AutismKB 2.0

Annotation Detail for PSME2


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Basic Information Top
Gene Symbol:PSME2 ( PA28B,PA28beta,REGbeta )
Gene Full Name: proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
Band: 14q12
Quick LinksEntrez ID:5721; OMIM: 602161; Uniprot ID:PSME2_HUMAN; ENSEMBL ID: ENSG00000100911; HGNC ID: 9569
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa03050Proteasome
hsa04612Antigen processing and presentation
Pathway IDPathway Name
Signaling by Wnt
Cell Cycle, Mitotic
DNA Replication
Apoptosis
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
HIV Infection
Cell Cycle Checkpoints
Regulation of activated PAK-2p34 by proteasome mediated degradation
Metabolism of amino acids and derivatives
No data
No data
Pathway IDPathway Name
500401Autodegradation of Cdh1 by Cdh1:APC/C
500372SCF(Skp2)-mediated degradation of p27/p21
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of PSME2 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of PSME2 mRNAaffects expression 16483693
D004391 Dust Dust results in decreased expression of PSME2 mRNAdecreases expression 17805423
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of PSME2 mRNAincreases expression 17108234
C066340 tolcapone tolcapone binds to PSME2 proteinaffects binding 19783845
D014212 Tretinoin Tretinoin results in increased expression of PSME2 mRNAincreases expression 17218384
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 4.0218287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.4617505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8714692618
MESH:D017109 Akathisia, Drug-Induced tolcapone 6.8111080934
MESH:D000505 Alopecia Tretinoin 3.8715955085
MESH:D000544 Alzheimer Disease tolcapone 3.3320150427
MESH:D000799 Angioedema Acetaminophen 4.3610982225
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.8811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 7.8015885639
MESH:D001169 Arthritis, Experimental Tretinoin 7.8016412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.3216292516
MESH:D001249 Asthma Tretinoin 2.4216456186
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001471 Barrett Esophagus Tretinoin 4.7816935849
MESH:D001778 Blood Coagulation Disorders Tretinoin 3.9316197459 16206674
MESH:D001943 Breast Neoplasms Tretinoin 2.2416443354 16873071 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 5.0516813970
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.6816168501
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.983084413
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 2.981917145
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 2.3616051514 16096774
MESH:D002386 Cataract Acetaminophen 7.7810977129
MESH:D002386 Cataract Tretinoin 7.7817460283
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 5.0516129372
MESH:D002779 Cholestasis Ethinyl Estradiol 3.1017333356 16105132 17110522 17681005 11677210 16919318 15861022
MESH:D002822 Choriocarcinoma Tretinoin 5.6816461808
MESH:D002972 Cleft Palate Tretinoin 2.789407595
MESH:D003092 Colitis Tretinoin 4.1217035595
MESH:D019465 Craniofacial Abnormalities Tretinoin 1.838800419 16925845 9224671 10589399 9664655 17551590 9211117 9142499 14991402 9125849
MESH:D003866 Depressive Disorder tolcapone 4.527768276 11224284
MESH:D003865 Depressive Disorder, Major tolcapone 5.1910440460
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 4.4317522070 11287661 16485898 14986274 12540782 19739265 12392966 12958197 17562736 16177239 16393943 11739529 10663392 16781746 12594235 12705907 12153990 11461765 15619225 16227642 11421492 11834606 2444490 17906064 19370779 14725611 14550746 18713872 19164858 16109766 19420014 19416960 10774834 18071297 19923254 16081117 11529661 11743745 19085960 15968718 10915739
MESH:D056486 Drug-Induced Liver Injury tolcapone 4.4319783845 16604736
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.6219426721
MESH:D004409 Dyskinesia, Drug-Induced tolcapone 5.9211455177
MESH:D004489 Edema, Cardiac Tretinoin 4.9918230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.5712538720
MESH:D016889 Endometrial Neoplasms Tretinoin 3.3016569247
MESH:D054908 Extensively Drug-Resistant Tuberculosis tolcapone 6.4719578428
MESH:D005124 Eye Abnormalities Tretinoin 3.819664655 16938888
MESH:D005234 Fatty Liver Ethinyl Estradiol 3.1415345470
MESH:D005355 Fibrosis Tretinoin 3.9317994277
MESH:D005756 Gastritis Acetaminophen 4.1916983495
