AutismKB 2.0

Annotation Detail for PTGER3


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Basic Information Top
Gene Symbol:PTGER3 ( EP3,EP3-I,EP3-II,EP3-III,EP3-IV,EP3e,MGC141828,MGC141829,MGC27302 )
Gene Full Name: prostaglandin E receptor 3 (subtype EP3)
Band: 1p31.1
Quick LinksEntrez ID:5733; OMIM: 176806; Uniprot ID:PE2R3_HUMAN; ENSEMBL ID: ENSG00000050628; HGNC ID: 9595
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04080Neuroactive ligand-receptor interaction
hsa04020Calcium signaling pathway
Pathway IDPathway Name
Signaling by GPCR
No data
No data
Pathway IDPathway Name
500420Prostanoid ligand receptors
Related Diseases/Disorders Top
No data
No data
Desease Name
asthma asthma, aspirin-intolerant
IMMUNE
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C032405 11-deoxy-16-phenoxy-17,18,19,20-tetranorprostaglandin E1 11-deoxy-16-phenoxy-17,18,19,20-tetranorprostaglandin E1 binds to and results in increased activity of PTGER3 proteinaffects binding|increases activity 10525081
C035207 4-amino-2,6-dinitrotoluene 4-amino-2,6-dinitrotoluene affects the expression of PTGER3 mRNAaffects expression 21346803
D020106 Acrylamide Acrylamide analog binds to and results in decreased activity of PTGER3 proteinaffects binding|decreases activity 18287210
D000643 Ammonium Chloride Ammonium Chloride affects the expression of PTGER3 mRNAaffects expression 16483693
C015001 arsenite arsenite results in decreased expression of PTGER3 mRNAdecreases expression 18929588
C015001 arsenite TRP53 protein affects the reaction [arsenite results in decreased expression of PTGER3 mRNA]affects reaction|decreases expression 18929588
C095105 bexarotene bexarotene results in decreased expression of PTGER3 mRNAdecreases expression 17849452
C006780 bisphenol A bisphenol A results in increased expression of PTGER3 mRNAincreases expression 16474171
D002118 Calcium PTGER3 protein affects the reaction [Dinoprostone results in decreased transport of Calcium]affects reaction|decreases transport 12535167
D002118 Calcium PTGER3 protein affects the reaction [ONO AE 248 results in decreased transport of Calcium]affects reaction|decreases transport 12535167
D015084 2,4-Dichlorophenoxyacetic Acid 2,4-Dichlorophenoxyacetic Acid results in decreased expression of PTGER3 mRNAdecreases expression 15878651
D004041 Dietary Fats Dietary Fats results in decreased expression of PTGER3 mRNAdecreases expression 18042831
D004052 Diethylnitrosamine Diethylnitrosamine results in decreased expression of PTGER3 mRNAdecreases expression 19638242
D015064 16,16-Dimethylprostaglandin E2 16,16-Dimethylprostaglandin E2 binds to and results in increased activity of PTGER3 proteinaffects binding|increases activity 11595431
D015064 16,16-Dimethylprostaglandin E2 PTGER3 gene mutant form affects the susceptibility to 16,16-Dimethylprostaglandin E2affects response to substance 11595431
D004958 Estradiol Estradiol affects the expression of PTGER3 mRNAaffects expression 14699072
D004958 Estradiol Estradiol results in increased expression of PTGER3 mRNAincreases expression 16474171
D019833 Genistein Genistein results in increased expression of PTGER3 mRNAincreases expression 16474171
D007052 Ibuprofen Ibuprofen affects the expression of PTGER3 mRNAaffects expression 17070997
C528911 N-((4-(5,9-diethoxy-6-oxo-6,8-dihydro-7H-pyrrolo(3,4-g)quinolin-7-yl)-3-methylbenzyl)sulfonyl)-2-(2-methoxyphenyl)acetamide N-((4-(5,9-diethoxy-6-oxo-6,8-dihydro-7H-pyrrolo(3,4-g)quinolin-7-yl)-3-methylbenzyl)sulfonyl)-2-(2-methoxyphenyl)acetamide results in decreased expression of PTGER3 mRNAdecreases expression 18287210
C029938 nickel sulfate nickel sulfate results in decreased expression of PTGER3 mRNAdecreases expression 16780908
