AutismKB 2.0

Annotation Detail for PTGDS


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Basic Information Top
Gene Symbol:PTGDS ( L-PGDS,LPGDS,PDS,PGD2,PGDS,PGDS2 )
Gene Full Name: prostaglandin D2 synthase 21kDa (brain)
Band: 9q34.3
Quick LinksEntrez ID:5730; OMIM: 176803; Uniprot ID:PTGDS_HUMAN; ENSEMBL ID: ENSG00000107317; HGNC ID: 9592
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY66-374prostanoid biosynthesis
Pathway IDPathway Name
hsa00590Arachidonic acid metabolism
hsa01100Metabolic pathways
No data
No data
No data
No data
Related Diseases/Disorders Top
No data
No data
Desease Name
periodontitis
CARDIOVASCULAR
IMMUNE
carotid atherosclerosis
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C054400 11-(dansylamino)undecanoic acid 11-(dansylamino)undecanoic acid binds to PTGDS proteinaffects binding 16461020
C477819 15-deoxyprostaglandin J2 PTGDS protein results in increased chemical synthesis of 15-deoxyprostaglandin J2increases chemical synthesis 12623786
C027132 1-anilino-8-naphthalenesulfonate 1-anilino-8-naphthalenesulfonate binds to PTGDS proteinaffects binding 16461020
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane affects the expression of PTGDS mRNAaffects expression 18648102
D000643 Ammonium Chloride Ammonium Chloride affects the expression of PTGDS mRNAaffects expression 16483693
D000983 Antipyrine Antipyrine results in decreased activity of PTGDS proteindecreases activity 15718289
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of PTGDS mRNAaffects cotreatment|increases expression 18164116
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of PTGDS mRNAincreases expression 20440473
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of PTGDS mRNAincreases expression 16644059
D003024 Clozapine Clozapine results in decreased expression of PTGDS mRNAdecreases expression 15542763
D003024 Clozapine Clozapine results in increased expression of PTGDS mRNAincreases expression 17266109
D003345 Corticosterone Corticosterone results in increased expression of PTGDS mRNAincreases expression 15755911
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of PTGDS mRNAaffects cotreatment|increases expression 18164116
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of PTGDS mRNAdecreases expression 16872691
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of PTGDS mRNAaffects expression 17555576
D004997 Ethinyl Estradiol [Ethinyl Estradiol co-treated with IL1B protein] results in increased expression of PTGDS mRNAaffects cotreatment|increases expression 12072388
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of PTGDS mRNAdecreases expression 17942748
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of PTGDS mRNAincreases expression 12072388
D005473 Fluoxetine Fluoxetine results in decreased expression of PTGDS mRNAdecreases expression 17105902
D018684 Glycine Agents Glycine Agents results in increased expression of PTGDS mRNAincreases expression 16532367
D015735 Mifepristone Mifepristone results in decreased expression of PTGDS mRNAdecreases expression 17584828
D009151 Mustard Gas Mustard Gas results in increased expression of PTGDS mRNAincreases expression 15674844
D005996 Nitroglycerin Nitroglycerin results in increased expression of PTGDS mRNAincreases expression 12102619
D010622 Phencyclidine Phencyclidine results in increased expression of PTGDS mRNAincreases expression 17266109
C025299 polyphenols polyphenols results in decreased expression of PTGDS mRNAdecreases expression 16293270
D020849 Raloxifene [Raloxifene co-treated with IL1B protein] results in increased expression of PTGDS mRNAaffects cotreatment|increases expression 12072388
D012643 Selenium Selenium results in increased expression of PTGDS mRNAincreases expression 19244175
D013629 Tamoxifen Tamoxifen affects the expression of PTGDS mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of PTGDS mRNAdecreases expression 17884332
D013752 Tetracycline Tetracycline results in increased expression of PTGDS mRNAincreases expression 16917069
D014212 Tretinoin Tretinoin results in decreased expression of PTGDS mRNAdecreases expression 18230668
D014212 Tretinoin Tretinoin binds to PTGDS proteinaffects binding 16461020
D014241 Trichloroethylene Trichloroethylene results in decreased expression of PTGDS mRNAdecreases expression 17905399
C025643 vinclozolin vinclozolin affects the expression of PTGDS mRNAaffects expression 19015723
D014801 Vitamin A Vitamin A binds to PTGDS proteinaffects binding 16461020
D014810 Vitamin E Vitamin E results in increased expression of PTGDS mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.2614745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.5711752688 14514962 15322242
