AutismKB 2.0

Annotation Detail for PTEN


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Basic Information Top
Gene Symbol:PTEN ( 10q23del,BZS,DEC,GLM2,MGC11227,MHAM,MMAC1,PTEN1,TEP1 )
Gene Full Name: phosphatase and tensin homolog
Band: 10q23.31
Quick LinksEntrez ID:5728; OMIM: 601728; Uniprot ID:PTEN_HUMAN; ENSEMBL ID: ENSG00000171862; HGNC ID: 9588
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY-6364D-myo-inositol (1,3,4)-trisphosphate biosynthesis
PWY-6358superpathway of D-myo-inositol (1,4,5)-trisphosphate metabolism
PWY-63683-phosphoinositide degradation
Pathway IDPathway Name
hsa00562Inositol phosphate metabolism
hsa04530Tight junction
hsa04115p53 signaling pathway
hsa05222Small cell lung cancer
hsa05218Melanoma
hsa05213Endometrial cancer
hsa05214Glioma
hsa05215Prostate cancer
hsa04510Focal adhesion
hsa05200Pathways in cancer
hsa04070Phosphatidylinositol signaling system
Pathway IDPathway Name
Signalling by NGF
Signaling in Immune system
Pathway IDPathway Name
200005BCR signaling pathway
200007RhoA signaling pathway
200156Signaling events mediated by Stem cell factor receptor (c-Kit)
200127PDGFR-beta signaling pathway
200098Class I PI3K signaling events
200118AP-1 transcription factor network
200022TCR signaling in naive CD4+ T cells
200101Direct p53 effectors
Pathway IDPathway Name
P04398p53 pathway feedback loops 2
P00033Insulin/IGF pathway-protein kinase B signaling cascade
P00048PI3 kinase pathway
P00030Hypoxia response via HIF activation
P00059p53 pathway
P00031Inflammation mediated by chemokine and cytokine signaling pathway
No data
Related Diseases/Disorders Top
Desease IDDesease Name
Cancers
Cancers of the digestive system
H00031Breast cancer
Cancers of the urinary system and male genital organs
H00013Small cell lung cancer
Skin cancers
H00029Vulvar cancer
H00024Prostate cancer
H00026Endometrial cancer
H00038Malignant melanoma
Cancers of the lung and pleura
H00042Glioma
H00048Hepatocellular carcinoma
Cancers of the breast and female genital organs
Cancers of the nervous system
No data
Desease Name
ovarian cancer
CHEMDEPENDENCY
anaplastic astrocytoma
prostate cancer
nicotine dependence
brain cancer
CANCER
METABOLIC
smoking behavior
diabetes, type 2
glioblastoma multiforme
No data
Desease Name
Cowden disease
Macrocephaly/autism syndrome
Bannayan-Riley-Ruvalcaba syndrome
VATER association with macrocephaly and ventriculomegaly
PTEN hamartoma tumor syndrome
Lhermitte-Duclos syndrome
Prostate cancer, somatic
Glioma susceptibility 2
Meningioma
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C097240 15-deoxy-delta(12,14)-prostaglandin J2 [15-deoxy-delta(12,14)-prostaglandin J2 co-treated with alitretinoin] results in increased expression of PTEN proteinaffects cotreatment|increases expression 16611854
C486182 2,3-bis(4-hydroxyphenyl)-propionitrile 2,3-bis(4-hydroxyphenyl)-propionitrile results in increased expression of PTEN proteinincreases expression 19264808
C486182 2,3-bis(4-hydroxyphenyl)-propionitrile ESR1 protein affects the reaction [2,3-bis(4-hydroxyphenyl)-propionitrile results in increased expression of PTEN protein]affects reaction|increases expression 19264808
C085911 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one [decitabine co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with Sirolimus] results in increased expression of PTEN mRNAaffects cotreatment|increases expression 18622747
C486184 4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol 4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol results in increased expression of PTEN proteinincreases expression 19264808
C103303 alitretinoin [15-deoxy-delta(12,14)-prostaglandin J2 co-treated with alitretinoin] results in increased expression of PTEN proteinaffects cotreatment|increases expression 16611854
D000643 Ammonium Chloride Ammonium Chloride affects the expression of PTEN mRNAaffects expression 16483693
D000643 Ammonium Chloride Ammonium Chloride results in decreased expression of PTEN proteindecreases expression 16483693
D001554 Benzene [Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in increased expression of PTEN mRNAaffects cotreatment|increases expression 17905399
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of PTEN mRNAincreases expression 20504355
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of PTEN mRNAdecreases expression 19150397
20018196
C053541 bicalutamide bicalutamide promotes the reaction [PTEN protein results in decreased expression of KLK3 mRNA]decreases expression|increases reaction 16637073
C053541 bicalutamide bicalutamide results in increased activity of PTEN proteinincreases activity 16637073
C006780 bisphenol A bisphenol A affects the expression of PTEN mRNAaffects expression 20170705
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of PTEN mRNAincreases expression 15336504
D002087 Butyrates Butyrates results in increased expression of PTEN mRNAincreases expression 16042588
C045645 cilostazol cilostazol results in decreased phosphorylation of PTEN proteindecreases phosphorylation 15978173
D003042 Cocaine Cocaine affects the expression of PTEN mRNAaffects expression 15681117
C014347 decitabine [decitabine affects the methylation of PTEN promoter] which affects the expression of PTEN mRNAaffects expression|affects methylation 18431742
C014347 decitabine [decitabine co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with Sirolimus] results in increased expression of PTEN mRNAaffects cotreatment|increases expression 18622747
C014347 decitabine decitabine results in decreased methylation of PTEN genedecreases methylation 21170675
C014347 decitabine decitabine results in increased expression of PTEN mRNAincreases expression 21170675
D002945 Cisplatin Cisplatin results in increased activity of PTEN proteinincreases activity 11707646
D004054 Diethylstilbestrol Diethylstilbestrol results in decreased expression of PTEN mRNAdecreases expression 16804899
D004317 Doxorubicin [Doxorubicin co-treated with trichostatin A] results in increased expression of PTEN mRNAaffects cotreatment|increases expression 17330857
D004317 Doxorubicin Doxorubicin results in increased activity of PTEN proteinincreases activity 11707646
D004317 Doxorubicin PTEN protein affects the susceptibility to [Doxorubicin co-treated with trichostatin A]affects cotreatment|affects response to substance 17330857
D004317 Doxorubicin PTEN protein inhibits the reaction [Doxorubicin results in increased phosphorylation of and results in increased activity of AKT1 protein]decreases reaction|increases activity|increases phosphorylation 17935137
D004317 Doxorubicin PTEN protein promotes the reaction [Doxorubicin results in decreased expression of AKT1 protein modified form]decreases expression|increases reaction 16438844
D004317 Doxorubicin PTEN protein promotes the reaction [Doxorubicin results in decreased expression of BAD protein modified form]decreases expression|increases reaction 16438844
D004317 Doxorubicin PTEN protein promotes the reaction [Doxorubicin results in decreased phosphorylation of AKT1 protein]decreases phosphorylation|increases reaction 17359293
D004317 Doxorubicin PTEN protein promotes the reaction [Doxorubicin results in decreased phosphorylation of BAD protein]decreases phosphorylation|increases reaction 17359293
D004317 Doxorubicin PTEN protein results in increased susceptibility to Doxorubicinincreases response to substance 17359293
17935137
16438844
D004317 Doxorubicin PTEN results in increased susceptibility to Doxorubicinincreases response to substance 15548710
D004317 Doxorubicin wortmannin inhibits the reaction [PTEN protein results in increased susceptibility to Doxorubicin]decreases reaction|increases response to substance 17935137
D004958 Estradiol ESR1 protein affects the reaction [Estradiol results in increased expression of PTEN mRNA]affects reaction|increases expression 19264808
D004958 Estradiol ESR1 protein affects the reaction [Estradiol results in increased expression of PTEN protein]affects reaction|increases expression 19264808
D004958 Estradiol ESR1 protein alternative form inhibits the reaction [Estradiol results in increased expression of PTEN mRNA]decreases reaction|increases expression 20302909
D004958 Estradiol ESR1 protein alternative form inhibits the reaction [Estradiol results in increased expression of PTEN protein]decreases reaction|increases expression 20302909
D004958 Estradiol Estradiol results in increased expression of PTEN mRNAincreases expression 20302909