MESH:D005909 Glioblastoma Tretinoin 3.1917312396
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.3816096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.6816084493
MESH:D006330 Heart Defects, Congenital Tretinoin 3.0414991402 9664655
MESH:D006930 Hyperalgesia Acetaminophen 8.4816870215
MESH:D006930 Hyperalgesia Tretinoin 8.4816870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.9916778211
MESH:D007021 Hypospadias Ethinyl Estradiol 4.2316945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.8112013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6817937319
MESH:D007410 Intestinal Diseases Tretinoin 4.1817994277
MESH:D007569 Jaw Abnormalities Tretinoin 4.2317551590 15992940
MESH:D007674 Kidney Diseases Acetaminophen 2.3615629191 12587719
MESH:D007938 Leukemia Tretinoin 2.9017143497
MESH:D007951 Leukemia, Myeloid Tretinoin 4.0216482212 19285840 16932348
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.1216294345 17596541 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.3416823087 17339181 17361223 17368321 16891316 15748426 19642359 17712046 19035177 17217047 17294898 12679006 9834237 16766008 19029980 17506722 19225113 17107899 16935935 16140955 17649720 16331271 16788101 19075265 17301526
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.539224671
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 1.8118397230 16248980
MESH:D008107 Liver Diseases Acetaminophen 1.6916610002 16611625 19784758 12969438 12587719 19460945 11587558 19014921
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5416871587 17185352
MESH:D008527 Medulloblastoma Tretinoin 2.8817453147
MESH:D008545 Melanoma Tretinoin 1.9716752155
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9819513568
MESH:D008591 Meningomyelocele Tretinoin 4.8416940565
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.2417596541
MESH:D009369 Neoplasms Tretinoin 2.5416946489 16594593
MESH:D009421 Nervous System Malformations Tretinoin 4.169125849
MESH:D009436 Neural Tube Defects Tretinoin 3.249142499
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1418514411
MESH:D010051 Ovarian Neoplasms Tretinoin 2.4216936753
MESH:D010146 Pain Acetaminophen 7.4916870215
MESH:D010146 Pain Tretinoin 7.4916870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.5515976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 4.0411578682
MESH:D010300 Parkinson Disease tolcapone 3.697566641 16758261 11793426 1977408 20334432 8635184 9333106 9591521 19783845 9708959 9754991 19578428 10651109 9305320 17089403 20216409 18328768 11746615 8739811 11586115 11432539
MESH:D011507 Proteinuria Tretinoin 3.9516636307
MESH:D011537 Pruritus Ethinyl Estradiol 3.7715861022 16919318
MESH:D011625 Pterygium Tretinoin 5.2616723453
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.4516283617 16116481
MESH:D012878 Skin Neoplasms Tretinoin 2.7316467112
MESH:D013088 Spermatocele Ethinyl Estradiol 4.4616709447
MESH:D013274 Stomach Neoplasms Tretinoin 1.8017261132
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.9711994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.4415669648
MESH:D013964 Thyroid Neoplasms Tretinoin 3.2617045167 16026305
MESH:D014062 Tongue Neoplasms Tretinoin 4.0916051514
MESH:D014376 Tuberculosis Tretinoin 3.4116040207
MESH:D018088 Tuberculosis, Multidrug-Resistant tolcapone 6.4719578428
MESH:D014581 Urticaria Acetaminophen 3.3310982225
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.9816129372
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.6814692618
MESH:D014604 Uveal Neoplasms Tretinoin 5.1316752155
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.8715869587 14671159
MESH:D014820 Vitiligo tolcapone 12.4010573327
MESH:D014820 Vitiligo Tretinoin 12.4016761959
MESH:D009396 Wilms Tumor Tretinoin 4.2516287080
Pathway ID Pathway Name
KEGG:04612 Antigen processing and presentation
REACT:578 Apoptosis
REACT:6850 Cdc20:Phospho-APC/C mediated degradation of Cyclin A
REACT:1538 Cell Cycle Checkpoints
REACT:152 Cell Cycle, Mitotic
REACT:383 DNA Replication
REACT:6185 HIV Infection
REACT:13 Metabolism of amino acids and derivatives
REACT:21257 Metabolism of RNA
KEGG:03050 Proteasome
REACT:13505 Proteasome mediated degradation of PAK-2p34
REACT:11045 Signaling by Wnt
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA33915
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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