AutismKB 2.0

Annotation Detail for PSMD8


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Basic Information Top
Gene Symbol:PSMD8 ( HIP6,HYPF,MGC1660,Nin1p,Rpn12,S14,p31 )
Gene Full Name: proteasome (prosome, macropain) 26S subunit, non-ATPase, 8
Band: 19q13.2
Quick LinksEntrez ID:5714; OMIM: NA; Uniprot ID:PSMD8_HUMAN; ENSEMBL ID: ENSG00000099341; HGNC ID: 9566
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa03050Proteasome
Pathway IDPathway Name
Signaling by Wnt
Cell Cycle, Mitotic
DNA Replication
Apoptosis
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
HIV Infection
Cell Cycle Checkpoints
Regulation of activated PAK-2p34 by proteasome mediated degradation
Metabolism of amino acids and derivatives
No data
No data
Pathway IDPathway Name
500401Autodegradation of Cdh1 by Cdh1:APC/C
500372SCF(Skp2)-mediated degradation of p27/p21
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C049325 1,2-dithiol-3-thione 1,2-dithiol-3-thione results in increased expression of PSMD8 mRNAincreases expression 15375163
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of PSMD8 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of PSMD8 mRNAaffects expression 17562736
C006632 arsenic trioxide arsenic trioxide results in increased expression of PSMD8 mRNAincreases expression 20458559
D016572 Cyclosporine Cyclosporine results in increased expression of PSMD8 mRNAincreases expression 20106945
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of PSMD8 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PSMD8 mRNAaffects cotreatment|increases expression 17942748
C056933 fumonisin B1 fumonisin B1 results in increased expression of PSMD8 mRNAincreases expression 16221962
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of PSMD8 mRNAaffects cotreatment|increases expression 17183730
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in increased expression of PSMD8 mRNA]affects reaction|increases expression 19482888
D010634 Phenobarbital Phenobarbital results in increased expression of PSMD8 mRNAincreases expression 19482888
C006253 pirinixic acid pirinixic acid results in increased expression of PSMD8 mRNAincreases expression 16221962
C031280 pyrazole pyrazole results in increased expression of PSMD8 mRNAincreases expression 17945193
C010327 salinomycin salinomycin results in decreased expression of PSMD8 mRNAdecreases expression 19682730
D012643 Selenium Selenium results in increased expression of PSMD8 mRNAincreases expression 19244175
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PSMD8 mRNAaffects cotreatment|increases expression 17942748
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of PSMD8 mRNAaffects cotreatment|increases expression 17183730
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 14.516195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 14.5114514962 11752688 15322242
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 14.518875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.9619490988
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.0017505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.1518653653
MESH:D000230 Adenocarcinoma arsenic trioxide 4.3119825857 11798837
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.3114692618
MESH:D018248 Adenoma, Liver Cell Phenobarbital 17.6017620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 17.6016434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 17.6016835633
MESH:D000550 Amblyopia Valproic Acid 5.3017688650
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.9711748828
MESH:D000799 Angioedema Acetaminophen 3.9110982225
MESH:D001008 Anxiety Disorders Valproic Acid 3.5917497229
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.5111256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6815885639
MESH:D001321 Autistic Disorder Acetaminophen 1.8518445737
MESH:D001321 Autistic Disorder Valproic Acid 1.8518775368 18940202 16609825 17507914 17688650 19460635 17157402 18316065 18177632 15238991 18558336 18985861 18396377 19232924 20603192
MESH:D001714 Bipolar Disorder Valproic Acid 3.0920046352 17594078
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 15.4616206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 15.4619483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 15.4612125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.8515340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 8.0815746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 8.088888407
MESH:D001943 Breast Neoplasms salinomycin 2.3819682730
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.3820435547
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.3611589617
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8216835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 6.6016705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.603084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 6.6014691202 15553829 16217749 11135700 15073043
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 6.6017173139 1701930 20007298 6705139 20935162
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.9419014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.1412490120
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3818670907 18850075 16120746
MESH:D002386 Cataract Acetaminophen 2.6010977129
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.5412371664
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.294080065
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7220734317
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.1916835633
MESH:D002779 Cholestasis Cyclosporine 13.4719486331
MESH:D002779 Cholestasis Ethinyl Estradiol 13.4716919318 11677210 17681005 15861022 16105132 17333356 17110522
MESH:D002779 Cholestasis pirinixic acid 13.4719176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1115668235 8697196 12621046 16354765 15340226
MESH:D003092 Colitis Selenium 3.8217936198
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0817141729 14669216
MESH:D023903 Coronary Restenosis arsenic trioxide 4.2212609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 3.7810525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.7815322242 10048152 20055451
MESH:D019465 Craniofacial Abnormalities Valproic Acid 3.788888407 17688650 16575769
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.0618551238
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.1315213294
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4418249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6717107852
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 18.8418551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 18.8416177239 16081117 14550746 19416960 10663392 11739529 19370779 19739265 11834606 11287661 16485898 14725611 10774834 10915739 19164858 11461765 12153990 16109766 12392966 12705907 12958197 11421492 19420014 17906064 19923254 11743745 19085960 17522070 2444490 16781746 16393943 15968718 14986274 18713872 11529661 18071297 12594235 15619225 17562736 12540782 16227642
MESH:D056486 Drug-Induced Liver Injury fumonisin B1 18.8416221962
MESH:D056486 Drug-Induced Liver Injury pyrazole 18.8412499123
MESH:D056486 Drug-Induced Liver Injury Selenium 18.8415131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 18.8420420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 18.841733752 19641884
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1619426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.7811462148
MESH:D004421 Dystonia Phenobarbital 10.541851702
MESH:D004421 Dystonia Valproic Acid 10.541851702
MESH:D004487 Edema pirinixic acid 6.6312083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.6311000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.9618230668 16714409 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.2212538720
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.0510568697 9294722
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 10.943659116
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 10.9417275665 3659116
MESH:D004828 Epilepsies, Partial Phenobarbital 10.193922381 11558140
MESH:D004828 Epilepsies, Partial Valproic Acid 10.193922381 16628512
MESH:D004827 Epilepsy Phenobarbital 6.7120417680
MESH:D004827 Epilepsy Valproic Acid 6.7120417680 18234410
MESH:D004832 Epilepsy, Absence Phenobarbital 8.956401628
MESH:D004832 Epilepsy, Absence Valproic Acid 8.957562514 6254150 6426943
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 11.447750514
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 11.447750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 10.653659116
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 10.653659116
MESH:D004938 Esophageal Neoplasms arsenic trioxide 2.3212903497
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0311564622
MESH:D005234 Fatty Liver arsenic trioxide 24.9815073043
MESH:D005234 Fatty Liver Cyclosporine 24.9819224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 24.9815345470
MESH:D005234 Fatty Liver pirinixic acid 24.9819236843 20131406
MESH:D005234 Fatty Liver Valproic Acid 24.9814986274 19224547
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5011858732
MESH:D005315 Fetal Diseases Valproic Acid 4.9516575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.1718558336 8888407
MESH:D005355 Fibrosis Cyclosporine 8.6212639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.6220067830
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.3016904648
MESH:D005756 Gastritis Acetaminophen 3.7416983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.278708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.6610696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3411294989 10048152
MESH:D006333 Heart Failure pirinixic acid 7.0120558911
MESH:D006333 Heart Failure Selenium 7.0117162251
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.4715720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3611000095
MESH:D006529 Hepatomegaly fumonisin B1 21.0916221962
MESH:D006529 Hepatomegaly Phenobarbital 21.0916109766
MESH:D006529 Hepatomegaly pirinixic acid 21.0918467677 16221962 19176532 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 21.0915340226 16120746 12621046
MESH:D006849 Hydrocephalus Valproic Acid 4.9217688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.1115340226 8697196 16354765 16959395 18606429
MESH:D006930 Hyperalgesia Acetaminophen 2.7216870215
MESH:D006943 Hyperglycemia pirinixic acid 3.2120558911
MESH:D006973 Hypertension Cyclosporine 4.9810903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.9818670907 18850075
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 4.6716612254
MESH:D007021 Hypospadias Ethinyl Estradiol 3.8516569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.4912013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5017937319
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.8712878042 12200463
MESH:D007251 Influenza, Human Selenium 4.2616624496
MESH:D007333 Insulin Resistance pirinixic acid 2.6516306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.3616580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.5015604871
MESH:D007674 Kidney Diseases Acetaminophen 5.8515629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 5.8510903974 8314463 18776723
MESH:D007676 Kidney Failure, Chronic Selenium 3.9116518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 7.3516705839
MESH:D007680 Kidney Neoplasms Cyclosporine 7.3512371664
MESH:D007938 Leukemia arsenic trioxide 2.8415070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.8217077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.3616972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.4514633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.7919077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 3.9216467208 16968895 17050201 19850784 20471514
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 3.9217596541 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.2317712046 17217047 19642359 19035177 19075265 16330433 9834237 11468182 17869043 12018890 15213294 16966277 17649720 15336539 12679006 16112521 16891316 15748426 12712474 19225113 16823087 11161223 17107899 16331271 15622746
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.3916882451
MESH:D008103 Liver Cirrhosis Phenobarbital 2.9121047994
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.1415474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.1412878042
MESH:D008107 Liver Diseases Acetaminophen 3.9516610002 12969438 19460945 16611625 19784758 19014921 11587558 12587719
MESH:D008107 Liver Diseases Phenobarbital 3.9519363144
MESH:D017114 Liver Failure, Acute Acetaminophen 3.2616871587 17185352