D004958 Estradiol Estradiol results in increased expression of PTEN proteinincreases expression 20302909
19264808
D004958 Estradiol PTEN protein affects the reaction [Estradiol promotes the reaction [AKT1 protein modified form binds to IRS1 protein]]affects binding|affects reaction|increases reaction 19435893
D004958 Estradiol [Estradiol co-treated with Norepinephrine] results in decreased expression of PTEN mRNAaffects cotreatment|decreases expression 16954335
D004958 Estradiol Estradiol results in decreased expression of PTEN mRNAdecreases expression 16954335
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of PTEN mRNAaffects expression 20170705
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PTEN mRNAaffects cotreatment|increases expression 17942748
D005038 Ethylnitrosourea Ethylnitrosourea results in increased mutagenesis of PTEN geneincreases mutagenesis 15755804
16724327
D005047 Etoposide PTEN protein inhibits the reaction [Etoposide results in increased phosphorylation of and results in increased activity of AKT1 protein]decreases reaction|increases activity|increases phosphorylation 17935137
D005047 Etoposide PTEN protein results in increased susceptibility to Etoposideincreases response to substance 17935137
D005047 Etoposide wortmannin inhibits the reaction [PTEN protein results in increased susceptibility to Etoposide]decreases reaction|increases response to substance 17935137
D005472 Fluorouracil Fluorouracil results in decreased expression of PTEN mRNAdecreases expression 17039268
C070081 fulvestrant PTEN protein results in increased susceptibility to fulvestrantincreases response to substance 19435893
C056507 gemcitabine gemcitabine affects the expression of PTEN mRNAaffects expression 17039268
D019833 Genistein Genistein affects the expression of PTEN mRNAaffects expression 18431742
D019833 Genistein Genistein affects the expression of PTEN proteinaffects expression 18431742
D019833 Genistein Genistein inhibits the reaction [HIST3H3 protein modified form binds to PTEN promoter]affects binding|decreases reaction 18431742
D019833 Genistein Genistein results in increased expression of PTEN mRNAincreases expression 15829497
D019833 Genistein Genistein results in increased expression of PTEN proteinincreases expression 15829497
D019833 Genistein [[Genistein results in increased expression of PTEN protein] which results in decreased activity of AKT1 protein] which results in increased activity of FOXO3 proteindecreases activity|increases activity|increases expression 18431742
D019833 Genistein [[Genistein results in increased expression of PTEN protein] which results in decreased activity of AKT1 protein] which results in increased expression of TP53 proteindecreases activity|increases expression 18431742
D006861 Hydrogen Peroxide Hydrogen Peroxide results in increased oxidation of and results in decreased activity of PTEN proteindecreases activity|increases oxidation 11916965
C030957 methylmercury II [Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in increased expression of PTEN mRNAaffects cotreatment|increases expression 17905399
D008770 Methylnitrosourea Methylnitrosourea results in decreased expression of PTEN mRNAdecreases expression 16616109
C008493 methylselenic acid methylselenic acid results in increased expression of PTEN mRNAincreases expression 12517777
D015741 Metribolone PTEN protein results in decreased susceptibility to Metribolonedecreases response to substance 16637073
C029938 nickel sulfate nickel sulfate results in increased expression of PTEN mRNAincreases expression 16780908
D009638 Norepinephrine [Estradiol co-treated with Norepinephrine] results in decreased expression of PTEN mRNAaffects cotreatment|decreases expression 16954335
D009638 Norepinephrine Norepinephrine inhibits the reaction [Testosterone results in decreased expression of PTEN mRNA]decreases expression|decreases reaction 16954335
D009638 Norepinephrine [Progesterone co-treated with Norepinephrine] results in increased expression of PTEN mRNAaffects cotreatment|increases expression 16954335
D017239 Paclitaxel Paclitaxel results in increased activity of PTEN proteinincreases activity 11707646
D017239 Paclitaxel PTEN results in increased susceptibility to Paclitaxelincreases response to substance 15548710
D010713 Phosphatidylcholines PTEN protein binds to Phosphatidylcholinesaffects binding 15313215
D010713 Phosphatidylcholines [TXN protein binds to PTEN protein] inhibits the reaction [PTEN protein binds to Phosphatidylcholines]affects binding|decreases reaction 15313215
C483858 phosphatidylethanolamine PTEN protein binds to phosphatidylethanolamineaffects binding 15313215
C483858 phosphatidylethanolamine [TXN protein binds to PTEN protein] inhibits the reaction [PTEN protein binds to phosphatidylethanolamine]affects binding|decreases reaction 15313215
C060974 phosphatidylinositol 3,4,5-triphosphate PTEN protein results in decreased phosphorylation of and results in increased activity of phosphatidylinositol 3,4,5-triphosphatedecreases phosphorylation|increases activity 12888921
C060974 phosphatidylinositol 3,4,5-triphosphate PTEN protein results in increased hydrolysis of and results in decreased activity of phosphatidylinositol 3,4,5-triphosphatedecreases activity|increases hydrolysis 15313215
D010718 Phosphatidylserines PTEN protein binds to Phosphatidylserinesaffects binding 15313215
D010718 Phosphatidylserines [TXN protein binds to PTEN protein] inhibits the reaction [PTEN protein binds to Phosphatidylserines]affects binding|decreases reaction 15313215
C035988 procymidone procymidone results in increased expression of PTEN mRNAincreases expression 15686871
D011374 Progesterone Progesterone affects the expression of PTEN mRNAaffects expression 17251523
D011374 Progesterone [Progesterone co-treated with Norepinephrine] results in increased expression of PTEN mRNAaffects cotreatment|increases expression 16954335
C031280 pyrazole pyrazole results in decreased expression of PTEN mRNAdecreases expression 17945193
D011794 Quercetin Quercetin results in increased expression of PTEN mRNAincreases expression 14715546
15829497
D011794 Quercetin Quercetin results in increased expression of PTEN proteinincreases expression 15829497
D011794 Quercetin Quercetin results in increased expression of PTEN mRNAincreases expression 18095365
C059514 resveratrol resveratrol results in increased expression of PTEN mRNAincreases expression 15829497
C059514 resveratrol resveratrol results in increased expression of PTEN proteinincreases expression 15829497
D020123 Sirolimus [decitabine co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with Sirolimus] results in increased expression of PTEN mRNAaffects cotreatment|increases expression 18622747
C009277 sodium arsenate sodium arsenate results in decreased expression of PTEN mRNAdecreases expression 14713550
C009277 sodium arsenate sodium arsenate results in decreased expression of PTEN proteindecreases expression 14713550
C017947 sodium arsenite sodium arsenite results in decreased expression of PTEN mRNAdecreases expression 20056578
C017947 sodium arsenite sodium arsenite results in decreased expression of PTEN mRNAdecreases expression 16014739
D013629 Tamoxifen PTEN protein results in increased susceptibility to Tamoxifenincreases response to substance 19435893
D013739 Testosterone Norepinephrine inhibits the reaction [Testosterone results in decreased expression of PTEN mRNA]decreases expression|decreases reaction 16954335
D013739 Testosterone Testosterone results in decreased expression of PTEN mRNAdecreases expression 16954335
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of PTEN mRNAdecreases expression 17101203
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PTEN mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of PTEN mRNAdecreases expression 18796159
D013752 Tetracycline Tetracycline results in increased expression of PTEN mRNAincreases expression 16917069
D014051 Toluene 2,4-Diisocyanate PTEN protein inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL17A mRNA]decreases reaction|increases expression 17982072
D014051 Toluene 2,4-Diisocyanate PTEN protein inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL17A protein]decreases reaction|increases expression 17982072
D014051 Toluene 2,4-Diisocyanate PTEN protein inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of RELA protein]decreases reaction|increases expression 17982072
D014051 Toluene 2,4-Diisocyanate Toluene 2,4-Diisocyanate results in decreased expression of and results in decreased activity of PTEN proteindecreases activity|decreases expression 17982072
