AutismKB 2.0

Annotation Detail for SLC39A10


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Basic Information Top
Gene Symbol:SLC39A10 ( DKFZp781L10106,LZT-Hs2,MGC126565,MGC138428 )
Gene Full Name: solute carrier family 39 (zinc transporter), member 10
Band: 2q32.3
Quick LinksEntrez ID:57181; OMIM: 608733; Uniprot ID:S39AA_HUMAN; ENSEMBL ID: ENSG00000196950; HGNC ID: 20861
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
Transmembrane transport of small molecules
No data
No data
Pathway IDPathway Name
500356Zinc influx into cells by the SLC39 gene family
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of SLC39A10 proteinaffects expression 20106945
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of SLC39A10 mRNAincreases expression 20106945
D002104 Cadmium Cadmium inhibits the reaction [SLC39A10 protein results in increased uptake of Zinc]decreases reaction|increases uptake 16804107
D016572 Cyclosporine Cyclosporine results in decreased expression of SLC39A10 mRNAdecreases expression 20106945
D004024 Dicyclohexylcarbodiimide Dicyclohexylcarbodiimide inhibits the reaction [SLC39A10 protein results in increased uptake of Zinc]decreases reaction|increases uptake 16804107
D004041 Dietary Fats Dietary Fats results in increased expression of SLC39A10 mRNAincreases expression 18042831
D004958 Estradiol Estradiol results in decreased expression of SLC39A10 mRNAdecreases expression 20106945
D007461 Iodoacetates Iodoacetates inhibits the reaction [SLC39A10 protein results in increased uptake of Zinc]decreases reaction|increases uptake 16804107
D008070 Lipopolysaccharides Lipopolysaccharides results in decreased expression of SLC39A10 mRNAdecreases expression 17126599
D008070 Lipopolysaccharides Lipopolysaccharides results in decreased expression of SLC39A10 proteindecreases expression 16892068
D008070 Lipopolysaccharides TICAM1 protein affects the reaction [Lipopolysaccharides results in decreased expression of SLC39A10 protein]affects reaction|decreases expression 16892068
D008623 Mercaptoethanol Mercaptoethanol inhibits the reaction [SLC39A10 protein results in increased uptake of Zinc]decreases reaction|increases uptake 16804107
C041786 palm oil palm oil results in increased expression of SLC39A10 mRNAincreases expression 18042831
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of SLC39A10 mRNAincreases expression 20106945
D015032 Zinc SLC39A10 protein results in increased transport of Zincincreases transport 18326752
D015032 Zinc Cadmium inhibits the reaction [SLC39A10 protein results in increased uptake of Zinc]decreases reaction|increases uptake 16804107
D015032 Zinc Dicyclohexylcarbodiimide inhibits the reaction [SLC39A10 protein results in increased uptake of Zinc]decreases reaction|increases uptake 16804107
D015032 Zinc Iodoacetates inhibits the reaction [SLC39A10 protein results in increased uptake of Zinc]decreases reaction|increases uptake 16804107
D015032 Zinc Mercaptoethanol inhibits the reaction [SLC39A10 protein results in increased uptake of Zinc]decreases reaction|increases uptake 16804107
D015032 Zinc SLC39A10 protein results in increased uptake of Zincincreases uptake 16804107
D015032 Zinc Zinc results in decreased expression of SLC39A10 mRNAdecreases expression 16804107
D015032 Zinc Zinc results in decreased expression of SLC39A10 proteindecreases expression 16804107
D015032 Zinc Zinc results in increased expression of SLC39A10 mRNAincreases expression 16804107
D015032 Zinc Zinc results in increased expression of SLC39A10 proteinincreases expression 16804107
D015032 Zinc Zinc results in decreased expression of SLC39A10 mRNAdecreases expression 16804107
D015032 Zinc Zinc results in increased expression of SLC39A10 mRNAincreases expression 16804107
D015032 Zinc SLC39A10 protein results in increased uptake of Zincincreases uptake 17126599
D019287 Zinc Sulfate Zinc Sulfate results in decreased expression of SLC39A10 mRNAdecreases expression 16804107
D019287 Zinc Sulfate Zinc Sulfate results in decreased expression of SLC39A10 proteindecreases expression 16804107
D019287 Zinc Sulfate Zinc Sulfate results in increased expression of SLC39A10 mRNAincreases expression 16804107
D019287 Zinc Sulfate Zinc Sulfate results in increased expression of SLC39A10 proteinincreases expression 16804107
D019287 Zinc Sulfate Zinc Sulfate results in decreased expression of SLC39A10 mRNAdecreases expression 16804107
D019287 Zinc Sulfate Zinc Sulfate results in increased expression of SLC39A10 mRNAincreases expression 16804107
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.9311752688 15322242 14514962
MESH:D000138 Acidosis Zinc Sulfate 4.997265320
MESH:D000169 Acrodermatitis Zinc 5.4917202136 17190629 16889938
MESH:D055371 Acute Lung Injury Lipopolysaccharides 4.0911850527 18653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.3220127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 4.3211473722
