AutismKB 2.0

Annotation Detail for SLC17A6


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Basic Information Top
Gene Symbol:SLC17A6 ( DNPI,VGLUT2 )
Gene Full Name: solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6
Band: 11p14.3
Quick LinksEntrez ID:57084; OMIM: 607563; Uniprot ID:VGLU2_HUMAN; ENSEMBL ID: ENSG00000091664; HGNC ID: 16703
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Transmembrane transport of small molecules
Amino acid and oligopeptide SLC transporters
No data
Pathway IDPathway Name
P00037Ionotropic glutamate receptor pathway
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of SLC17A6 mRNAaffects expression 16483693
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of SLC17A6 mRNAaffects cotreatment|increases expression 18164116
D003024 Clozapine Clozapine results in increased expression of SLC17A6 mRNAincreases expression 18155072
17266109
D003024 Clozapine Clozapine results in increased expression of SLC17A6 proteinincreases expression 18155072
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of SLC17A6 mRNAaffects cotreatment|increases expression 18164116
D006220 Haloperidol Haloperidol results in increased expression of SLC17A6 mRNAincreases expression 18155072
D006220 Haloperidol Haloperidol results in increased expression of SLC17A6 proteinincreases expression 18155072
D007657 Ketone Bodies Ketone Bodies results in decreased expression of SLC17A6 mRNAdecreases expression 16807920
D008094 Lithium Lithium results in increased expression of SLC17A6 mRNAincreases expression 18155072
D008094 Lithium Lithium results in increased expression of SLC17A6 proteinincreases expression 18155072
D010622 Phencyclidine Phencyclidine results in increased expression of SLC17A6 mRNAincreases expression 17266109
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of SLC17A6 mRNAaffects binding|increases activity|increases expression 19710929
C025299 polyphenols polyphenols results in decreased expression of SLC17A6 mRNAdecreases expression 16293270
D018967 Risperidone Risperidone results in increased expression of SLC17A6 mRNAincreases expression 18155072
D018967 Risperidone Risperidone results in increased expression of SLC17A6 proteinincreases expression 18155072
C009250 sevoflurane sevoflurane affects the expression of SLC17A6 mRNAaffects expression 15967596
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.7118287403
MESH:D055371 Acute Lung Injury pirinixic acid 3.2318653653
MESH:D000236 Adenoma beta-Naphthoflavone 7.0819389873
MESH:D000236 Adenoma Diethylnitrosamine 7.086695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 10.6116434500 19061943 17620307 19052882 17162532 18056438
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.6116434500
MESH:D000380 Agranulocytosis Clozapine 5.1912649775 14617031 16160616
MESH:D000544 Alzheimer Disease Lithium 3.4819621015
MESH:D020817 Asperger Syndrome Risperidone 5.6116401163
MESH:D001289 Attention Deficit Disorder with Hyperactivity Risperidone 4.8618349709
MESH:D001321 Autistic Disorder Haloperidol 2.8718080171 19368416
MESH:D001321 Autistic Disorder Risperidone 2.8719232924 18349709 16601648 16239862 17019624 19368416 16730335 19013209 18080171 16379507 17929164 18278980 19154706 18026891 15543515 16948927 15994720 17069546 15930063 18775368 15492353
MESH:D001714 Bipolar Disorder Lithium 8.3220046352 20338123 17594078 19153942
MESH:D001714 Bipolar Disorder Risperidone 8.3218278980 19154706
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.2619483382
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.2217474063
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 1.8618971187 20084675 18056438 20935162 19919837 17138121 18788625 16698587 18393292 3084413 16681979 19107877 20432363 19383236 18665156 18210153 20727157 17173139 18691550 19701751 16878318 16540662 16502159 11831363 16569478 20007298 16328049 19171122 10672840 16830150 10737359 17162532 20514400 18785209 19052882 18494052 17761372 19539802 19208518 18506893 16935385 16288022 19418558 18978308 20214788 16807293 17055752 19822196 17978847 20512989 20524982 17428255 20101231 19519916 21159647 16779866 3581430 19335982 19394651
MESH:D002375 Catalepsy Haloperidol 5.061977408 15215559
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 2.932727394 7505956 17174075 21159647
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.7819052882
MESH:D002779 Cholestasis pirinixic acid 2.9119176532
MESH:D003072 Cognition Disorders Clozapine 5.1017123785
MESH:D003110 Colonic Neoplasms polyphenols 2.6916293270
MESH:D007644 Darier Disease Lithium 6.0620338123
MESH:D016757 Death, Sudden, Cardiac Haloperidol 11.8520210726
MESH:D016757 Death, Sudden, Cardiac Risperidone 11.8520210726
MESH:D003704 Dementia Haloperidol 10.9211575062
MESH:D003704 Dementia Risperidone 10.9211575062
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4718249437
MESH:D018500 Diabetes Insipidus, Nephrogenic Lithium 5.8819244398
MESH:D003924 Diabetes Mellitus, Type 2 Clozapine 4.7816402076
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.7820387270
MESH:D006970 Disorders of Excessive Somnolence Clozapine 15.0415331141
MESH:D006970 Disorders of Excessive Somnolence Risperidone 15.0416379507
MESH:D053207 Diurnal Enuresis Risperidone 6.8517822346
MESH:D004314 Down Syndrome Risperidone 5.1318349709
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 4.2719107877
MESH:D056486 Drug-Induced Liver Injury polyphenols 4.2719370779
MESH:D050171 Dyslipidemias Clozapine 4.2616402076
MESH:D004487 Edema pirinixic acid 2.5912083418
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.2916302075
MESH:D005234 Fatty Liver Diethylnitrosamine 8.0520387270 21071580
MESH:D005234 Fatty Liver pirinixic acid 8.0519236843 20131406
MESH:D006330 Heart Defects, Congenital Lithium 4.2719638421
MESH:D006333 Heart Failure pirinixic acid 2.6020558911
MESH:D006529 Hepatomegaly pirinixic acid 3.1319176532 16221962 19772884 18467677
MESH:D006943 Hyperglycemia pirinixic acid 10.0020558911
MESH:D006943 Hyperglycemia Risperidone 10.0018278980
MESH:D006948 Hyperkinesis Clozapine 5.0616046005
MESH:D007249 Inflammation Diethylnitrosamine 5.5218785209
MESH:D007249 Inflammation polyphenols 5.5216366677
MESH:D007333 Insulin Resistance pirinixic acid 2.7016306350
MESH:D007859 Learning Disorders sevoflurane 4.9119212262
MESH:D008064 Lipidoses Clozapine 4.0417567588
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.8818665156 19638242 18522880 18407596 20032147
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3415474484
MESH:D008107 Liver Diseases Diethylnitrosamine 4.4117034775
MESH:D008107 Liver Diseases polyphenols 4.4116698588
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 7.7019389873 21295105
MESH:D008113 Liver Neoplasms Diethylnitrosamine 7.7021278145 19254457 20583210 15175105 19073162 19294768 20137499 18754104 18644402 18977376 19426721 20101389 19256749 19642983 12112319 20452335 19833225 18648771 19427195 2422723 19255062 19090486 19499222 20118626 20434301 19551842 19638242 20501860 21167192 19812893 19996281 18978307 16942905 2862719 19850985 21071580 9163691 21047994 15885732 12771043 20492335 10737359 19690152 20405173
MESH:D008113 Liver Neoplasms pirinixic acid 7.7016377806 15890375 20007298
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 6.3518164116
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 6.3518079962 17942915 16267830 19519916 2563599 18093689 19539802 18253720 17174075 17854601 9362446 19126423 19009564 21159647 19004024 18775883 18544905 18308698 3124819 16842330 18282651 18164116
MESH:D008175 Lung Neoplasms Diethylnitrosamine 1.7620512841 20970405 21163286 6695378
MESH:D008569 Memory Disorders sevoflurane 4.8719212262
MESH:D001523 Mental Disorders Clozapine 14.3916856516
MESH:D001523 Mental Disorders Haloperidol 14.3916856516
MESH:D001523 Mental Disorders Risperidone 14.3916856516 16596465
MESH:D008607 Mental Retardation Risperidone 4.1418349709
MESH:D024821 Metabolic Syndrome X Clozapine 10.5019142101
MESH:D024821 Metabolic Syndrome X Risperidone 10.5019142101
MESH:D019964 Mood Disorders Risperidone 5.9717019624
MESH:D009135 Muscular Diseases pirinixic acid 3.6416239165
MESH:D009203 Myocardial Infarction Lithium 6.2116288908
MESH:D009203 Myocardial Infarction pirinixic acid 6.2119151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0316411023
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.609029167 3581430
MESH:D009369 Neoplasms pirinixic acid 1.9917405874
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.4320387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.2920387270
MESH:D053206 Nocturnal Enuresis Risperidone 6.5017822346
MESH:D009765 Obesity Clozapine 4.7819142110 18515891
MESH:D009765 Obesity pirinixic acid 4.7820558911
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.4516540662
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.652563599
MESH:D011595 Psychomotor Agitation Haloperidol 5.0911575062
MESH:D011618 Psychotic Disorders Clozapine 9.4215331141
MESH:D011618 Psychotic Disorders Haloperidol 9.4211575062
MESH:D015427 Reperfusion Injury pirinixic acid 2.4319058328
MESH:D012559 Schizophrenia Clozapine 6.0018855531 11151749 20452607 20168265 11763009 20107430 19369910 20521320 17123785 17667964 20521326 20580759 18806925 16141801 17726453
MESH:D012559 Schizophrenia Haloperidol 6.0020107430 1830565 18513383 19369910
MESH:D012559 Schizophrenia Risperidone 6.0020107430 19154706 18278980
MESH:D012640 Seizures Lithium 4.0519660546
MESH:D012893 Sleep Disorders Risperidone 5.6618278980
MESH:D013226 Status Epilepticus Lithium 5.9619430551 19951488 19570321
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7618456281
MESH:D017180 Tachycardia, Ventricular Haloperidol 11.4120210726
MESH:D017180 Tachycardia, Ventricular Risperidone 11.4120210726
MESH:D013705 Temporomandibular Joint Disorders polyphenols 5.4317997062
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 3.077505956
MESH:D005879 Tourette Syndrome Risperidone 6.0819154706
MESH:D015430 Weight Gain Clozapine 10.7116141801 16402076 20107430 20521320 17502770 20564506
MESH:D015430 Weight Gain Risperidone 10.7120564506 16379507
MESH:D015431 Weight Loss Clozapine 5.2317933447
Pathway ID Pathway Name
REACT:19419 Amino acid and oligopeptide SLC transporters
KEGG:04724 Glutamatergic synapse
REACT:15518 Transmembrane transport of small molecules
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA424
    • Releated gene ID Related gene Name
    PA424SLC17A6
    Releated disease ID Related disease Name
    PA447199Bipolar Disorder
    PA447216Schizophrenia
    No data
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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