AutismKB 2.0

Annotation Detail for RTN4


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:RTN4 ( ASY,NI220/250,NOGO,NOGO-A,NOGOC,NSP,NSP-CL,Nbla00271,Nbla10545,Nogo-B,Nogo-C,RTN-X,RTN4-A,RTN4-B1,RTN4-B2,RTN4-C )
Gene Full Name: reticulon 4
Band: 2p16.1
Quick LinksEntrez ID:57142; OMIM: 604475; Uniprot ID:RTN4_HUMAN; ENSEMBL ID: ENSG00000115310; HGNC ID: 14085
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Signalling by NGF
No data
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1740Alzheimer's disease
1799Epilepsy
1848Embryoma
1877Multiple sclerosis
1907Depression
2045Bipolar disorder
2051Leukemia
2069Schizophrenia
2075Heart failure
2134Amyotrophic lateral sclerosis
2239Lymphoma
2256Aortic aneurysm
Desease Name
PSYCH
obesity (extreme)
schizophrenia
METABOLIC
Desease Name
Obesity (extreme)
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of RTN4 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of RTN4 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of RTN4 mRNAaffects expression 16483693
C006632 arsenic trioxide arsenic trioxide results in increased expression of RTN4 mRNAincreases expression 20458559
D001554 Benzene [Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in increased expression of RTN4 mRNAaffects cotreatment|increases expression 17905399
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of RTN4 mRNAaffects expression 20382639
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of RTN4 mRNAaffects expression 17484886
D003024 Clozapine Clozapine results in increased expression of RTN4 mRNAincreases expression 17266109
D004041 Dietary Fats Dietary Fats results in increased expression of RTN4 mRNAincreases expression 15238619
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of RTN4 mRNAincreases expression 19638242
D004958 Estradiol Estradiol results in decreased expression of RTN4 mRNAdecreases expression 17912697
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of RTN4 mRNAaffects expression 17555576
D005419 Flavonoids Flavonoids results in decreased expression of RTN4 mRNAdecreases expression 18035473
D006220 Haloperidol Haloperidol results in decreased expression of RTN4 mRNAdecreases expression 18797397
D007657 Ketone Bodies Ketone Bodies results in increased expression of RTN4 mRNAincreases expression 16807920
C030957 methylmercury II [Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in increased expression of RTN4 mRNAaffects cotreatment|increases expression 17905399
C076029 olanzapine olanzapine results in decreased expression of RTN4 mRNAdecreases expression 18797397
C023036 perfluorooctanoic acid perfluorooctanoic acid results in increased expression of RTN4 mRNAincreases expression 16221955
D010622 Phencyclidine Phencyclidine results in increased expression of RTN4 mRNAincreases expression 17266109
C006253 pirinixic acid pirinixic acid results in increased expression of RTN4 mRNAincreases expression 17426115
18301758
D018038 Sodium Selenite Sodium Selenite results in increased expression of RTN4 mRNAincreases expression 18175754
D013629 Tamoxifen Tamoxifen affects the expression of RTN4 mRNAaffects expression 17555576
D013629 Tamoxifen Tamoxifen results in decreased expression of RTN4 mRNAdecreases expression 19457130
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of RTN4 mRNAdecreases expression 19465110
D014241 Trichloroethylene [Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in increased expression of RTN4 mRNAaffects cotreatment|increases expression 17905399
C025643 vinclozolin vinclozolin affects the expression of RTN4 mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.3514745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.6615322242 14514962 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.3718287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.7517505938
MESH:D055371 Acute Lung Injury pirinixic acid 2.9418653653
MESH:D000230 Adenocarcinoma arsenic trioxide 6.7511798837 19825857
MESH:D000230 Adenocarcinoma Estradiol 6.7511473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 6.7514692618
MESH:D000236 Adenoma Diethylnitrosamine 2.746695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 16.1618056438 19052882 17162532 16434500 17620307 19061943
MESH:D018248 Adenoma, Liver Cell pirinixic acid 16.1616434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 16.1616835633
MESH:D000380 Agranulocytosis Clozapine 4.8712649775 14617031 16160616
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.7811748828
MESH:D000741 Anemia, Aplastic Benzene 4.2214761424 11369114 17661222
MESH:D000799 Angioedema Acetaminophen 3.6510982225
MESH:D001008 Anxiety Disorders vinclozolin 3.4919015723
MESH:D001161 Arteriosclerosis Dietary Fats 9.2815238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 9.2811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.5515885639
