AutismKB 2.0

Annotation Detail for CXCR7


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Basic Information Top
Gene Symbol:CXCR7 ( CMKOR1,GPR159,RDC1 )
Gene Full Name: chemokine (C-X-C motif) receptor 7
Band: 2q37.3
Quick LinksEntrez ID:57007; OMIM: 610376; Uniprot ID:CXCR7_HUMAN; ENSEMBL ID: ENSG00000144476; HGNC ID:
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04060Cytokine-cytokine receptor interaction
Pathway IDPathway Name
Signaling by GPCR
No data
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1934Cancer
2066Lung cancer
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of CXCR7 mRNAdecreases expression 19933214
C003585 22-hydroxycholesterol 22-hydroxycholesterol results in increased expression of CXCR7 mRNAincreases expression 19426978
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of CXCR7 proteinaffects expression 20106945
D000643 Ammonium Chloride Ammonium Chloride affects the expression of CXCR7 mRNAaffects expression 16483693
C015001 arsenite arsenite results in decreased expression of CXCR7 mRNAdecreases expression 18191166
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of CXCR7 mRNAdecreases expression 17944540
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of CXCR7 mRNAdecreases expression 15336504
D016572 Cyclosporine Cyclosporine results in increased expression of CXCR7 mRNAincreases expression 20106945
D003907 Dexamethasone Dexamethasone results in decreased expression of CXCR7 mRNAdecreases expression 17998272
D002117 Calcitriol Calcitriol results in decreased expression of CXCR7 mRNAdecreases expression 16002434
D004958 Estradiol [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of CXCR7 mRNAaffects cotreatment|increases expression 19619570
D004958 Estradiol Estradiol results in decreased expression of CXCR7 mRNAdecreases expression 19619570
D005472 Fluorouracil TP53 protein affects the reaction [Fluorouracil results in decreased expression of CXCR7 mRNA]affects reaction|decreases expression 15016801
D005492 Folic Acid Folic Acid affects the expression of CXCR7 mRNAaffects expression 17320366
D015735 Mifepristone Mifepristone results in decreased expression of CXCR7 mRNAdecreases expression 17584828
D017239 Paclitaxel CXCR7 mRNA results in decreased susceptibility to Paclitaxeldecreases response to substance 16322897
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in increased expression of CXCR7 mRNA]affects reaction|increases expression 19482888
D010634 Phenobarbital Phenobarbital results in increased expression of CXCR7 mRNAincreases expression 19482888
19270015
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of CXCR7 mRNAaffects binding|increases activity|increases expression 19710929
D020849 Raloxifene Raloxifene affects the expression of CXCR7 mRNAaffects expression 14699072
D020849 Raloxifene [Raloxifene co-treated with ESR2 protein] results in decreased expression of CXCR7 mRNAaffects cotreatment|decreases expression 19059307
D013629 Tamoxifen Tamoxifen affects the expression of CXCR7 mRNAaffects expression 14699072
D013629 Tamoxifen [Tamoxifen co-treated with ESR2 protein] results in decreased expression of CXCR7 mRNAaffects cotreatment|decreases expression 19059307
D013749 Tetrachlorodibenzodioxin [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of CXCR7 mRNAaffects cotreatment|increases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of CXCR7 mRNAdecreases expression 19619570
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of CXCR7 mRNAaffects binding|increases expression 16214954
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of CXCR7 mRNAdecreases expression 18691609
19933214
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of CXCR7 mRNAincreases expression 18796159
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of CXCR7 mRNAincreases expression 16054898
18796159
D002762 Cholecalciferol Cholecalciferol results in increased expression of CXCR7 mRNAincreases expression 17170073
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.4414745880
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 7.936195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 7.9311752688 15322242 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.4518287403
MESH:D058186 Acute Kidney Injury Folic Acid 4.2317003819 16316344 16595132
MESH:D055371 Acute Lung Injury pirinixic acid 3.0118653653
MESH:D000230 Adenocarcinoma Estradiol 4.3511473722
MESH:D000230 Adenocarcinoma Fluorouracil 4.3517638652
MESH:D000236 Adenoma Folic Acid 3.7316963246
MESH:D018248 Adenoma, Liver Cell Phenobarbital 16.6617620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 16.6616434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 16.6616835633
MESH:D000419 Albuminuria Raloxifene 4.4917308373 17451421