MESH:D000015 Abnormalities, Multiple Vitamin A 4.6110992263
MESH:D000138 Acidosis Ammonium Chloride 3.2818287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.6617505938
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 3.9320127859 20464547
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 3.9314692618
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 14.653712494
MESH:D000236 Adenoma Benzo(a)pyrene 14.656695378
MESH:D000236 Adenoma beta-Naphthoflavone 14.6519389873
MESH:D000236 Adenoma Diethylnitrosamine 14.656695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 9.1218056438 16434500 17620307 17162532 19061943 19052882
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.1216835633
MESH:D000380 Agranulocytosis Clozapine 4.7814617031 16160616 12649775
MESH:D000419 Albuminuria Raloxifene 4.3317451421 17308373
MESH:D000505 Alopecia Tretinoin 3.4015955085
MESH:D000544 Alzheimer Disease Raloxifene 2.4815800139
MESH:D000740 Anemia Tetrachlorodibenzodioxin 8.1811748828
MESH:D000740 Anemia Vitamin A 8.1816960172
MESH:D018798 Anemia, Iron-Deficiency Vitamin A 4.5616960172
MESH:D001008 Anxiety Disorders Fluoxetine 8.6318083778
MESH:D001008 Anxiety Disorders vinclozolin 8.6319015723
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.8019183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.1911256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 6.6415885639
MESH:D001169 Arthritis, Experimental Tretinoin 6.6416412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2016292516
MESH:D001249 Asthma Mustard Gas 7.5310378619
MESH:D001249 Asthma Tretinoin 7.5316456186
MESH:D001249 Asthma Vitamin A 7.5316732791
MESH:D001321 Autistic Disorder Fluoxetine 3.3918775368 19232924
MESH:D001471 Barrett Esophagus Tretinoin 4.1416935849
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.731440618 11289319
MESH:D001768 Blister Mustard Gas 4.8819167455
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.1112125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 8.1116206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.5115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.5915746008
MESH:D001930 Brain Injuries Raloxifene 4.2016580743
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 3.5820146248 17474063
MESH:D001943 Breast Neoplasms Diethylnitrosamine 3.5817474063
MESH:D001943 Breast Neoplasms Raloxifene 3.5815572757 15775269 17893378 17049068 17242785 17440819 17595753 17261762 15758505 17952589 16912660 16837676
MESH:D001943 Breast Neoplasms Tamoxifen 3.5815565566 20859285 19011961 18984771 11161223 16202921 18351453 19066611 19487384 19142967 16873071 20390343 19115204 19103187 18815881 19288272 17893378 16818667 18855134 20005174 19410462 18821012 21138602 19244106 17440819 21152245 15668708 19200415 17049068 18425577 19189212 17261762 20135344 18997820 19189210 18629630 20544844 16273361 19155303 19059307 19221464 19289846 19084267 20065188 17242785
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 3.5820435547
MESH:D001943 Breast Neoplasms Tretinoin 3.5816443354 16873071 16166294
MESH:D001943 Breast Neoplasms Trichloroethylene 3.5815986119
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 4.8815286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 4.6917687719 10378619
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 12.0916813970
MESH:D001997 Bronchopulmonary Dysplasia Vitamin A 12.0917377406 17426644
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 9.0216192424 3786805 15721981 16124888 15673190 16011737 16227642 16097048 15700767 10355542 16050911 18705752
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 9.0216050911
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.5816835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.2319066611
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.8716168501
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 8.357296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 8.3518788625
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 8.3520512989 19539802 19919837 19208518 16830150 16807293 19418558 3084413 18494052 19052882 20007298 16502159 16698587 20214788 16779866 18210153 17055752 19519916 19107877 19171122 10737359 17978847 21159647 20524982 20101231 17761372 16878318 18785209 16681979 16935385 19383236 19701751 16540662 11831363 20514400 16288022 18056438 20727157 20935162 16328049 17428255 18506893 20432363 19394651 3581430 17138121 19335982 17173139 18788625 20084675 18691550 18393292 18971187 16569478 18665156 19822196 18978308 17162532 10672840
