AutismKB 2.0

Annotation Detail for PSMD11


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Basic Information Top
Gene Symbol:PSMD11 ( MGC3844,Rpn6,S9,p44.5 )
Gene Full Name: proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
Band: 17q11.2
Quick LinksEntrez ID:5717; OMIM: 604449; Uniprot ID:PSD11_HUMAN; ENSEMBL ID: ENSG00000108671; HGNC ID: 9556
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa03050Proteasome
Pathway IDPathway Name
Signaling by Wnt
Cell Cycle, Mitotic
DNA Replication
Apoptosis
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
HIV Infection
Cell Cycle Checkpoints
Regulation of activated PAK-2p34 by proteasome mediated degradation
Metabolism of amino acids and derivatives
No data
Pathway IDPathway Name
P00013Cell cycle
Pathway IDPathway Name
500401Autodegradation of Cdh1 by Cdh1:APC/C
500372SCF(Skp2)-mediated degradation of p27/p21
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of PSMD11 mRNAincreases expression 16788091
D000082 Acetaminophen Acetaminophen affects the expression of PSMD11 mRNAaffects expression 17562736
D000638 Amiodarone Amiodarone results in increased expression of PSMD11 mRNAincreases expression 19774075
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of PSMD11 mRNAdecreases expression 19150397
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of PSMD11 mRNAdecreases expression 15336504
D016572 Cyclosporine Cyclosporine results in increased expression of PSMD11 mRNAincreases expression 20106945
D015525 Fatty Acids, Omega-3 Fatty Acids, Omega-3 results in increased expression of PSMD11 mRNAincreases expression 16823509
D008466 Mechlorethamine Mechlorethamine results in increased expression of PSMD11 mRNAincreases expression 17107856
D008701 Methapyrilene Methapyrilene results in increased expression of PSMD11 mRNAincreases expression 16393664
D043371 Fatty Acids, Omega-6 Fatty Acids, Omega-6 results in increased expression of PSMD11 mRNAincreases expression 16823509
C006253 pirinixic acid pirinixic acid results in increased expression of PSMD11 mRNAincreases expression 18301758
C045950 propiconazole propiconazole results in increased expression of PSMD11 mRNAincreases expression 19363144
C031280 pyrazole pyrazole results in increased expression of PSMD11 mRNAincreases expression 17945193
D020123 Sirolimus Sirolimus results in decreased expression of PSMD11 mRNAdecreases expression 15782132
D020123 Sirolimus Sirolimus results in decreased expression of PSMD11 proteindecreases expression 15782132
D014212 Tretinoin Tretinoin results in decreased expression of PSMD11 mRNAdecreases expression 16054129
C032910 triadimefon triadimefon results in increased expression of PSMD11 mRNAincreases expression 19363144
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.1218653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.5016434500
MESH:D000505 Alopecia Tretinoin 3.6215955085
MESH:D000799 Angioedema Acetaminophen 3.8710982225
MESH:D001145 Arrhythmias, Cardiac Amiodarone 3.8018218290 20041841 18057881
MESH:D001169 Arthritis, Experimental Tretinoin 3.0816412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2616292516
MESH:D001249 Asthma Tretinoin 2.3416456186
MESH:D001281 Atrial Fibrillation Amiodarone 3.9019698954 18651412
MESH:D001289 Attention Deficit Disorder with Hyperactivity Fatty Acids, Omega-3 9.2718448859
MESH:D001289 Attention Deficit Disorder with Hyperactivity Fatty Acids, Omega-6 9.2718448859
MESH:D001321 Autistic Disorder Acetaminophen 2.4718445737
MESH:D001321 Autistic Disorder Fatty Acids, Omega-3 2.4716920077
MESH:D001321 Autistic Disorder Sirolimus 2.4721115397
MESH:D001471 Barrett Esophagus Tretinoin 4.4116935849
MESH:D001778 Blood Coagulation Disorders Amiodarone 15.4219483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 15.4219483382
MESH:D001778 Blood Coagulation Disorders Tretinoin 15.4216206674 16197459
MESH:D001943 Breast Neoplasms Tretinoin 2.2816166294 16443354 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.6116813970
MESH:D002057 Burns, Chemical Mechlorethamine 6.269625245
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.1916168501
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.723084413
MESH:D006528 Carcinoma, Hepatocellular Sirolimus 4.7219335982
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 4.721917145
MESH:D002294 Carcinoma, Squamous Cell Sirolimus 5.1319435901
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 5.1316051514 16096774
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.8919225199 15710769
MESH:D002341 Carotid Artery Thrombosis Amiodarone 5.1018974383
MESH:D002386 Cataract Acetaminophen 7.2310977129
