AutismKB 2.0

Annotation Detail for THAP11


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Basic Information Top
Gene Symbol:THAP11 ( CTG-B43a,CTG-B45d,RONIN )
Gene Full Name: THAP domain containing 11
Band: 16q22.1
Quick LinksEntrez ID:57215; OMIM: 609119; Uniprot ID:THA11_HUMAN; ENSEMBL ID: ENSG00000168286; HGNC ID: 23194
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of THAP11 mRNAdecreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of THAP11 mRNAaffects expression 17562736
D001151 Arsenic Arsenic affects the expression of THAP11 mRNAaffects expression 18414638
C006253 pirinixic acid pirinixic acid results in decreased expression of THAP11 mRNAdecreases expression 18445702
D012643 Selenium Selenium results in increased expression of THAP11 mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.5218653653
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.933712494
MESH:D018248 Adenoma, Liver Cell pirinixic acid 4.0216434500
MESH:D018246 Adrenocortical Adenoma Arsenic 5.8217306315
MESH:D000799 Angioedema Acetaminophen 4.4510982225
MESH:D020261 Arsenic Poisoning Arsenic 2.9412569548 16835338 16251483 18414634
MESH:D050197 Atherosclerosis Arsenic 3.4419371607 12928151
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.6311289319 1440618
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.5219483382
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.7615504454 17687452
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 4.833581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.833084413
MESH:D006528 Carcinoma, Hepatocellular Arsenic 4.8316507464 17306315
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.817296757
MESH:D002294 Carcinoma, Squamous Cell Arsenic 2.7718922899 15504454 17687452
MESH:D002295 Carcinoma, Transitional Cell Arsenic 4.4218640142
MESH:D002318 Cardiovascular Diseases Arsenic 3.6815738583 19152805 17938729
MESH:D002340 Carotid Artery Diseases Arsenic 4.6418022660 16973168
MESH:D002386 Cataract Acetaminophen 2.7710977129
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 2.997505956
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 8.729022650 19486331
MESH:D002779 Cholestasis pirinixic acid 8.7219176532
MESH:D003092 Colitis Selenium 4.2617936198
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.2811906362 8970840 12868966 11298694 2524372 18759878 14531868 8156756
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5618249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.892952479 3621924
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 6.708291058 16192314 18692083 9328219 9653073 6679447 18648102 7440962 6482804 1440618 9022650 11289319 18289764
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.7012540782 17562736 11421492 15619225 11461765 10774834 17906064 16177239 11287661 12594235 19739265 19164858 16781746 12958197 14725611 15968718 11529661 16393943 18071297 16227642 14550746 11739529 12705907 11743745 19416960 12392966 17522070 16109766 10915739 18713872 19420014 12153990 2444490 19923254 16081117 19085960 10663392 19370779 14986274 11834606 16485898
MESH:D056486 Drug-Induced Liver Injury Selenium 6.7015131321
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.7119426721
MESH:D004487 Edema pirinixic acid 2.8512083418
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.173581430
MESH:D005234 Fatty Liver pirinixic acid 3.1420131406 19236843
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.636705139
MESH:D005534 Foot Diseases Arsenic 6.176392382
MESH:D005756 Gastritis Acetaminophen 4.2916983495
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.447505956
MESH:D006333 Heart Failure pirinixic acid 7.6220558911
MESH:D006333 Heart Failure Selenium 7.6217162251
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.956705139
MESH:D006529 Hepatomegaly pirinixic acid 3.4819772884 18467677 16221962 19176532
MESH:D006930 Hyperalgesia Acetaminophen 2.9916870215
MESH:D006943 Hyperglycemia pirinixic acid 3.5320558911
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.8017050553
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.4215034207
MESH:D006973 Hypertension Arsenic 2.9816076760 9931084 11953799
MESH:D006987 Hypesthesia Arsenic 6.1716093927
MESH:D007251 Influenza, Human Selenium 4.8116624496
MESH:D007333 Insulin Resistance pirinixic acid 2.8516306350
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.638074119 9022650
MESH:D007642 Keratosis Arsenic 5.5312749816 16930632
MESH:D007674 Kidney Diseases Acetaminophen 2.3815629191 12587719
MESH:D007676 Kidney Failure, Chronic Selenium 4.2616518626
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 3.276582329
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 3.7717339181
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.4015034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3515474484
MESH:D008107 Liver Diseases Acetaminophen 4.3119784758 12969438 19014921 12587719 19460945 11587558 16610002 16611625
MESH:D008107 Liver Diseases Arsenic 4.3111134558
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5816871587 17185352
MESH:D008113 Liver Neoplasms Arsenic 4.9716368122
MESH:D008113 Liver Neoplasms pirinixic acid 4.9715890375 20007298 16377806
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 2.73598648 6587162 3712494 1399818
MESH:D008175 Lung Neoplasms Arsenic 2.2117976673 17306315 19168569
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.9715318939
MESH:D008546 Melanoma, Experimental Acetaminophen 4.0519513568
MESH:D008654 Mesothelioma Selenium 2.9015107826
MESH:D009135 Muscular Diseases pirinixic acid 3.9916239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2619151258
MESH:D017202 Myocardial Ischemia Arsenic 4.2715371236
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.2216411023
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.583581430
MESH:D009369 Neoplasms pirinixic acid 2.0917405874
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 8.106679447
MESH:D009436 Neural Tube Defects Arsenic 8.1016620997
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1818514411
MESH:D020078 Neurogenic Inflammation Arsenic 4.7817056641
MESH:D009765 Obesity pirinixic acid 1.8820558911
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.774026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.633988306
MESH:D010051 Ovarian Neoplasms Arsenic 2.8317306315
MESH:D010146 Pain Acetaminophen 2.6916870215
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.977296757
MESH:D010523 Peripheral Nervous System Diseases Arsenic 4.6216093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 5.5315371236 16905509 6392382
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 5.086228378
MESH:D010954 Plasmacytoma Selenium 5.5015087411
MESH:D011471 Prostatic Neoplasms Arsenic 3.5516140617
MESH:D011507 Proteinuria Arsenic 4.4121343184
MESH:D015427 Reperfusion Injury pirinixic acid 2.5319058328
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.643692021
MESH:D012871 Skin Diseases Arsenic 2.8216702368 15952646 18709164 17050553 6392382 17548696 16759981 19834688 16353154 17938729 17453740
MESH:D012878 Skin Neoplasms Arsenic 3.1517029826 17976673 16251483 19538983 17050553 15504454
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.151399818 6582329 6587162 3712494 7505956
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.598074119
MESH:D001749 Urinary Bladder Neoplasms Arsenic 5.5911144890 17306315 15987713 19322015 18640142 19429237 17976673
MESH:D014581 Urticaria Acetaminophen 3.3810982225
MESH:D014652 Vascular Diseases Arsenic 5.2817056641
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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