MESH:D001321 Autistic Disorder Acetaminophen 2.3518445737
MESH:D001321 Autistic Disorder Haloperidol 2.3519368416 18080171
MESH:D001321 Autistic Disorder olanzapine 2.3518685284 17069543
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 14.2816206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 14.2819483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 14.2812125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.6015340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6415746008
MESH:D001855 Bone Marrow Diseases Benzene 5.0416183116
MESH:D001943 Breast Neoplasms Benzene 3.6517162533 11921183
MESH:D001943 Breast Neoplasms Dietary Fats 3.6520435547
MESH:D001943 Breast Neoplasms Diethylnitrosamine 3.6517474063
MESH:D001943 Breast Neoplasms Estradiol 3.6517018787 19861407 12948864 16675129 18497071 17261762 14630087 17289903
MESH:D001943 Breast Neoplasms Tamoxifen 3.6519115204 19410462 18425577 15668708 18351453 19221464 19289846 20065188 18629630 19288272 16202921 17049068 20135344 19244106 19142967 19487384 11161223 18821012 18855134 18997820 19155303 19189210 17242785 19011961 20544844 17440819 18984771 20859285 20005174 21152245 19103187 15565566 18815881 19200415 19066611 17261762 19059307 16818667 16873071 16273361 17893378 21138602 19189212 19084267 20390343
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 3.6520435547
MESH:D001943 Breast Neoplasms Trichloroethylene 3.6515986119
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.1511589617
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.2716111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.5915721981 16011737 16227642 16124888 15700767 16097048 10355542 16050911 3786805 18705752 15673190 16192424
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.6516835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.3219066611
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 13.6016705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 13.603084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 13.6014691202 16217749 15553829 11135700 15073043
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 13.6018788625
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 13.6016830150 3581430 17978847 21159647 16698587 16779866 18665156 16681979 19052882 18494052 18210153 19822196 17055752 18506893 18978308 17428255 16540662 17761372 16569478 16807293 19171122 18056438 17138121 20007298 19418558 18691550 18971187 19519916 10737359 19335982 16935385 20935162 16328049 11831363 18393292 17162532 19701751 20524982 16288022 20101231 17173139 19383236 19208518 19107877 10672840 20432363 16878318 20084675 20514400 18785209 20727157 19394651 18788625 20512989 20214788 19919837 3084413 16502159 19539802
MESH:D006528 Carcinoma, Hepatocellular Estradiol 13.6016924424
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 13.6016924424
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.6819014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 3.9512490120
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.4517572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2618670907 16120746 18850075
MESH:D002375 Catalepsy Haloperidol 4.7215215559 1977408
MESH:D002386 Cataract Acetaminophen 2.4710977129
MESH:D002389 Catatonia olanzapine 6.0618071103 16772815
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 14.956135515
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 14.9520889678
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 14.9517174075 7505956 2727394 21159647
MESH:D002471 Cell Transformation, Neoplastic Estradiol 14.9518566989
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 8.7919052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.7916835633
MESH:D002779 Cholestasis Ethinyl Estradiol 7.2817333356 15861022 11677210 17110522 17681005 16919318 16105132
MESH:D002779 Cholestasis pirinixic acid 7.2819176532
MESH:D019457 Chromosome Breakage Sodium Selenite 4.5615894690
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.038697196 12621046 15668235 15340226 16354765
MESH:D003072 Cognition Disorders Clozapine 4.7717123785
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9017141729 14669216
MESH:D023903 Coronary Restenosis arsenic trioxide 4.0012609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 3.7210525206
MESH:D019465 Craniofacial Abnormalities Benzene 3.7215643154
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.7210048152 20055451 15322242
MESH:D003456 Cryptorchidism vinclozolin 4.1614966744
MESH:D003490 Cyanosis 2,6-dinitrotoluene 3.8318551238
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 10.3315213294
MESH:D016757 Death, Sudden, Cardiac Haloperidol 10.3320210726
MESH:D003704 Dementia Haloperidol 4.4111575062
