AutismKB 2.0

Annotation Detail for ZMIZ1


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Basic Information Top
Gene Symbol:ZMIZ1 ( FLJ13541,KIAA1224,MIZ,RAI17,TRAFIP10,ZIMP10,hZIMP10 )
Gene Full Name: zinc finger, MIZ-type containing 1
Band: 10q22.3
Quick LinksEntrez ID:57178; OMIM: 607159; Uniprot ID:ZMIZ1_HUMAN; ENSEMBL ID: ENSG00000108175; HGNC ID: 16493
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
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Pathway IDPathway Name
200038Coregulation of Androgen receptor activity
No data
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Related Diseases/Disorders Top
No data
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Desease Name
Celiac Disease
multiple sclerosis
IMMUNE
inflammatory bowel disease (early onset)
Desease Name
Celiac disease
Multiple sclerosis
Breast cancer
Inflammatory bowel disease (early onset)
Vitiligo
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D001564 Benzo(a)pyrene Benzo(a)pyrene affects the expression of ZMIZ1 mRNAaffects expression 20106945
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of ZMIZ1 mRNAdecreases expression 20064835
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of ZMIZ1 mRNAdecreases expression 19150397
20382639
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of ZMIZ1 mRNAincreases expression 15336504
D016572 Cyclosporine Cyclosporine results in increased expression of ZMIZ1 mRNAincreases expression 20106945
D009151 Mustard Gas Mustard Gas affects the expression of ZMIZ1 mRNAaffects expression 15651846
D020849 Raloxifene Raloxifene affects the expression of ZMIZ1 mRNAaffects expression 14699072
D020849 Raloxifene [Raloxifene co-treated with ESR2 protein] results in decreased expression of ZMIZ1 mRNAaffects cotreatment|decreases expression 19059307
D013629 Tamoxifen Tamoxifen affects the expression of ZMIZ1 mRNAaffects expression 14699072
D013629 Tamoxifen [Tamoxifen co-treated with ESR2 protein] results in decreased expression of ZMIZ1 mRNAaffects cotreatment|decreases expression 19059307
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of ZMIZ1 mRNAincreases expression 20106945
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.9214745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.1815322242 11752688 14514962
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0320127859 20464547
MESH:D000236 Adenoma Benzo(a)pyrene 2.786695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.7116835633
MESH:D000419 Albuminuria Raloxifene 4.8817308373 17451421
MESH:D000544 Alzheimer Disease Raloxifene 2.5815800139
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1711748828
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.3819183758
MESH:D001249 Asthma Mustard Gas 2.7710378619
MESH:D001768 Blister Mustard Gas 5.5019167455
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.2912125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1715340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9115746008
MESH:D001930 Brain Injuries Raloxifene 4.7816580743
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.9720146248 17474063
MESH:D001943 Breast Neoplasms Raloxifene 1.9717242785 17595753 16837676 17440819 16912660 15758505 17952589 17261762 17893378 15775269 15572757 17049068
MESH:D001943 Breast Neoplasms Tamoxifen 1.9717242785 18815881 18351453 21152245 20065188 19410462 16818667 16202921 18997820 19059307 18855134 19221464 18425577 19189210 19155303 20005174 20135344 18984771 18821012 20390343 19289846 19244106 19142967 20544844 19066611 15565566 18629630 15668708 11161223 16873071 19011961 19084267 17893378 17049068 16273361 19288272 19487384 17440819 19200415 17261762 19103187 19189212 19115204 20859285 21138602
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9720435547
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 5.5015286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 5.3517687719 10378619
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9916835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.8119066611
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 1.8416924424
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1020419170
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 10.2717572228
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 10.2717572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4918850075 18670907 16120746
MESH:D002318 Cardiovascular Diseases Raloxifene 3.6015775269
MESH:D002446 Celiac Disease marker/mechanism 20190752
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.0920889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 7.0912371664
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3816835633
MESH:D002779 Cholestasis Cyclosporine 3.0919486331
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1915668235 15340226 12621046 16354765 8697196
MESH:D003072 Cognition Disorders Raloxifene 4.9215800139
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2717141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2620055451 10048152 15322242
MESH:D003711 Demyelinating Diseases Tamoxifen 4.6719031437
MESH:D003865 Depressive Disorder, Major Raloxifene 4.3817474826
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7117107852
MESH:D003928 Diabetic Nephropathies Raloxifene 9.7617451421 17308373 15920148
MESH:D003928 Diabetic Nephropathies Tamoxifen 9.7619279558
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.5920420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9311462148
MESH:D004487 Edema Mustard Gas 12.9911402378 11428631 11428647 9260866
MESH:D004487 Edema Raloxifene 12.9915860553
MESH:D004487 Edema Tetrachlorodibenzodioxin 12.9911000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.2818230668 16714409 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 10.2015845917
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 10.2019031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.1919155303 20544844 16202921 17893378
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.259294722 10568697
MESH:D004890 Erythema Mustard Gas 5.509357497
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.5220426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.5216530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1911564622