MESH:D000544 Alzheimer Disease Folic Acid 4.5117116317
MESH:D000544 Alzheimer Disease Raloxifene 4.5115800139
MESH:D000740 Anemia Fluorouracil 8.3517963324 16511603 15504547
MESH:D000740 Anemia Tetrachlorodibenzodioxin 8.3511748828
MESH:D001169 Arthritis, Experimental Dexamethasone 3.4717659584
MESH:D001321 Autistic Disorder Folic Acid 2.8421388746
MESH:D001327 Autoimmune Diseases Cholecalciferol 4.9216142846
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.4319483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.4312125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.6915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6915746008
MESH:D001859 Bone Neoplasms Paclitaxel 4.4615867366
MESH:D001930 Brain Injuries Raloxifene 4.3716580743
MESH:D001943 Breast Neoplasms Calcitriol 4.6511237771
MESH:D001943 Breast Neoplasms Estradiol 4.6517261762 12948864 17289903 17018787 19861407 14630087 16675129 18497071
MESH:D001943 Breast Neoplasms Fluorouracil 4.6516110121 18608205 18357371 15136595 19217205 16557594 16595493
MESH:D001943 Breast Neoplasms Folic Acid 4.6516777985
MESH:D001943 Breast Neoplasms Paclitaxel 4.6518234424 16244791 18223236 18323546 11325840 15136595 16115903 16273361
MESH:D001943 Breast Neoplasms Raloxifene 4.6517049068 17595753 17440819 16837676 15572757 17242785 16912660 15775269 17893378 17952589 15758505 17261762
MESH:D001943 Breast Neoplasms Tamoxifen 4.6518425577 19189210 17440819 15668708 19059307 19189212 19289846 19084267 19200415 16202921 19288272 19155303 21152245 16818667 16873071 20065188 19103187 18351453 17242785 17893378 18984771 19221464 20005174 19244106 20859285 19011961 20544844 20135344 19115204 18997820 19410462 15565566 20390343 19066611 21138602 11161223 17049068 18629630 19487384 18855134 17261762 19142967 18815881 18821012 16273361
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 4.6520435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.3516111702
MESH:D002276 Carcinoid Tumor Fluorouracil 4.5616051944
MESH:D002277 Carcinoma Fluorouracil 7.8917121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.8916835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.4019066611
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 11.1721507988 12619106 12907637
MESH:D006528 Carcinoma, Hepatocellular Estradiol 11.1716924424
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 11.1716799960 17971768 16332177 18930000 17045692 17088986
MESH:D006528 Carcinoma, Hepatocellular Paclitaxel 11.1716313753
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 11.171701930 17173139 6705139 20007298 20935162
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 11.1716924424
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 2.9718695887
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 4.7511237771
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 4.7516280240 17066447 18986760 16757204
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 9.1717572228
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 9.1717572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3118670907 18850075 16120746
MESH:D002318 Cardiovascular Diseases Folic Acid 7.4916755160
MESH:D002318 Cardiovascular Diseases Raloxifene 7.4915775269
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 10.7020889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 10.7012371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 10.7018566989
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.144080065
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.0716835633
MESH:D002779 Cholestasis Cyclosporine 7.4919486331
MESH:D002779 Cholestasis pirinixic acid 7.4919176532
MESH:D002971 Cleft Lip Folic Acid 3.9221254359
MESH:D002972 Cleft Palate Folic Acid 5.958946559 21254359
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.958697196 12621046 15340226 16354765 15668235
MESH:D003072 Cognition Disorders Raloxifene 4.5115800139
MESH:D003110 Colonic Neoplasms arsenite 5.8315037631
MESH:D003110 Colonic Neoplasms Dexamethasone 5.8315824018
MESH:D003110 Colonic Neoplasms Fluorouracil 5.8317169374 16510598 17016597 17725105 17018589 15001691 18772588 16340194 17287894 17172411
MESH:D015179 Colorectal Neoplasms Fluorouracil 3.5818383874 20501625 18802399 18448328 16524972 16391804 17454858 17255274 16303861 15289873 18509181 16331619 16282729 17094418 17695437 17401013 17594712 15148649 18288408 17016601 18949393 14970324
MESH:D015179 Colorectal Neoplasms Folic Acid 3.5817245555 17116713 17087956 16985020 16963246
MESH:D015179 Colorectal Neoplasms Paclitaxel 3.5818802399
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9614669216 17141729
MESH:D019465 Craniofacial Abnormalities Dexamethasone 2.5817728286