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 8.3516924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 8.351917145
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.547296757
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.2820419170
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 4.2816096774 16051514
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 8.7017572228
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 8.7017572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2118850075 18670907 16120746
MESH:D002318 Cardiovascular Diseases Raloxifene 3.2615775269
MESH:D002386 Cataract Tretinoin 2.9317460283
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 6.067505956
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 6.0617174075 21159647 2727394 7505956
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.3116129372
MESH:D015362 Child Nutrition Disorders Vitamin A 5.1916153327
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 8.5519052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.5516835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 12.3919486331 9022650
MESH:D002779 Cholestasis Ethinyl Estradiol 12.3917681005 17110522 16105132 11677210 16919318 15861022 17333356
MESH:D002779 Cholestasis Vitamin A 12.3916175620
MESH:D002822 Choriocarcinoma Tretinoin 4.8716461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 9.2215340226 16354765 12621046 8697196 15668235
MESH:D002972 Cleft Palate Tretinoin 9.229407595
MESH:D002972 Cleft Palate Vitamin A 9.2216054864
MESH:D003072 Cognition Disorders Clozapine 10.7717123785
MESH:D003072 Cognition Disorders Raloxifene 10.7715800139
MESH:D003092 Colitis Selenium 8.5917936198
MESH:D003092 Colitis Tretinoin 8.5917035595
MESH:D003110 Colonic Neoplasms polyphenols 4.1116293270
MESH:D003110 Colonic Neoplasms Vitamin A 4.1116267017 17219422
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.8317141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 5.1715322242 10048152 20055451
MESH:D019465 Craniofacial Abnormalities Tretinoin 5.179224671 17551590 14991402 10589399 9142499 16925845 9211117 9664655 9125849 8800419
MESH:D019465 Craniofacial Abnormalities Vitamin A 5.1710992263
MESH:D019465 Craniofacial Abnormalities Vitamin E 5.1719769572
MESH:D003456 Cryptorchidism vinclozolin 4.0714966744
MESH:D003711 Demyelinating Diseases Tamoxifen 4.0919031437
MESH:D003866 Depressive Disorder Fluoxetine 4.4115014590
MESH:D003865 Depressive Disorder, Major Raloxifene 3.9317474826
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.5414531868 11298694 2524372 8156756 11906362 8970840 12868966 18759878
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.233621924 2952479
MESH:D003922 Diabetes Mellitus, Type 1 Vitamin A 3.4216506275
MESH:D003924 Diabetes Mellitus, Type 2 Clozapine 6.7416402076
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 6.7420387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 6.7417107852
MESH:D003928 Diabetic Nephropathies Raloxifene 8.2617308373 15920148 17451421
MESH:D003928 Diabetic Nephropathies Tamoxifen 8.2619279558
MESH:D006970 Disorders of Excessive Somnolence Clozapine 5.2715331141
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 20.716679447 18648102 7440962 8291058 9022650 18289764 1440618 18692083 11289319 6482804 9328219 16192314 9653073
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 20.713786805 7440962 15027814 17522070 7120509 11566570 3732212 4309450 6884620 19336974 21278145 10915739 2869522 19085960 15998439 9327722 10092053 15968718 7179309 16227642 6623471 16177239
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 20.7119107877
MESH:D056486 Drug-Induced Liver Injury polyphenols 20.7119370779
MESH:D056486 Drug-Induced Liver Injury Selenium 20.7115131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 20.7120420201
MESH:D056486 Drug-Induced Liver Injury Tetracycline 20.7117522070
MESH:D056486 Drug-Induced Liver Injury Trichloroethylene 20.717120509
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.5611462148
MESH:D015352 Dry Eye Syndromes Vitamin A 5.5216146918
MESH:D050171 Dyslipidemias Clozapine 3.9916402076
MESH:C538011 Eales disease Vitamin A 12.189068938
MESH:C538011 Eales disease Vitamin E 12.189068938
MESH:D004480 Ectromelia Vitamin A 5.5416054864
MESH:D004487 Edema Fluoxetine 14.5012798668
MESH:D004487 Edema Mustard Gas 14.5011428631 9260866 11402378 11428647
MESH:D004487 Edema Raloxifene 14.5015860553
MESH:D004487 Edema Tetrachlorodibenzodioxin 14.5011000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 11.0018230668 15322242 16714409