D014241 Trichloroethylene [Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in increased expression of PTEN mRNAaffects cotreatment|increases expression 17905399
C012589 trichostatin A [Doxorubicin co-treated with trichostatin A] results in increased expression of PTEN mRNAaffects cotreatment|increases expression 17330857
C012589 trichostatin A PTEN protein affects the susceptibility to [Doxorubicin co-treated with trichostatin A]affects cotreatment|affects response to substance 17330857
C012589 trichostatin A trichostatin A promotes the reaction [[EP300 protein co-treated with EGR1 protein] results in increased expression of PTEN mRNA]affects cotreatment|increases expression|increases reaction 17330857
C012589 trichostatin A trichostatin A promotes the reaction [HIST3H3 protein modified form binds to PTEN promoter]affects binding|increases reaction 17330857
C012589 trichostatin A trichostatin A promotes the reaction [HIST4H4 protein modified form binds to PTEN promoter]affects binding|increases reaction 17330857
C012589 trichostatin A trichostatin A results in increased expression of PTEN mRNAincreases expression 17330857
C012589 trichostatin A trichostatin A results in increased expression of PTEN proteinincreases expression 17330857
C025643 vinclozolin vinclozolin results in increased expression of PTEN mRNAincreases expression 15686871
C017963 vinyl carbamate vinyl carbamate results in decreased expression of PTEN mRNAdecreases expression 17849452
D002762 Cholecalciferol Cholecalciferol results in increased expression of PTEN mRNAincreases expression 16508948
C009687 wortmannin wortmannin inhibits the reaction [PTEN protein results in increased susceptibility to Doxorubicin]decreases reaction|increases response to substance 17935137
C009687 wortmannin wortmannin inhibits the reaction [PTEN protein results in increased susceptibility to Etoposide]decreases reaction|increases response to substance 17935137
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 3.9314745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.2615322242 14514962 11752688
MESH:D000015 Abnormalities, Multiple marker/mechanism 18759867
MESH:D000138 Acidosis Ammonium Chloride 2.9618287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.3317505938
MESH:D058186 Acute Kidney Injury Cisplatin 7.1017670903 15814532 12690470
MESH:D058186 Acute Kidney Injury resveratrol 7.1016538975
MESH:D055371 Acute Lung Injury nickel sulfate 3.7616100012 19131640 12718980 11954676
MESH:D000230 Adenocarcinoma marker/mechanism 17909629
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 24.8720464547 20127859
MESH:D000230 Adenocarcinoma Cisplatin 24.8711798837 17638652
MESH:D000230 Adenocarcinoma Doxorubicin 24.8717418594
MESH:D000230 Adenocarcinoma Estradiol 24.8711473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 24.8714692618
MESH:D000230 Adenocarcinoma Fluorouracil 24.8717638652
MESH:D000230 Adenocarcinoma Genistein 24.8711473722
MESH:D000230 Adenocarcinoma Methylnitrosourea 24.8715688392 15113128
MESH:D000230 Adenocarcinoma vinyl carbamate 24.8717363558 16247444
MESH:D000236 Adenoma Benzo(a)pyrene 9.136695378
MESH:D000236 Adenoma Ethylnitrosourea 9.136695378
MESH:D000236 Adenoma resveratrol 9.1315688382
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 8.7016835633
MESH:D018248 Adenoma, Liver Cell vinyl carbamate 8.7012371669
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.0915276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.2917306315 16712894
MESH:D000419 Albuminuria Doxorubicin 3.9721441931
MESH:D000544 Alzheimer Disease resveratrol 2.4216183991 16162502
MESH:D000686 Amyloidosis Diethylstilbestrol 3.9115469931
MESH:D000740 Anemia Fluorouracil 6.9416511603 15504547 17963324
MESH:D000740 Anemia Tetrachlorodibenzodioxin 6.9411748828
MESH:D000741 Anemia, Aplastic Benzene 3.9011369114 14761424 17661222
MESH:D000743 Anemia, Hemolytic Quercetin 3.7017084956
MESH:D015858 Anisometropia marker/mechanism 9286463
MESH:D000987 Antisocial Personality Disorder Testosterone 5.247506515
MESH:D001008 Anxiety Disorders vinclozolin 3.1619015723
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.4919183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 2.8811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 6.0415885639
MESH:D001169 Arthritis, Experimental resveratrol 6.0417115116
MESH:D001249 Asthma therapeutic 17982072
MESH:D001249 Asthma Toluene 2,4-Diisocyanate 3.2918394133 10934080 16210060 170078 8156442 6091946 7684630 12762349 19187332 11077013 15590890 20032816 10797510 12585506 12684321 16792590 15590891 11742282 3040596 17015710 15855793 11467998 6091945
MESH:D001260 Ataxia Telangiectasia Quercetin 4.3815336622
MESH:D050197 Atherosclerosis resveratrol 2.9016873680 17967414
MESH:D001284 Atrophy fulvestrant 4.2811514358
MESH:D001321 Autistic Disorder marker/mechanism 19211884 11496368 18759867 19265751
MESH:D001321 Autistic Disorder Norepinephrine 3.028570775
MESH:D001321 Autistic Disorder Sirolimus 3.0221115397
MESH:D001327 Autoimmune Diseases Cholecalciferol 9.1216142846
MESH:D001327 Autoimmune Diseases Quercetin 9.1219761891
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 2.5112125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.1815340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.3615746008
MESH:D001855 Bone Marrow Diseases Benzene 4.6216183116
MESH:D019046 Bone Marrow Neoplasms Cisplatin 16.8414601052
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 16.8414601052
MESH:D019046 Bone Marrow Neoplasms Etoposide 16.8414601052
MESH:D001859 Bone Neoplasms Paclitaxel 4.0115867366
MESH:D001862 Bone Resorption bisphenol A 3.3311985600
MESH:D001927 Brain Diseases Ethylnitrosourea 4.3514991843
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 4.7217868700
MESH:D001930 Brain Injuries Progesterone 3.6715665606 15845082 15380490
MESH:D002545 Brain Ischemia resveratrol 3.6917600658
MESH:D001932 Brain Neoplasms Doxorubicin 7.3617150277
MESH:D001932 Brain Neoplasms Ethylnitrosourea 7.3616436596 15144691 16651633 16357521 18412241
MESH:D001943 Breast Neoplasms marker/mechanism 20400965 19685490 18066063 19968660
MESH:D001943 Breast Neoplasms alitretinoin 29.0016344269
MESH:D001943 Breast Neoplasms Benzene 29.0011921183 17162533
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 29.0017474063 20146248
MESH:D001943 Breast Neoplasms bisphenol A 29.0017123778
MESH:D001943 Breast Neoplasms Cisplatin 29.0018382427 19526202
MESH:D001943 Breast Neoplasms decitabine 29.0018320071 19208741
MESH:D001943 Breast Neoplasms Diethylstilbestrol 29.0015324884 17129689
MESH:D001943 Breast Neoplasms Doxorubicin 29.0015668708 17369602 16096432 17983394 18234424 15136595 18695136 16322301 19526202 18382427 16264153 15993339 15939500 16595493 18628466 15692762 16826403 15634643 16935488 11325840 15567936 16115903 15994142 17426702
MESH:D001943 Breast Neoplasms Estradiol 29.0017289903 12948864 17261762 18497071 14630087 19861407 17018787 16675129
MESH:D001943 Breast Neoplasms Etoposide 29.0016322251
MESH:D001943 Breast Neoplasms Fluorouracil 29.0019217205 16557594 18608205 18357371 16110121 16595493 15136595
MESH:D001943 Breast Neoplasms fulvestrant 29.0018984771
MESH:D001943 Breast Neoplasms gemcitabine 29.0017039268 18382427
MESH:D001943 Breast Neoplasms Genistein 29.0016873071 17200150 16541309
MESH:D001943 Breast Neoplasms Methylnitrosourea 29.0016253758 14633655 11306469
MESH:D001943 Breast Neoplasms Paclitaxel 29.0018223236 15136595 16115903 18323546 11325840 16244791 18234424 16273361
MESH:D001943 Breast Neoplasms Progesterone 29.0016175315 15562024 17614352
MESH:D001943 Breast Neoplasms Quercetin 29.0018628248
MESH:D001943 Breast Neoplasms resveratrol 29.0017534123 17651959 16393696
MESH:D001943 Breast Neoplasms Tamoxifen 29.0020859285 19244106 20390343 18821012 20544844 19189210 19288272 18629630 17049068 16202921 19487384 11161223 21152245 16273361 19221464 15668708 19410462 20065188 19115204 18997820 19103187 20135344 19200415 19066611 15565566 16818667 17440819 19189212 20005174 19142967 16873071 19155303 17893378 19011961 18984771 18855134 19289846 18351453 18815881 19059307 17261762 19084267 21138602 17242785 18425577
MESH:D001943 Breast Neoplasms Testosterone 29.0017261762
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 29.0020435547
MESH:D001943 Breast Neoplasms Toluene 2,4-Diisocyanate 29.0011921183
MESH:D001943 Breast Neoplasms Trichloroethylene 29.0015986119
