AutismKB 2.0

Annotation Detail for PTGER1


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Basic Information Top
Gene Symbol:PTGER1 ( EP1 )
Gene Full Name: prostaglandin E receptor 1 (subtype EP1), 42kDa
Band: 19p13.1
Quick LinksEntrez ID:5731; OMIM: 176802; Uniprot ID:PE2R1_HUMAN; ENSEMBL ID: ENSG00000160951; HGNC ID: 9593
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04080Neuroactive ligand-receptor interaction
hsa04020Calcium signaling pathway
Pathway IDPathway Name
Signaling by GPCR
No data
Pathway IDPathway Name
P00048PI3 kinase pathway
Pathway IDPathway Name
500420Prostanoid ligand receptors
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C092396 17-phenyltrinorprostaglandin E2 17-phenyltrinorprostaglandin E2 binds to and results in increased activity of PTGER1 proteinaffects binding|increases activity 11809688
C092396 17-phenyltrinorprostaglandin E2 17-phenyltrinorprostaglandin E2 inhibits the reaction [PTGER1 protein results in increased abundance of Calcium]decreases reaction|increases abundance 11809688
C092396 17-phenyltrinorprostaglandin E2 17-phenyltrinorprostaglandin E2 binds to and results in increased activity of PTGER1 proteinaffects binding|increases activity 10525081
11595431
C053876 6-isopropoxy-9-oxoxanthene-2-carboxylic acid 6-isopropoxy-9-oxoxanthene-2-carboxylic acid binds to and results in decreased activity of PTGER1 proteinaffects binding|decreases activity 11882577
D000643 Ammonium Chloride Ammonium Chloride affects the expression of PTGER1 mRNAaffects expression 16483693
D002118 Calcium 17-phenyltrinorprostaglandin E2 inhibits the reaction [PTGER1 protein results in increased abundance of Calcium]decreases reaction|increases abundance 11809688
D002118 Calcium PTGER1 protein results in increased abundance of Calciumincreases abundance 11809688
D002251 Carbon Tetrachloride Carbon Tetrachloride results in decreased expression of PTGER1 mRNAdecreases expression 16644059
D003993 Dibutyl Phthalate Dibutyl Phthalate results in decreased expression of PTGER1 mRNAdecreases expression 15620428
D015064 16,16-Dimethylprostaglandin E2 16,16-Dimethylprostaglandin E2 binds to and results in increased activity of PTGER1 proteinaffects binding|increases activity 11595431
D015064 16,16-Dimethylprostaglandin E2 PTGER1 gene mutant form affects the susceptibility to 16,16-Dimethylprostaglandin E2affects response to substance 11595431
D005620 Freund's Adjuvant [Urethane co-treated with Freund's Adjuvant] results in increased expression of PTGER1 mRNAaffects cotreatment|increases expression 12400877
D006845 Hydrocarbons, Fluorinated Hydrocarbons, Fluorinated analog binds to and results in decreased activity of PTGER1 proteinaffects binding|decreases activity 18287210
C009042 pristane pristane results in increased expression of PTGER1 mRNAincreases expression 15075356
C016767 sulprostone sulprostone binds to and results in increased activity of PTGER1 proteinaffects binding|increases activity 11882577
D014520 Urethane IFNG protein promotes the reaction [Urethane results in increased expression of PTGER1 mRNA]increases expression|increases reaction 12810352
D014520 Urethane [Urethane co-treated with Freund's Adjuvant] results in increased expression of PTGER1 mRNAaffects cotreatment|increases expression 12400877
D014520 Urethane Urethane results in increased expression of PTGER1 mRNAincreases expression 12810352
C017963 vinyl carbamate vinyl carbamate results in decreased expression of PTGER1 mRNAdecreases expression 17849452
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.6818287403
MESH:D000230 Adenocarcinoma Urethane 5.5018316556
MESH:D000230 Adenocarcinoma vinyl carbamate 5.5017363558 16247444
MESH:D002282 Adenocarcinoma, Bronchiolo-Alveolar Urethane 5.8415814487
MESH:D000236 Adenoma Urethane 4.046695378 17093202 10822126 17195641 11497255 16926031 10530776
MESH:D018248 Adenoma, Liver Cell vinyl carbamate 5.7312371669
MESH:D001862 Bone Resorption Freund's Adjuvant 5.2116769263
MESH:D002252 Carbon Tetrachloride Poisoning 16,16-Dimethylprostaglandin E2 11.063786805
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 11.063786805 16192424 10355542 16227642 16124888 15673190 16097048 16050911 16011737 15721981 18705752 15700767
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 3.6818788625
MESH:D006528 Carcinoma, Hepatocellular vinyl carbamate 3.6812371669
MESH:D002289 Carcinoma, Non-Small-Cell Lung vinyl carbamate 4.2016247446
MESH:D002972 Cleft Palate Urethane 3.8012810352
MESH:D003456 Cryptorchidism Dibutyl Phthalate 5.5416037377
MESH:D056486 Drug-Induced Liver Injury 16,16-Dimethylprostaglandin E2 4.813786805
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 4.813786805 9327722 15998439 4309450 10915739 19336974 15027814 17522070 7120509 16177239 6623471 21278145 7179309 15968718 6884620 2869522 3732212 7440962 10092053 19085960 16227642 11566570
MESH:D004381 Duodenal Ulcer 16,16-Dimethylprostaglandin E2 5.8711595431 16699067 10671773 11991626
MESH:D005234 Fatty Liver Carbon Tetrachloride 3.2516045604 12795759 19224547 12631006 17595544 16239168 61145 15959796
MESH:D005355 Fibrosis Carbon Tetrachloride 3.5618705752
MESH:D006331 Heart Diseases Urethane 4.2916046796
MESH:D006505 Hepatitis Carbon Tetrachloride 3.6919900420 19110552
MESH:D006930 Hyperalgesia Freund's Adjuvant 4.7416769263
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.6516899240
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.1915338365
MESH:D007249 Inflammation Freund's Adjuvant 3.9216793879
MESH:D007683 Kidney Tubular Necrosis, Acute Calcium 5.1816316344
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.8516943688 17334410 16239168 11408273 16221502 21278145 17157831 17174718 11903743
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 1.7512667390 12609069 17976157 12389079 18187930 17823541 18339082 18420326 15362042 17714472 12586293 15818738 18412020 18395095 16011737 15370692 11481614 14512876 18279442 15925388 16027843 17481882 18317297 14716496 18395914 18166357 20821823 16015684 15673190 18705752 15730626 12666154 12741479 18277467 15893842 15931870 18210741 14620537 15996030 12445418 15876570 17922224 18205269 14716833 12632514 18472332 13678700 17900296 18418968 16097048 15338365 16638106 16116963 18006644 17721639 18054572 15052691 17698563 14724832 12649538 15650968 17708605 17565644 17761835 17557913 16136751 12546737 14748882 17525996 18481824 18156304 16033810 17631135 18251166 16192424 18376398 12632512 17869086 12898905 18472094 18263696 17944888 17640975 15057751 12958196 16248980 18429990 15123356 10355542 15959796 12445421 17805973 17766677
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.1017285989 16964402 16246199 15830285 15720792
MESH:D017093 Liver Failure Carbon Tetrachloride 4.2715123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.7714706259 16899240
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 5.1019294768
MESH:D008113 Liver Neoplasms Urethane 5.1017093202 17559639 16391232
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 2.6615583823 12014681
MESH:D008175 Lung Neoplasms Urethane 3.5212765245 11246140 16289808 16391232 11074608 15166089 11893704 16007126 11307925 15902970 11544531 11497255 12466968 15136453 14587096 11062179 11807781 16788158 11552296 10530776 16926031 7750092 11992545 16337739 10997738 10779650 16204055 17195641 11323394 12117781 17255336 17093202 12957351 6695378 10822126
MESH:D008175 Lung Neoplasms vinyl carbamate 3.5212117777 11195469 17163412 12438228 17361011 15172992 11134547 15824018 16247444 12765245 17363558 16885199 14755239
MESH:D009369 Neoplasms Urethane 3.5415625555
MESH:D009374 Neoplasms, Experimental Urethane 4.7815582191
MESH:D009422 Nervous System Diseases Hydrocarbons, Fluorinated 6.8712122564
MESH:D010024 Osteoporosis Calcium 3.8317882678
MESH:D010051 Ovarian Neoplasms Urethane 3.4716391232
MESH:D010911 Pituitary Neoplasms Urethane 5.5216391232
MESH:D010954 Plasmacytoma pristane 7.4315087411
MESH:D012878 Skin Neoplasms Urethane 3.7411807781
MESH:D013276 Stomach Ulcer 16,16-Dimethylprostaglandin E2 9.4211595431
MESH:D013276 Stomach Ulcer 17-phenyltrinorprostaglandin E2 9.4211595431
MESH:D019043 Vascular Neoplasms Urethane 6.0510620525
Pathway ID Pathway Name
KEGG:04020 Calcium signaling pathway
KEGG:04080 Neuroactive ligand-receptor interaction
REACT:14797 Signaling by GPCR
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA286
    • No data
    No data
    Releated drug ID Related drug Name
    PA449345dinoprostone
    PA449479epoprostenol
    PA164712740Epoxides
    PA164743471adenosine triphosphate
    PA448334alprostadil
    PA449470epinephrine
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00297 other/unknown Sensorcaine Forte Anesthetics, Local
    DB00429 agonist Carboprost Tromethamine Oxytocics;Abortifacient Agents, Nonsteroidal
    DB00770 agonist Caverject Sterile Powder - Kit 23.2mcg/Vial Vasodilator Agents;Platelet Aggregation Inhibitors;Fibrinolytic Agents
    DB00905 agonist Bimatoprost Antihypertensive Agents;Antiglaucomic Agents
    DB00917 agonist Dinoprostone Oxytocics;Prostaglandins
    DB01088 agonist Iloprost Antihypertensive Agents
    No data
    No data
    No data

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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