AutismKB 2.0

Annotation Detail for NHSL1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:NHSL1 ( C6orf63,KIAA1357 )
Gene Full Name: NHS-like 1
Band: 6q24.1
Quick LinksEntrez ID:57224; OMIM: NA; Uniprot ID:NHSL1_HUMAN; ENSEMBL ID: ENSG00000135540; HGNC ID: 21021
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of NHSL1 mRNAaffects expression 17562736
D017638 Asbestos, Crocidolite Asbestos, Crocidolite results in increased expression of NHSL1 mRNAincreases expression 18687144
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of NHSL1 mRNAdecreases expression 19150397
20382639
D016572 Cyclosporine Cyclosporine results in increased expression of NHSL1 mRNAincreases expression 20106945
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NHSL1 mRNAaffects cotreatment|increases expression 17942748
D007213 Indomethacin Indomethacin results in decreased expression of NHSL1 mRNAdecreases expression 16984733
C006253 pirinixic acid pirinixic acid results in decreased expression of NHSL1 mRNAdecreases expression 17426115
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NHSL1 mRNAaffects cotreatment|increases expression 17942748
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.1814514962 15322242 11752688
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.3217505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.3818653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.6414692618
MESH:D000230 Adenocarcinoma Indomethacin 4.6416537180
MESH:D000236 Adenoma Indomethacin 3.5811497255
MESH:D018248 Adenoma, Liver Cell pirinixic acid 11.0516434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 11.0516835633
MESH:D016301 Alveolar Bone Loss Indomethacin 5.7517225004
MESH:D000544 Alzheimer Disease Indomethacin 2.7417627676 15579461
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1711748828
MESH:D000799 Angioedema Acetaminophen 4.2210982225
MESH:D001014 Aortic Aneurysm Indomethacin 5.1310231640
MESH:D017544 Aortic Aneurysm, Abdominal Indomethacin 5.1810388637
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.7711256880
MESH:D018771 Arthralgia Indomethacin 5.552160914
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8015885639
MESH:D001172 Arthritis, Rheumatoid Indomethacin 2.8711248219
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001477 Bartter Syndrome Indomethacin 5.2910684365
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.5919483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.5912125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1715340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9115746008
MESH:D001929 Brain Edema Indomethacin 5.4011481608
MESH:D002545 Brain Ischemia Indomethacin 4.7512524144
MESH:D001943 Breast Neoplasms Indomethacin 2.1717401462
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.1720435547
MESH:D002056 Burns Indomethacin 5.0110459503
MESH:D002100 Cachexia Indomethacin 5.3411239499 15625704 16537180 15141370
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9916835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 3.163084413
MESH:D006528 Carcinoma, Hepatocellular Indomethacin 3.1616391822
MESH:D018827 Carcinoma, Lewis Lung Indomethacin 5.0611053908
MESH:D018276 Carcinoma, Medullary Indomethacin 5.6918791128 14736730 11352223
MESH:D002292 Carcinoma, Renal Cell Indomethacin 3.4717341418
MESH:D002294 Carcinoma, Squamous Cell Indomethacin 2.9015482327 12636206
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4918850075 18670907 16120746
MESH:D002386 Cataract Acetaminophen 2.7110977129
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.0920889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 7.0912371664
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3816835633
MESH:D002764 Cholecystitis Indomethacin 5.5511181007
MESH:D002779 Cholestasis Cyclosporine 14.3819486331
MESH:D002779 Cholestasis Ethinyl Estradiol 14.3817110522 16105132 17681005 17333356 16919318 15861022 11677210
MESH:D002779 Cholestasis pirinixic acid 14.3819176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.198697196 12621046 15668235 15340226 16354765
MESH:D003110 Colonic Neoplasms Indomethacin 2.6215786552 11260862 15963497 15936596 15625704 15637740
MESH:D015179 Colorectal Neoplasms Indomethacin 2.3612606626 17054584 18059344 11197048
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2717141729 14669216
MESH:D018352 Coronavirus Infections Indomethacin 6.0917302372
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 20055451 15322242
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5218249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7117107852
MESH:D003967 Diarrhea Indomethacin 4.077907874 7237001
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.7514986274 16781746 16109766 12153990 10774834 11529661 16177239 19739265 16227642 16393943 11834606 18713872 16081117 2444490 18071297 19420014 11461765 17562736 11287661 19164858 15968718 10663392 10915739 16485898 17906064 15619225 11421492 19923254 12392966 11743745 19085960 11739529 17522070 14725611 12705907 14550746 19416960 12594235 12958197 12540782 19370779