MESH:D008113 Liver Neoplasms arsenic trioxide 10.7714682389
MESH:D008113 Liver Neoplasms Phenobarbital 10.7719073162 19482888 21047994 8742319 19812893 15975961
MESH:D008113 Liver Neoplasms pirinixic acid 10.7720007298 16377806 15890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 10.7716984957
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 9.9220377131
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 9.926150874 1399818 18308698 17172636 2563599
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 9.9212151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.3715213294
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.3217228818
MESH:D008175 Lung Neoplasms arsenic trioxide 2.3011798837 19825857
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.3011884234 19555203
MESH:D008325 Mammary Neoplasms, Experimental salinomycin 6.5219682730
MESH:D008325 Mammary Neoplasms, Experimental Selenium 6.5215318939
MESH:D008546 Melanoma, Experimental Acetaminophen 3.6119513568
MESH:D008654 Mesothelioma Selenium 2.8015107826
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.8516801185
MESH:D008881 Migraine Disorders Valproic Acid 3.2118803445 18765137
MESH:D009101 Multiple Myeloma arsenic trioxide 3.1214977855 19417148 11468182 15949261 19549372
MESH:D009135 Muscular Diseases pirinixic acid 3.5516239165
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.068888407
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.7318349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 7.4716105982 16882451
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 7.4717596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.1519151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0412213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.9716411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.5317484760
MESH:D009336 Necrosis 2,4-dinitrotoluene 3.9118551238
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.0016624393
MESH:D009369 Neoplasms pirinixic acid 1.9617405874
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.5017954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3118481113 19348381
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.2514600291
MESH:D009436 Neural Tube Defects arsenic trioxide 7.3910525206
MESH:D009436 Neural Tube Defects Valproic Acid 7.3916359493 8888407
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.8918514411
MESH:D009765 Obesity pirinixic acid 1.8220558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.4512819281 16049721
MESH:D010018 Osteomalacia Phenobarbital 4.4117016548
MESH:D010051 Ovarian Neoplasms arsenic trioxide 2.4119769630 16624393 12452020
MESH:D010146 Pain Acetaminophen 2.4116870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 5.3315580305
MESH:D010190 Pancreatic Neoplasms Phenobarbital 5.3316965848
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.7211578682
MESH:D010235 Paraganglioma arsenic trioxide 4.1919927285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3112520081
MESH:D010954 Plasmacytoma Selenium 4.9515087411
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5918163543
MESH:D011230 Precancerous Conditions Cyclosporine 9.0512371664
MESH:D011230 Precancerous Conditions Phenobarbital 9.052563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.6311118676 11896295 11222880 11399792
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 9.6320603192
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.2719131511
MESH:D011537 Pruritus Ethinyl Estradiol 3.3615861022 16919318
MESH:D019310 Pseudolymphoma Phenobarbital 12.4012752131
MESH:D019310 Pseudolymphoma Valproic Acid 12.4011422049 12752131
MESH:D011565 Psoriasis Cyclosporine 2.2416882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.4019058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8718990726
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.2119155313
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.0016646077
MESH:D012559 Schizophrenia Valproic Acid 2.0719110320 15737665
MESH:D012640 Seizures 2,4-dinitrotoluene 9.9518551238
MESH:D012640 Seizures Phenobarbital 9.9511442880 4039156 3137016 16876388
MESH:D012640 Seizures Valproic Acid 9.9511044598 11738929 3137016 17978042 1511512 15475178 14763951 16876388
MESH:D003294 Seizures, Febrile Phenobarbital 4.876407741
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.0516192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.0016709447
MESH:D016135 Spinal Dysraphism Valproic Acid 3.8019490988
MESH:D013226 Status Epilepticus Valproic Acid 4.6012833885
MESH:D013274 Stomach Neoplasms arsenic trioxide 1.8617007042
MESH:D013733 Testicular Diseases pyrazole 4.876499806
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.6511994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.1815669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.9612697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 7.2919014326
MESH:D013964 Thyroid Neoplasms Phenobarbital 7.291399818
MESH:D016171 Torsades de Pointes arsenic trioxide 4.0115213294
MESH:D014178 Translocation, Genetic Valproic Acid 5.3017262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.573119515
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.1216049721
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 5.1220435036 12973940 11780464 12845720
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.688888407
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.3710091137
MESH:D014581 Urticaria Acetaminophen 3.0110982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.3314692618
MESH:D014605 Uveitis Cyclosporine 4.051336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.6612125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5715869587 14671159
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3115886252
MESH:D014985 Xerophthalmia Cyclosporine 4.5017120751
Pathway ID Pathway Name
REACT:578 Apoptosis
REACT:6850 Cdc20:Phospho-APC/C mediated degradation of Cyclin A
REACT:1538 Cell Cycle Checkpoints
REACT:152 Cell Cycle, Mitotic
REACT:383 DNA Replication
REACT:6185 HIV Infection
REACT:13 Metabolism of amino acids and derivatives
REACT:21257 Metabolism of RNA
KEGG:03050 Proteasome
REACT:13505 Proteasome mediated degradation of PAK-2p34
REACT:11045 Signaling by Wnt
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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