MESH:D000236 Adenoma Benzo(a)pyrene 2.686695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.4616835633
MESH:D000544 Alzheimer Disease Zinc 2.7616410023 16325427 17119284 16580781
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0011748828
MESH:D000755 Anemia, Sickle Cell Zinc 4.9716916123
MESH:D000860 Anoxia Zinc Sulfate 5.107265320
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.1519183758
MESH:D001161 Arteriosclerosis Dietary Fats 3.9615238619
MESH:D001249 Asthma Zinc 2.9717085522
MESH:D050197 Atherosclerosis Cadmium 3.6715687053
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.1012125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.8915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8015746008
MESH:D001930 Brain Injuries Zinc 4.7617109824
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.9220146248 17474063
MESH:D001943 Breast Neoplasms Dietary Fats 1.9220435547
MESH:D001943 Breast Neoplasms Estradiol 1.9217018787 12948864 18497071 17289903 14630087 16675129 19861407 17261762
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9220435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.5516111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8416835633
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 3.0621507988 12619106 12907637
MESH:D006528 Carcinoma, Hepatocellular Estradiol 3.0616924424
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.8420419170
MESH:D002294 Carcinoma, Squamous Cell Zinc 4.8416543248
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3918670907 18850075 16120746
MESH:D002318 Cardiovascular Diseases Zinc 3.6916936243
MESH:D002471 Cell Transformation, Neoplastic Cadmium 11.4917332340
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 11.4912371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 11.4918566989
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2116835633
MESH:D002779 Cholestasis Cyclosporine 2.9519486331
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1216354765 12621046 8697196 15340226 15668235
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1114669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.6915322242 20055451 10048152
MESH:D019465 Craniofacial Abnormalities Zinc 2.6919302082
MESH:D003920 Diabetes Mellitus Zinc 4.2516479319
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6817107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.4619279558
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.5520420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8011462148
MESH:D050171 Dyslipidemias Dietary Fats 3.4918367378
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.4312711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0015322242 18230668 16714409
MESH:D016889 Endometrial Neoplasms Estradiol 3.0111473722 18566989 19148513
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.0710568697 9294722
MESH:D019446 Endotoxemia Lipopolysaccharides 4.4817637181 15821434 15328337
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.6816530937
MESH:D004938 Esophageal Neoplasms Zinc 4.6816543248
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0511564622
MESH:D005234 Fatty Liver Cyclosporine 7.9219224547
MESH:D005234 Fatty Liver Dietary Fats 7.9219551842 18296743 17967931 19004024
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5311858732
MESH:D005334 Fever Lipopolysaccharides 4.0611852909 9205823
MESH:D005355 Fibrosis Cyclosporine 15.1612639820 12168785
MESH:D005355 Fibrosis Dietary Fats 15.1618296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 15.1620067830
MESH:D005756 Gastritis Zinc 4.8917241300
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.308708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.6910696789
MESH:D006130 Growth Disorders Zinc 3.9917217573
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.5420471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.5411294989 10048152
MESH:D006333 Heart Failure Zinc 3.6417162251
MESH:D006335 Heart Injuries Zinc 5.8717074742
MESH:D016481 Helicobacter Infections Zinc 4.5917241300
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.5015720958
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 4.4316366002
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3911000095
MESH:D006527 Hepatolenticular Degeneration Zinc 11.5617276780
MESH:D006527 Hepatolenticular Degeneration Zinc Sulfate 11.5617063115
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.9612621046 16120746 15340226
MESH:D006558 Herpes Genitalis Estradiol 5.1315709030
MESH:D019584 Hot Flashes Estradiol 3.8517088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.1415340226 18606429 8697196 16354765 16959395
MESH:D006937 Hypercholesterolemia Dietary Fats 3.6521332399
MESH:D006949 Hyperlipidemias Dietary Fats 3.6721332399
MESH:D006973 Hypertension Cyclosporine 5.0110903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.0118670907 18850075
MESH:D007022 Hypotension Zinc Sulfate 4.537265320
MESH:D007249 Inflammation Dietary Fats 8.5020412841