MESH:D016535 Bronchial Hyperreactivity Toluene 2,4-Diisocyanate 4.0612507178 8156442 15590891
MESH:D002105 Cadmium Poisoning Quercetin 4.9316962696
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 3.8616111702
MESH:D002276 Carcinoid Tumor Doxorubicin 10.3216051944
MESH:D002276 Carcinoid Tumor Fluorouracil 10.3216051944
MESH:D002277 Carcinoma Fluorouracil 6.5817121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 6.5816835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 3.9219066611
MESH:D006528 Carcinoma, Hepatocellular Cisplatin 28.9317982673
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 28.9315948411 16924424
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 28.9317876044 18059187 16234567 16023760
MESH:D006528 Carcinoma, Hepatocellular Estradiol 28.9316924424
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 28.9316799960 16332177 17088986 17971768 18930000 17045692
MESH:D006528 Carcinoma, Hepatocellular Genistein 28.9316924424
MESH:D006528 Carcinoma, Hepatocellular Paclitaxel 28.9316313753
MESH:D006528 Carcinoma, Hepatocellular Quercetin 28.9312508355 19519916
MESH:D006528 Carcinoma, Hepatocellular resveratrol 28.9316227395 19321006
MESH:D006528 Carcinoma, Hepatocellular Sirolimus 28.9319335982
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 28.9317306315 15276417 16507464
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 28.9316924424
MESH:D006528 Carcinoma, Hepatocellular vinyl carbamate 28.9312371669
MESH:D002278 Carcinoma in Situ bisphenol A 4.3917123778
MESH:D018827 Carcinoma, Lewis Lung resveratrol 3.9916675471
MESH:D002289 Carcinoma, Non-Small-Cell Lung Cisplatin 5.3916685392 12023789
MESH:D002289 Carcinoma, Non-Small-Cell Lung vinyl carbamate 5.3916247446
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 4.3717234771
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 5.611485588 16201981
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 5.6118695887
MESH:D002294 Carcinoma, Squamous Cell marker/mechanism
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 22.1820419170
MESH:D002294 Carcinoma, Squamous Cell Cisplatin 22.1818337622 6189445 17066447
MESH:D002294 Carcinoma, Squamous Cell decitabine 22.1819215824
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 22.186189445
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 22.1818986760 16757204 16280240 17066447
MESH:D002294 Carcinoma, Squamous Cell resveratrol 22.1816227395
MESH:D002294 Carcinoma, Squamous Cell Sirolimus 22.1819435901
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 22.1818572023
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.0917572228
MESH:D006332 Cardiomegaly Norepinephrine 9.4711179087
MESH:D006332 Cardiomegaly Quercetin 9.4719794523
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 9.4716120746 18670907 18850075
MESH:D009202 Cardiomyopathies Doxorubicin 3.1215505089 17928571 16109756 17974986 15476868 16952015 16364871 16278810 17519947 17007740 17308081 16455267 17329180 17382496 17131338 18627295 16731534 17351982 16651473 15811867 16269455 15792986 16612575 17924179 16242529
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.7117334414 16243910
MESH:D002318 Cardiovascular Diseases Genistein 9.7516332659
MESH:D002318 Cardiovascular Diseases Hydrogen Peroxide 9.7516936243
MESH:D002318 Cardiovascular Diseases resveratrol 9.7515458977
MESH:D002375 Catalepsy Norepinephrine 4.948216760
MESH:D002386 Cataract Methylnitrosourea 3.6112484553
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 16.5620889678
MESH:D002471 Cell Transformation, Neoplastic Estradiol 16.5618566989
MESH:D002471 Cell Transformation, Neoplastic Ethylnitrosourea 16.5616003739
MESH:D002471 Cell Transformation, Neoplastic Methylnitrosourea 16.567505956 2727394
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 16.5619524636 20056578
MESH:D016543 Central Nervous System Neoplasms Ethylnitrosourea 5.3717160924
MESH:D002659 Child Development Disorders, Pervasive Testosterone 3.4320678186
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.6516835633
MESH:D002779 Cholestasis Ethinyl Estradiol 2.4217110522 16919318 17333356 15861022 11677210 16105132 17681005
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 1.8216354765 15340226 12621046 8697196 15668235
MESH:D019970 Cocaine-Related Disorders Cocaine 5.1219606084
MESH:D003092 Colitis resveratrol 3.5516474422
MESH:D003110 Colonic Neoplasms Butyrates 12.0815936596
MESH:D003110 Colonic Neoplasms decitabine 12.0817616700
MESH:D003110 Colonic Neoplasms Fluorouracil 12.0817725105 17287894 16510598 16340194 15001691 17018589 17172411 18772588 17169374 17016597
MESH:D003110 Colonic Neoplasms Genistein 12.0817182828
MESH:D003110 Colonic Neoplasms Quercetin 12.0817148506 11134977 15741050 17191121 19440933 19056647 16640504
MESH:D003110 Colonic Neoplasms resveratrol 12.0816338953
MESH:D015179 Colorectal Neoplasms Cisplatin 9.1815273666
MESH:D015179 Colorectal Neoplasms decitabine 9.1818981723
MESH:D015179 Colorectal Neoplasms Doxorubicin 9.1818802399 18259882
MESH:D015179 Colorectal Neoplasms Fluorouracil 9.1816303861 17255274 16282729 16331619 17695437 18448328 16524972 16391804 17454858 18949393 20501625 18288408 18383874 15148649 18509181 17401013 18802399 17094418 17594712 14970324 17016601 15289873
MESH:D015179 Colorectal Neoplasms Paclitaxel 9.1818802399
MESH:D015179 Colorectal Neoplasms Quercetin 9.1818852136 18095365
MESH:D015179 Colorectal Neoplasms resveratrol 9.1816550006
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.5517141729 14669216
MESH:D003327 Coronary Disease resveratrol 3.3416507316
MESH:D019465 Craniofacial Abnormalities marker/mechanism 9286463 14574156 19265751 19321504 17427195 18759867
MESH:D019465 Craniofacial Abnormalities Benzene 3.4615643154
MESH:D019465 Craniofacial Abnormalities sodium arsenate 3.4610525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.4615322242 20055451 10048152
MESH:D003456 Cryptorchidism Diethylstilbestrol 9.4712952375 16002989
MESH:D003456 Cryptorchidism vinclozolin 9.4714966744
MESH:D007644 Darier Disease Fluorouracil 4.1916733453
MESH:D003711 Demyelinating Diseases Tamoxifen 3.7719031437
MESH:D003872 Dermatitis Benzene 4.1815902427
MESH:D017449 Dermatitis, Allergic Contact nickel sulfate 5.7316823706 11298694 16780908
MESH:D017449 Dermatitis, Allergic Contact Toluene 2,4-Diisocyanate 5.7318759878 12956900 15491423
MESH:D003877 Dermatitis, Contact Toluene 2,4-Diisocyanate 4.2417010967
MESH:D002658 Developmental Disabilities marker/mechanism 18759867 19265751 19321504
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 6.9119496084
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 6.9116873680
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 3.7016647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 3.7017107852
MESH:D003928 Diabetic Nephropathies Estradiol 12.0819279558
MESH:D003928 Diabetic Nephropathies resveratrol 12.0816286809
MESH:D003928 Diabetic Nephropathies Tamoxifen 12.0819279558
MESH:D003929 Diabetic Neuropathies Progesterone 3.9117187935
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 12.3717416283
MESH:D056486 Drug-Induced Liver Injury pyrazole 12.3712499123
MESH:D056486 Drug-Induced Liver Injury sodium arsenate 12.3718186108
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 12.3720420201
MESH:D056486 Drug-Induced Liver Injury Tetracycline 12.3717522070
MESH:D056486 Drug-Induced Liver Injury Trichloroethylene 12.377120509
MESH:D004362 Drug Toxicity Cisplatin 11.1212231392 19839026 12649298 15033597
MESH:D004362 Drug Toxicity Doxorubicin 11.1218602426
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 11.1211462148
MESH:D004476 Ectodermal Dysplasia Ethylnitrosourea 5.3718357618
MESH:D004487 Edema resveratrol 5.128985016
MESH:D004487 Edema Tetrachlorodibenzodioxin 5.1211000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.2915322242 16714409 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental 15-deoxy-delta(12,14)-prostaglandin J2 22.7316844232
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 22.7312538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 22.7317692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 22.7317872969
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 22.7319031437
MESH:D004701 Endocrine Gland Neoplasms decitabine 11.9919294695
MESH:D004701 Endocrine Gland Neoplasms trichostatin A 11.9919294695
MESH:D004714 Endometrial Hyperplasia marker/mechanism 16402032
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 9.9016402032
MESH:D004714 Endometrial Hyperplasia Genistein 9.9016402032
