AutismKB 2.0

Annotation Detail for PSME1


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Basic Information Top
Gene Symbol:PSME1 ( IFI5111,MGC8628,PA28A,PA28alpha,REGalpha )
Gene Full Name: proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
Band: 14q12
Quick LinksEntrez ID:5720; OMIM: 600654; Uniprot ID:PSME1_HUMAN; ENSEMBL ID: ENSG00000092010; HGNC ID: 9568
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa03050Proteasome
hsa04612Antigen processing and presentation
Pathway IDPathway Name
Signaling by Wnt
Cell Cycle, Mitotic
DNA Replication
Apoptosis
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
HIV Infection
Cell Cycle Checkpoints
Regulation of activated PAK-2p34 by proteasome mediated degradation
Metabolism of amino acids and derivatives
No data
No data
Pathway IDPathway Name
500401Autodegradation of Cdh1 by Cdh1:APC/C
500372SCF(Skp2)-mediated degradation of p27/p21
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of PSME1 mRNAaffects expression 17562736
D019386 Alendronate Alendronate affects the expression of PSME1 mRNAaffects expression 16079270
C040534 alpha-hexachlorocyclohexane alpha-hexachlorocyclohexane results in decreased expression of PSME1 mRNAdecreases expression 16940010
D000643 Ammonium Chloride Ammonium Chloride affects the expression of PSME1 mRNAaffects expression 16483693
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of PSME1 mRNAincreases expression 20498004
C032036 bromobenzene bromobenzene metabolite binds to PSME1 proteinaffects binding 17305373
D003687 Dehydroepiandrosterone Dehydroepiandrosterone results in decreased expression of PSME1 mRNAdecreases expression 16940010
C121718 dicyclanil dicyclanil results in increased expression of PSME1 mRNAincreases expression 15664270
D004051 Diethylhexyl Phthalate Diethylhexyl Phthalate results in decreased expression of PSME1 proteindecreases expression 16400681
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of PSME1 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of PSME1 mRNAaffects expression 16079270
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of PSME1 mRNAincreases expression 16940010
C424943 glutamyl-Se-methylselenocysteine glutamyl-Se-methylselenocysteine results in decreased expression of PSME1 mRNAdecreases expression 11306469
C006253 pirinixic acid pirinixic acid results in increased expression of PSME1 mRNAincreases expression 18301758
15375163
D028321 Plant Preparations Plant Preparations affects the expression of PSME1 mRNAaffects expression 16046712
D020849 Raloxifene Raloxifene affects the expression of PSME1 mRNAaffects expression 16079270
D012643 Selenium Selenium results in increased expression of PSME1 mRNAincreases expression 19244175
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of PSME1 mRNAincreases expression 18796159
C025643 vinclozolin vinclozolin affects the expression of PSME1 mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Diethylhexyl Phthalate 8.686734493
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.6815322242 11752688 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.5518287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.9417505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.1018653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.1620464547 20127859
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.1614692618
MESH:D000236 Adenoma Benzo(a)pyrene 2.646695378
MESH:D018248 Adenoma, Liver Cell dicyclanil 17.4017162532
MESH:D018248 Adenoma, Liver Cell pirinixic acid 17.4016434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 17.4016835633
MESH:D000309 Adrenal Insufficiency Dehydroepiandrosterone 5.7517302879
MESH:D000419 Albuminuria Raloxifene 4.5817308373 17451421
MESH:D000544 Alzheimer Disease Raloxifene 2.5415800139
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.9311748828
MESH:D000799 Angioedema Acetaminophen 3.8410982225
MESH:D001008 Anxiety Disorders vinclozolin 3.6219015723
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.0619183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.4511256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6515885639
MESH:D001321 Autistic Disorder Acetaminophen 1.4218445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.7119483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.7112125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.7915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7515746008
MESH:D001930 Brain Injuries Raloxifene 4.4616580743
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.3820146248 17474063
MESH:D001943 Breast Neoplasms glutamyl-Se-methylselenocysteine 2.3811306469
MESH:D001943 Breast Neoplasms Plant Preparations 2.3817398067
MESH:D001943 Breast Neoplasms Raloxifene 2.3817261762 17242785 17440819 16837676 17049068 17595753 15775269 16912660 17893378 17952589 15758505 15572757
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.3820435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.7816835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 3.283084413
MESH:D006528 Carcinoma, Hepatocellular dicyclanil 3.2817162532
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 5.0420419170
