AutismKB 2.0

Annotation Detail for PLSCR4


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Basic Information Top
Gene Symbol:PLSCR4 ( TRA1 )
Gene Full Name: phospholipid scramblase 4
Band: 3q24
Quick LinksEntrez ID:57088; OMIM: 607612; Uniprot ID:PLS4_HUMAN; ENSEMBL ID: ENSG00000114698; HGNC ID: 16497
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of PLSCR4 mRNAaffects expression 17562736
C004984 apocarotenal apocarotenal results in increased expression of PLSCR4 mRNAincreases expression 17034753
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of PLSCR4 mRNAincreases expression 20382639
D019207 beta Carotene beta Carotene results in increased expression of PLSCR4 mRNAincreases expression 17034753
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of PLSCR4 mRNAdecreases expression 15336504
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of PLSCR4 mRNAaffects expression 17484886
D016572 Cyclosporine Cyclosporine affects the expression of PLSCR4 mRNAaffects expression 20106945
D004041 Dietary Fats Dietary Fats results in increased expression of PLSCR4 mRNAincreases expression 18042831
18457598
D008070 Lipopolysaccharides Lipopolysaccharides results in decreased expression of PLSCR4 mRNAdecreases expression 17590392
C041786 palm oil palm oil results in increased expression of PLSCR4 mRNAincreases expression 18042831
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of PLSCR4 mRNAdecreases expression 20106945
D013752 Tetracycline Tetracycline results in increased expression of PLSCR4 mRNAincreases expression 16917069
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0011752688 15322242 14514962
MESH:D055371 Acute Lung Injury Lipopolysaccharides 4.1511850527 18653653
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.5316835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0511748828
MESH:D000799 Angioedema Acetaminophen 4.0210982225
MESH:D001161 Arteriosclerosis Dietary Fats 4.0315238619
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.1512125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8315746008
MESH:D002545 Brain Ischemia beta Carotene 5.2416157235
MESH:D001943 Breast Neoplasms Dietary Fats 1.9820435547
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9820435547
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.9216011737 10355542 15673190 16124888 15700767 3786805 15721981 18705752 16227642 16192424 16050911 16097048
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8916835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.893084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 2.8918788625
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4218670907 16120746 18850075
MESH:D002386 Cataract Acetaminophen 2.6410977129
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 6.8020889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.8012371664
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2616835633
MESH:D002779 Cholestasis Cyclosporine 3.0019486331
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1415668235 16354765 12621046 8697196 15340226
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1617141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2620055451 10048152 15322242
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6917107852
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 9.2417906064 18713872 19085960 17562736 19420014 19164858 15619225 10663392 11421492 16485898 12958197 18071297 15968718 11461765 10915739 11529661 16081117 12392966 16109766 11743745 16227642 16393943 14986274 19923254 11287661 12153990 10774834 12540782 11834606 19416960 17522070 12594235 16177239 12705907 19739265 2444490 16781746 11739529 14550746 19370779 14725611
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 9.2416227642 6623471 10915739 19336974 10092053 15968718 2869522 16177239 15027814 7440962 4309450 3732212 17522070 7179309 9327722 11566570 21278145 19085960 3786805 15998439 6884620 7120509
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 9.2420420201
MESH:D056486 Drug-Induced Liver Injury Tetracycline 9.2417522070
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.2719426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8411462148
MESH:D050171 Dyslipidemias Dietary Fats 3.5318367378
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.4811000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0818230668 16714409 15322242
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.1210568697 9294722
MESH:D019446 Endotoxemia Lipopolysaccharides 4.5515821434 15328337 17637181
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.1020426865
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0911564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 19.7617595544 12631006 16239168 19224547 15959796 61145 16045604 12795759
MESH:D005234 Fatty Liver Cyclosporine 19.7619224547
MESH:D005234 Fatty Liver Dietary Fats 19.7617967931 19551842 18296743 19004024
MESH:D005234 Fatty Liver Tetracycline 19.7616917069 19224547
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5911858732
MESH:D005334 Fever Lipopolysaccharides 4.129205823 11852909
MESH:D005355 Fibrosis Carbon Tetrachloride 22.3618705752
MESH:D005355 Fibrosis Cyclosporine 22.3612639820 12168785
MESH:D005355 Fibrosis Dietary Fats 22.3618296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 22.3620067830
MESH:D005756 Gastritis Acetaminophen 3.8516983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.378708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7710696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3811294989 10048152
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.5815720958
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 4.4916366002
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4411000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.7219900420 19110552
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.0316120746 15340226 12621046
MESH:D015658 HIV Infections beta Carotene 4.1016960176
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.2216354765 8697196 18606429 15340226 16959395
MESH:D006930 Hyperalgesia Acetaminophen 2.7916870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.6916899240
MESH:D006937 Hypercholesterolemia Dietary Fats 3.7021332399
MESH:D006949 Hyperlipidemias Dietary Fats 3.7321332399
MESH:D006973 Hypertension Cyclosporine 5.0710903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.0718850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.2315338365
MESH:D007249 Inflammation Dietary Fats 8.6620412841
MESH:D007249 Inflammation Lipopolysaccharides 8.6612878042 17963957 17237260 9205823 17255318
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.6612200463 12878042
MESH:D007333 Insulin Resistance Dietary Fats 3.1711836018 18457598
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 4.7517255318
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4416580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.6215604871
MESH:D007674 Kidney Diseases Acetaminophen 5.9912587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 5.9918776723 10903974 8314463
MESH:D007680 Kidney Neoplasms Cyclosporine 2.8212371664
MESH:D007970 Leukopenia Lipopolysaccharides 4.8515821434
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 6.8216943688 17334410 17157831 21278145 11408273 16239168 17174718 16221502 11903743
MESH:D008103 Liver Cirrhosis Dietary Fats 6.8218296743
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 3.5714724832 15730626 16192424 15876570 18263696 18006644 11481614 18279442 16033810 17640975 15931870 12389079 17766677 17525996 12741479 15370692 17944888 18205269 15123356 14748882 16027843 18472332 12958196 15818738 18395095 17761835 17481882 17698563 12649538 15338365 20821823 17557913 14716833 18277467 18420326 18429990 18472094 10355542 18166357 17708605 18339082 18395914 15057751 12666154 17869086 12667390 12445418 16248980 18187930 13678700 18317297 14716496 17631135 12546737 16136751 16015684 17900296 18418968 18156304 17714472 16011737 17823541 15650968 18412020 12586293 12632514 15362042 17721639 16638106 18251166 12609069 18210741 18705752 18376398 12632512 14512876 18054572 12445421 17976157 12898905 17565644 15925388 15052691 14620537 16116963 17805973 16097048 15673190 15893842 15996030 17922224 15959796 18481824
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 3.5712878042
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.5712878042
MESH:D008107 Liver Diseases Acetaminophen 3.9816611625 12969438 16610002 19014921 11587558 19784758 12587719 19460945
MESH:D008107 Liver Diseases Carbon Tetrachloride 3.9816964402 15830285 17285989 16246199 15720792
MESH:D017093 Liver Failure Carbon Tetrachloride 4.3015123358
MESH:D017114 Liver Failure, Acute Acetaminophen 9.7616871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 9.7614706259 16899240
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 4.5219294768
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.5216984957
MESH:D008114 Liver Neoplasms, Experimental beta Carotene 10.3617113696
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 10.3615583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.3612151625
MESH:D055370 Lung Injury Lipopolysaccharides 4.1521114838
MESH:D008175 Lung Neoplasms beta Carotene 2.7516401635
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.7519555203 11884234
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7119513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.9616801185
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1112213967
MESH:D009369 Neoplasms beta Carotene 3.6917051425
MESH:D009395 Nephritis, Interstitial Tetracycline 4.969884423
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.6217954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3819348381 18481113
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.3414600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9618514411
MESH:D009765 Obesity Dietary Fats 2.3118457598 21332399 18674790 17217161 20518802 11836018 16723640 20132043 19632207
MESH:D010146 Pain Acetaminophen 2.4816870215
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4212520081
MESH:D010391 Pemphigoid, Bullous Tetracycline 5.6111026799
MESH:D011014 Pneumonia Lipopolysaccharides 4.7112224865 11605937
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6918163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.3212371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3411399792 11896295 11118676 11222880
MESH:D017096 Prion Diseases Tetracycline 5.5710903871
MESH:D011565 Psoriasis Cyclosporine 2.2616882103
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.8010835634
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9618990726
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 5.758532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.7516192470
MESH:D013272 Stomach Diseases beta Carotene 5.2417638125
MESH:D013276 Stomach Ulcer beta Carotene 4.3612500499
MESH:D013921 Thrombocytopenia Lipopolysaccharides 4.2715821434
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0812697716
MESH:D014581 Urticaria Acetaminophen 3.0910982225
MESH:D014605 Uveitis Cyclosporine 4.161336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7712125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4215886252
MESH:D015430 Weight Gain Dietary Fats 3.8316723640
MESH:D014985 Xerophthalmia Cyclosporine 4.6217120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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