569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.8112013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6817937319
MESH:D007249 Inflammation Tamoxifen 5.3719457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.3712200463 12878042
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.6616580747
MESH:D007680 Kidney Neoplasms Tamoxifen 3.3118625569
MESH:D008064 Lipidoses Tamoxifen 3.3717567588 15342952
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.9617174718 16943688 17334410 11903743 21278145 11408273 16239168 17157831 16221502
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 3.6017721639 12632514 18472094 18187930 14620537 18395914 15650968 15673190 16097048 12958196 14716496 18376398 15123356 17761835 12389079 17766677 16116963 17557913 18263696 15338365 12609069 16248980 18395095 12898905 18418968 17631135 18317297 13678700 17823541 18412020 18429990 15818738 18420326 15730626 15057751 18251166 16011737 17805973 17525996 17714472 15362042 12632512 11481614 12546737 10355542 16192424 17976157 18210741 14748882 17708605 12667390 17922224 16015684 15959796 12586293 15925388 17944888 16136751 15370692 16638106 18166357 18156304 18054572 12649538 16027843 14716833 17869086 18277467 15893842 14724832 18006644 17698563 18481824 18472332 12445418 17481882 18205269 14512876 18279442 18705752 15931870 18339082 15052691 15996030 12666154 17565644 16033810 17640975 12445421 12741479 17900296 20821823 15876570
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 3.6018564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.6012878042
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.1416246199 15830285 16964402 15720792 17285989
MESH:D017093 Liver Failure Carbon Tetrachloride 4.5815123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.9916899240 14706259
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 11.5220195826 21137059
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 11.5219294768
MESH:D008113 Liver Neoplasms Tamoxifen 11.5216684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 11.5216984957
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 6.3715583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.3712151625
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.5020464547 6695378 18520028 20064080 18569708 20869020 18816296 20135361 17053015
MESH:D008175 Lung Neoplasms Tamoxifen 3.5018625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.5011884234 19555203
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.2219428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.8114580682 11731420 19196723 16827153 19196722
MESH:D020149 Manganese Poisoning Tamoxifen 5.0719453300
MESH:D008545 Melanoma Tamoxifen 1.9119393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.6415990972
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.4316381670
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2712213967
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.6519393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.6019410462
MESH:D009369 Neoplasms Benzo(a)pyrene 2.3011141357
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.5219200415 19196722 19189210
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.5914600291
MESH:D016584 Panic Disorder Ethinyl Estradiol 4.0411578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.7712520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.9418163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.6511399792 11222880 11896295 11118676
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.0617292933
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.0615067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.7715861022 16919318
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.2218990726
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.9019755658 10029692
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.9016192470
MESH:D013088 Spermatocele Ethinyl Estradiol 13.3616709447
MESH:D013088 Spermatocele Tamoxifen 13.3616709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.5019457130
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.562093021 20155912
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.9711994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.4415669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.4212697716
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.3417053015
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 5.3416712894 17572228 8653321
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.6814692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.1212125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.8714671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.7715886252
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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