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5810048152 20055451 15322242
MESH:D007644 Darier Disease Fluorouracil 4.6816733453
MESH:D003711 Demyelinating Diseases Tamoxifen 4.2519031437
MESH:D003865 Depressive Disorder, Major Raloxifene 4.0717474826
MESH:D017449 Dermatitis, Allergic Contact Dexamethasone 3.3012438553
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3818249437
MESH:D003924 Diabetes Mellitus, Type 2 Folic Acid 4.4816886840
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.4817107852
MESH:D003928 Diabetic Nephropathies Estradiol 14.4719279558
MESH:D003928 Diabetic Nephropathies Raloxifene 14.4717308373 15920148 17451421
MESH:D003928 Diabetic Nephropathies Tamoxifen 14.4719279558
MESH:D003967 Diarrhea Dexamethasone 3.597237001
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.5120420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.6811462148
MESH:D004421 Dystonia Phenobarbital 3.901851702
MESH:D004485 Eczema Dexamethasone 4.3512438553
MESH:D004487 Edema Dexamethasone 15.6219703484
MESH:D004487 Edema pirinixic acid 15.6212083418
MESH:D004487 Edema Raloxifene 15.6215860553
MESH:D004487 Edema Tetrachlorodibenzodioxin 15.6211000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.8018230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 14.8315138306
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 14.8315845917
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 14.8319031437
MESH:D016889 Endometrial Neoplasms Estradiol 12.1319148513 11473722 18566989
MESH:D016889 Endometrial Neoplasms Folic Acid 12.1317301261
MESH:D016889 Endometrial Neoplasms Tamoxifen 12.1316202921 19155303 17893378 20544844
MESH:D004715 Endometriosis Mifepristone 8.8216134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 8.829294722 10568697
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.003659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.7711558140 3922381
MESH:D004827 Epilepsy Phenobarbital 2.8320417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.456401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.147750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 3.913659116
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.1820426865
MESH:D004938 Esophageal Neoplasms Fluorouracil 7.1816785472 15173087 17638652 16337965 16481741
MESH:D004938 Esophageal Neoplasms Paclitaxel 7.1816481741
MESH:D017889 Exfoliation Syndrome Folic Acid 5.3816504073
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.9311564622
MESH:D005234 Fatty Liver arsenite 23.5818296743
MESH:D005234 Fatty Liver Cyclosporine 23.5819224547
MESH:D005234 Fatty Liver pirinixic acid 23.5819236843 20131406
MESH:D005234 Fatty Liver Raloxifene 23.5817473493
MESH:D005234 Fatty Liver Tamoxifen 23.5819224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.1716709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.3511858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.4214745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.0719069698
MESH:D005355 Fibrosis arsenite 14.1618296743
MESH:D005355 Fibrosis Cyclosporine 14.1612639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 14.1620067830
MESH:D005756 Gastritis Folic Acid 4.9817171786
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.118708960
MESH:D005901 Glaucoma Folic Acid 4.9716504073
MESH:D005910 Glioma Fluorouracil 2.8316145905
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.4910696789
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.3118337622 15162350 15102660
MESH:D006330 Heart Defects, Congenital Folic Acid 6.6817286298 16524890
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.6810048152 11294989
MESH:D006331 Heart Diseases Raloxifene 3.4611110106
MESH:D006333 Heart Failure pirinixic acid 2.4720558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.3115720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2311000095
MESH:D006529 Hepatomegaly Phenobarbital 13.7516109766
MESH:D006529 Hepatomegaly pirinixic acid 13.7519176532 18467677 19772884 16221962
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 13.7516120746 15340226 12621046
MESH:D006548 Hernia, Diaphragmatic Dexamethasone 3.037520565
MESH:D006558 Herpes Genitalis Estradiol 4.9315709030
MESH:D006679 HIV Seropositivity Folic Acid 5.3817209195
MESH:D019584 Hot Flashes Estradiol 3.6517088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.9418606429 16959395 16354765 15340226 8697196
MESH:D006943 Hyperglycemia pirinixic acid 3.0820558911
MESH:D020138 Hyperhomocysteinemia Folic Acid 4.4016395265 16755160 16865747 16433478 16397167
MESH:D006973 Hypertension Cyclosporine 12.0410903974
MESH:D006973 Hypertension Dexamethasone 12.0417042910
MESH:D006973 Hypertension Raloxifene 12.0417577099 15787275