MESH:D004489 Edema, Cardiac Tretinoin 11.0018230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 13.8112538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 13.8115845917
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 13.8119031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 6.8420544844 19155303 16202921 17893378
MESH:D016889 Endometrial Neoplasms Tretinoin 6.8416569247
MESH:D004715 Endometriosis Mifepristone 8.3516134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 8.359294722 10568697
MESH:D004890 Erythema Mustard Gas 4.889357497
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.8316302075
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.113581430
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.1116530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.1511564622
MESH:D005124 Eye Abnormalities Tretinoin 8.159664655 16938888
MESH:D005234 Fatty Liver Carbon Tetrachloride 27.4719224547 16239168 61145 15959796 16045604 12631006 17595544 12795759
MESH:D005234 Fatty Liver Diethylnitrosamine 27.4721071580 20387270
MESH:D005234 Fatty Liver Ethinyl Estradiol 27.4715345470
MESH:D005234 Fatty Liver Raloxifene 27.4717473493
MESH:D005234 Fatty Liver Tamoxifen 27.4719224547 14986274
MESH:D005234 Fatty Liver Tetracycline 27.4719224547 16917069
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.0716709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.1811858732
MESH:D005327 Fetal Resorption Vitamin A 5.0816054864
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.736705139
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.2514745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 3.9019069698
MESH:D005355 Fibrosis Carbon Tetrachloride 13.1718705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 13.1720067830
MESH:D005355 Fibrosis Tretinoin 13.1717994277
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.6516973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.0216417039
MESH:D005909 Glioblastoma Tretinoin 2.8317312396
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.787505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.3110696789
MESH:D006261 Headache Nitroglycerin 4.9111284996 11554966
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.0016096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.8716084493
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 19.4820471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 19.4811294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 19.4814991402 9664655
MESH:D006330 Heart Defects, Congenital Vitamin A 19.4816080930 10992263
MESH:D006330 Heart Defects, Congenital Vitamin E 19.4816080930
MESH:D006331 Heart Diseases Raloxifene 3.3511110106
MESH:D006333 Heart Failure Selenium 2.9117162251
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.0911000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 8.346705139
MESH:D006505 Hepatitis Carbon Tetrachloride 8.3419900420 19110552
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.6212621046 15340226 16120746
MESH:D006548 Hernia, Diaphragmatic Vitamin A 5.8417436238 16490937 16292552 15707848 16877224 16863852
MESH:D006548 Hernia, Diaphragmatic Vitamin E 5.8416490937 16863852
MESH:D015658 HIV Infections Vitamin A 3.6816960176
MESH:D006679 HIV Seropositivity Vitamin A 5.3217209195
MESH:D019584 Hot Flashes Fluoxetine 9.6814716179
MESH:D019584 Hot Flashes Vitamin E 9.6814716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.7618606429 15340226 16959395 8697196 16354765
MESH:D006930 Hyperalgesia Tretinoin 3.0016870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.2516899240
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.2916778211
MESH:D006948 Hyperkinesis Clozapine 4.6316046005
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.6715034207
MESH:D006973 Hypertension Raloxifene 4.8717577099 15787275
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.8718850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.8115338365
MESH:D006986 Hypervitaminosis A Vitamin A 5.8816054864
MESH:D007021 Hypospadias Ethinyl Estradiol 3.5416945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.2012013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.0517937319
MESH:D007248 Infertility, Male vinclozolin 6.0516467254
MESH:D007249 Inflammation Diethylnitrosamine 18.0818785209
MESH:D007249 Inflammation Fluoxetine 18.0812798668
MESH:D007249 Inflammation Mustard Gas 18.0817524151 11402378 11428631 16001271 8975870 11428647 9357497 11428620 9260866
MESH:D007249 Inflammation polyphenols 18.0816366677
MESH:D007249 Inflammation Tamoxifen 18.0819457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 18.0812200463 12878042
MESH:D007251 Influenza, Human Selenium 10.0116624496
MESH:D007251 Influenza, Human Vitamin E 10.0116624496
MESH:D007410 Intestinal Diseases Tretinoin 3.4917994277
MESH:D019586 Intracranial Hypertension Vitamin A 5.5415955940
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.738074119 9022650
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.1016580747
MESH:D007569 Jaw Abnormalities Tretinoin 9.1017551590 15992940
MESH:D007674 Kidney Diseases Vitamin E 2.6512488133
MESH:D007676 Kidney Failure, Chronic Selenium 3.6416518626
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 6.646582329
MESH:D007680 Kidney Neoplasms Tamoxifen 6.6418625569
MESH:D007889 Leiomyoma Raloxifene 4.2416973256
MESH:D007938 Leukemia Tretinoin 2.6317143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.4516482212 19285840 16932348
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.0316294345 17596541 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 2.9717301526 17712046 16935935 17506722 19642359 12679006 19035177 17217047 9834237 17107899 17294898 17368321 19225113 16140955 16823087 15748426 16891316 16766008 17361223 17339181 17649720 16331271 16788101 19029980 19075265
MESH:D007984 Leydig Cell Tumor vinclozolin 4.4516417039
MESH:D017880 Limb Deformities, Congenital Tretinoin 7.849224671
MESH:D017880 Limb Deformities, Congenital Vitamin A 7.8416054864
MESH:D008064 Lipidoses Clozapine 12.2417567588
MESH:D008064 Lipidoses Fluoxetine 12.2415342952 17567588
MESH:D008064 Lipidoses Tamoxifen 12.2417567588 15342952
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 10.2616943688 17157831 17334410 16239168 21278145 11903743 11408273 16221502 17174718
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 10.2618665156 18522880 19638242 20032147 18407596
MESH:D008103 Liver Cirrhosis Vitamin A 10.2616256175
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.0215034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 8.2514724832 14512876 17805973 18054572 12632512 17565644 16192424 12389079 20821823 17761835 17631135 12649538 18418968 12445418 15673190 17922224 18210741 17869086 17900296 17976157 12632514 17708605 14716833 17823541 15650968 16015684 12667390 15959796 15876570 18376398 15893842 16011737 18395914 16638106 15996030 15052691 15730626 18472094 12958196 18472332 12546737 14748882 10355542 18263696 12741479 15370692 15338365 17714472 13678700 17698563 18205269 18006644 18279442 15925388 18156304 15818738 11481614 18317297 16027843 14620537 17525996 16116963 12609069 15931870 18395095 18251166 17557913 17481882 16097048 16136751 18481824 18277467 15362042 12666154 18166357 14716496 18420326 18339082 18187930 12586293 16033810 17766677 18412020 15057751 18705752 15123356 12898905 18429990 17944888 17640975 12445421 17721639 16248980
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 8.2518564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 8.2512878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 8.2518397230 16248980
MESH:D008106 Liver Cirrhosis, Experimental Vitamin A 8.2516248980
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 8.2516169303
MESH:D008107 Liver Diseases Carbon Tetrachloride 8.8315720792 16246199 15830285 17285989 16964402
MESH:D008107 Liver Diseases Diethylnitrosamine 8.8317034775
MESH:D008107 Liver Diseases polyphenols 8.8316698588
MESH:D008107 Liver Diseases Vitamin A 8.8316175620
MESH:D008108 Liver Diseases, Alcoholic Vitamin A 4.8816762690
MESH:D017093 Liver Failure Carbon Tetrachloride 3.8915123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.4514706259 16899240
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 16.5621137059 20195826
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 16.5619389873 21295105
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 16.5619294768
MESH:D008113 Liver Neoplasms Diethylnitrosamine 16.5619850985 18644402 19073162 10737359 19551842 20405173 20583210 18754104 19255062 20101389 20434301 19426721 19256749 15175105 19996281 19294768 20118626 21278145 19090486 20492335 15885732 12771043 16942905 19690152 19427195 20452335 19833225 18977376 20501860 18648771 21047994 19254457 9163691 12112319 2422723 19812893 21071580 20137499 21167192 19499222 19642983 19638242 2862719 18978307
MESH:D008113 Liver Neoplasms Tamoxifen 16.5616684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 16.5616984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 25.621399818 598648 3712494 6587162
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 25.6218164116
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 25.6212014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 25.6218093689 18253720 16267830 17942915 18282651 18164116 2563599 18544905 19004024 18079962 17854601 18775883 19519916 19539802 3124819 17174075 21159647 18308698 19009564 9362446 19126423 16842330
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 25.6212151625
MESH:D008114 Liver Neoplasms, Experimental Trichloroethylene 25.627955063
MESH:D008114 Liver Neoplasms, Experimental Vitamin A 25.6217113696
MESH:D008171 Lung Diseases Mustard Gas 11.4218161513 18702808
MESH:D008171 Lung Diseases Vitamin A 11.4216863852
MESH:D008171 Lung Diseases Vitamin E 11.4216863852
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 8.0620869020 20135361 20064080 20464547 18520028 6695378 17053015 18816296 18569708
MESH:D008175 Lung Neoplasms Diethylnitrosamine 8.0621163286 20970405 6695378 20512841
MESH:D008175 Lung Neoplasms Mustard Gas 8.068781369 3148597
MESH:D008175 Lung Neoplasms Tamoxifen 8.0618625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 8.0619555203 11884234
MESH:D008175 Lung Neoplasms Vitamin E 8.0611062179
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.4819428831
MESH:D008325 Mammary Neoplasms, Experimental Corticosterone 9.0712807724
MESH:D008325 Mammary Neoplasms, Experimental Selenium 9.0715318939
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 9.0711731420 16827153 14580682 19196722 19196723
MESH:D020149 Manganese Poisoning Tamoxifen 4.2619453300
MESH:D008527 Medulloblastoma Tretinoin 2.6717453147
MESH:D008545 Melanoma Tamoxifen 3.1212393984 19393235
MESH:D008545 Melanoma Tretinoin 3.1216752155
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.9015990972
MESH:D008591 Meningomyelocele Tretinoin 4.1516940565
MESH:D001523 Mental Disorders Clozapine 7.6716856516
MESH:D001523 Mental Disorders Fluoxetine 7.6716856516
MESH:D008654 Mesothelioma Selenium 2.6815107826
MESH:D024821 Metabolic Syndrome X Clozapine 4.1819142101
MESH:D008708 Methemoglobinemia Nitroglycerin 4.483537620
MESH:D020326 Migraine without Aura Nitroglycerin 4.8614659530
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.2715863610
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 2.9816381670
MESH:D009101 Multiple Myeloma Raloxifene 7.1116497877
MESH:D009101 Multiple Myeloma Vitamin A 7.1116374440
MESH:D009190 Myelodysplastic Syndromes Tretinoin 2.9217596541
MESH:D009203 Myocardial Infarction Nitroglycerin 3.6714729435
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.8012213967
MESH:D009207 Myoclonus Fluoxetine 5.608041377
MESH:D009232 Myxoma Raloxifene 5.2716343187
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 8.803581430
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 8.803581430 9029167
MESH:D009362 Neoplasm Metastasis Tamoxifen 8.8019393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4219410462
MESH:D009369 Neoplasms Benzo(a)pyrene 7.6011141357
MESH:D009369 Neoplasms Tretinoin 7.6016946489 16594593
MESH:D009369 Neoplasms Trichloroethylene 7.6011911487
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.7219189210 19196722 19200415
MESH:D009395 Nephritis, Interstitial Tetracycline 4.509884423
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 8.6314600291
MESH:D009421 Nervous System Malformations Tretinoin 8.639125849
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 11.206679447
MESH:D009436 Neural Tube Defects Tretinoin 11.209142499
MESH:D009436 Neural Tube Defects Vitamin A 11.2017400914
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.1220387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.8320387270
MESH:D009503 Neutropenia Mustard Gas 3.7116761898 7688884
MESH:D009765 Obesity Clozapine 2.9519142110 18515891
MESH:D009771 Obsessive-Compulsive Disorder Fluoxetine 5.1920418887
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.186482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.733988306
MESH:D010024 Osteoporosis Raloxifene 3.2215775268 17882678 19059307
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 3.9717893378 15579764 17823083 15758505
MESH:D010051 Ovarian Neoplasms Mifepristone 4.8416525653
MESH:D010051 Ovarian Neoplasms Tretinoin 4.8416936753
MESH:D010146 Pain Fluoxetine 6.5712798668
MESH:D010146 Pain Tretinoin 6.5716870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 4.9116540662
MESH:D010190 Pancreatic Neoplasms Tretinoin 4.9115976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.4311578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.217296757
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.9612520081
MESH:D010391 Pemphigoid, Bullous Tetracycline 5.1511026799
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.196228378
MESH:D020774 Pick Disease of the Brain Fluoxetine 5.738041377
MESH:D010954 Plasmacytoma Selenium 4.6015087411