MESH:D007249 Inflammation Lipopolysaccharides 8.509205823 12878042 17963957 17237260 17255318
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.5012878042 12200463
MESH:D007333 Insulin Resistance Dietary Fats 7.4811836018 18457598
MESH:D007333 Insulin Resistance Estradiol 7.4816393666 16627594
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 4.6917255318
MESH:D007511 Ischemia Zinc 4.7016584753
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.3916580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.5415604871
MESH:D007674 Kidney Diseases Cadmium 14.7616962696 16322080 16226777
MESH:D007674 Kidney Diseases Cyclosporine 14.7610903974 8314463 18776723
MESH:D007674 Kidney Diseases Estradiol 14.7615618244
MESH:D007674 Kidney Diseases Zinc 14.7616960431
MESH:D007676 Kidney Failure, Chronic Zinc 4.4716518626
MESH:D007680 Kidney Neoplasms Cyclosporine 7.4212371664
MESH:D007680 Kidney Neoplasms Estradiol 7.4215610895
MESH:D016773 Leishmaniasis, Cutaneous Zinc Sulfate 4.3115237267
MESH:D007970 Leukopenia Lipopolysaccharides 4.7815821434
MESH:D008103 Liver Cirrhosis Dietary Fats 2.9018296743
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.5314659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 3.5312878042
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.5312878042
MESH:D008113 Liver Neoplasms Aflatoxin B1 7.492125692 15890375 9163691 18177683
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 7.4921137059 20195826
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.4916984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 5.918603461
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.9112151625
MESH:D055370 Lung Injury Lipopolysaccharides 4.0821114838
MESH:D008175 Lung Neoplasms Aflatoxin B1 3.3914755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.3920464547 17053015 20869020 18520028 20135361 6695378 18816296 20064080 18569708
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.3911884234 19555203
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 6.3311807958 17203775 16891317 11408345
MESH:D008325 Mammary Neoplasms, Experimental Zinc 6.3312773700
MESH:D020149 Manganese Poisoning Estradiol 4.5819453300
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.8816801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.2316381670
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0612213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.3216810080
MESH:D009369 Neoplasms Benzo(a)pyrene 2.1911141357
MESH:D009389 Neovascularization, Pathologic Estradiol 3.8117289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.5417954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3319348381 18481113
MESH:D009421 Nervous System Malformations Estradiol 9.6816427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.6814600291
MESH:D009765 Obesity Dietary Fats 2.3021332399 16723640 17217161 18674790 19632207 11836018 20518802 18457598 20132043
MESH:D010051 Ovarian Neoplasms Estradiol 2.2319401270
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3512520081
MESH:D016491 Peripheral Vascular Diseases Cadmium 5.4615687053
MESH:D011014 Pneumonia Lipopolysaccharides 4.6412224865 11605937
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6218163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.2712371664
MESH:D011225 Pre-Eclampsia Zinc 4.2217114810
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.2711118676 11399792 11222880 11896295
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.9420887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.1117292933
MESH:D011471 Prostatic Neoplasms Cadmium 2.1117075824
MESH:D011471 Prostatic Neoplasms Estradiol 2.1116740699
MESH:D011471 Prostatic Neoplasms Zinc 2.1116700911 16606632 12429649 16517595
MESH:D011565 Psoriasis Cyclosporine 2.2416882103
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.7610835634
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9018990726
MESH:D012162 Retinal Degeneration Zinc 4.1616584753
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.5510029692 19755658
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.5516192470
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.562093021 20155912
MESH:D013921 Thrombocytopenia Lipopolysaccharides 4.2115821434
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0012697716
MESH:D013978 Tibial Fractures Estradiol 4.7819048282
MESH:D014062 Tongue Neoplasms Zinc 4.4516543248
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.2017053015
MESH:D014605 Uveitis Cyclosporine 4.081336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.6912125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3515886252
MESH:D015430 Weight Gain Dietary Fats 3.7916723640
MESH:D014985 Xerophthalmia Cyclosporine 4.5417120751
Pathway ID Pathway Name
REACT:15518 Transmembrane transport of small molecules
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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