MESH:D003711 Demyelinating Diseases Tamoxifen 4.1719031437
MESH:D003872 Dermatitis Benzene 4.5815902427
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3418249437
MESH:D002658 Developmental Disabilities olanzapine 4.5617069543
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.6216285004
MESH:D003924 Diabetes Mellitus, Type 2 Clozapine 6.8916402076
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 6.8920387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 6.8917107852
MESH:D003928 Diabetic Nephropathies Estradiol 8.3019279558
MESH:D003928 Diabetic Nephropathies Tamoxifen 8.3019279558
MESH:D006970 Disorders of Excessive Somnolence Clozapine 5.3615331141
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 17.8021346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 17.8019164858 16227642 12540782 11834606 17906064 17522070 16485898 19085960 12594235 16081117 11739529 16781746 18713872 12958197 11743745 16177239 19416960 15619225 14550746 14725611 19370779 10774834 12153990 16109766 19420014 11421492 19923254 14986274 2444490 12392966 16393943 15968718 18071297 12705907 19739265 11529661 17562736 10915739 11461765 10663392 11287661
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 17.8021278145 7440962 10092053 19336974 16177239 11566570 19085960 7120509 15968718 9327722 10915739 17522070 2869522 16227642 15027814 7179309 6884620 3786805 15998439 4309450 3732212 6623471
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 17.8019107877
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 17.8015131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 17.8020420201
MESH:D056486 Drug-Induced Liver Injury Trichloroethylene 17.807120509
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.9119426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.6211462148
MESH:D050171 Dyslipidemias Clozapine 8.4116402076
MESH:D050171 Dyslipidemias Dietary Fats 8.4118367378
MESH:D004487 Edema perfluorooctanoic acid 10.4717259670 12083418
MESH:D004487 Edema pirinixic acid 10.4712083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 10.4712711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.7115322242 16714409 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 8.3312538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 8.3319031437
MESH:D016889 Endometrial Neoplasms Estradiol 6.9811473722 18566989 19148513
MESH:D016889 Endometrial Neoplasms Tamoxifen 6.9817893378 19155303 16202921 20544844
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.8610568697 9294722
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.9216302075
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.2920426865
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.2912903497
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.8711564622
MESH:D005234 Fatty Liver arsenic trioxide 34.3215073043
MESH:D005234 Fatty Liver Carbon Tetrachloride 34.3212795759 16045604 61145 16239168 15959796 17595544 19224547 12631006
MESH:D005234 Fatty Liver Dietary Fats 34.3218296743 17967931 19004024 19551842
MESH:D005234 Fatty Liver Diethylnitrosamine 34.3220387270 21071580
MESH:D005234 Fatty Liver Ethinyl Estradiol 34.3215345470
MESH:D005234 Fatty Liver pirinixic acid 34.3219236843 20131406
MESH:D005234 Fatty Liver Tamoxifen 34.3219224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.1216709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2711858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.3414745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 3.9919069698
MESH:D005355 Fibrosis Carbon Tetrachloride 13.6718705752
MESH:D005355 Fibrosis Dietary Fats 13.6718296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 13.6720067830
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.0816904648
MESH:D005756 Gastritis Acetaminophen 3.4816983495
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.7416973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.1116417039
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.4010696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.2311294989 10048152
MESH:D006333 Heart Failure pirinixic acid 2.4220558911
MESH:D006402 Hematologic Diseases Benzene 4.4816183116
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1611000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.4119900420 19110552
MESH:D006529 Hepatomegaly perfluorooctanoic acid 13.373609246
MESH:D006529 Hepatomegaly pirinixic acid 13.3716221962 19772884 18467677 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 13.3716120746 15340226 12621046
MESH:D006558 Herpes Genitalis Estradiol 4.8415709030
MESH:D019584 Hot Flashes Estradiol 3.5617088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.858697196 16959395 18606429 15340226 16354765
MESH:D006930 Hyperalgesia Acetaminophen 7.3616870215
MESH:D006930 Hyperalgesia perfluorooctanoic acid 7.3612083418