MESH:D002294 Carcinoma, Squamous Cell Plant Preparations 5.0417418620
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 4.0517572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3518670907 16120746 18850075
MESH:D002318 Cardiovascular Diseases Plant Preparations 7.8516862667
MESH:D002318 Cardiovascular Diseases Raloxifene 7.8515775269
MESH:D016893 Carotid Stenosis Plant Preparations 6.1315158307
MESH:D002386 Cataract Acetaminophen 2.5710977129
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.1416835633
MESH:D002779 Cholestasis Ethinyl Estradiol 7.6915861022 16919318 17333356 16105132 17110522 11677210 17681005
MESH:D002779 Cholestasis pirinixic acid 7.6919176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0915340226 8697196 12621046 16354765 15668235
MESH:D003072 Cognition Disorders Raloxifene 4.6015800139
MESH:D003092 Colitis Selenium 3.7717936198
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0417141729 14669216
MESH:D003324 Coronary Artery Disease Plant Preparations 3.9815158307
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2520055451 15322242 10048152
MESH:D003456 Cryptorchidism vinclozolin 4.3214966744
MESH:D003865 Depressive Disorder, Major Raloxifene 4.1417474826
MESH:D003876 Dermatitis, Atopic Diethylhexyl Phthalate 6.9416882537
MESH:D003876 Dermatitis, Atopic pirinixic acid 6.9418249437
MESH:D003922 Diabetes Mellitus, Type 1 Dehydroepiandrosterone 3.6916616286
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6617107852
MESH:D003928 Diabetic Nephropathies Raloxifene 3.9217308373 17451421 15920148
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 8.9618071297 16485898 16081117 15619225 19739265 19420014 10915739 11739529 17906064 18713872 10663392 19923254 16177239 16393943 12153990 11421492 16109766 19164858 16227642 15968718 19416960 19370779 11287661 2444490 11461765 17562736 12540782 17522070 11834606 12594235 12958197 12392966 16781746 10774834 14725611 11743745 11529661 14550746 14986274 12705907 19085960
MESH:D056486 Drug-Induced Liver Injury bromobenzene 8.9610092053 12628495
MESH:D056486 Drug-Induced Liver Injury Selenium 8.9615131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 8.9620420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1019426721
MESH:D004362 Drug Toxicity Plant Preparations 8.4311033412
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 8.4311462148
MESH:D004487 Edema pirinixic acid 11.3212083418
MESH:D004487 Edema Raloxifene 11.3215860553
MESH:D004487 Edema Tetrachlorodibenzodioxin 11.3212711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.9016714409 15322242 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.0612538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 9.0615845917
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.009294722 10568697
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.8916530937
MESH:D004938 Esophageal Neoplasms Plant Preparations 4.8916510608
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0011564622
MESH:D005234 Fatty Liver Ethinyl Estradiol 13.0015345470
MESH:D005234 Fatty Liver pirinixic acid 13.0020131406 19236843
MESH:D005234 Fatty Liver Raloxifene 13.0017473493
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.4411858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 2.9320067830
MESH:D005756 Gastritis Acetaminophen 3.6816983495
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.9316973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.3016417039
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.5910696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.4120471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.4111294989 10048152
MESH:D006331 Heart Diseases Raloxifene 3.5211110106
MESH:D006333 Heart Failure pirinixic acid 6.9120558911
MESH:D006333 Heart Failure Selenium 6.9117162251
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3211000095
MESH:D006529 Hepatomegaly pirinixic acid 8.2219772884 18467677 19176532 16221962
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.2215340226 16120746 12621046
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.0516354765 8697196 16959395 18606429 15340226
MESH:D006930 Hyperalgesia Acetaminophen 8.1216870215
MESH:D006930 Hyperalgesia Alendronate 8.1216769263
MESH:D006943 Hyperglycemia pirinixic acid 3.1620558911
MESH:D006973 Hypertension Raloxifene 5.2015787275 17577099
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.2018850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 3.8016569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.4412013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.6117937319
MESH:D007248 Infertility, Male vinclozolin 6.6116467254
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.8412878042 12200463
MESH:D007251 Influenza, Human Selenium 4.2016624496
MESH:D007333 Insulin Resistance pirinixic acid 2.6216306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.3216580747
MESH:D007674 Kidney Diseases Acetaminophen 2.1915629191 12587719
MESH:D007676 Kidney Failure, Chronic Selenium 3.8716518626
MESH:D007889 Leiomyoma Raloxifene 4.4816973256
MESH:D007984 Leydig Cell Tumor vinclozolin 4.7216417039
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.5615474484
