AutismKB 2.0

Annotation Detail for ACTR3B


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Basic Information Top
Gene Symbol:ACTR3B ( ARP11,ARP3BETA,DKFZp686O24114 )
Gene Full Name: ARP3 actin-related protein 3 homolog B (yeast)
Band: 7q36.1-q36.2
Quick LinksEntrez ID:57180; OMIM: NA; Uniprot ID:ARP3B_HUMAN; ENSEMBL ID: ENSG00000133627; HGNC ID: 17256
Relate to Another Database: SFARIGene; denovo-db
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000638 Amiodarone Amiodarone results in increased expression of ACTR3B mRNAincreases expression 19774075
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of ACTR3B mRNAdecreases expression 15336504
D002251 Carbon Tetrachloride Carbon Tetrachloride results in decreased expression of ACTR3B mRNAdecreases expression 17484886
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of ACTR3B mRNAdecreases expression 20106945
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.4714514962 11752688 15322242
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 4.0116835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.3411748828
MESH:D001145 Arrhythmias, Cardiac Amiodarone 4.2018218290 20041841 18057881
MESH:D001281 Atrial Fibrillation Amiodarone 4.2019698954 18651412
MESH:D001778 Blood Coagulation Disorders Amiodarone 10.5019483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 10.5012125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.5115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 3.0015746008
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.6720435547
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 4.3415700767 15721981 18705752 15673190 3786805 16227642 16192424 16124888 16097048 16050911 16011737 10355542
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.1216835633
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 1.8618788625
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5616120746 18670907 18850075
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 3.0015710769 19225199
MESH:D002341 Carotid Artery Thrombosis Amiodarone 5.7218974383
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.5316835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2416354765 15340226 12621046 15668235 8697196
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.4317141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2710048152 20055451 15322242
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7417107852
MESH:D056486 Drug-Induced Liver Injury Amiodarone 6.7818218290 15265979
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 6.7819336974 21278145 17522070 16227642 15968718 6884620 4309450 15027814 7440962 7179309 7120509 10092053 19085960 10915739 3786805 2869522 16177239 9327722 3732212 15998439 11566570 6623471
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.7820420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 3.0511462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.8011000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.6218230668 15322242 16714409
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.4210568697 9294722
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.3111564622
MESH:D005234 Fatty Liver Amiodarone 9.4014986274
MESH:D005234 Fatty Liver Carbon Tetrachloride 9.4061145 15959796 12795759 17595544 12631006 16239168 19224547 16045604
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 4.0211858732
MESH:D005355 Fibrosis Carbon Tetrachloride 10.5318705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 10.5320067830
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.3210696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.5110048152 11294989
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.7611000095
MESH:D006505 Hepatitis Carbon Tetrachloride 4.1019900420 19110552
MESH:D006529 Hepatomegaly Amiodarone 10.4715265979
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 10.4716120746 15340226 12621046
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.7716354765 18606429 8697196 16959395 15340226
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 5.1616899240
MESH:D006937 Hypercholesterolemia Amiodarone 4.308137927 9751232
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 2.0218850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.6515338365
MESH:D007037 Hypothyroidism Amiodarone 5.0817991464 18020914
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 2.0312878042 12200463
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.7616580747
MESH:D008064 Lipidoses Amiodarone 3.7915342952 17567588
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 3.0016221502 17157831 17174718 21278145 16943688 16239168 11903743 17334410 11408273
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 2.3815730626 15057751 14620537 18395095 12632514 18187930 15818738 15959796 18006644 15123356 17761835 15650968 17805973 16011737 15925388 17565644 17698563 16116963 12389079 18472094 12666154 17869086 17823541 17944888 14512876 18166357 17708605 18705752 15370692 15931870 15338365 12632512 14716496 16192424 14748882 18472332 15673190 14724832 16248980 18277467 12445418 18420326 16015684 18317297 18054572 16136751 18210741 16033810 12898905 16638106 12586293 20821823 18412020 17976157 18376398 15893842 12741479 16097048 17721639 11481614 17640975 18263696 18205269 18481824 18251166 15362042 17714472 17481882 15996030 18339082 18418968 17766677 12667390 14716833 18156304 15052691 15876570 12609069 12546737 17922224 17557913 17631135 10355542 17900296 12445421 12649538 18279442 13678700 18429990 18395914 17525996 12958196 16027843
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.3812878042
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.1515830285 16964402 16246199 17285989 15720792
MESH:D017093 Liver Failure Carbon Tetrachloride 4.7315123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 4.0814706259 16899240
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 4.8019294768
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.8016984957
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 6.5312014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.5312151625
MESH:D008133 Long QT Syndrome Amiodarone 3.8911989578 15350150 17391786
MESH:D008171 Lung Diseases Amiodarone 3.6212587719
MESH:D017563 Lung Diseases, Interstitial Amiodarone 5.2018516814
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 1.2411884234 19555203
MESH:D009181 Mycoses Amiodarone 5.6217974566 12754197
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.3412213967
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.7214600291
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.9712520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 4.0718163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.8211896295 11399792 11118676 11222880
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.9712832656 11597910 12490602
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.3518990726
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 5.7218724381
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 6.128532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 6.1216192470
MESH:D013276 Stomach Ulcer Amiodarone 3.7418087811
MESH:D013610 Tachycardia Amiodarone 4.8011238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 4.7019225199
MESH:D013959 Thyroid Diseases Amiodarone 14.6019731979
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 14.6012697716
MESH:D013971 Thyrotoxicosis Amiodarone 5.4218020914 19584973
MESH:D016171 Torsades de Pointes Amiodarone 4.8217467628 11989578
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.3212125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.9715886252
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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