AutismKB 2.0

Annotation Detail for ANKRD50


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Basic Information Top
Gene Symbol:ANKRD50 ( KIAA1223 )
Gene Full Name: ankyrin repeat domain 50
Band: 4q28.1
Quick LinksEntrez ID:57182; OMIM: NA; Uniprot ID:ANR50_HUMAN; ENSEMBL ID: ENSG00000151458; HGNC ID: 29223
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of ANKRD50 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of ANKRD50 mRNAaffects expression 17562736
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of ANKRD50 mRNAdecreases expression 19150397
D003474 Curcumin Curcumin results in decreased expression of ANKRD50 mRNAdecreases expression 17999991
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D019973 Alcohol-Related Disorders Curcumin 5.8017887948
MESH:D000544 Alzheimer Disease Curcumin 2.6815590663
MESH:D000799 Angioedema Acetaminophen 4.5710982225
MESH:D001172 Arthritis, Rheumatoid Curcumin 2.8016807698
MESH:D050197 Atherosclerosis Curcumin 3.5318704882
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001327 Autoimmune Diseases Curcumin 5.0519761891
MESH:D002545 Brain Ischemia Curcumin 4.9616770732
MESH:D001932 Brain Neoplasms Curcumin 4.3317596214
MESH:D001943 Breast Neoplasms Curcumin 2.7016243823 19250217 18462866 18593918
MESH:D002277 Carcinoma Curcumin 4.1618593918
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 2.9616705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.963084413
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 3.0818414057
MESH:D002294 Carcinoma, Squamous Cell Curcumin 2.8518462866
MESH:D002386 Cataract Acetaminophen 2.7910977129
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.9820889678
MESH:D003092 Colitis Curcumin 4.7418200517 16804969 16782535
MESH:D003103 Coloboma Curcumin 4.9818809619
MESH:D003110 Colonic Neoplasms Curcumin 2.5516340194 19359593
MESH:D016510 Corneal Neovascularization Curcumin 5.4618497527
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.5818551238
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 2.7718403477
MESH:D003928 Diabetic Nephropathies Curcumin 4.3818204486
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 4.0218551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 4.0212392966 11529661 19085960 10663392 16177239 12540782 19420014 12705907 16081117 14550746 16227642 16781746 10774834 11461765 14986274 18071297 16109766 14725611 15968718 11834606 18713872 11287661 19923254 12153990 2444490 17906064 16393943 19739265 15619225 12958197 19164858 10915739 17562736 17522070 12594235 11421492 19370779 19416960 16485898 11739529 11743745
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.8219426721
MESH:D004381 Duodenal Ulcer Curcumin 4.5517351913
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.1520426865
MESH:D005234 Fatty Liver Curcumin 4.1219297423
MESH:D005355 Fibrosis Curcumin 4.5418705752
MESH:D005756 Gastritis Acetaminophen 4.4016983495
MESH:D005770 Gastrointestinal Neoplasms Curcumin 5.2618462866
MESH:D005909 Glioblastoma Curcumin 3.7217596214
MESH:D006258 Head and Neck Neoplasms Curcumin 3.9118829502 18462866
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 5.6017701891
MESH:D006930 Hyperalgesia Acetaminophen 3.0216870215
MESH:D006937 Hypercholesterolemia Curcumin 4.4818704882
MESH:D007249 Inflammation Curcumin 3.0617151092 16956363 18403477
MESH:D015212 Inflammatory Bowel Diseases Curcumin 3.3318200517 18596194
MESH:D007414 Intestinal Neoplasms Curcumin 4.6110783313
MESH:D007674 Kidney Diseases Acetaminophen 2.4015629191 12587719
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 3.3216705839
MESH:D007889 Leiomyoma Curcumin 5.0318555241
MESH:D007938 Leukemia Curcumin 3.4118462866
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 4.6316106398
MESH:D015458 Leukemia, T-Cell Curcumin 5.2716106398
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 2.2817355460 18705752 18006644
MESH:D008107 Liver Diseases Acetaminophen 4.3619460945 12969438 19784758 16610002 19014921 12587719 11587558 16611625
MESH:D008107 Liver Diseases Curcumin 4.3616956363
MESH:D017114 Liver Failure, Acute Acetaminophen 3.6316871587 17185352
MESH:D008175 Lung Neoplasms Curcumin 2.2819359593 16243823 18462866
MESH:D008223 Lymphoma Curcumin 3.8618462866
MESH:D016399 Lymphoma, T-Cell Curcumin 5.2616173963
MESH:D008545 Melanoma Curcumin 2.4517885582 18462866
MESH:D008546 Melanoma, Experimental Acetaminophen 4.1319513568
MESH:D008569 Memory Disorders Curcumin 4.6617263510
MESH:D009101 Multiple Myeloma Curcumin 3.7919372569
MESH:D009134 Muscular Atrophy, Spinal Curcumin 5.5517962980
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.4918551238
MESH:D009361 Neoplasm Invasiveness Curcumin 4.8818495463
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 5.2612497104
MESH:D009423 Nervous System Neoplasms Curcumin 6.3518462866
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.2118514411
MESH:D009765 Obesity Curcumin 2.8219297423
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.8212819281 16049721
MESH:D010024 Osteoporosis Curcumin 3.6918719352
MESH:D010051 Ovarian Neoplasms Curcumin 2.9118462866 19020741
MESH:D010146 Pain Acetaminophen 2.7316870215
MESH:D010190 Pancreatic Neoplasms Curcumin 3.0419401701 19196508 17440100
MESH:D011471 Prostatic Neoplasms Curcumin 3.6211398177 18226269 10851300 18769126 18156803 15129424 12497104
MESH:D011656 Pulmonary Emphysema Curcumin 4.9219168576
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 4.4910666014 18379247
MESH:D012509 Sarcoma Curcumin 4.5118462866
MESH:D012640 Seizures 2,4-dinitrotoluene 2.7918551238
MESH:D018805 Sepsis Curcumin 4.4218389075
MESH:D013276 Stomach Ulcer Curcumin 3.9216631530 19188055
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.6616049721
MESH:D001749 Urinary Bladder Neoplasms Curcumin 5.6618593936
MESH:D014565 Urogenital Neoplasms Curcumin 5.9018462866
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.9510091137
MESH:D014581 Urticaria Acetaminophen 3.4410982225
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA128394695
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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