MESH:D008106 Liver Cirrhosis, Experimental Plant Preparations 3.5617724770
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.5612878042
MESH:D008107 Liver Diseases Acetaminophen 1.6219460945 11587558 19014921 16610002 12969438 16611625 19784758 12587719
MESH:D017114 Liver Failure, Acute Acetaminophen 3.2217185352 16871587
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 17.9121137059 20195826
MESH:D008113 Liver Neoplasms Dehydroepiandrosterone 17.9118709148
MESH:D008113 Liver Neoplasms dicyclanil 17.9120118626
MESH:D008113 Liver Neoplasms Diethylhexyl Phthalate 17.9111940454
MESH:D008113 Liver Neoplasms pirinixic acid 17.9115890375 20007298 16377806
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 17.9116984957
MESH:D008114 Liver Neoplasms, Experimental Dehydroepiandrosterone 6.188603461
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.1812151625
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.186695378 18816296 18520028 18569708 17053015 20869020 20135361 20064080 20464547
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.1811884234 19555203
MESH:D008325 Mammary Neoplasms, Experimental Dehydroepiandrosterone 6.4616457693
MESH:D008325 Mammary Neoplasms, Experimental Selenium 6.4615318939
MESH:D008546 Melanoma, Experimental Acetaminophen 3.5519513568
MESH:D008654 Mesothelioma Selenium 2.7815107826
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.5515863610
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 8.8916381670
MESH:D009062 Mouth Neoplasms Plant Preparations 8.8917418620
MESH:D009101 Multiple Myeloma Raloxifene 3.4216497877
MESH:D009135 Muscular Diseases pirinixic acid 3.4916239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1319151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0012213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.9316411023
MESH:D009232 Myxoma Raloxifene 5.5516343187
MESH:D009369 Neoplasms Benzo(a)pyrene 4.7911141357
MESH:D009369 Neoplasms pirinixic acid 4.7917405874
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.2014600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.8518514411
MESH:D009765 Obesity pirinixic acid 1.8120558911
MESH:D010024 Osteoporosis Alendronate 7.7517882678
MESH:D010024 Osteoporosis Raloxifene 7.7517882678 15775268 19059307
MESH:D015663 Osteoporosis, Postmenopausal Dehydroepiandrosterone 10.4316397352
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 10.4317823083 17893378 15579764 15758505
MESH:D010146 Pain Acetaminophen 2.3716870215
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.6711578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.2512520081
MESH:D010954 Plasmacytoma Selenium 4.8915087411
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5418163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.4611896295 11222880 11399792 11118676
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 9.4619015723 18220299 18042343
MESH:D011469 Prostatic Diseases vinclozolin 4.9318220299
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.3117292933
MESH:D011471 Prostatic Neoplasms Raloxifene 3.3116220300 16536755 15731164
MESH:D011472 Prostatitis vinclozolin 4.9318629315
MESH:D011537 Pruritus Ethinyl Estradiol 3.3016919318 15861022
MESH:D011693 Purpura Raloxifene 5.5515770314
MESH:D015427 Reperfusion Injury pirinixic acid 2.3819058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8218990726
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.4410029692 19755658
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.4416192470
MESH:D013088 Spermatocele Ethinyl Estradiol 3.9416709447
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.562093021 20155912
MESH:D020521 Stroke Raloxifene 3.8016837676
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.6011994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.1315669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.9012697716
MESH:D013978 Tibial Fractures Raloxifene 5.2119048282
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 8.4917053015
MESH:D001749 Urinary Bladder Neoplasms Plant Preparations 8.4911251952
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 8.4917572228
MESH:D014581 Urticaria Acetaminophen 2.9610982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.2814692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.5912125929
MESH:D054556 Venous Thromboembolism Raloxifene 5.2116837676
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5214671159 15869587
MESH:D014846 Vulvar Neoplasms Raloxifene 5.5516343187
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.2515886252
Pathway ID Pathway Name
KEGG:04612 Antigen processing and presentation
REACT:578 Apoptosis
REACT:6850 Cdc20:Phospho-APC/C mediated degradation of Cyclin A
REACT:1538 Cell Cycle Checkpoints
REACT:152 Cell Cycle, Mitotic
REACT:383 DNA Replication
REACT:6185 HIV Infection
REACT:13 Metabolism of amino acids and derivatives
REACT:21257 Metabolism of RNA
KEGG:03050 Proteasome
REACT:13505 Proteasome mediated degradation of PAK-2p34
REACT:11045 Signaling by Wnt
Pharmacogenomics Knowledge Base Top
Drug Bank Top

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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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