AutismKB 2.0

Annotation Detail for PSMC3


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Basic Information Top
Gene Symbol:PSMC3 ( MGC8487,TBP1 )
Gene Full Name: proteasome (prosome, macropain) 26S subunit, ATPase, 3
Band: 11p11.2
Quick LinksEntrez ID:5702; OMIM: 186852; Uniprot ID:PRS6A_HUMAN; ENSEMBL ID: ENSG00000165916; HGNC ID: 9549
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa03050Proteasome
Pathway IDPathway Name
Signaling by Wnt
Cell Cycle, Mitotic
DNA Replication
Apoptosis
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
HIV Infection
Cell Cycle Checkpoints
Regulation of activated PAK-2p34 by proteasome mediated degradation
Metabolism of amino acids and derivatives
No data
No data
Pathway IDPathway Name
500401Autodegradation of Cdh1 by Cdh1:APC/C
500372SCF(Skp2)-mediated degradation of p27/p21
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C040534 alpha-hexachlorocyclohexane alpha-hexachlorocyclohexane results in increased expression of PSMC3 mRNAincreases expression 16940010
D000638 Amiodarone Amiodarone affects the expression of PSMC3 mRNAaffects expression 19483382
D000643 Ammonium Chloride Ammonium Chloride affects the expression of PSMC3 mRNAaffects expression 16483693
D001205 Ascorbic Acid [Tretinoin co-treated with Ascorbic Acid] results in increased expression of PSMC3 mRNAaffects cotreatment|increases expression 16443354
D001553 Benzbromarone Benzbromarone affects the expression of PSMC3 mRNAaffects expression 19483382
C032036 bromobenzene bromobenzene metabolite binds to PSMC3 proteinaffects binding 17305373
D002994 Clofibrate Clofibrate affects the expression of PSMC3 mRNAaffects expression 19483382
D016572 Cyclosporine Cyclosporine results in increased expression of PSMC3 mRNAincreases expression 20106945
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PSMC3 mRNAaffects cotreatment|increases expression 17942748
D005001 Ethionine Ethionine affects the expression of PSMC3 mRNAaffects expression 19483382
C029424 hydrazine hydrazine results in increased expression of PSMC3 mRNAincreases expression 15282401
D006861 Hydrogen Peroxide Hydrogen Peroxide results in decreased expression of PSMC3 mRNAdecreases expression 12419474
D015741 Metribolone Metribolone results in increased expression of PSMC3 proteinincreases expression 17152098
D009853 Omeprazole Omeprazole affects the expression of PSMC3 mRNAaffects expression 19483382
D010852 Picrotoxin Picrotoxin results in decreased expression of PSMC3 mRNAdecreases expression 15170462
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of PSMC3 mRNAaffects binding|decreases expression|increases activity 19710929
C006253 pirinixic acid pirinixic acid affects the expression of PSMC3 mRNAaffects expression 19483382
C025299 polyphenols polyphenols results in decreased expression of PSMC3 mRNAdecreases expression 16293270
D011441 Propylthiouracil Propylthiouracil affects the expression of PSMC3 mRNAaffects expression 19483382
C031280 pyrazole pyrazole results in increased expression of PSMC3 mRNAincreases expression 17945193
C017947 sodium arsenite sodium arsenite affects the expression of PSMC3 mRNAaffects expression 16507464
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PSMC3 mRNAaffects cotreatment|increases expression 17942748
D013853 Thioacetamide Thioacetamide affects the expression of PSMC3 mRNAaffects expression 19483382
D014212 Tretinoin [Tretinoin co-treated with Ascorbic Acid] results in increased expression of PSMC3 mRNAaffects cotreatment|increases expression 16443354
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.7015322242 14514962 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.4118287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.7917505938
MESH:D055371 Acute Lung Injury pirinixic acid 2.9718653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.7814692618
MESH:D018248 Adenoma, Liver Cell pirinixic acid 9.3916434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.3916835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.5515276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.7516712894 17306315
MESH:D000505 Alopecia Tretinoin 3.4915955085
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.8111748828
MESH:D001145 Arrhythmias, Cardiac Amiodarone 3.6718218290 18057881 20041841
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.3111256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 6.9015885639
MESH:D001169 Arthritis, Experimental Tretinoin 6.9016412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2316292516
MESH:D001249 Asthma Tretinoin 2.3016456186
MESH:D001281 Atrial Fibrillation Amiodarone 3.7919698954 18651412
MESH:D001471 Barrett Esophagus Tretinoin 4.2516935849
MESH:D001778 Blood Coagulation Disorders Amiodarone 63.4319483382
MESH:D001778 Blood Coagulation Disorders Benzbromarone 63.4319483382
MESH:D001778 Blood Coagulation Disorders Clofibrate 63.4319483382
MESH:D001778 Blood Coagulation Disorders Ethionine 63.4319483382
MESH:D001778 Blood Coagulation Disorders Omeprazole 63.4319483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 63.4319483382
MESH:D001778 Blood Coagulation Disorders Propylthiouracil 63.4319483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 63.4312125929
MESH:D001778 Blood Coagulation Disorders Thioacetamide 63.4319483382
MESH:D001778 Blood Coagulation Disorders Tretinoin 63.4316206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.6415340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6715746008
MESH:D001943 Breast Neoplasms Ascorbic Acid 1.9616443354
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9620435547
MESH:D001943 Breast Neoplasms Tretinoin 1.9616873071 16443354 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.4416813970
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.6816835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.0116168501
MESH:D006528 Carcinoma, Hepatocellular Benzbromarone 6.461701930
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 6.4615276417 17306315 16507464
MESH:D006528 Carcinoma, Hepatocellular Thioacetamide 6.4617997003
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 6.461917145
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 4.5418572023
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 4.5416096774 16051514
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2818850075 18670907 16120746
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.8419225199 15710769
MESH:D002318 Cardiovascular Diseases Hydrogen Peroxide 3.4116936243
MESH:D002341 Carotid Artery Thrombosis Amiodarone 4.9318974383
MESH:D002386 Cataract Tretinoin 3.0117460283
MESH:D002471 Cell Transformation, Neoplastic Clofibrate 10.671399818
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 10.6712371664
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 10.6720056578 19524636
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.4416129372
MESH:D002637 Chest Pain Omeprazole 4.9615447763
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.1216835633
MESH:D018281 Cholangiocarcinoma Thioacetamide 9.1218291259
MESH:D002779 Cholestasis Cyclosporine 12.6919486331
MESH:D002779 Cholestasis Ethinyl Estradiol 12.6916919318 15861022 17681005 17333356 16105132 17110522 11677210
MESH:D002779 Cholestasis pirinixic acid 12.6919176532
MESH:D002822 Choriocarcinoma Tretinoin 5.0116461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.5615340226 8697196 16354765 15668235 12621046
MESH:D002972 Cleft Palate Tretinoin 5.569407595
MESH:D003092 Colitis Tretinoin 3.5517035595
MESH:D003110 Colonic Neoplasms polyphenols 2.6516293270
MESH:D003139 Common Cold Ascorbic Acid 5.3217323712
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9317141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.4020055451 15322242 10048152
MESH:D019465 Craniofacial Abnormalities Tretinoin 2.4010589399 9125849 9224671 9664655 9142499 14991402 9211117 8800419 16925845 17551590
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3618249437
MESH:D003924 Diabetes Mellitus, Type 2 Ascorbic Acid 4.4316506275
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.4317107852
MESH:D056486 Drug-Induced Liver Injury Amiodarone 14.6915265979 18218290
MESH:D056486 Drug-Induced Liver Injury bromobenzene 14.6910092053 12628495
MESH:D056486 Drug-Induced Liver Injury polyphenols 14.6919370779