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 12.0418850075 18670907
MESH:D007249 Inflammation Dexamethasone 8.008960868 11099482
MESH:D007249 Inflammation Tamoxifen 8.0019457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.0012200463 12878042
MESH:D007333 Insulin Resistance Estradiol 6.9616393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 6.9616306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.2316580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.3415604871
MESH:D007674 Kidney Diseases Cyclosporine 5.738314463 18776723 10903974
MESH:D007674 Kidney Diseases Estradiol 5.7315618244
MESH:D007680 Kidney Neoplasms Cyclosporine 17.0112371664
MESH:D007680 Kidney Neoplasms Estradiol 17.0115610895
MESH:D007680 Kidney Neoplasms Fluorouracil 17.0116985049
MESH:D007680 Kidney Neoplasms Tamoxifen 17.0118625569
MESH:D007889 Leiomyoma Raloxifene 4.3916973256
MESH:D008064 Lipidoses Tamoxifen 3.0815342952 17567588
MESH:D008080 Liposarcoma Paclitaxel 4.7217353645
MESH:D008103 Liver Cirrhosis arsenite 6.6618296743
MESH:D008103 Liver Cirrhosis Phenobarbital 6.6621047994
MESH:D008106 Liver Cirrhosis, Experimental Dexamethasone 6.5816718785
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 6.5814716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 6.5815474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 6.5818564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.5812878042
MESH:D008107 Liver Diseases Folic Acid 4.3616877991
MESH:D008107 Liver Diseases Phenobarbital 4.3619363144
MESH:D008113 Liver Neoplasms Aflatoxin B1 17.4518177683 9163691 15890375 2125692
MESH:D008113 Liver Neoplasms Fluorouracil 17.4518383874 16603448 17045692 15113037
MESH:D008113 Liver Neoplasms Phenobarbital 17.4519812893 19482888 15975961 21047994 19073162 8742319
MESH:D008113 Liver Neoplasms pirinixic acid 17.4520007298 15890375 16377806
MESH:D008113 Liver Neoplasms Tamoxifen 17.4516684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 17.4516984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 9.428603461
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 9.426150874 1399818 2563599 17172636 18308698
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 9.4212151625
MESH:D008175 Lung Neoplasms Aflatoxin B1 8.3914755239
MESH:D008175 Lung Neoplasms arsenite 8.3916809336
MESH:D008175 Lung Neoplasms Dexamethasone 8.3915824018 11195469
MESH:D008175 Lung Neoplasms Fluorouracil 8.3915246190
MESH:D008175 Lung Neoplasms Tamoxifen 8.3918625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 8.3919555203 11884234
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.6815086387
MESH:D008180 Lupus Erythematosus, Systemic Folic Acid 3.3117718048
MESH:D008228 Lymphoma, Non-Hodgkin Paclitaxel 4.0014749477
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.6519428831
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 5.7311807958 11408345 17203775 16891317
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 5.7319196723 14580682 16827153 19196722 11731420
MESH:D020149 Manganese Poisoning Estradiol 12.2919453300
MESH:D020149 Manganese Poisoning Tamoxifen 12.2919453300
MESH:D019767 Maxillofacial Abnormalities Folic Acid 5.5816832597
MESH:D008545 Melanoma Paclitaxel 3.4612025231 12040289 16342250
MESH:D008545 Melanoma Tamoxifen 3.4619393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.0715990972
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.6816801185
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.4515863610
MESH:D009062 Mouth Neoplasms Fluorouracil 3.5516757204 18986760
MESH:D009101 Multiple Myeloma Dexamethasone 11.8215867202 15744524 16118317
MESH:D009101 Multiple Myeloma Paclitaxel 11.8214749477
MESH:D009101 Multiple Myeloma Raloxifene 11.8216497877
MESH:D009135 Muscular Diseases pirinixic acid 3.4016239165
MESH:D009190 Myelodysplastic Syndromes Dexamethasone 3.489809623
MESH:D009203 Myocardial Infarction pirinixic acid 2.1019151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.9312213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 7.9716810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 7.9716411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.3717484760
MESH:D009232 Myxoma Raloxifene 5.4516343187
MESH:D009362 Neoplasm Metastasis Paclitaxel 5.8415867366
MESH:D009362 Neoplasm Metastasis Tamoxifen 5.8419393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4819410462
MESH:D009369 Neoplasms Fluorouracil 4.8018600527 18239605 16928823
MESH:D009369 Neoplasms pirinixic acid 4.8017405874
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.8919189210 19196722 19200415
MESH:D009389 Neovascularization, Pathologic arsenite 9.7915738583