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.7520420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4719426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9311462148
MESH:D004374 Ductus Arteriosus, Patent Indomethacin 5.4918446180 17190690 18043480 12774134 16326151 16133044
MESH:D004381 Duodenal Ulcer Indomethacin 4.4217045617 11595431 11535926 10671773 16699067 11991626 17151854 17202747 17329845 17351913 11595415
MESH:D004487 Edema Indomethacin 12.907907874 7990266 16100529 19703484 10653021 8985016 8273558
MESH:D004487 Edema pirinixic acid 12.9012083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 12.9012711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.2818230668 16714409 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.4712538720
MESH:D004715 Endometriosis Indomethacin 9.8415652904
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 9.8410568697 9294722
MESH:D019446 Endotoxemia Indomethacin 4.8418509659
MESH:D004751 Enteritis Indomethacin 5.1210567023 16328016 17763956
MESH:D020345 Enterocolitis, Necrotizing Indomethacin 5.2917980183
MESH:D004802 Eosinophilia Indomethacin 4.3611298111
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.8220426865
MESH:D004938 Esophageal Neoplasms Indomethacin 4.8211005569
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1911564622
MESH:D005234 Fatty Liver Cyclosporine 14.4619224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 14.4615345470
MESH:D005234 Fatty Liver pirinixic acid 14.4620131406 19236843
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7611858732
MESH:D005334 Fever Indomethacin 4.3511852909 17627676 10431976
MESH:D005354 Fibrosarcoma Indomethacin 5.2310962813
MESH:D005355 Fibrosis Cyclosporine 16.6712168785 12639820
MESH:D005355 Fibrosis Indomethacin 16.6717994277
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 16.6720067830
MESH:D005499 Folliculitis Indomethacin 5.5511298111
MESH:D005756 Gastritis Acetaminophen 12.4416983495
MESH:D005756 Gastritis Indomethacin 12.4415046732
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.568708960
MESH:D005909 Glioblastoma Indomethacin 3.7112870263
MESH:D005910 Glioma Indomethacin 3.3016487511 18371953
MESH:D005923 Glomerulosclerosis, Focal Segmental Indomethacin 4.4811849393
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9710696789
MESH:D006073 Gout Indomethacin 5.6911248219
MESH:D006258 Head and Neck Neoplasms Indomethacin 3.9015482327
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4411294989 10048152
MESH:D006333 Heart Failure pirinixic acid 2.6720558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.7615720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5811000095
MESH:D006501 Hepatic Encephalopathy Indomethacin 4.8115633222
MESH:D019698 Hepatitis C, Chronic Indomethacin 4.9615135802
MESH:D006529 Hepatomegaly pirinixic acid 9.3016221962 19176532 19772884 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 9.3012621046 16120746 15340226
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.4215340226 16354765 8697196 18606429 16959395
MESH:D006930 Hyperalgesia Acetaminophen 8.4816870215
MESH:D006930 Hyperalgesia Indomethacin 8.4812727271
MESH:D034321 Hyperamylasemia Indomethacin 6.0917883296
MESH:D006940 Hyperemia Indomethacin 5.3412524144
MESH:D006943 Hyperglycemia pirinixic acid 3.4120558911
MESH:D006949 Hyperlipidemias Indomethacin 4.4217546600
MESH:D006973 Hypertension Cyclosporine 5.2110903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.2118670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 4.1216945680 16569931
MESH:D007077 Ileal Diseases Indomethacin 5.4018306037 10574470
MESH:D007079 Ileitis Indomethacin 5.6910647630 10651667 16133968
MESH:D007235 Infant, Premature, Diseases Indomethacin 5.7516133044
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.7212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6417937319
MESH:D007249 Inflammation Indomethacin 5.493291741 7812673 12568917
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.4912200463 12878042
MESH:D007333 Insulin Resistance pirinixic acid 2.7816306350
MESH:D007410 Intestinal Diseases Indomethacin 4.6318236018 15831440 11713966 17329856 10210152 17994277 11855677 11686837 15610444
MESH:D019586 Intracranial Hypertension Indomethacin 5.7515241188
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5816580747
MESH:D007579 Jejunal Diseases Indomethacin 5.4010574470 18306037 16133968
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.8215604871
MESH:D007674 Kidney Diseases Acetaminophen 10.8215629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 10.828314463 10903974 18776723
MESH:D007674 Kidney Diseases Indomethacin 10.8217190690
MESH:D007680 Kidney Neoplasms Cyclosporine 2.9312371664
MESH:D016773 Leishmaniasis, Cutaneous Indomethacin 4.1012228301 11703811 10320625
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Indomethacin 4.1010785260 16572323 15631656
MESH:D015470 Leukemia, Myeloid, Acute Indomethacin 2.6718360721
MESH:D007964 Leukocytosis Indomethacin 5.7516537180