MESH:D016889 Endometrial Neoplasms marker/mechanism 16804899 16402032 12888921
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 18.9616804899 15700306
MESH:D016889 Endometrial Neoplasms Doxorubicin 18.9617359293
MESH:D016889 Endometrial Neoplasms Estradiol 18.9619148513 18566989 11473722
MESH:D016889 Endometrial Neoplasms Genistein 18.9611473722
MESH:D016889 Endometrial Neoplasms Tamoxifen 18.9617893378 20544844 16202921 19155303
MESH:D004715 Endometriosis Progesterone 7.1916134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 7.1910568697 9294722
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 4.5418037988
MESH:D020345 Enterocolitis, Necrotizing resveratrol 4.2617923197
MESH:D004802 Eosinophilia Toluene 2,4-Diisocyanate 4.078156442
MESH:D004827 Epilepsy Norepinephrine 3.96821787
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 11.7020426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 11.7016530937
MESH:D004938 Esophageal Neoplasms Cisplatin 11.7015464296 16481741 15173087 16785472 17638652
MESH:D004938 Esophageal Neoplasms Fluorouracil 11.7016481741 15173087 16785472 16337965 17638652
MESH:D004938 Esophageal Neoplasms Paclitaxel 11.7016481741
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.5511564622
MESH:D005128 Eye Diseases Toluene 2,4-Diisocyanate 5.1418447907
MESH:D005234 Fatty Liver Ethinyl Estradiol 10.1215345470
MESH:D005234 Fatty Liver Tamoxifen 10.1214986274 19224547
MESH:D005234 Fatty Liver Tetracycline 10.1219224547 16917069
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 6.9116513791 16611131 16002989 16534752 15751030
MESH:D052776 Female Urogenital Diseases Tamoxifen 6.9116709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 2.8711858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 3.9314745880
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 9.4519069698
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 9.4519069698
MESH:D005354 Fibrosarcoma Methylnitrosourea 4.6311555667
MESH:D005355 Fibrosis Quercetin 6.8319474275
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 6.8320067830
MESH:D005391 Firesetting Behavior Testosterone 5.247506515
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.3316973722
MESH:D005832 Genital Diseases, Male vinclozolin 4.6916417039
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 10.8216452187
MESH:D005833 Genital Neoplasms, Female sodium arsenite 10.8216452187
MESH:D005909 Glioblastoma Doxorubicin 22.4217150277
MESH:D005909 Glioblastoma Ethylnitrosourea 22.4216436596
MESH:D005909 Glioblastoma Genistein 22.4216598420
MESH:D005909 Glioblastoma Quercetin 22.4219804834
MESH:D005909 Glioblastoma Testosterone 22.4217162496
MESH:D005909 Glioblastoma trichostatin A 22.4218801729
MESH:D005910 Glioma marker/mechanism
MESH:D005910 Glioma Ethylnitrosourea 11.8918412241 16651633 16357521
MESH:D005910 Glioma Fluorouracil 11.8916145905
MESH:D005910 Glioma Methylnitrosourea 11.899825942
MESH:D005910 Glioma Quercetin 11.8917643826
MESH:D018149 Glucose Intolerance sodium arsenate 4.5219446573
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 3.9810696789
MESH:D006223 Hamartoma Syndrome, Multiple marker/mechanism 11496368 9286463 10353779 10400993 11685670 11748304 14574156 15805158 19321504 17427195 19968660
MESH:D006258 Head and Neck Neoplasms marker/mechanism
MESH:D006258 Head and Neck Neoplasms Cisplatin 19.7215464296 15102660
MESH:D006258 Head and Neck Neoplasms decitabine 19.7219215824
MESH:D006258 Head and Neck Neoplasms Doxorubicin 19.7215692506
MESH:D006258 Head and Neck Neoplasms Fluorouracil 19.7215162350 15102660 18337622
MESH:D006258 Head and Neck Neoplasms Sirolimus 19.7219435901
MESH:D034381 Hearing Loss Cisplatin 3.7919898482
MESH:D006319 Hearing Loss, Sensorineural Cisplatin 3.9215464296
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 5.2820471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 5.2810048152 11294989
MESH:D006331 Heart Diseases Doxorubicin 3.0514766674 16144979 16707910 12587719 16879835 16495754 18674790 17888722 18006777 16244371 17875725 16244372 16330681
MESH:D006333 Heart Failure Doxorubicin 2.9517481944
MESH:D006391 Hemangioma marker/mechanism 9286463
MESH:D006394 Hemangiosarcoma Doxorubicin 3.3715692506
MESH:D006402 Hematologic Diseases Benzene 4.1016183116
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.8011000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.3216120746 15340226 12621046
MESH:D006558 Herpes Genitalis Estradiol 4.4215709030
MESH:D006561 Herpes Simplex Etoposide 8.1110809021
MESH:D006561 Herpes Simplex resveratrol 8.1116876885
MESH:D006628 Hirsutism Testosterone 5.0417019078
MESH:D006689 Hodgkin Disease Cisplatin 13.3816200630 16170182
MESH:D006689 Hodgkin Disease Doxorubicin 13.3815147373 17606976 18501091
MESH:D006689 Hodgkin Disease Etoposide 13.3817606976 15147373 18180244 16200630 16135485
MESH:D006689 Hodgkin Disease sodium arsenite 13.3812676792
MESH:D019584 Hot Flashes Estradiol 3.1417088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.4316354765 16959395 8697196 15340226 18606429
MESH:D017588 Hyperandrogenism Testosterone 4.7017019078
MESH:D006937 Hypercholesterolemia resveratrol 3.4717188708
MESH:D006943 Hyperglycemia Quercetin 3.5111834736 18262572
MESH:D006949 Hyperlipidemias resveratrol 3.4816873680
MESH:D006965 Hyperplasia Diethylstilbestrol 3.8514722030 12960047
MESH:D006967 Hypersensitivity Toluene 2,4-Diisocyanate 4.0811019492 10880147
MESH:D006973 Hypertension Benzene 7.1417940673
MESH:D006973 Hypertension Quercetin 7.1418356687
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 7.1418850075 18670907
MESH:D006984 Hypertrophy marker/mechanism 19211884
MESH:D006984 Hypertrophy Sirolimus 4.6919211884
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 3.7817488730
MESH:D007006 Hypogonadism Testosterone 4.1412002444
MESH:D007018 Hypopituitarism Testosterone 5.5917426086
MESH:D007021 Hypospadias Diethylstilbestrol 9.2916002989
MESH:D007021 Hypospadias Ethinyl Estradiol 9.2916945680 16569931
MESH:D007022 Hypotension Norepinephrine 4.446740701
MESH:D007174 Impulse Control Disorders Testosterone 5.247506515
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 9.5415869954
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 9.5417600658
MESH:D007246 Infertility Diethylstilbestrol 3.7815036965
MESH:D007247 Infertility, Female Ethinyl Estradiol 2.9112013081
MESH:D007248 Infertility, Male decitabine 20.9317581917
MESH:D007248 Infertility, Male Ethinyl Estradiol 20.9317937319
MESH:D007248 Infertility, Male fulvestrant 20.9311514358
MESH:D007248 Infertility, Male Methylnitrosourea 20.937193160
MESH:D007248 Infertility, Male sodium arsenite 20.9312646999 15346721
MESH:D007248 Infertility, Male vinclozolin 20.9316467254
MESH:D007249 Inflammation Progesterone 9.1315869954
MESH:D007249 Inflammation resveratrol 9.1316366677
MESH:D007249 Inflammation Tamoxifen 9.1319457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 9.1312200463 12878042
MESH:D007251 Influenza, Human Quercetin 9.1616624496
MESH:D007251 Influenza, Human resveratrol 9.1616624496
MESH:D007333 Insulin Resistance bisphenol A 6.0616393666
MESH:D007333 Insulin Resistance Estradiol 6.0616627594 16393666
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 2.8016580747
MESH:C537702 Juvenile polyposis syndrome marker/mechanism
MESH:D007627 Keloid Quercetin 4.3717086741
MESH:D017492 Keratosis, Seborrheic alitretinoin 5.0416144296
MESH:D007673 Kidney Cortex Necrosis Cisplatin 4.5315464296
MESH:D007674 Kidney Diseases Cisplatin 15.1019839026 18289764 15190930 12649298 12231392
MESH:D007674 Kidney Diseases Doxorubicin 15.1015369732 15699352 16775033
MESH:D007674 Kidney Diseases Estradiol 15.1015618244
MESH:D007674 Kidney Diseases Quercetin 15.1016962696
MESH:D007674 Kidney Diseases sodium arsenite 15.1020008137
MESH:D007676 Kidney Failure, Chronic Doxorubicin 8.3316707910
MESH:D007676 Kidney Failure, Chronic Hydrogen Peroxide 8.3316518626
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 18.1514681315 16762066 15003126
MESH:D007680 Kidney Neoplasms Estradiol 18.1515610895
MESH:D007680 Kidney Neoplasms Ethylnitrosourea 18.1517379185
MESH:D007680 Kidney Neoplasms Fluorouracil 18.1516985049
MESH:D007680 Kidney Neoplasms Tamoxifen 18.1518625569
MESH:D007683 Kidney Tubular Necrosis, Acute Cisplatin 4.1811231351
MESH:D007805 Language Development Disorders marker/mechanism 9286463
MESH:D007859 Learning Disorders Diethylstilbestrol 3.4817184923
MESH:D044542 LEOPARD Syndrome marker/mechanism 11685670
MESH:D007938 Leukemia marker/mechanism 12970779