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.3416899240
MESH:D006937 Hypercholesterolemia Dietary Fats 3.4221332399
MESH:D006943 Hyperglycemia pirinixic acid 3.0220558911
MESH:D006948 Hyperkinesis Clozapine 4.7216046005
MESH:D006949 Hyperlipidemias Dietary Fats 3.4421332399
MESH:D006963 Hyperphagia olanzapine 6.0417933447
MESH:D006973 Hypertension Benzene 5.0717940673
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.0718670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.9015338365
MESH:D007021 Hypospadias Ethinyl Estradiol 3.6216569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.2812013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.2417937319
MESH:D007248 Infertility, Male vinclozolin 6.2416467254
MESH:D007249 Inflammation Dietary Fats 18.6920412841
MESH:D007249 Inflammation Diethylnitrosamine 18.6918785209
MESH:D007249 Inflammation Flavonoids 18.6917296493
MESH:D007249 Inflammation perfluorooctanoic acid 18.6912083418
MESH:D007249 Inflammation Tamoxifen 18.6919457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 18.6912878042 12200463
MESH:D007333 Insulin Resistance Dietary Fats 16.6218457598 11836018
MESH:D007333 Insulin Resistance Estradiol 16.6216393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 16.6216306350
MESH:D007333 Insulin Resistance Sodium Selenite 16.6214714311
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.1616580747
MESH:D007674 Kidney Diseases Acetaminophen 5.5215629191 12587719
MESH:D007674 Kidney Diseases Estradiol 5.5215618244
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 11.5116705839
MESH:D007680 Kidney Neoplasms Estradiol 11.5115610895
MESH:D007680 Kidney Neoplasms Tamoxifen 11.5118625569
MESH:D007938 Leukemia arsenic trioxide 6.2615070760
MESH:D007938 Leukemia Benzene 6.2615935818 18335105 17119257 14694614
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.6217077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.1116972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.2914633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 9.1319077051
MESH:D007951 Leukemia, Myeloid Benzene 9.1317506065
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 3.9916467208 17050201 16968895 19850784 20471514
MESH:D015470 Leukemia, Myeloid, Acute Benzene 3.9919478238
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.0916331271 9834237 15748426 19075265 12679006 19035177 16966277 12712474 15213294 19642359 19225113 17712046 16823087 16112521 16891316 11468182 12018890 17107899 17217047 16330433 15622746 11161223 17869043 15336539 17649720
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.1716882451
MESH:D007984 Leydig Cell Tumor perfluorooctanoic acid 12.298812269
MESH:D007984 Leydig Cell Tumor vinclozolin 12.2916417039
MESH:D008064 Lipidoses Clozapine 7.6317567588
MESH:D008064 Lipidoses Tamoxifen 7.6317567588 15342952
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 10.4117157831 11903743 16943688 21278145 11408273 16221502 17334410 17174718 16239168
MESH:D008103 Liver Cirrhosis Dietary Fats 10.4118296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 10.4118522880 20032147 18407596 19638242 18665156
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 6.4616136751 16011737 18412020 16097048 15338365 15925388 15730626 15052691 18472332 12389079 17708605 16027843 17869086 14716833 18339082 17944888 12632514 17698563 12898905 16116963 12958196 11481614 18187930 15931870 18251166 18395095 17557913 18705752 14716496 18279442 12632512 18166357 17481882 17922224 15362042 15650968 17640975 17565644 15673190 16638106 12445421 18156304 12667390 17721639 12649538 14512876 17631135 17976157 18429990 18205269 17714472 18420326 12546737 18006644 18277467 14724832 15876570 18317297 16192424 16033810 15996030 18263696 15123356 13678700 18472094 18481824 12666154 14620537 17823541 15057751 17766677 12445418 18395914 20821823 16248980 17900296 17761835 15893842 12741479 18054572 18210741 15959796 18418968 12609069 16015684 15370692 15818738 10355542 14748882 12586293 17525996 18376398 17805973
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 6.4614659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 6.4615474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 6.4618564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.4612878042
MESH:D008107 Liver Diseases Acetaminophen 6.1716610002 19460945 11587558 19014921 12587719 12969438 19784758 16611625
MESH:D008107 Liver Diseases Carbon Tetrachloride 6.1716964402 17285989 16246199 15720792 15830285
MESH:D008107 Liver Diseases Diethylnitrosamine 6.1717034775
MESH:D017093 Liver Failure Carbon Tetrachloride 3.9715123358
MESH:D017114 Liver Failure, Acute Acetaminophen 8.8516871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 8.8514706259 16899240