MESH:D011041 Poisoning Mustard Gas 3.5415727166
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.2918163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.322563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 8.5611399792 11896295 11222880 11118676
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 8.5618042343 19015723 18220299
MESH:D017096 Prion Diseases Tetracycline 5.1310903871
MESH:D011469 Prostatic Diseases vinclozolin 4.6518220299
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.1317292933
MESH:D011471 Prostatic Neoplasms Raloxifene 2.1315731164 16220300 16536755
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.1315067354
MESH:D011471 Prostatic Neoplasms Vitamin E 2.1315084515
MESH:D011472 Prostatitis vinclozolin 4.6518629315
MESH:D011507 Proteinuria Tretinoin 3.3516636307
MESH:D011537 Pruritus Ethinyl Estradiol 8.5915861022 16919318
MESH:D011537 Pruritus Mustard Gas 8.5918058305
MESH:D011618 Psychotic Disorders Clozapine 3.9915331141
MESH:D011625 Pterygium Tretinoin 4.5116723453
MESH:D011658 Pulmonary Fibrosis Mustard Gas 2.8217266442 10334151 17720292 17894541 17620002
MESH:D011693 Purpura Raloxifene 5.2715770314
MESH:D012127 Respiratory Distress Syndrome, Newborn Vitamin A 5.5216877224
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.5718990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.173692021
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.8416116481 16283617
MESH:D012559 Schizophrenia Clozapine 2.7019369910 20168265 11151749 20452607 16141801 18855531 17123785 17667964 20521320 20580759 18806925 17726453 20521326 11763009 20107430
MESH:D020230 Serotonin Syndrome Fluoxetine 5.618704074
MESH:D012871 Skin Diseases Mustard Gas 7.6415451306 12880345 16961503
MESH:D012871 Skin Diseases Vitamin A 7.6418709164
MESH:D012871 Skin Diseases Vitamin E 7.6418709164
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 8.6119755658 10029692
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 8.6116192470
MESH:D012878 Skin Neoplasms Tretinoin 8.6116467112
MESH:D013088 Spermatocele Ethinyl Estradiol 10.6116709447
MESH:D013088 Spermatocele Tamoxifen 10.6116709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.7619457130
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 3.1720155912 2093021
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 3.1718456281
MESH:D013274 Stomach Neoplasms Tretinoin 3.1717261132
MESH:D020521 Stroke Raloxifene 7.9916837676
MESH:D020521 Stroke Vitamin E 7.9916517955
MESH:D013705 Temporomandibular Joint Disorders polyphenols 4.9717997062
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.3611994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.9215669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.6212697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 10.741399818 6587162 7505956 6582329 3712494
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 10.747505956
MESH:D013964 Thyroid Neoplasms Tretinoin 10.7416026305 17045167
MESH:D013978 Tibial Fractures Raloxifene 4.9219048282
MESH:D014062 Tongue Neoplasms Tretinoin 3.5516051514
MESH:D014376 Tuberculosis Tretinoin 3.0616040207
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 11.008074119
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 11.0017053015
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 11.0017572228
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 11.0016712894 17572228 8653321
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.4416129372
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.0314692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.3316752155
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.3112125929
MESH:D054556 Venous Thromboembolism Raloxifene 4.9216837676
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.2915869587 14671159
MESH:D014802 Vitamin A Deficiency Vitamin A 5.0216175781 16960172 16146918
MESH:D014820 Vitiligo Tretinoin 3.7916761959
MESH:D014846 Vulvar Neoplasms Raloxifene 5.2716343187
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.9615886252
MESH:D015430 Weight Gain Clozapine 4.2320521320 16141801 20564506 17502770 16402076 20107430
MESH:D015431 Weight Loss Clozapine 4.8017933447
MESH:D009396 Wilms Tumor Tretinoin 3.7316287080
Pathway ID Pathway Name
KEGG:00590 Arachidonic acid metabolism
KEGG:01100 Metabolic pathways
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA33945
    • Releated gene ID Related gene Name
    PA33945PTGDS
    No data
    Releated drug ID Related drug Name
    PA448871celecoxib
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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