MESH:D007938 Leukemia 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 16.1712970779
MESH:D007938 Leukemia Benzene 16.1714694614 18335105 15935818 17119257
MESH:D007938 Leukemia decitabine 16.1719235587 18980019
MESH:D007938 Leukemia Genistein 16.1718980019 17468513
MESH:D007938 Leukemia Quercetin 16.1717468513
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 4.5416085563
MESH:D007951 Leukemia, Myeloid Benzene 8.0017506065
MESH:D007951 Leukemia, Myeloid decitabine 8.0017236224 19117987 18454857
MESH:D015470 Leukemia, Myeloid, Acute Benzene 5.4619478238
MESH:D015470 Leukemia, Myeloid, Acute decitabine 5.4619010910 18460780 18704418 17679729 19387464 18206229
MESH:D015470 Leukemia, Myeloid, Acute trichostatin A 5.4618206229
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 4.8518055864
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 3.1716087638
MESH:D007984 Leydig Cell Tumor vinclozolin 4.1316417039
MESH:D017880 Limb Deformities, Congenital Methylnitrosourea 3.7615526292
MESH:D008064 Lipidoses Tamoxifen 2.7117567588 15342952
MESH:D008067 Lipoma marker/mechanism 9286463
MESH:D008068 Lipomatosis marker/mechanism 11748304
MESH:D008080 Liposarcoma Paclitaxel 4.2617353645
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 11.3616439617 16595196
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 11.3614659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Genistein 11.3617823541
MESH:D008106 Liver Cirrhosis, Experimental Phosphatidylcholines 11.3616169303
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 11.3612741479
MESH:D008106 Liver Cirrhosis, Experimental Sirolimus 11.3617050028
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 11.3618564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 11.3612878042
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 21.1720195826 21137059
MESH:D008113 Liver Neoplasms Diethylstilbestrol 21.1715890375 16712894
MESH:D008113 Liver Neoplasms Fluorouracil 21.1716603448 18383874 17045692 15113037
MESH:D008113 Liver Neoplasms Quercetin 21.1718980244
MESH:D008113 Liver Neoplasms resveratrol 21.1719073162 20405173 19321006 19812893
MESH:D008113 Liver Neoplasms sodium arsenite 21.1715276417 16712894
MESH:D008113 Liver Neoplasms Tamoxifen 21.1716684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 21.1716984957
MESH:D008114 Liver Neoplasms, Experimental Benzene 14.4612562636
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 14.4616842330 17085340
MESH:D008114 Liver Neoplasms, Experimental Quercetin 14.4619519916
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 14.4612151625
MESH:D008114 Liver Neoplasms, Experimental Trichloroethylene 14.467955063
MESH:D038061 Lower Extremity Deformities, Congenital Methylnitrosourea 4.8816080182
MESH:D008171 Lung Diseases sodium arsenite 2.7519095001
MESH:D017563 Lung Diseases, Interstitial Benzene 4.2014698565
MESH:D008175 Lung Neoplasms marker/mechanism 17909629
MESH:D008175 Lung Neoplasms alitretinoin 23.0316413115
MESH:D008175 Lung Neoplasms Benzene 23.0312562636
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 23.036695378 17053015 20064080 18816296 18569708 18520028 20869020 20464547 20135361
MESH:D008175 Lung Neoplasms Cisplatin 23.036189445 11798837 17225452
MESH:D008175 Lung Neoplasms Doxorubicin 23.036189445 17418594
MESH:D008175 Lung Neoplasms Ethylnitrosourea 23.0316271038 17703301 16019985 6695378
MESH:D008175 Lung Neoplasms Fluorouracil 23.0315246190
MESH:D008175 Lung Neoplasms Methylnitrosourea 23.0318062963
MESH:D008175 Lung Neoplasms Quercetin 23.0316280456
MESH:D008175 Lung Neoplasms sodium arsenite 23.0315276417 16712894 19931552 17077188 17306315
MESH:D008175 Lung Neoplasms Tamoxifen 23.0318625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 23.0319555203 11884234
MESH:D008175 Lung Neoplasms vinyl carbamate 23.0317361011 12117777 11134547 12765245 15824018 11195469 17163412 14755239 16885199 15172992 17363558 12438228 16247444
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.1915086387
MESH:D008181 Lupus Nephritis Diethylstilbestrol 4.5515166399
MESH:D008223 Lymphoma Benzene 28.3917119257 17584886
MESH:D008223 Lymphoma decitabine 28.3919470736
MESH:D008223 Lymphoma Diethylstilbestrol 28.3915700306
MESH:D008223 Lymphoma Doxorubicin 28.3916098063
MESH:D008223 Lymphoma Ethylnitrosourea 28.3915790496
MESH:D008223 Lymphoma Etoposide 28.3912556972 12854902
MESH:D008223 Lymphoma Methylnitrosourea 28.3916257854 11418001
MESH:D016393 Lymphoma, B-Cell Methylnitrosourea 8.6914633661
MESH:D016393 Lymphoma, B-Cell resveratrol 8.6917088997
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 11.7717654614
MESH:D008228 Lymphoma, Non-Hodgkin Paclitaxel 11.7714749477
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 11.7714749477
MESH:D016399 Lymphoma, T-Cell Doxorubicin 9.7515621674
MESH:D016399 Lymphoma, T-Cell Ethylnitrosourea 9.7515375218
OMIM:605309 MACROCEPHALY/AUTISM SYNDROME marker/mechanism 15805158 17286265 17427195
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 4.9016002989
MESH:D015674 Mammary Neoplasms, Animal Benzene 13.3612562636
MESH:D015674 Mammary Neoplasms, Animal resveratrol 13.3615688416
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 13.3619428831
MESH:D008325 Mammary Neoplasms, Experimental Benzene 30.6611921183
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 30.6615458769
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 30.6611408345 11807958 16891317 17203775
MESH:D008325 Mammary Neoplasms, Experimental Ethylnitrosourea 30.6610767621 18041768 10838139
MESH:D008325 Mammary Neoplasms, Experimental Genistein 30.6614578162 12929590
MESH:D008325 Mammary Neoplasms, Experimental Methylnitrosourea 30.6611751437 16051031 15113128 17131329 15313902 17020996 14999141 16619500 11807958 16944150 10838139 14633655 16827153 12931682 19196723 10767621 15688392
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 30.6617203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 30.668985016 11606380
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 30.6614580682 19196722 19196723 16827153 11731420
MESH:D020149 Manganese Poisoning Estradiol 10.6119453300
MESH:D020149 Manganese Poisoning Tamoxifen 10.6119453300
MESH:D008545 Melanoma marker/mechanism 19282848
MESH:D008545 Melanoma Cisplatin 18.6818332650 17761969 12883367 18505091 12393984 16432458 15577323 12374674 11135225 16248763 18176117 17023156 16809738
MESH:D008545 Melanoma decitabine 18.6816505122 17785578
MESH:D008545 Melanoma Doxorubicin 18.6816827129
MESH:D008545 Melanoma Paclitaxel 18.6812025231 12040289 16342250
MESH:D008545 Melanoma resveratrol 18.6817992120
MESH:D008545 Melanoma Sirolimus 18.6819282848
MESH:D008545 Melanoma sodium arsenite 18.6819082730 16487513
MESH:D008545 Melanoma Tamoxifen 18.6812393984 19393235
MESH:D008545 Melanoma trichostatin A 18.6816505122
MESH:D018328 Melanoma, Amelanotic Cisplatin 9.5115990972
MESH:D018328 Melanoma, Amelanotic Tamoxifen 9.5115990972
OMIM:155600 MELANOMA, CUTANEOUS MALIGNANT marker/mechanism
MESH:D008579 Meningioma Ethylnitrosourea 5.3717943659
MESH:C537443 Meningioma, familial marker/mechanism
MESH:D008607 Mental Retardation marker/mechanism 11496368 14574156 18759867 19265751 17427195
MESH:D008654 Mesothelioma Cisplatin 5.5217638057
MESH:D008654 Mesothelioma Doxorubicin 5.5217638057
MESH:D008659 Metabolic Diseases resveratrol 3.8417112576
MESH:D028361 Mitochondrial Diseases Doxorubicin 3.9615792986
MESH:D019957 Motor Skills Disorders marker/mechanism 9286463
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 11.7916381670
MESH:D009062 Mouth Neoplasms Fluorouracil 11.7916757204 18986760
MESH:D009062 Mouth Neoplasms Sirolimus 11.7919435901
MESH:D052016 Mucositis Doxorubicin 4.1917415656
MESH:D009101 Multiple Myeloma Benzene 18.0017119195
MESH:D009101 Multiple Myeloma decitabine 18.0018172295
MESH:D009101 Multiple Myeloma Paclitaxel 18.0014749477
MESH:D009101 Multiple Myeloma resveratrol 18.0014749477 17049120 16267019 17164350 17935668 16490592
MESH:D009101 Multiple Myeloma trichostatin A 18.0018172295
MESH:D009134 Muscular Atrophy, Spinal resveratrol 4.2717962980
MESH:D009139 Musculoskeletal Abnormalities sodium arsenate 4.3118186108
MESH:D009190 Myelodysplastic Syndromes decitabine 3.0119157545 18608210 19010910 16882708
MESH:D009203 Myocardial Infarction Cocaine 14.8418072171
MESH:D009203 Myocardial Infarction Doxorubicin 14.8415857846 19429709
MESH:D009203 Myocardial Infarction Genistein 14.8417141266
MESH:D009203 Myocardial Infarction Quercetin 14.8419595682