MESH:D009389 Neovascularization, Pathologic Estradiol 9.7917289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.3417954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.1919348381 18481113
MESH:D009421 Nervous System Malformations Estradiol 9.1111399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.1114600291
MESH:D009436 Neural Tube Defects Folic Acid 3.8817438019
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.3616436463
MESH:D009503 Neutropenia Folic Acid 4.4016322990
MESH:D009765 Obesity pirinixic acid 1.7920558911
MESH:D010014 Osteolysis Paclitaxel 4.8715867366
MESH:D010018 Osteomalacia Phenobarbital 4.2617016548
MESH:D010024 Osteoporosis Raloxifene 3.3319059307 17882678 15775268
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 4.1217823083 17893378 15758505 15579764
MESH:D010051 Ovarian Neoplasms Estradiol 7.8519401270
MESH:D010051 Ovarian Neoplasms Mifepristone 7.8516525653
MESH:D010051 Ovarian Neoplasms Paclitaxel 7.8511161223
MESH:D010190 Pancreatic Neoplasms Fluorouracil 5.2215113037 16929163 16500647 19003803
MESH:D010190 Pancreatic Neoplasms Phenobarbital 5.2216965848
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1412520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.4518163543
MESH:D011230 Precancerous Conditions Cyclosporine 8.6512371664
MESH:D011230 Precancerous Conditions Phenobarbital 8.652563599
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Dexamethasone 3.4821297632
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.0811399792 11896295 11118676 11222880
MESH:D011470 Prostatic Hyperplasia Calcitriol 4.6715572423
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.7820887781
MESH:D011471 Prostatic Neoplasms Calcitriol 2.0916289102 15754350 18247401 12479363 16644109
MESH:D011471 Prostatic Neoplasms Cholecalciferol 2.0917024972
MESH:D011471 Prostatic Neoplasms Estradiol 2.0916740699
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.0919082440 18626508
MESH:D011471 Prostatic Neoplasms Paclitaxel 2.0917172428 17136230 16729912 16356831
MESH:D011471 Prostatic Neoplasms Raloxifene 2.0915731164 16220300 16536755
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.0915067354
MESH:D019310 Pseudolymphoma Phenobarbital 4.3912752131
MESH:D011565 Psoriasis Cyclosporine 2.1916882103
MESH:D011693 Purpura Raloxifene 5.4515770314
MESH:D012004 Rectal Neoplasms Fluorouracil 3.9218722050 18286688 15538739 16160472
MESH:D051437 Renal Insufficiency Folic Acid 4.6715728788
MESH:D015427 Reperfusion Injury pirinixic acid 2.3319058328
MESH:D012128 Respiratory Distress Syndrome, Adult Dexamethasone 3.9111700416 18379247
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.7318990726
MESH:D012559 Schizophrenia Folic Acid 2.8816641680
MESH:D012640 Seizures Phenobarbital 2.623137016 16876388 11442880 4039156
MESH:D003294 Seizures, Febrile Phenobarbital 4.716407741
MESH:D012871 Skin Diseases Folic Acid 3.2218709164
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 5.428532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.4216192470
MESH:D013088 Spermatocele Tamoxifen 4.1916709447
MESH:D013118 Spinal Cord Diseases Folic Acid 5.3816361298
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.9319457130
MESH:D013272 Stomach Diseases Dexamethasone 4.2115472012
MESH:D013274 Stomach Neoplasms Fluorouracil 3.5417522103 16951190 18396642 17498489 16424979 15786421 18567086 17172411 19084572 19015929
MESH:D013274 Stomach Neoplasms Folic Acid 3.5417171786
MESH:D013274 Stomach Neoplasms Paclitaxel 3.5418506536 18396642
MESH:D013276 Stomach Ulcer Dexamethasone 3.3915138204
MESH:D020521 Stroke Folic Acid 8.7116517955
MESH:D020521 Stroke Raloxifene 8.7116837676
MESH:D024801 Tauopathies Paclitaxel 4.7016930453
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.8012697716
MESH:D013964 Thyroid Neoplasms Phenobarbital 2.971399818
MESH:D013978 Tibial Fractures Estradiol 13.3619048282
MESH:D013978 Tibial Fractures Raloxifene 13.3619048282
MESH:D014062 Tongue Neoplasms Fluorouracil 3.8916280240
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 5.0917572228
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 5.0916712894 8653321 17572228
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 3.7816803524
MESH:D014605 Uveitis Cyclosporine 11.421336536
MESH:D014605 Uveitis Dexamethasone 11.421336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.4912125929
MESH:D054556 Venous Thromboembolism Raloxifene 5.1016837676
MESH:D014846 Vulvar Neoplasms Raloxifene 5.4516343187
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1415886252
MESH:D014985 Xerophthalmia Cyclosporine 4.3417120751
Pathway ID Pathway Name
KEGG:04060 Cytokine-cytokine receptor interaction
REACT:14797 Signaling by GPCR
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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