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 24.707678174
MESH:D008113 Liver Neoplasms arsenic trioxide 24.7014682389
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 24.7019294768
MESH:D008113 Liver Neoplasms Diethylnitrosamine 24.7020452335 21071580 19499222 18754104 20501860 19690152 10737359 20101389 21047994 18648771 20118626 19254457 19638242 20583210 19427195 20137499 9163691 12771043 2422723 19294768 19256749 19255062 20405173 2862719 19090486 19850985 19073162 18644402 18978307 19426721 16942905 19551842 19812893 19996281 21278145 15175105 19833225 21167192 15885732 18977376 20492335 12112319 20434301 19642983
MESH:D008113 Liver Neoplasms perfluorooctanoic acid 24.7018709148 14757943
MESH:D008113 Liver Neoplasms pirinixic acid 24.7015890375 16377806 20007298
MESH:D008113 Liver Neoplasms Tamoxifen 24.7016684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 24.7016984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 26.472876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 26.4720377131
MESH:D008114 Liver Neoplasms, Experimental Benzene 26.4712562636
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 26.4712014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 26.4718308698 18093689 2563599 21159647 9362446 17942915 17854601 3124819 19519916 19004024 16842330 19126423 19539802 18775883 16267830 18164116 19009564 18544905 18282651 18253720 18079962 17174075
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 26.4712151625
MESH:D008114 Liver Neoplasms, Experimental Trichloroethylene 26.477955063
MESH:D008133 Long QT Syndrome arsenic trioxide 8.1415213294
MESH:D008133 Long QT Syndrome olanzapine 8.1420210726
MESH:D017563 Lung Diseases, Interstitial Benzene 4.6214698565
MESH:D008175 Lung Neoplasms arsenic trioxide 6.3411798837 19825857
MESH:D008175 Lung Neoplasms Benzene 6.3412562636
MESH:D008175 Lung Neoplasms Diethylnitrosamine 6.3421163286 20970405 20512841 6695378
MESH:D008175 Lung Neoplasms Tamoxifen 6.3418625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 6.3411884234 19555203
MESH:D008223 Lymphoma Benzene 3.6017584886 17119257
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 3.8814737004
MESH:D015674 Mammary Neoplasms, Animal Benzene 9.4312562636
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 9.4319428831
MESH:D008325 Mammary Neoplasms, Experimental Benzene 9.3311921183
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 9.3311408345 11807958 16891317 17203775
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 9.3311731420 16827153 14580682 19196723 19196722
MESH:D020149 Manganese Poisoning Estradiol 12.0019453300
MESH:D020149 Manganese Poisoning Tamoxifen 12.0019453300
MESH:D008545 Melanoma Tamoxifen 1.8619393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.9915990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.3819513568
MESH:D001523 Mental Disorders Clozapine 12.3416856516
MESH:D001523 Mental Disorders Haloperidol 12.3416856516
MESH:D001523 Mental Disorders olanzapine 12.3416856516
MESH:D008659 Metabolic Diseases olanzapine 5.2219142110
MESH:D024821 Metabolic Syndrome X Clozapine 4.2519142101
MESH:D009101 Multiple Myeloma arsenic trioxide 7.0519417148 19549372 15949261 11468182 14977855
MESH:D009101 Multiple Myeloma Benzene 7.0517119195
MESH:D009135 Muscular Diseases pirinixic acid 3.3216239165
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.4818349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.0316882451 16105982
MESH:D009203 Myocardial Infarction pirinixic acid 2.0719151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.8712213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 7.7716810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 7.7716411023
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.6718551238 7678174
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.7816624393
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.483581430 9029167
MESH:D009362 Neoplasm Metastasis Tamoxifen 5.4819393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4519410462
MESH:D009369 Neoplasms pirinixic acid 5.0217405874
MESH:D009369 Neoplasms Trichloroethylene 5.0211911487
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.8119189210 19196722 19200415
MESH:D009389 Neovascularization, Pathologic Estradiol 3.5417289903
MESH:D009421 Nervous System Malformations Estradiol 8.8511399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 8.8514600291
MESH:D009436 Neural Tube Defects arsenic trioxide 7.1210525206
MESH:D009436 Neural Tube Defects Benzene 7.1215643154
MESH:D019636 Neurodegenerative Diseases Acetaminophen 7.6618514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 7.6620387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.9220387270
MESH:D052556 Niemann-Pick Disease, Type C perfluorooctanoic acid 4.769802331