MESH:D009203 Myocardial Infarction resveratrol 14.8417188708 17015251 16525036 17125593 16456233 16317513
MESH:D017202 Myocardial Ischemia resveratrol 7.4017125593 17015251
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 7.4012213967
MESH:D015428 Myocardial Reperfusion Injury marker/mechanism 19038262
MESH:D015428 Myocardial Reperfusion Injury Estradiol 16.5316810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 16.5317141266
MESH:D015428 Myocardial Reperfusion Injury Norepinephrine 16.5315642760
MESH:D015428 Myocardial Reperfusion Injury Quercetin 16.5319207477
MESH:D009205 Myocarditis resveratrol 4.1617322642
MESH:D009362 Neoplasm Metastasis Doxorubicin 7.9818259882
MESH:D009362 Neoplasm Metastasis Paclitaxel 7.9815867366
MESH:D009362 Neoplasm Metastasis Tamoxifen 7.9819393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.2919410462
MESH:D009369 Neoplasms alitretinoin 30.1916946489
MESH:D009369 Neoplasms Benzo(a)pyrene 30.1911141357
MESH:D009369 Neoplasms Cisplatin 30.1916773208
MESH:D009369 Neoplasms decitabine 30.1917925555 19470736 19116145
MESH:D009369 Neoplasms Diethylstilbestrol 30.1915313581
MESH:D009369 Neoplasms Fluorouracil 30.1918600527 18239605 16928823
MESH:D009369 Neoplasms Methylnitrosourea 30.1915533788
MESH:D009369 Neoplasms Quercetin 30.1915185748
MESH:D009369 Neoplasms sodium arsenite 30.1911559025
MESH:D009369 Neoplasms Trichloroethylene 30.1911911487
MESH:D009374 Neoplasms, Experimental Ethylnitrosourea 22.3216707424
MESH:D009374 Neoplasms, Experimental Methylnitrosourea 22.3212696579
MESH:D009374 Neoplasms, Experimental resveratrol 22.328985016
MESH:D009374 Neoplasms, Experimental sodium arsenite 22.3220056578
MESH:D009374 Neoplasms, Experimental Toluene 2,4-Diisocyanate 22.321670384
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.3919196722 19189210 19200415
MESH:D009389 Neovascularization, Pathologic Estradiol 3.1417289903
MESH:D009395 Nephritis, Interstitial Cisplatin 8.8115464296
MESH:D009395 Nephritis, Interstitial Tetracycline 8.819884423
MESH:D009401 Nephrosis Doxorubicin 4.1816636307 16899518
MESH:D009404 Nephrotic Syndrome Doxorubicin 3.4915640375 16889571
MESH:D009421 Nervous System Malformations bisphenol A 24.7211399458 16427766
MESH:D009421 Nervous System Malformations Diethylstilbestrol 24.7211399458
MESH:D009421 Nervous System Malformations Estradiol 24.7216427766 11399458
MESH:D009421 Nervous System Malformations Genistein 24.7216427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 24.7214600291
MESH:D009436 Neural Tube Defects Benzene 9.9515643154
MESH:D009436 Neural Tube Defects sodium arsenate 9.9511749123 10525206 19446573 18186108
MESH:D009436 Neural Tube Defects sodium arsenite 9.9512854658
MESH:D009442 Neurilemmoma Ethylnitrosourea 11.2917160924 16003739 16651423
MESH:D009442 Neurilemmoma Methylnitrosourea 11.2911555667
MESH:D009447 Neuroblastoma Cisplatin 6.008761367
MESH:D009447 Neuroblastoma Doxorubicin 6.0015555623
MESH:D019636 Neurodegenerative Diseases resveratrol 3.3217652729
MESH:D017599 Neuroectodermal Tumors Cisplatin 4.108761367
MESH:D020078 Neurogenic Inflammation Quercetin 8.8517929310
MESH:D020078 Neurogenic Inflammation resveratrol 8.8517929310
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.0116436463
MESH:D009784 Occupational Diseases Benzene 7.8915612468 15576619 15727169 17479406 17119257 16737584 15935809 17178637 15913788
MESH:D009784 Occupational Diseases Toluene 2,4-Diisocyanate 7.8918394133 3040596 12585506 6091945 6091946 11077013 8156442
MESH:D009837 Oligodendroglioma Ethylnitrosourea 5.3717160924
MESH:D010014 Osteolysis Paclitaxel 4.3815867366
MESH:D010024 Osteoporosis Genistein 2.8619401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 13.6916169203
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 13.6919495926
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 13.6917513867
MESH:D012516 Osteosarcoma Doxorubicin 3.6315930896
MESH:D010049 Ovarian Diseases bisphenol A 4.3911985600
MESH:D010051 Ovarian Neoplasms 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 34.8716211241
MESH:D010051 Ovarian Neoplasms Benzene 34.8712562636
MESH:D010051 Ovarian Neoplasms Cisplatin 34.876897625 19769630 15464296 17225452
MESH:D010051 Ovarian Neoplasms decitabine 34.8719259094 19331143
MESH:D010051 Ovarian Neoplasms Estradiol 34.8719401270
MESH:D010051 Ovarian Neoplasms Genistein 34.8719005980
MESH:D010051 Ovarian Neoplasms Paclitaxel 34.8711161223
MESH:D010051 Ovarian Neoplasms Progesterone 34.8716525653 17393432
MESH:D010051 Ovarian Neoplasms Quercetin 34.8719005980
MESH:D010051 Ovarian Neoplasms sodium arsenite 34.8715276417 17306315
MESH:D010051 Ovarian Neoplasms trichostatin A 34.8719331143
MESH:D010190 Pancreatic Neoplasms Cisplatin 24.8219003803
MESH:D010190 Pancreatic Neoplasms decitabine 24.8219294695
MESH:D010190 Pancreatic Neoplasms Etoposide 24.8219003803
MESH:D010190 Pancreatic Neoplasms Fluorouracil 24.8219003803 16929163 16500647 15113037
MESH:D010190 Pancreatic Neoplasms gemcitabine 24.8211504793 18992248 16929163 17440100 18383843
MESH:D010190 Pancreatic Neoplasms Methylnitrosourea 24.8216965848
MESH:D010190 Pancreatic Neoplasms Quercetin 24.8216965848
MESH:D010190 Pancreatic Neoplasms trichostatin A 24.8219294695
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.1311578682
MESH:D010212 Papilloma Hydrogen Peroxide 3.5112065085
MESH:D010300 Parkinson Disease Sirolimus 3.4919682553
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.6312520081
MESH:D010391 Pemphigoid, Bullous Tetracycline 4.8211026799
MESH:D010523 Peripheral Nervous System Diseases Cisplatin 3.7415464296
MESH:D003557 Phyllodes Tumor Doxorubicin 4.5417983394
MESH:D010900 Pituitary Diseases Diethylstilbestrol 4.5614722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.0815687265 16977796
MESH:D010997 Pleural Neoplasms Cisplatin 11.9017638057
MESH:D010997 Pleural Neoplasms Doxorubicin 11.9017638057
MESH:D017689 Polydactyly marker/mechanism 17427195
MESH:D017499 Porokeratosis alitretinoin 5.3916144296
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 2.9918163543
MESH:D011230 Precancerous Conditions Quercetin 3.4719056647
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 24.1310548101
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 24.1317184923
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 24.1316679765
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 24.1311399792 11118676 11222880 11896295
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 24.1318220299 18042343 19015723
MESH:D055728 Primary Myelofibrosis decitabine 10.4817616702
MESH:D055728 Primary Myelofibrosis trichostatin A 10.4817616702
MESH:D017096 Prion Diseases Tetracycline 4.8110903871
MESH:D011469 Prostatic Diseases vinclozolin 4.3318220299
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 14.9220887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 14.9220887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Testosterone 14.9220887781
MESH:D011471 Prostatic Neoplasms marker/mechanism 19396168 16421604 17173048
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 10.2917292933
MESH:D011471 Prostatic Neoplasms bicalutamide 10.2919011039 19240160 18487222 17914592 15638997
MESH:D011471 Prostatic Neoplasms bisphenol A 10.2916740699
MESH:D011471 Prostatic Neoplasms Cholecalciferol 10.2917024972
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 10.2915846301 15046698 17136230
MESH:D011471 Prostatic Neoplasms Doxorubicin 10.2916868541 15897917 15749863 16729912 16888761 18437689
MESH:D011471 Prostatic Neoplasms Estradiol 10.2916740699
MESH:D011471 Prostatic Neoplasms Etoposide 10.2917172428
MESH:D011471 Prostatic Neoplasms Fluorouracil 10.2919082440 18626508
MESH:D011471 Prostatic Neoplasms Genistein 10.2915378649 15256057 16925846
MESH:D011471 Prostatic Neoplasms Methylnitrosourea 10.2915682402 12376480
MESH:D011471 Prostatic Neoplasms methylselenic acid 10.2916205645
MESH:D011471 Prostatic Neoplasms Paclitaxel 10.2917136230 17172428 16729912 16356831
MESH:D011471 Prostatic Neoplasms Quercetin 10.2917292933 14715546
MESH:D011471 Prostatic Neoplasms resveratrol 10.2917804756 17675339 17636462 15767336 16731767 17718901
MESH:D011471 Prostatic Neoplasms sodium arsenite 10.2916039940
MESH:D011471 Prostatic Neoplasms Tamoxifen 10.2915067354
MESH:D011471 Prostatic Neoplasms trichostatin A 10.2919789329 18798265
MESH:D011472 Prostatitis vinclozolin 4.3318629315
MESH:D016715 Proteus Syndrome marker/mechanism 11748304 17427195
MESH:D011537 Pruritus Ethinyl Estradiol 2.7216919318 15861022
MESH:D011618 Psychotic Disorders Cocaine 4.3816134406
MESH:D011629 Puberty, Precocious bisphenol A 4.1810548101
MESH:D011657 Pulmonary Eosinophilia Toluene 2,4-Diisocyanate 5.0114606601
MESH:D012004 Rectal Neoplasms Fluorouracil 3.5018722050 16160472 15538739 18286688
MESH:D051437 Renal Insufficiency Cisplatin 8.4415464296
MESH:D051437 Renal Insufficiency Doxorubicin 8.4417922066
MESH:D051436 Renal Insufficiency, Chronic resveratrol 4.9716325855
MESH:D015427 Reperfusion Injury marker/mechanism 19038262
MESH:D015427 Reperfusion Injury resveratrol 2.9516314181 17520802 15827377 17058453 16317513
MESH:D012130 Respiratory Hypersensitivity Toluene 2,4-Diisocyanate 4.0216940033 7692837 20219652
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.2618990726
MESH:D012140 Respiratory Tract Diseases Toluene 2,4-Diisocyanate 4.5118447907
MESH:D012162 Retinal Degeneration Methylnitrosourea 3.9518172121 18155124
MESH:D012175 Retinoblastoma Methylnitrosourea 4.8811555667
MESH:D012208 Rhabdomyosarcoma decitabine 3.8519155313
MESH:D012220 Rhinitis Toluene 2,4-Diisocyanate 4.0619050374
MESH:D012221 Rhinitis, Allergic, Perennial Toluene 2,4-Diisocyanate 4.6712617775 15015336
MESH:D006255 Rhinitis, Allergic, Seasonal Toluene 2,4-Diisocyanate 4.9019075512
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.6118045962
MESH:D012509 Sarcoma Doxorubicin 3.4717203757 16767912 17710206 15625365 15675481 18313854
MESH:D012512 Sarcoma, Ewing's Cisplatin 14.0914601052
MESH:D012512 Sarcoma, Ewing's Doxorubicin 14.0916326096 14601052
MESH:D012512 Sarcoma, Ewing's Etoposide 14.0914601052
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.1917846226
MESH:D012554 Schistosomiasis japonica Quercetin 4.9316862918
MESH:D012640 Seizures Cocaine 3.6510454489
MESH:D012735 Sexual Dysfunction, Physiological Testosterone 5.5916631401
MESH:D012871 Skin Diseases marker/mechanism 19321504
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 22.3019755658 10029692
MESH:D012878 Skin Neoplasms Doxorubicin 22.3015692506
MESH:D012878 Skin Neoplasms Hydrogen Peroxide 22.3012065085
MESH:D012878 Skin Neoplasms resveratrol 22.308985016 15837718
MESH:D012878 Skin Neoplasms sodium arsenite 22.3019524636 18572023
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 22.308532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 22.3016192470
MESH:D055752 Small Cell Lung Carcinoma Cisplatin 4.7315464296
MESH:D012912 Sneezing Toluene 2,4-Diisocyanate 4.9019075512 19050374
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 3.9817203757 15625365 16767912
MESH:D013088 Spermatocele Diethylstilbestrol 16.6016002989 16709447
MESH:D013088 Spermatocele Ethinyl Estradiol 16.6016709447
MESH:D013088 Spermatocele Tamoxifen 16.6016709447
MESH:D013119 Spinal Cord Injuries Progesterone 8.8815862959 16503802
MESH:D013119 Spinal Cord Injuries Tamoxifen 8.8819457130
MESH:D016135 Spinal Dysraphism sodium arsenite 3.3212854658
OMIM:275355 SQUAMOUS CELL CARCINOMA, HEAD AND NECK marker/mechanism
MESH:D013274 Stomach Neoplasms Benzene 9.0312562636
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 9.032093021 20155912
MESH:D013274 Stomach Neoplasms Cisplatin 9.0317522103 15958060 18396642
MESH:D013274 Stomach Neoplasms decitabine 9.0319037991
MESH:D013274 Stomach Neoplasms Fluorouracil 9.0317522103 17498489 18396642 18567086 16951190 15786421 19084572 16424979 17172411 19015929
MESH:D013274 Stomach Neoplasms Methylnitrosourea 9.0318593901 15930296 16257854
MESH:D013274 Stomach Neoplasms Paclitaxel 9.0318396642 18506536
OMIM:601367 STROKE, ISCHEMIC resveratrol 3.9516321402
MESH:D019966 Substance-Related Disorders bisphenol A 3.3916045194 16684133
MESH:D013610 Tachycardia Norepinephrine 4.863261545
MESH:D024801 Tauopathies Paclitaxel 4.2116930453
MESH:D013733 Testicular Diseases pyrazole 4.226499806
MESH:D013736 Testicular Neoplasms Cisplatin 4.0715464296 17225452
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.0611994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.6415669648
MESH:D013953 Thymus Neoplasms Benzene 16.8810850423
MESH:D013953 Thymus Neoplasms Ethylnitrosourea 16.8815790496
MESH:D013953 Thymus Neoplasms Methylnitrosourea 16.8811418001
OMIM:188470 THYROID CARCINOMA, FOLLICULAR marker/mechanism
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.2912697716
MESH:D013964 Thyroid Neoplasms Butyrates 13.4017967635
MESH:D013964 Thyroid Neoplasms decitabine 13.4017967635
MESH:D013964 Thyroid Neoplasms Doxorubicin 13.4017909728 16010429
MESH:D013964 Thyroid Neoplasms Methylnitrosourea 13.407505956 3078959
MESH:D013978 Tibial Fractures Estradiol 4.0719048282
MESH:D014062 Tongue Neoplasms Fluorouracil 8.2416280240
MESH:D014062 Tongue Neoplasms resveratrol 8.2416227395
MESH:D014402 Tuberous Sclerosis Sirolimus 4.9918495876 21115397
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 23.6417053015
MESH:D001749 Urinary Bladder Neoplasms Cisplatin 23.6415464296 12973940 17225452
MESH:D001749 Urinary Bladder Neoplasms decitabine 23.6417616700 19087683
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 23.6417306315 16452187 16712894
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 23.6417653716
MESH:D001749 Urinary Bladder Neoplasms Quercetin 23.6416720314
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 23.6411723127 17306315 16452187 16712894
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 23.6416712894 17572228 8653321
MESH:D002583 Uterine Cervical Neoplasms Cisplatin 24.1016803524
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 24.1016175088
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 24.1016803524
MESH:D002583 Uterine Cervical Neoplasms resveratrol 24.1017473185
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 24.1011813266
MESH:D014591 Uterine Diseases bisphenol A 11.7814652134
MESH:D014591 Uterine Diseases Diethylstilbestrol 11.7814652134
MESH:D014594 Uterine Neoplasms Benzene 18.2612562636
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 18.2615809267 16690809
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 18.2614692618
MESH:D014594 Uterine Neoplasms resveratrol 18.2617044934
MESH:D014604 Uveal Neoplasms decitabine 4.3017785578
MESH:D014605 Uveitis Sirolimus 5.021336536
OMIM:276950 VACTERL ASSOCIATION WITH HYDROCEPHALUS marker/mechanism 11748304
MESH:D014625 Vaginal Neoplasms Cisplatin 9.1315577323
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 9.1316002989 16513791
MESH:D014652 Vascular Diseases sodium arsenite 3.8217056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 3.9812125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.0014671159 15869587
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 8.4017678736 16364871 17334414 17638931
MESH:D018487 Ventricular Dysfunction, Left resveratrol 8.4017488730
MESH:D014839 Vomiting Cisplatin 4.1111897121
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.6315886252
Pathway ID Pathway Name
KEGG:05213 Endometrial cancer
KEGG:04510 Focal adhesion
KEGG:05214 Glioma
KEGG:00562 Inositol phosphate metabolism
REACT:6313 Insulin receptor mediated signaling
KEGG:05218 Melanoma
KEGG:04115 p53 signaling pathway
KEGG:05200 Pathways in cancer
KEGG:04070 Phosphatidylinositol signaling system
KEGG:05215 Prostate cancer
REACT:6900 Signaling in Immune system
REACT:11061 Signalling by NGF
KEGG:05222 Small cell lung cancer
KEGG:04530 Tight junction
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA33942
    • Releated gene ID Related gene Name
    PA34335RET
    PA28054FBXW7
    PA164722590MIR21
    PA164722572MIR19A
    PA28360FRAP1
    Releated disease ID Related disease Name
    PA445425Prostatic Neoplasms
    PA444283Glioblastoma
    PA443610Carcinoma
    PA443624Carcinoma, Renal Cell
    PA162372591Cowden-like Syndrome
    PA445062Neoplasms
    PA444184Fibrosarcoma
    PA445601Osteosarcoma
    PA443622Carcinoma, Non-Small-Cell Lung
    PA443756Colonic Neoplasms
    PA446167Leukemia-Lymphoma, Adult T-Cell
    PA443560Breast Neoplasms
    PA152238047Juvenile Polyposis of Infancy
    PA444342Hamartoma Syndrome, Multiple
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    PA446411Endometrial Neoplasms
    PA445857Thyroid Neoplasms
    Releated drug ID Related drug Name
    PA451365sirolimus
    PA10804imatinib
    PA451365sirolimus
    PA448710caffeine
    PA449014cisplatin
    PA449383docetaxel
    PA128406956fluorouracil
    PA450198leucovorin
    PA450205levamisole
    PA451743trastuzumab
    PA450970pioglitazone
    PA451283rosiglitazone
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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