MESH:D005234 Fatty Liver Cyclosporine 14.6219224547
MESH:D005234 Fatty Liver Raloxifene 14.6217473493
MESH:D005234 Fatty Liver Tamoxifen 14.6214986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.3716709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7611858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.8714745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.5219069698
MESH:D005355 Fibrosis Cyclosporine 9.5212168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.5220067830
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.568708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9710696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.8220471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.8211294989 10048152
MESH:D006331 Heart Diseases Raloxifene 3.6911110106
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.7615720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5811000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.2015340226 16120746 12621046
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.428697196 18606429 16354765 15340226 16959395
MESH:D006973 Hypertension Cyclosporine 9.0410903974
MESH:D006973 Hypertension Raloxifene 9.0417577099 15787275
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 9.0418670907 18850075
MESH:D007249 Inflammation Mustard Gas 8.9911428647 8975870 9260866 17524151 11428631 9357497 11402378 11428620 16001271
MESH:D007249 Inflammation Tamoxifen 8.9919457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.9912200463 12878042
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5816580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.8215604871
MESH:D007674 Kidney Diseases Cyclosporine 2.468314463 10903974 18776723
MESH:D007680 Kidney Neoplasms Cyclosporine 7.9812371664
MESH:D007680 Kidney Neoplasms Tamoxifen 7.9818625569
MESH:D007889 Leiomyoma Raloxifene 4.7616973256
MESH:D008064 Lipidoses Tamoxifen 3.3217567588 15342952
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 2.3418564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.3412878042
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 7.8220195826 21137059
MESH:D008113 Liver Neoplasms Tamoxifen 7.8216684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.8216984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.2412151625
MESH:D008171 Lung Diseases Mustard Gas 3.6018161513 18702808
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 5.0320464547 17053015 6695378 20135361 18569708 20064080 18520028 20869020 18816296
MESH:D008175 Lung Neoplasms Mustard Gas 5.033148597 8781369
MESH:D008175 Lung Neoplasms Tamoxifen 5.0318625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 5.0311884234 19555203
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.1019428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.7611731420 19196723 14580682 19196722 16827153
MESH:D020149 Manganese Poisoning Tamoxifen 4.9219453300
MESH:D008545 Melanoma Tamoxifen 1.9119393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.5215990972
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.1616801185
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.9315863610
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3716381670
MESH:D009101 Multiple Myeloma Raloxifene 3.6016497877
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2112213967
MESH:D009232 Myxoma Raloxifene 5.9316343187
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.6319393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5819410462
MESH:D009369 Neoplasms Benzo(a)pyrene 2.2711141357
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.3819189210 19196722 19200415
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.8217954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.5019348381 18481113
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4914600291
MESH:D009503 Neutropenia Mustard Gas 4.2316761898 7688884
MESH:D010024 Osteoporosis Raloxifene 3.5315775268 19059307 17882678
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 4.4915758505 17823083 17893378 15579764
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.6212520081
MESH:D011041 Poisoning Mustard Gas 4.0615727166
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8418163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.4412371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.5311118676 11222880 11896295 11399792
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.5317292933
MESH:D011471 Prostatic Neoplasms Raloxifene 2.5316536755 15731164 16220300
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.5315067354
MESH:D011537 Pruritus Mustard Gas 4.4318058305
MESH:D011565 Psoriasis Cyclosporine 2.3016882103
MESH:D011658 Pulmonary Fibrosis Mustard Gas 3.0017720292 17894541 17620002 17266442 10334151
MESH:D011693 Purpura Raloxifene 5.9315770314
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.1218990726
MESH:D012871 Skin Diseases Mustard Gas 2.7615451306 12880345 16961503
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 9.9810029692 19755658
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 9.988532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 9.9816192470
MESH:D013088 Spermatocele Tamoxifen 4.6716709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.3819457130
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.5620155912 2093021
MESH:D020521 Stroke Raloxifene 4.0116837676
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2812697716
MESH:D013978 Tibial Fractures Raloxifene 5.5819048282
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 8.8217053015
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 8.8217572228
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 8.8216712894 8653321 17572228
MESH:D014605 Uveitis Cyclosporine 4.361336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9712125929
MESH:D054556 Venous Thromboembolism Raloxifene 5.5816837676
MESH:D014846 Vulvar Neoplasms Raloxifene 5.9316343187
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.6215886252
MESH:D014985 Xerophthalmia Cyclosporine 4.8217120751
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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