AutismKB 2.0

Annotation Detail for PTGDR


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Basic Information Top
Gene Symbol:PTGDR ( AS1,ASRT1,DP,DP1,MGC49004 )
Gene Full Name: prostaglandin D2 receptor (DP)
Band: 14q22.1
Quick LinksEntrez ID:5729; OMIM: 604687; Uniprot ID:PD2R_HUMAN; ENSEMBL ID: ENSG00000168229; HGNC ID: 9591
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04080Neuroactive ligand-receptor interaction
Pathway IDPathway Name
Signaling by GPCR
No data
No data
Pathway IDPathway Name
500420Prostanoid ligand receptors
Related Diseases/Disorders Top
No data
No data
Desease Name
Asthma
IMMUNE
No data
Desease Name
Asthma, susceptibility to, 1
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000241 Adenosine [Prostaglandin D2 results in increased activity of PTGDR protein] which results in increased metabolism of Adenosineincreases activity|increases metabolic processing 11562489
D000241 Adenosine [Prostaglandin D2 results in increased activity of PTGDR protein] which results in increased secretion of Adenosineincreases activity|increases secretion 11562489
D000643 Ammonium Chloride Ammonium Chloride affects the expression of PTGDR mRNAaffects expression 16483693
C030669 BW 245C BW 245C binds to and results in increased activity of PTGDR proteinaffects binding|increases activity 15528449
C058848 BW A868C BW A868C binds to and results in decreased activity of PTGDR proteinaffects binding|decreases activity 15528449
C058848 BW A868C BW A868C results in decreased activity of PTGDR proteindecreases activity 10644584
D015230 Prostaglandin D2 [Prostaglandin D2 results in increased activity of PTGDR protein] which results in increased metabolism of Adenosineincreases activity|increases metabolic processing 11562489
D015230 Prostaglandin D2 [Prostaglandin D2 results in increased activity of PTGDR protein] which results in increased secretion of Adenosineincreases activity|increases secretion 11562489
D003993 Dibutyl Phthalate Dibutyl Phthalate results in increased expression of PTGDR mRNAincreases expression 15620428
D004041 Dietary Fats Dietary Fats results in increased expression of PTGDR mRNAincreases expression 18042831
C025256 nonylphenol nonylphenol results in increased expression of PTGDR mRNAincreases expression 15620428
C041786 palm oil palm oil results in increased expression of PTGDR mRNAincreases expression 18042831
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.8418287403
MESH:D001161 Arteriosclerosis Dietary Fats 4.1515238619
OMIM:607277 ASTHMA-RELATED TRAITS, SUSCEPTIBILITY TO, 1 marker/mechanism
MESH:D001321 Autistic Disorder Adenosine 3.8620468076
MESH:D001943 Breast Neoplasms Dietary Fats 2.2620435547
MESH:D003456 Cryptorchidism Dibutyl Phthalate 5.6916037377
MESH:D050171 Dyslipidemias Dietary Fats 3.6018367378
MESH:D004827 Epilepsy Adenosine 4.8911404469
MESH:D005234 Fatty Liver Dietary Fats 3.4419551842 17967931 19004024 18296743
MESH:D005355 Fibrosis Dietary Fats 3.7818296743
MESH:D006937 Hypercholesterolemia Dietary Fats 3.8021332399
MESH:D006949 Hyperlipidemias Dietary Fats 3.8321332399
MESH:D007249 Inflammation Dietary Fats 2.5220412841
MESH:D007333 Insulin Resistance Dietary Fats 3.2318457598 11836018
MESH:D008103 Liver Cirrhosis Dietary Fats 2.9818296743
MESH:D008106 Liver Cirrhosis, Experimental Adenosine 3.7518263696
MESH:D009765 Obesity Dietary Fats 2.3311836018 17217161 20132043 20518802 18674790 21332399 19632207 16723640 18457598
MESH:D015430 Weight Gain Dietary Fats 3.9216723640
Pathway ID Pathway Name
KEGG:04080 Neuroactive ligand-receptor interaction
REACT:14797 Signaling by GPCR
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA285
    • Releated gene ID Related gene Name
    PA285PTGDR
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    Releated drug ID Related drug Name
    PA448478l-arginine
    PA450635nitric oxide
    PA450617niacin
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00716 unknown Nedocromil Anti-Asthmatic Agents;Anti-inflammatory Agents;Anti-Allergic Agents
    No data
    No data
    No data

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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