MESH:D009765 Obesity Clozapine 10.3319142110 18515891
MESH:D009765 Obesity Dietary Fats 10.3321332399 17217161 18457598 11836018 18674790 20518802 19632207 16723640 20132043
MESH:D009765 Obesity olanzapine 10.3318515891
MESH:D009765 Obesity pirinixic acid 10.3320558911
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 8.6116049721
MESH:D009784 Occupational Diseases Benzene 8.6117479406 17119257 15935809 15612468 15576619 16737584 17178637 15727169 15913788
MESH:D010051 Ovarian Neoplasms arsenic trioxide 7.6019769630 16624393 12452020
MESH:D010051 Ovarian Neoplasms Benzene 7.6012562636
MESH:D010051 Ovarian Neoplasms Estradiol 7.6019401270
MESH:D010146 Pain Acetaminophen 2.2416870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 5.0415580305
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 5.0416540662
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.5111578682
MESH:D010235 Paraganglioma arsenic trioxide 3.9819927285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.0612520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3718163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.392563599
MESH:D011297 Prenatal Exposure Delayed Effects perfluorooctanoic acid 15.2017132714
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 15.2011399792 11118676 11222880 11896295
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 15.2019015723 18220299 18042343
MESH:D011469 Prostatic Diseases vinclozolin 4.7418220299
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.7120887781
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.1019131511
MESH:D011471 Prostatic Neoplasms Estradiol 2.1016740699
MESH:D011471 Prostatic Neoplasms Sodium Selenite 2.1018760546
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.1015067354
MESH:D011472 Prostatitis vinclozolin 4.7418629315
MESH:D011537 Pruritus Ethinyl Estradiol 3.1216919318 15861022
MESH:D011595 Psychomotor Agitation Haloperidol 11.1911575062
MESH:D011595 Psychomotor Agitation olanzapine 11.1918685284
MESH:D011618 Psychotic Disorders Clozapine 8.7115331141
MESH:D011618 Psychotic Disorders Haloperidol 8.7111575062
MESH:D015427 Reperfusion Injury pirinixic acid 2.2919058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6518990726
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 3.7816646077
MESH:D012559 Schizophrenia marker/mechanism 20071518
MESH:D012559 Schizophrenia Clozapine 5.7220580759 18855531 17726453 20168265 20452607 16141801 20521326 20521320 18806925 20107430 11763009 11151749 17123785 17667964 19369910
MESH:D012559 Schizophrenia Haloperidol 5.7218513383 19369910 1830565 20107430
MESH:D012559 Schizophrenia olanzapine 5.7220521326 20107430 17726453
MESH:D012640 Seizures 2,6-dinitrotoluene 2.4118551238
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 1.9616192470
MESH:D013088 Spermatocele Ethinyl Estradiol 10.9216709447
MESH:D013088 Spermatocele Tamoxifen 10.9216709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.8519457130
MESH:D013274 Stomach Neoplasms arsenic trioxide 3.3517007042
MESH:D013274 Stomach Neoplasms Benzene 3.3512562636
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 3.3518456281
MESH:D017180 Tachycardia, Ventricular Haloperidol 10.3420210726
MESH:D017180 Tachycardia, Ventricular olanzapine 10.3420210726
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.4411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.9915669648
MESH:D013953 Thymus Neoplasms Benzene 4.7610850423
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.7112697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 6.7119014326
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 6.717505956
MESH:D013978 Tibial Fractures Estradiol 4.4919048282
MESH:D016171 Torsades de Pointes arsenic trioxide 3.7715213294
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 7.8816049721
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 7.8812973940 11780464 20435036 12845720
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 7.8817572228 8653321 16712894
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.1310091137
MESH:D014581 Urticaria Acetaminophen 2.8010982225
MESH:D014594 Uterine Neoplasms Benzene 8.9612562636
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 8.9614692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.4012125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.3714671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.0615886252
MESH:D015430 Weight Gain Clozapine 15.4920521320 20564506 16141801 16402076 20107430 17502770
MESH:D015430 Weight Gain Dietary Fats 15.4916723640
MESH:D015430 Weight Gain olanzapine 15.4917933447 19434072 20107430
MESH:D015431 Weight Loss Clozapine 4.8817933447
Pathway ID Pathway Name
REACT:11061 Signalling by NGF
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved