AutismKB 2.0

Annotation Detail for TWSG1


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Basic Information Top
Gene Symbol:TWSG1 ( TSG )
Gene Full Name: twisted gastrulation homolog 1 (Drosophila)
Band: 18p11.22
Quick LinksEntrez ID:57045; OMIM: 605049; Uniprot ID:TWSG1_HUMAN; ENSEMBL ID: ENSG00000128791; HGNC ID: 12429
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of TWSG1 mRNA]affects reaction|increases expression 18700144
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of TWSG1 proteinaffects expression 20106945
D001151 Arsenic Arsenic results in decreased expression of TWSG1 mRNAdecreases expression 19654921
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of TWSG1 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TWSG1 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of TWSG1 mRNAaffects binding|increases expression 16214954
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TWSG1 mRNAaffects cotreatment|increases expression 17942748
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.3814514962 11752688 15322242
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.5517505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8814692618
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.9216835633
MESH:D018246 Adrenocortical Adenoma Arsenic 5.8217306315
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2911748828
MESH:D000799 Angioedema Acetaminophen 4.4510982225
MESH:D020261 Arsenic Poisoning Arsenic 2.9418414634 16251483 16835338 12569548
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.9511256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8615885639
MESH:D050197 Atherosclerosis Arsenic 3.4419371607 12928151
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.4212125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.4015340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9715746008
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.6720435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.0916835633
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.7615504454 17687452
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.853084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 4.8521507988 12619106 12907637
MESH:D006528 Carcinoma, Hepatocellular Arsenic 4.8517306315 16507464
MESH:D002294 Carcinoma, Squamous Cell Arsenic 2.7718922899 15504454 17687452
MESH:D002295 Carcinoma, Transitional Cell Arsenic 4.4218640142
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5416120746 18850075 18670907
MESH:D002318 Cardiovascular Diseases Arsenic 3.6817938729 19152805 15738583
MESH:D002340 Carotid Artery Diseases Arsenic 4.6418022660 16973168
MESH:D002386 Cataract Acetaminophen 2.7710977129
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4916835633
MESH:D002779 Cholestasis Ethinyl Estradiol 3.1311677210 15861022 16919318 17110522 16105132 17681005 17333356
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2216354765 12621046 8697196 15668235 15340226
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3817141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2710048152 20055451 15322242
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7317107852
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.8319085960 11743745 17562736 18713872 14986274 12705907 11739529 14550746 19164858 10915739 11834606 12540782 16109766 12153990 2444490 11287661 12594235 11529661 16177239 17906064 18071297 10663392 19370779 15619225 16393943 14725611 12392966 16781746 15968718 17522070 16081117 19923254 11421492 19420014 16485898 16227642 10774834 19739265 12958197 11461765 19416960
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.8320420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.7119426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 3.0211462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.7412711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.5115322242 16714409 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.6312538720
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.379294722 10568697
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2711564622
MESH:D005234 Fatty Liver Ethinyl Estradiol 3.1815345470
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.9411858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.4320067830
MESH:D005534 Foot Diseases Arsenic 6.176392382
MESH:D005756 Gastritis Acetaminophen 4.2916983495
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.2110696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4910048152 11294989
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.7111000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.3716120746 15340226 12621046
MESH:D016142 Holoprosencephaly marker/mechanism 15013800
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.6615340226 16959395 18606429 16354765 8697196
MESH:D006930 Hyperalgesia Acetaminophen 2.9916870215
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.8017050553
MESH:D006973 Hypertension Arsenic 5.609931084 11953799 16076760
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.6018670907 18850075
MESH:D006987 Hypesthesia Arsenic 6.1716093927
MESH:D007021 Hypospadias Ethinyl Estradiol 4.2916945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.8712013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.7117937319
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 2.0112200463 12878042
MESH:D007569 Jaw Abnormalities marker/mechanism 15013800
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.7116580747
MESH:D007642 Keratosis Arsenic 5.5312749816 16930632
MESH:D007674 Kidney Diseases Acetaminophen 2.3815629191 12587719
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 3.7717339181
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2512878042
MESH:D008107 Liver Diseases Acetaminophen 4.3116610002 12969438 19784758 19460945 11587558 16611625 12587719 19014921
MESH:D008107 Liver Diseases Arsenic 4.3111134558
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5817185352 16871587
MESH:D008113 Liver Neoplasms Aflatoxin B1 8.1218177683 9163691 2125692 15890375
MESH:D008113 Liver Neoplasms Arsenic 8.1216368122
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 8.1216984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 6.498603461
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.4912151625
MESH:D008175 Lung Neoplasms Aflatoxin B1 3.6214755239
MESH:D008175 Lung Neoplasms Arsenic 3.6217976673 17306315 19168569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.6219555203 11884234
MESH:D008546 Melanoma, Experimental Acetaminophen 4.0519513568
MESH:D017202 Myocardial Ischemia Arsenic 9.9815371236
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 9.9812213967
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.6514600291
MESH:D009436 Neural Tube Defects Arsenic 3.6716620997
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1818514411
MESH:D020078 Neurogenic Inflammation Arsenic 4.7817056641
MESH:D010051 Ovarian Neoplasms Arsenic 2.8317306315
MESH:D010146 Pain Acetaminophen 2.6916870215
MESH:D016584 Panic Disorder Ethinyl Estradiol 4.0911578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.8612520081
MESH:D010523 Peripheral Nervous System Diseases Arsenic 4.6216093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 5.536392382 15371236 16905509
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 4.0018163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.7311896295 11399792 11118676 11222880
MESH:D011471 Prostatic Neoplasms Arsenic 3.5516140617
MESH:D011507 Proteinuria Arsenic 4.4121343184
MESH:D011537 Pruritus Ethinyl Estradiol 3.8515861022 16919318
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.2818990726
MESH:D012871 Skin Diseases Arsenic 2.8217938729 19834688 18709164 16353154 15952646 17050553 17453740 6392382 16702368 17548696 16759981
MESH:D012878 Skin Neoplasms Arsenic 6.1817029826 15504454 17050553 16251483 19538983 17976673
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 6.1816192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.5516709447
MESH:D019851 Thrombophilia Ethinyl Estradiol 4.0211994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.4815669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.5112697716
MESH:D001749 Urinary Bladder Neoplasms Arsenic 2.9311144890 15987713 19322015 17976673 18640142 19429237 17306315
MESH:D014581 Urticaria Acetaminophen 3.3810982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.7414692618
MESH:D014652 Vascular Diseases Arsenic 5.2817056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.2112125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.9114671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.8615886252
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA37089
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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