MESH:D002386 Cataract Tretinoin 7.2317460283
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 6.5620889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.5612371664
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.6116129372
MESH:D002779 Cholestasis Cyclosporine 7.7619486331
MESH:D002779 Cholestasis pirinixic acid 7.7619176532
MESH:D002822 Choriocarcinoma Tretinoin 5.1916461808
MESH:D002972 Cleft Palate Tretinoin 6.379407595
MESH:D002972 Cleft Palate triadimefon 6.3716781842
MESH:D003092 Colitis Tretinoin 3.7217035595
MESH:D019465 Craniofacial Abnormalities Tretinoin 3.0417551590 9142499 8800419 9224671 16925845 9211117 10589399 9664655 14991402 9125849
MESH:D019465 Craniofacial Abnormalities triadimefon 3.0416875885 15834900
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4318249437
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.3810774834 10915739 19420014 19370779 11421492 18713872 11461765 12594235 17522070 11743745 15968718 12540782 11834606 11739529 12705907 11287661 14725611 19164858 12958197 17562736 18071297 12153990 16109766 19923254 15619225 2444490 16177239 14550746 14986274 17906064 19085960 11529661 19416960 16393943 12392966 10663392 16781746 16485898 16227642 19739265 16081117
MESH:D056486 Drug-Induced Liver Injury Amiodarone 6.3818218290 15265979
MESH:D056486 Drug-Induced Liver Injury pyrazole 6.3812499123
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1319426721
MESH:D004487 Edema pirinixic acid 2.4912083418
MESH:D004489 Edema, Cardiac Tretinoin 4.5018230668
MESH:D016889 Endometrial Neoplasms Tretinoin 3.1116569247
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.0720426865
MESH:D005124 Eye Abnormalities Tretinoin 3.589664655 16938888
MESH:D005234 Fatty Liver Amiodarone 13.1314986274
MESH:D005234 Fatty Liver Cyclosporine 13.1319224547
MESH:D005234 Fatty Liver pirinixic acid 13.1319236843 20131406
MESH:D005355 Fibrosis Cyclosporine 8.7312639820 12168785
MESH:D005355 Fibrosis Tretinoin 8.7317994277
MESH:D005756 Gastritis Acetaminophen 3.7116983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.248708960
MESH:D005909 Glioblastoma Tretinoin 3.0117312396
MESH:D006258 Head and Neck Neoplasms Sirolimus 8.1919435901
MESH:D006258 Head and Neck Neoplasms Tretinoin 8.1916096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.1916084493
MESH:D006330 Heart Defects, Congenital Tretinoin 2.9014991402 9664655
MESH:D006333 Heart Failure pirinixic acid 2.5420558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.4415720958
MESH:D006529 Hepatomegaly Amiodarone 20.9515265979
MESH:D006529 Hepatomegaly pirinixic acid 20.9518467677 19772884 19176532 16221962
MESH:D006529 Hepatomegaly propiconazole 20.9517178689 17178688
MESH:D006529 Hepatomegaly triadimefon 20.9517178689 17178688
MESH:D006930 Hyperalgesia Acetaminophen 7.6316870215
MESH:D006930 Hyperalgesia Tretinoin 7.6316870215
MESH:D006937 Hypercholesterolemia Amiodarone 3.888137927 9751232
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.5816778211
MESH:D006943 Hyperglycemia pirinixic acid 3.1920558911
MESH:D006973 Hypertension Cyclosporine 2.1010903974
MESH:D006984 Hypertrophy Sirolimus 5.2319211884
MESH:D007037 Hypothyroidism Amiodarone 4.5318020914 17991464
MESH:D007249 Inflammation Fatty Acids, Omega-3 3.9717296493
MESH:D007333 Insulin Resistance pirinixic acid 2.6316306350
MESH:D007410 Intestinal Diseases Tretinoin 3.7817994277
MESH:D007569 Jaw Abnormalities Tretinoin 10.5517551590 15992940
MESH:D007569 Jaw Abnormalities triadimefon 10.5515992940 15834900
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.4715604871
MESH:D007674 Kidney Diseases Acetaminophen 5.8012587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 5.808314463 10903974 18776723
MESH:D007680 Kidney Neoplasms Cyclosporine 2.7412371664
MESH:D007938 Leukemia Tretinoin 2.7717143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.7016482212 16932348 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.0816294345 19850784 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.1517649720 17506722 16140955 16935935 17107899 16766008 16891316 19029980 9834237 17301526 19035177 16788101 16823087 19225113 17361223 12679006 17712046 17368321 19642359 19075265 17294898 17217047 17339181 16331271 15748426
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.319224671
MESH:D008064 Lipidoses Amiodarone 3.5117567588 15342952
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.6415474484
MESH:D008106 Liver Cirrhosis, Experimental Sirolimus 3.6417050028
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 3.6418397230 16248980
MESH:D008107 Liver Diseases Acetaminophen 6.7812587719 19014921 16610002 19460945 19784758 12969438 16611625 11587558