MESH:D007969 Leukomalacia, Periventricular Indomethacin 6.0917980183
MESH:D008101 Liver Abscess, Amebic Indomethacin 6.0911479899
MESH:D008106 Liver Cirrhosis, Experimental Indomethacin 3.6018194892
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.6015474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.6012878042
MESH:D008107 Liver Diseases Acetaminophen 1.6712969438 12587719 19784758 11587558 19014921 16611625 19460945 16610002
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4616871587 17185352
MESH:D008113 Liver Neoplasms pirinixic acid 4.5115890375 16377806 20007298
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.5116984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.2412151625
MESH:D055370 Lung Injury Asbestos, Crocidolite 4.3317365036
MESH:D008175 Lung Neoplasms Indomethacin 2.5311053908 11497255 16537180
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.5311884234 19555203
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8719513568
MESH:D008654 Mesothelioma Asbestos, Crocidolite 3.2618303189 16966607 16166281
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.1616801185
MESH:D008881 Migraine Disorders Indomethacin 3.8411903285
MESH:D009062 Mouth Neoplasms Indomethacin 4.1712636206
MESH:D009135 Muscular Diseases pirinixic acid 3.8116239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2219151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2112213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1316411023
MESH:D009362 Neoplasm Metastasis Indomethacin 3.2511053908 16537180 11239499
MESH:D009369 Neoplasms pirinixic acid 2.0517405874
MESH:D009374 Neoplasms, Experimental Indomethacin 4.4410663608 15625704
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.8217954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.5018481113 19348381
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4914600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 9.0918514411
MESH:D019636 Neurodegenerative Diseases Indomethacin 9.0912349958
MESH:D009765 Obesity pirinixic acid 1.8620558911
MESH:D007752 Obstetric Labor, Premature Indomethacin 5.556374098
MESH:D010003 Osteoarthritis Indomethacin 3.807009135
MESH:D010146 Pain Acetaminophen 7.4716870215
MESH:D010146 Pain Indomethacin 7.473291741 17440234 13679232 17627676
MESH:D010149 Pain, Postoperative Indomethacin 5.0612538197 18702446
MESH:D010195 Pancreatitis Indomethacin 4.1815028970 17883296
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9511578682
MESH:D010257 Paraneoplastic Syndromes Indomethacin 6.0916537180
MESH:D020734 Parkinsonian Disorders Indomethacin 4.3512349958
MESH:D051302 Paroxysmal Hemicrania Indomethacin 6.0911903285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.6212520081
MESH:D010437 Peptic Ulcer Indomethacin 5.4911148446
MESH:D010518 Periodontitis Indomethacin 5.2917225004
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 5.2010923243
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8418163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.4412371664
MESH:D047928 Premature Birth Indomethacin 5.4317000239
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.5311896295 11222880 11399792 11118676
MESH:D011507 Proteinuria Indomethacin 4.4211849393
MESH:D011537 Pruritus Ethinyl Estradiol 3.6516919318 15861022
MESH:D011565 Psoriasis Cyclosporine 2.3016882103
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 3.1017365031 17975199 17322281 15814490
MESH:D015427 Reperfusion Injury pirinixic acid 2.4919058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.1218990726
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1416192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.3216709447
MESH:D013272 Stomach Diseases Indomethacin 4.7516280098 17207306 16113693 15038085 18209964 16184426 10192188 10486359 17638125 10215738 17160473 15472012 18545984
MESH:D013274 Stomach Neoplasms Indomethacin 2.3615609394
MESH:D013276 Stomach Ulcer Indomethacin 3.8216150113 15255614 18726076 16169175 18209962 18181030 1323529 12467913 10750652 18237397 12787963 18193104 11906479 17657623 18431645 14567935 17918041 11523592 17135157 11145282 17895592 16252198 18543354 15104355 17654042 12500499 16631530 11595431 17627676 18299717 10423059 11729361 10878458 12498302 17977527 11595415 12077510 18087811 15138204 16755016 16934674 16397915
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3715669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2812697716
MESH:D013964 Thyroid Neoplasms Indomethacin 3.7611352223 14736730 18791128
MESH:D014456 Ulcer Indomethacin 5.2317380554 10574470
MESH:D014581 Urticaria Acetaminophen 3.2410982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5814692618
MESH:D014605 Uveitis Cyclosporine 4.361336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9712125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7814671159 15869587
MESH:D014839 Vomiting Indomethacin 5.1211897121
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.6215886252
MESH:D014985 Xerophthalmia Cyclosporine 4.8217120751
No data
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved