AutismKB 2.0

Annotation Detail for PLXDC1


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Basic Information Top
Gene Symbol:PLXDC1 ( DKFZp686F0937,FLJ36270,FLJ45632,TEM3,TEM7 )
Gene Full Name: plexin domain containing 1
Band: 17q12
Quick LinksEntrez ID:57125; OMIM: 606826; Uniprot ID:PXDC1_HUMAN; ENSEMBL ID: ENSG00000161381; HGNC ID: 20945
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1904Diabetes mellitus
2237Neoplasm metastasis
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of PLXDC1 mRNAaffects expression 17484886
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of PLXDC1 mRNAaffects cotreatment|increases expression 17183730
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of PLXDC1 mRNAaffects cotreatment|increases expression 17183730
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 4.238875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.4119490988
MESH:D000550 Amblyopia Valproic Acid 6.1017688650
MESH:D001008 Anxiety Disorders Valproic Acid 3.9417497229
MESH:D001321 Autistic Disorder Valproic Acid 1.9818396377 20603192 17688650 18177632 16609825 18316065 18940202 18985861 17157402 17507914 19232924 18558336 18775368 15238991 19460635
MESH:D001714 Bipolar Disorder Valproic Acid 3.2620046352 17594078
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.668888407
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 4.433786805 15700767 16192424 16227642 16050911 15673190 16097048 15721981 16011737 10355542 16124888 18705752
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 1.8618788625
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.8320734317
MESH:D019465 Craniofacial Abnormalities Valproic Acid 1.918888407 16575769 17688650
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 4.2911566570 2869522 19336974 21278145 3732212 16227642 7179309 3786805 10092053 10915739 6884620 15998439 15027814 17522070 4309450 15968718 19085960 6623471 7120509 7440962 16177239 9327722
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 4.2919641884 1733752
MESH:D004421 Dystonia Valproic Acid 4.581851702
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.813659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 4.7816628512 3922381
MESH:D004827 Epilepsy Valproic Acid 3.1218234410 20417680
MESH:D004832 Epilepsy, Absence Valproic Acid 4.006254150 6426943 7562514
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.957750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.813659116
MESH:D005234 Fatty Liver Carbon Tetrachloride 9.5217595544 61145 12631006 16045604 12795759 16239168 15959796 19224547
MESH:D005234 Fatty Liver Valproic Acid 9.5214986274 19224547
MESH:D005315 Fetal Diseases Valproic Acid 5.7516575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.718888407 18558336
MESH:D005355 Fibrosis Carbon Tetrachloride 4.1018705752
MESH:D006505 Hepatitis Carbon Tetrachloride 4.1819110552 19900420
MESH:D006849 Hydrocephalus Valproic Acid 5.6117688650
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 5.2716899240
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.7415338365
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 5.2816612254
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.2017596541 16294345
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 3.0216221502 16943688 11408273 17157831 16239168 17334410 21278145 11903743 17174718
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 1.7515959796 17805973 17565644 15818738 15362042 16033810 12609069 18054572 18429990 16638106 18156304 12389079 16027843 17481882 15650968 14748882 12445421 17922224 17766677 18472332 15876570 14512876 16116963 15338365 15893842 16097048 17640975 18277467 15996030 12666154 18420326 18481824 17525996 17869086 12741479 16136751 12958196 16015684 18395095 12632514 12632512 15370692 18418968 18210741 17631135 15057751 15123356 20821823 18251166 14716496 17976157 18395914 16011737 14724832 12586293 11481614 12667390 17944888 18187930 12898905 18376398 17900296 18317297 12546737 17714472 17761835 15052691 18705752 13678700 18166357 18205269 15673190 18279442 17823541 17708605 15925388 10355542 18472094 18339082 14620537 17721639 15931870 18263696 12445418 14716833 15730626 16192424 18412020 12649538 18006644 17698563 16248980 17557913
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.1615830285 16246199 17285989 16964402 15720792
MESH:D017093 Liver Failure Carbon Tetrachloride 4.8215123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 4.1416899240 14706259
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 2.3519294768
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 2.8612014681 15583823
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 5.1317228818
MESH:D008881 Migraine Disorders Valproic Acid 3.5018803445 18765137
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.518888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.3717596541
MESH:D009436 Neural Tube Defects Valproic Acid 3.398888407 16359493
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 4.5720603192
MESH:D019310 Pseudolymphoma Valproic Acid 5.4112752131 11422049
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.7019155313
MESH:D012559 Schizophrenia Valproic Acid 2.1119110320 15737665
MESH:D012640 Seizures Valproic Acid 3.0214763951 11738929 16876388 11044598 3137016 17978042 15475178 1511512
MESH:D016135 Spinal Dysraphism Valproic Acid 4.1319490988
MESH:D013226 Status Epilepticus Valproic Acid 5.4112833885
MESH:D014178 Translocation, Genetic Valproic Acid 6.1017262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 5.263119515
MESH:D014564 Urogenital Abnormalities Valproic Acid 5.308888407
No data
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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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