MESH:D008107 Liver Diseases propiconazole 6.7819363144
MESH:D008107 Liver Diseases triadimefon 6.7819363144
MESH:D017114 Liver Failure, Acute Acetaminophen 3.2416871587 17185352
MESH:D008113 Liver Neoplasms Methapyrilene 10.8715890375
MESH:D008113 Liver Neoplasms pirinixic acid 10.8716377806 20007298 15890375
MESH:D008113 Liver Neoplasms propiconazole 10.8719028983
MESH:D008113 Liver Neoplasms triadimefon 10.8719028983
MESH:D008114 Liver Neoplasms, Experimental propiconazole 6.7817178689
MESH:D008114 Liver Neoplasms, Experimental triadimefon 6.7817178689
MESH:D008133 Long QT Syndrome Amiodarone 3.5815350150 11989578 17391786
MESH:D008171 Lung Diseases Amiodarone 3.3712587719
MESH:D017563 Lung Diseases, Interstitial Amiodarone 4.5118516814
MESH:D008527 Medulloblastoma Tretinoin 2.7817453147
MESH:D008545 Melanoma Sirolimus 3.7819282848
MESH:D008545 Melanoma Tretinoin 3.7816752155
MESH:D008546 Melanoma, Experimental Acetaminophen 3.5819513568
MESH:D008591 Meningomyelocele Tretinoin 4.4416940565
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.8216801185
MESH:D009062 Mouth Neoplasms Sirolimus 4.7119435901
MESH:D009135 Muscular Diseases pirinixic acid 3.5216239165
MESH:D009181 Mycoses Amiodarone 4.9312754197 17974566
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.0817596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.1419151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.9516411023
MESH:D009369 Neoplasms pirinixic acid 4.9117405874
MESH:D009369 Neoplasms Tretinoin 4.9116594593 16946489
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.4717954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.2918481113 19348381
MESH:D009421 Nervous System Malformations Tretinoin 3.799125849
MESH:D009436 Neural Tube Defects Tretinoin 3.059142499
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.8718514411
MESH:D009765 Obesity pirinixic acid 1.8120558911
MESH:D010051 Ovarian Neoplasms Tretinoin 2.3516936753
MESH:D010146 Pain Acetaminophen 6.5916870215
MESH:D010146 Pain Tretinoin 6.5916870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.4615976015
MESH:D010300 Parkinson Disease Sirolimus 3.7419682553
MESH:D011230 Precancerous Conditions Cyclosporine 3.2212371664
MESH:D011507 Proteinuria Tretinoin 3.6116636307
MESH:D011565 Psoriasis Cyclosporine 2.2316882103
MESH:D011625 Pterygium Tretinoin 4.8116723453
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.8512490602 12832656 11597910
MESH:D015427 Reperfusion Injury pirinixic acid 2.3919058328
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.1116283617 16116481
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 5.1018724381
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 5.808532709
MESH:D012878 Skin Neoplasms Tretinoin 5.8016467112
MESH:D013274 Stomach Neoplasms Tretinoin 1.8017261132
MESH:D013276 Stomach Ulcer Amiodarone 3.3218087811
MESH:D013610 Tachycardia Amiodarone 4.3011238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 4.2019225199
MESH:D013733 Testicular Diseases pyrazole 4.846499806
MESH:D013959 Thyroid Diseases Amiodarone 4.7919731979
MESH:D013964 Thyroid Neoplasms Tretinoin 7.5817045167 16026305
MESH:D013964 Thyroid Neoplasms triadimefon 7.5817178689
MESH:D013971 Thyrotoxicosis Amiodarone 4.8718020914 19584973
MESH:D014062 Tongue Neoplasms Tretinoin 3.7916051514
MESH:D016171 Torsades de Pointes Amiodarone 4.2117467628 11989578
MESH:D014376 Tuberculosis Tretinoin 3.2316040207
MESH:D014402 Tuberous Sclerosis Sirolimus 5.5821115397 18495876
MESH:D014581 Urticaria Acetaminophen 2.9810982225
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.6816129372
MESH:D014604 Uveal Neoplasms Tretinoin 4.6416752155
MESH:D014605 Uveitis Cyclosporine 12.171336536
MESH:D014605 Uveitis Sirolimus 12.171336536
MESH:D014820 Vitiligo Tretinoin 4.0716761959
MESH:D009396 Wilms Tumor Tretinoin 3.9716287080
MESH:D014985 Xerophthalmia Cyclosporine 4.4717120751
Pathway ID Pathway Name
REACT:578 Apoptosis
REACT:6850 Cdc20:Phospho-APC/C mediated degradation of Cyclin A
REACT:1538 Cell Cycle Checkpoints
REACT:152 Cell Cycle, Mitotic
REACT:383 DNA Replication
REACT:6185 HIV Infection
REACT:13 Metabolism of amino acids and derivatives
REACT:21257 Metabolism of RNA
KEGG:03050 Proteasome
REACT:13505 Proteasome mediated degradation of PAK-2p34
REACT:11045 Signaling by Wnt
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA33902
    • No data
    No data
    Releated drug ID Related drug Name
    PA164743471adenosine triphosphate
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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