C121546 ONO AE 248 PTGER3 protein affects the reaction [ONO AE 248 results in decreased transport of Calcium]affects reaction|decreases transport 12535167
C095324 ONO-NT 012 ONO-NT 012 binds to and results in increased activity of PTGER3 proteinaffects binding|increases activity 11595431
C041786 palm oil palm oil results in decreased expression of PTGER3 mRNAdecreases expression 18042831
D010269 Paraquat Paraquat results in decreased expression of PTGER3 mRNAdecreases expression 17077588
D011078 Polychlorinated Biphenyls Polychlorinated Biphenyls analog results in increased expression of PTGER3 mRNAincreases expression 16474171
C009042 pristane pristane results in increased expression of PTGER3 mRNAincreases expression 15075356
D015232 Dinoprostone PTGER3 protein affects the reaction [Dinoprostone results in decreased transport of Calcium]affects reaction|decreases transport 12535167
D020849 Raloxifene [Raloxifene co-treated with ESR2 protein] results in decreased expression of PTGER3 mRNAaffects cotreatment|decreases expression 19059307
C116926 rofecoxib rofecoxib results in decreased expression of PTGER3 mRNAdecreases expression 17070997
C016767 sulprostone sulprostone binds to and results in increased activity of PTGER3 proteinaffects binding|increases activity 10525081
11882577
D013629 Tamoxifen [Tamoxifen co-treated with ESR2 protein] results in decreased expression of PTGER3 mRNAaffects cotreatment|decreases expression 19059307
D014212 Tretinoin Tretinoin results in decreased expression of PTGER3 mRNAdecreases expression 16604517
C017963 vinyl carbamate vinyl carbamate results in increased expression of PTGER3 mRNAincreases expression 17849452
D002762 Cholecalciferol Cholecalciferol results in increased expression of PTGER3 mRNAincreases expression 17170073
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.2514745880
MESH:D000014 Abnormalities, Drug-Induced 4-amino-2,6-dinitrotoluene 3.667525203
MESH:D000138 Acidosis Ammonium Chloride 3.2618287403
MESH:D058186 Acute Kidney Injury Ibuprofen 4.196375363
MESH:D055371 Acute Lung Injury nickel sulfate 4.0411954676 16100012 19131640 12718980
MESH:D000230 Adenocarcinoma Estradiol 9.6611473722
MESH:D000230 Adenocarcinoma Genistein 9.6611473722
MESH:D000230 Adenocarcinoma Ibuprofen 9.6610697514
MESH:D000230 Adenocarcinoma vinyl carbamate 9.6616247444 17363558
MESH:D000236 Adenoma Diethylnitrosamine 2.6810737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 9.8917162532 19052882 18056438 17620307 16434500 19061943
MESH:D018248 Adenoma, Liver Cell vinyl carbamate 9.8912371669
MESH:D011125 Adenomatous Polyposis Coli Dinoprostone 4.7717942926
MESH:D000382 Agricultural Workers' Diseases 2,4-Dichlorophenoxyacetic Acid 8.2716132792
MESH:D000382 Agricultural Workers' Diseases Paraquat 8.2711874814
MESH:D000419 Albuminuria Raloxifene 4.3117451421 17308373
MESH:D000505 Alopecia Tretinoin 3.3815955085
MESH:D000544 Alzheimer Disease Ibuprofen 4.4018351690
MESH:D000544 Alzheimer Disease Raloxifene 4.4015800139
MESH:D000707 Anaphylaxis Ibuprofen 4.969532969
MESH:D001014 Aortic Aneurysm Dinoprostone 5.3310231640
MESH:D017544 Aortic Aneurysm, Abdominal Dinoprostone 5.3410388637
MESH:D001161 Arteriosclerosis Dietary Fats 3.6015238619
MESH:D001169 Arthritis, Experimental N-((4-(5,9-diethoxy-6-oxo-6,8-dihydro-7H-pyrrolo(3,4-g)quinolin-7-yl)-3-methylbenzyl)sulfonyl)-2-(2-methoxyphenyl)acetamide 11.7418287210
MESH:D001169 Arthritis, Experimental rofecoxib 11.7416690336
MESH:D001169 Arthritis, Experimental Tretinoin 11.7416412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.1916292516
MESH:D001249 Asthma Tretinoin 2.2516456186
MESH:D001327 Autoimmune Diseases Cholecalciferol 4.7416142846