MESH:D056486 Drug-Induced Liver Injury pyrazole 14.6912499123
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 14.6920420201
MESH:D056486 Drug-Induced Liver Injury Thioacetamide 14.6912963478
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.6511462148
MESH:D004381 Duodenal Ulcer Omeprazole 4.1815991576 16613094 21218061 17151854
MESH:D050171 Dyslipidemias Clofibrate 3.9616707586
MESH:C538011 Eales disease Ascorbic Acid 5.329068938
MESH:D004487 Edema pirinixic acid 6.0812083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.0811000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 11.4418230668 15322242 16714409
MESH:D004489 Edema, Cardiac Tretinoin 11.4418230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.0412538720
MESH:D016889 Endometrial Neoplasms Tretinoin 3.0116569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.8910568697 9294722
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.4611564622
MESH:D005124 Eye Abnormalities Tretinoin 8.4616938888 9664655
MESH:D005218 Fat Necrosis Thioacetamide 5.5716456712
MESH:D005234 Fatty Liver Amiodarone 23.1814986274
MESH:D005234 Fatty Liver Clofibrate 23.1819224547
MESH:D005234 Fatty Liver Cyclosporine 23.1819224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 23.1815345470
MESH:D005234 Fatty Liver pirinixic acid 23.1820131406 19236843
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.3111858732
MESH:D005355 Fibrosis Cyclosporine 13.8412168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 13.8420067830
MESH:D005355 Fibrosis Tretinoin 13.8417994277
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.5316452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.078708960
MESH:D005909 Glioblastoma Tretinoin 2.9117312396
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.4410696789
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.0816096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.0116084493
MESH:D006330 Heart Defects, Congenital Ascorbic Acid 10.7816080930
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 10.7810048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 10.789664655 14991402
MESH:D006333 Heart Failure pirinixic acid 2.4420558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.2715720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2011000095
MESH:D006501 Hepatic Encephalopathy Thioacetamide 4.4318665440 17276928 15929193
MESH:D006505 Hepatitis Thioacetamide 4.0716456712
MESH:D006529 Hepatomegaly Amiodarone 13.5415265979
MESH:D006529 Hepatomegaly pirinixic acid 13.5419176532 19772884 18467677 16221962
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 13.5412621046 16120746 15340226
MESH:D006548 Hernia, Diaphragmatic Ascorbic Acid 3.4216863852 16490937
MESH:D006689 Hodgkin Disease sodium arsenite 3.0312676792
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.898697196 18606429 16354765 15340226 16959395
MESH:D006930 Hyperalgesia Tretinoin 3.0916870215
MESH:D006937 Hypercholesterolemia Amiodarone 3.739751232 8137927
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.4216778211
MESH:D006943 Hyperglycemia pirinixic acid 3.0520558911
MESH:D006973 Hypertension Cyclosporine 4.7510903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.7518670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 3.6616569931 16945680
MESH:D007037 Hypothyroidism Amiodarone 11.1117991464 18020914
MESH:D007037 Hypothyroidism Propylthiouracil 11.1118031379 8137927
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.3212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.3117937319
MESH:D007248 Infertility, Male sodium arsenite 6.3112646999 15346721
MESH:D007249 Inflammation polyphenols 4.8916366677
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 4.8912200463 12878042
MESH:D007333 Insulin Resistance pirinixic acid 2.5316306350
MESH:D007410 Intestinal Diseases Tretinoin 3.6217994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.4716580747
MESH:D007569 Jaw Abnormalities Tretinoin 9.4717551590 15992940
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.2915604871
MESH:D007674 Kidney Diseases Cyclosporine 5.738314463 10903974 18776723
MESH:D007674 Kidney Diseases sodium arsenite 5.7320008137
MESH:D007676 Kidney Failure, Chronic Hydrogen Peroxide 4.1316518626
MESH:D007680 Kidney Neoplasms Cyclosporine 2.6112371664
MESH:D016773 Leishmaniasis, Cutaneous Omeprazole 3.9719248655
MESH:D007938 Leukemia Tretinoin 2.7017143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.5616932348 16482212 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.0516294345 19850784 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.0519642359 16823087 16935935 16788101 17368321 17361223 17107899 19225113 16140955 17712046 17301526 19075265 16331271 16891316 15748426 19029980 16766008 17294898 17217047 17649720 17339181 9834237 19035177 17506722 12679006
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.209224671
MESH:D008064 Lipidoses Amiodarone 3.4015342952 17567588
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 4.8015474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 4.8012878042
MESH:D008106 Liver Cirrhosis, Experimental Thioacetamide 4.8012557150 12679928 15158331 15474484 17050028 11682029 18263696 15075984 10677585 15288473 15288472 18295389 18615449 18458672 12175628 11172339 15465738 11481614 16511523 16126171 17127702 12531686 17355460 18380797 16489207 16248980 16097051 15716488 12085344 17292413 16343077 15334695 15362042 18032466 18606216 18031379 12891558 16098781 18395095 18416461 14739098 15095483 15316131 15078482 17629604
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 4.8016248980 18397230
MESH:D008107 Liver Diseases polyphenols 4.4216698588
MESH:D008107 Liver Diseases Thioacetamide 4.4218374380 15158337 16337175
MESH:D017114 Liver Failure, Acute Thioacetamide 4.1815633222 12479984 17276928 15313186
MESH:D008113 Liver Neoplasms pirinixic acid 7.0215890375 20007298 16377806
MESH:D008113 Liver Neoplasms sodium arsenite 7.0216712894 15276417
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.0216984957
MESH:D008114 Liver Neoplasms, Experimental Ascorbic Acid 5.7918544905
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.7912151625
MESH:D008133 Long QT Syndrome Amiodarone 3.4611989578 15350150 17391786
MESH:D008171 Lung Diseases Amiodarone 11.8912587719
MESH:D008171 Lung Diseases Ascorbic Acid 11.8916863852
MESH:D008171 Lung Diseases sodium arsenite 11.8919095001
MESH:D017563 Lung Diseases, Interstitial Amiodarone 4.3318516814
MESH:D008175 Lung Neoplasms Ascorbic Acid 3.4116401635
MESH:D008175 Lung Neoplasms sodium arsenite 3.4115276417 17077188 19931552 17306315 16712894
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.4119555203 11884234
MESH:D008527 Medulloblastoma Tretinoin 2.7317453147
MESH:D008545 Melanoma sodium arsenite 3.2519082730 16487513
MESH:D008545 Melanoma Tretinoin 3.2516752155
MESH:D008591 Meningomyelocele Tretinoin 4.2716940565
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.6416801185
MESH:D009135 Muscular Diseases pirinixic acid 3.3616239165
MESH:D009181 Mycoses Amiodarone 4.7512754197 17974566
MESH:D009190 Myelodysplastic Syndromes Tretinoin 2.9917596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.0819151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.9012213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.8316411023
MESH:D009369 Neoplasms pirinixic acid 7.8017405874
MESH:D009369 Neoplasms sodium arsenite 7.8011559025
MESH:D009369 Neoplasms Tretinoin 7.8016594593 16946489
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.5220056578
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.2917954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.1518481113 19348381
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.0214600291
MESH:D009421 Nervous System Malformations Tretinoin 9.029125849
MESH:D009436 Neural Tube Defects sodium arsenite 6.9812854658
MESH:D009436 Neural Tube Defects Tretinoin 6.989142499
MESH:D052556 Niemann-Pick Disease, Type C Clofibrate 4.799802331
MESH:D009765 Obesity Ascorbic Acid 4.6217217161
MESH:D009765 Obesity pirinixic acid 4.6220558911
MESH:D010051 Ovarian Neoplasms sodium arsenite 4.7317306315 15276417
MESH:D010051 Ovarian Neoplasms Tretinoin 4.7316936753
MESH:D010146 Pain Tretinoin 2.7816870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.4115976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.5411578682
MESH:D010212 Papilloma Hydrogen Peroxide 3.9412065085
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1012520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.4118163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.0912371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.0411399792 11896295 11118676 11222880
MESH:D011471 Prostatic Neoplasms sodium arsenite 3.3416039940
MESH:D011507 Proteinuria Tretinoin 3.4616636307
MESH:D011537 Pruritus Ethinyl Estradiol 3.1615861022 16919318
MESH:D011565 Psoriasis Cyclosporine 2.1816882103
MESH:D011625 Pterygium Tretinoin 4.6416723453
MESH:D011657 Pulmonary Eosinophilia Ascorbic Acid 5.1814606601
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.8012490602 12832656 11597910
MESH:D015427 Reperfusion Injury pirinixic acid 2.3119058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6918990726
MESH:D012174 Retinitis Pigmentosa Ascorbic Acid 3.2716849425
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.9616283617 16116481
MESH:D012640 Seizures Picrotoxin 3.898635557 8954991
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 4.9318724381
MESH:D012871 Skin Diseases Ascorbic Acid 3.1718709164
MESH:D012878 Skin Neoplasms Hydrogen Peroxide 13.0012065085
MESH:D012878 Skin Neoplasms sodium arsenite 13.0018572023 19524636
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 13.0016192470
MESH:D012878 Skin Neoplasms Tretinoin 13.0016467112
MESH:D013088 Spermatocele Ethinyl Estradiol 3.7916709447
MESH:D016135 Spinal Dysraphism sodium arsenite 3.6812854658
MESH:D013272 Stomach Diseases Omeprazole 4.4618545984
MESH:D013274 Stomach Neoplasms Tretinoin 1.7917261132
MESH:D013276 Stomach Ulcer Amiodarone 11.4518087811
MESH:D013276 Stomach Ulcer Ascorbic Acid 11.4518726076
MESH:D013276 Stomach Ulcer Omeprazole 11.4518237397 15991576 10750652 11906479 16755016 17977527
MESH:D020521 Stroke Ascorbic Acid 4.1716403987 16517955
MESH:D013610 Tachycardia Amiodarone 4.1411238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 4.0419225199
MESH:D013705 Temporomandibular Joint Disorders polyphenols 5.1017997062
MESH:D013733 Testicular Diseases pyrazole 4.666499806
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.4811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.0215669648
MESH:D013959 Thyroid Diseases Amiodarone 11.5519731979
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 11.5512697716
MESH:D013964 Thyroid Neoplasms Propylthiouracil 7.0415710170
MESH:D013964 Thyroid Neoplasms Tretinoin 7.0417045167 16026305
MESH:D013971 Thyrotoxicosis Amiodarone 4.7119584973 18020914
MESH:D014062 Tongue Neoplasms Tretinoin 3.6516051514
MESH:D016171 Torsades de Pointes Amiodarone 4.0411989578 17467628
MESH:D014376 Tuberculosis Tretinoin 3.1316040207
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 2.4516712894 17306315 11723127 16452187
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 8.9611813266
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 8.9616129372
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.1514692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.4616752155
MESH:D014605 Uveitis Cyclosporine 3.831336536
MESH:D014652 Vascular Diseases sodium arsenite 4.2717056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.4412125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.4014671159 15869587
MESH:D014820 Vitiligo Tretinoin 3.9116761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1015886252
MESH:D009396 Wilms Tumor Tretinoin 3.8416287080
MESH:D014985 Xerophthalmia Cyclosporine 4.2917120751
Pathway ID Pathway Name
REACT:578 Apoptosis
REACT:6850 Cdc20:Phospho-APC/C mediated degradation of Cyclin A
REACT:1538 Cell Cycle Checkpoints
REACT:152 Cell Cycle, Mitotic
REACT:383 DNA Replication
REACT:6185 HIV Infection
REACT:13 Metabolism of amino acids and derivatives
REACT:21257 Metabolism of RNA
KEGG:03050 Proteasome
REACT:13505 Proteasome mediated degradation of PAK-2p34
REACT:11045 Signaling by Wnt
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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