MESH:D001471 Barrett Esophagus Tretinoin 4.1216935849
MESH:D001477 Bartter Syndrome Dinoprostone 5.4515976003
MESH:D001778 Blood Coagulation Disorders Tretinoin 3.3516206674 16197459
MESH:D001862 Bone Resorption bisphenol A 3.6011985600
MESH:D001930 Brain Injuries Raloxifene 4.1916580743
MESH:D002545 Brain Ischemia Ibuprofen 4.5915837124
MESH:D001943 Breast Neoplasms Acrylamide 6.6716253758 18183576
MESH:D001943 Breast Neoplasms bexarotene 6.6716344269 16818667
MESH:D001943 Breast Neoplasms bisphenol A 6.6717123778
MESH:D001943 Breast Neoplasms Dietary Fats 6.6720435547
MESH:D001943 Breast Neoplasms Diethylnitrosamine 6.6717474063
MESH:D001943 Breast Neoplasms Estradiol 6.6714630087 19861407 17261762 16675129 17289903 17018787 18497071 12948864
MESH:D001943 Breast Neoplasms Genistein 6.6716541309 17200150 16873071
MESH:D001943 Breast Neoplasms Raloxifene 6.6717049068 15775269 17893378 17595753 15572757 16912660 15758505 16837676 17242785 17261762 17440819 17952589
MESH:D001943 Breast Neoplasms Tamoxifen 6.6718815881 16273361 18984771 19066611 17049068 11161223 19115204 18629630 15565566 19059307 19221464 19084267 21138602 17242785 19103187 19189212 19410462 19011961 21152245 15668708 17440819 19155303 17261762 19142967 19289846 16818667 19487384 16202921 19200415 19244106 18425577 18821012 20859285 18997820 20005174 20065188 17893378 20135344 16873071 18855134 19288272 19189210 20390343 18351453 20544844
MESH:D001943 Breast Neoplasms Tretinoin 6.6716166294 16443354 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.2916813970
MESH:D002100 Cachexia Ibuprofen 5.1715141370
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.1716111702
MESH:D002252 Carbon Tetrachloride Poisoning 16,16-Dimethylprostaglandin E2 5.743786805
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.2219066611
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.8616168501
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 10.7218210153 20935162 16830150 19539802 16935385 16288022 19383236 19418558 3084413 18971187 16698587 18785209 17761372 17978847 16878318 19394651 10672840 3581430 19107877 20084675 20512989 21159647 20101231 18665156 19208518 16807293 19919837 10737359 20727157 19822196 20214788 18978308 16328049 17173139 17162532 11831363 20514400 20432363 16502159 18056438 19052882 19519916 18393292 16779866 17055752 19171122 16569478 20524982 16540662 20007298 18788625 16681979 18494052 18691550 19335982 19701751 17138121 18506893 17428255
MESH:D006528 Carcinoma, Hepatocellular Estradiol 10.7216924424
MESH:D006528 Carcinoma, Hepatocellular Genistein 10.7216924424
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 10.7216924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 10.721917145
MESH:D006528 Carcinoma, Hepatocellular vinyl carbamate 10.7212371669
MESH:D002278 Carcinoma in Situ bisphenol A 4.6917123778
MESH:D002289 Carcinoma, Non-Small-Cell Lung bexarotene 5.9416247446
MESH:D002289 Carcinoma, Non-Small-Cell Lung vinyl carbamate 5.9416247446
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 2.2116096774 16051514
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 8.6517572228
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 8.6517572228
MESH:D002318 Cardiovascular Diseases Genistein 6.8316332659
MESH:D002318 Cardiovascular Diseases Raloxifene 6.8315775269
MESH:D002386 Cataract 4-amino-2,6-dinitrotoluene 7.0414694615
MESH:D002386 Cataract Tretinoin 7.0417460283
MESH:D002418 Cattle Diseases Acrylamide 5.1512510666
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 10.217505956 21159647 2727394 17174075
MESH:D002471 Cell Transformation, Neoplastic Dinoprostone 10.2116192471
MESH:D002471 Cell Transformation, Neoplastic Estradiol 10.2118566989
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.2916129372
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.4419052882
MESH:D002822 Choriocarcinoma Tretinoin 4.8616461808
MESH:D002972 Cleft Palate Tretinoin 2.549407595
MESH:D003072 Cognition Disorders Raloxifene 4.3315800139
MESH:D003092 Colitis Tretinoin 3.4217035595
MESH:D003110 Colonic Neoplasms arsenite 5.7115037631
MESH:D003110 Colonic Neoplasms Genistein 5.7117182828
MESH:D003110 Colonic Neoplasms rofecoxib 5.7112902858
MESH:D015179 Colorectal Neoplasms Polychlorinated Biphenyls 2.7215531428
MESH:D000013 Congenital Abnormalities 4-amino-2,6-dinitrotoluene 3.9115095906
MESH:D019465 Craniofacial Abnormalities Tretinoin 1.8117551590 8800419 14991402 9224671 9664655 16925845 10589399 9211117 9142499 9125849
MESH:D003704 Dementia Polychlorinated Biphenyls 4.4416140633
MESH:D003711 Demyelinating Diseases Tamoxifen 4.0719031437
MESH:D003865 Depressive Disorder, Major Raloxifene 3.9217474826
MESH:D017449 Dermatitis, Allergic Contact nickel sulfate 3.4016823706 11298694 16780908
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.2620387270
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 4.2616647724
MESH:D003928 Diabetic Nephropathies Estradiol 13.6019279558
MESH:D003928 Diabetic Nephropathies Raloxifene 13.6017451421 17308373 15920148
MESH:D003928 Diabetic Nephropathies Tamoxifen 13.6019279558
MESH:D003967 Diarrhea Dinoprostone 4.2811488427 10446763 7237001
MESH:D056486 Drug-Induced Liver Injury 16,16-Dimethylprostaglandin E2 6.103786805
MESH:D056486 Drug-Induced Liver Injury 4-amino-2,6-dinitrotoluene 6.1021346803
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 6.1019107877
MESH:D004374 Ductus Arteriosus, Patent Ibuprofen 5.3218446180 16133044 18450898
MESH:D004381 Duodenal Ulcer 16,16-Dimethylprostaglandin E2 9.9311595431 11991626 10671773 16699067
MESH:D004381 Duodenal Ulcer ONO-NT 012 9.9311991626 11595431
MESH:D050171 Dyslipidemias Dietary Fats 3.2418367378
MESH:D004487 Edema Raloxifene 3.0915860553
MESH:D004489 Edema, Cardiac Tretinoin 4.1718230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 8.3115845917
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 8.3119031437
MESH:D004714 Endometrial Hyperplasia Genistein 4.2916402032
MESH:D016889 Endometrial Neoplasms Estradiol 16.2019148513 18566989 11473722
MESH:D016889 Endometrial Neoplasms Genistein 16.2011473722
MESH:D016889 Endometrial Neoplasms Tamoxifen 16.2017893378 20544844 16202921 19155303
MESH:D016889 Endometrial Neoplasms Tretinoin 16.2016569247
MESH:D004715 Endometriosis Ibuprofen 9.0715652904
MESH:D004715 Endometriosis rofecoxib 9.0715652904
MESH:D019446 Endotoxemia Ibuprofen 4.6711545620
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.8216302075
MESH:D005124 Eye Abnormalities Tretinoin 3.369664655 16938888
MESH:D005234 Fatty Liver arsenite 21.8718296743
MESH:D005234 Fatty Liver Dietary Fats 21.8718296743 17967931 19004024 19551842
MESH:D005234 Fatty Liver Diethylnitrosamine 21.8721071580 20387270
MESH:D005234 Fatty Liver Raloxifene 21.8717473493
MESH:D005234 Fatty Liver Tamoxifen 21.8714986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.0616709447
MESH:D005334 Fever Dinoprostone 9.0011852909 16997862
MESH:D005334 Fever Ibuprofen 9.0016997862
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.2314745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 3.8919069698
MESH:D005355 Fibrosis arsenite 13.2518296743
MESH:D005355 Fibrosis Dietary Fats 13.2518296743
MESH:D005355 Fibrosis Tretinoin 13.2517994277
MESH:D005909 Glioblastoma Genistein 6.5716598420
MESH:D005909 Glioblastoma Tretinoin 6.5717312396
MESH:D005911 Gliosis Paraquat 4.8611124998
MESH:D006258 Head and Neck Neoplasms Tretinoin 2.9916096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.8616084493
MESH:D006330 Heart Defects, Congenital Tretinoin 2.749664655 14991402
MESH:D006331 Heart Diseases Raloxifene 3.3311110106
MESH:D006558 Herpes Genitalis Estradiol 4.7315709030
MESH:D019584 Hot Flashes Estradiol 3.4517088409
MESH:D006930 Hyperalgesia Dinoprostone 7.5316793879
MESH:D006930 Hyperalgesia Tretinoin 7.5316870215
MESH:D006937 Hypercholesterolemia Dietary Fats 3.3321332399
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.2816778211
MESH:D006949 Hyperlipidemias Dietary Fats 3.3421332399
MESH:D006973 Hypertension Raloxifene 2.7615787275 17577099
MESH:D006984 Hypertrophy Ibuprofen 4.7116672835
MESH:D007235 Infant, Premature, Diseases Ibuprofen 5.5416133044
MESH:D007247 Infertility, Female Acrylamide 4.9311020651
MESH:D007248 Infertility, Male 2,4-Dichlorophenoxyacetic Acid 10.5612948887
MESH:D007248 Infertility, Male Acrylamide 10.5612507653 15749267 15355880 11020651
MESH:D007248 Infertility, Male Paraquat 10.564850670
MESH:D007249 Inflammation Dietary Fats 10.7420412841
MESH:D007249 Inflammation Diethylnitrosamine 10.7418785209
MESH:D007249 Inflammation Ibuprofen 10.743291741
MESH:D007249 Inflammation Tamoxifen 10.7419457130
MESH:D007333 Insulin Resistance bisphenol A 11.2716393666
MESH:D007333 Insulin Resistance Dietary Fats 11.2711836018 18457598
MESH:D007333 Insulin Resistance Estradiol 11.2716627594 16393666
MESH:D007410 Intestinal Diseases rofecoxib 9.1815831440
MESH:D007410 Intestinal Diseases Tretinoin 9.1817994277
MESH:D007417 Intestinal Polyps rofecoxib 5.1011245490
MESH:D007569 Jaw Abnormalities Tretinoin 3.6415992940 17551590
MESH:D007674 Kidney Diseases Estradiol 2.4215618244
MESH:D007680 Kidney Neoplasms Estradiol 6.6015610895
MESH:D007680 Kidney Neoplasms Tamoxifen 6.6018625569
MESH:D007683 Kidney Tubular Necrosis, Acute Calcium 4.7516316344
MESH:D007889 Leiomyoma Raloxifene 4.2216973256
MESH:D007938 Leukemia Genistein 5.9218980019 17468513
MESH:D007938 Leukemia Tretinoin 5.9217143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.4416932348 16482212 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.0317596541 16294345 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 2.9612679006 16891316 17506722 9834237 17301526 17107899 17217047 15748426 19029980 17361223 17649720 16766008 19225113 19075265 16823087 17368321 17294898 19642359 16935935 19035177 16140955 16331271 17712046 16788101 17339181
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.109224671
MESH:D008064 Lipidoses Tamoxifen 2.9517567588 15342952
MESH:D008103 Liver Cirrhosis arsenite 10.1518296743
MESH:D008103 Liver Cirrhosis Dietary Fats 10.1518296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 10.1520032147 19638242 18665156 18407596 18522880
MESH:D008106 Liver Cirrhosis, Experimental Dinoprostone 8.2315816358
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 8.2314659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Genistein 8.2317823541
MESH:D008106 Liver Cirrhosis, Experimental rofecoxib 8.2317565644
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 8.2318564211
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 8.2318397230 16248980
MESH:D008107 Liver Diseases Diethylnitrosamine 4.3117034775
MESH:D008107 Liver Diseases Dinoprostone 4.3115816358
MESH:D008113 Liver Neoplasms Diethylnitrosamine 4.2119294768 20137499 19850985 19642983 20452335 16942905 20101389 21278145 18648771 20405173 20583210 19690152 15885732 21047994 19255062 19090486 18977376 20118626 19812893 18978307 18754104 12771043 15175105 19073162 18644402 19551842 20434301 20492335 19254457 10737359 19996281 19426721 2862719 19638242 19499222 2422723 21071580 12112319 19833225 21167192 9163691 20501860 19256749 19427195
MESH:D008113 Liver Neoplasms Tamoxifen 4.2116684651
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 5.7118282651 18164116 18079962 3124819 21159647 17174075 19009564 2563599 19539802 19126423 17854601 9362446 16267830 16842330 18544905 17942915 18775883 19519916 18093689 19004024 18253720 18308698
MESH:D008114 Liver Neoplasms, Experimental Polychlorinated Biphenyls 5.711423854
MESH:D008175 Lung Neoplasms arsenite 6.2216809336
MESH:D008175 Lung Neoplasms bexarotene 6.2217849452
MESH:D008175 Lung Neoplasms Diethylnitrosamine 6.2220970405 6695378 21163286 20512841
MESH:D008175 Lung Neoplasms Tamoxifen 6.2218625569
MESH:D008175 Lung Neoplasms vinyl carbamate 6.2215824018 17163412 17361011 16885199 11134547 11195469 12765245 12117777 17363558 16247444 12438228 14755239 15172992
MESH:D008228 Lymphoma, Non-Hodgkin 2,4-Dichlorophenoxyacetic Acid 4.9116132792
MESH:D016410 Lymphoma, T-Cell, Cutaneous bexarotene 4.8611161223
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.4719428831
MESH:D008325 Mammary Neoplasms, Experimental bexarotene 16.8419196722 15591091 19196723
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 16.8411408345 17203775 16891317 11807958
MESH:D008325 Mammary Neoplasms, Experimental Genistein 16.8414578162 12929590
MESH:D008325 Mammary Neoplasms, Experimental Ibuprofen 16.8410697514
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 16.8419196722 19196723 14580682 11731420 16827153
MESH:D020149 Manganese Poisoning Estradiol 11.6519453300
MESH:D020149 Manganese Poisoning Tamoxifen 11.6519453300
MESH:D008527 Medulloblastoma Tretinoin 2.6717453147
MESH:D008545 Melanoma Tamoxifen 3.1112393984 19393235
MESH:D008545 Melanoma Tretinoin 3.1116752155
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.8915990972
MESH:D008591 Meningomyelocele Tretinoin 4.1416940565
MESH:D020326 Migraine without Aura Dinoprostone 4.9811304026
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.2515863610
MESH:D009101 Multiple Myeloma Raloxifene 3.2316497877
MESH:D009190 Myelodysplastic Syndromes Tretinoin 2.9117596541
MESH:D009203 Myocardial Infarction Genistein 2.7417141266
MESH:D015428 Myocardial Reperfusion Injury Estradiol 7.7716810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 7.7717141266
MESH:D009232 Myxoma Raloxifene 5.2516343187
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.333581430 9029167
MESH:D009362 Neoplasm Metastasis Tamoxifen 5.3319393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4219410462
MESH:D009369 Neoplasms Tretinoin 2.2716946489 16594593
MESH:D009376 Neoplasms, Hormone-Dependent bexarotene 9.9319196722
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 9.9319200415 19196722 19189210
MESH:D009389 Neovascularization, Pathologic arsenite 9.1715738583
MESH:D009389 Neovascularization, Pathologic Estradiol 9.1717289903
MESH:D009395 Nephritis, Interstitial Ibuprofen 4.696375363
MESH:D009410 Nerve Degeneration Acrylamide 13.0311264303 12387366 12387367
MESH:D009410 Nerve Degeneration Ibuprofen 13.0310961664
MESH:D009410 Nerve Degeneration Paraquat 13.0316893418
MESH:D009422 Nervous System Diseases Acrylamide 4.7412164553 12507653
MESH:D009421 Nervous System Malformations bisphenol A 21.1611399458 16427766
MESH:D009421 Nervous System Malformations Estradiol 21.1611399458 16427766
MESH:D009421 Nervous System Malformations Genistein 21.1616427766
MESH:D009421 Nervous System Malformations Tretinoin 21.169125849
MESH:D009436 Neural Tube Defects Tretinoin 2.869142499
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.1020387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.8220387270
MESH:D009765 Obesity Dietary Fats 2.2111836018 20518802 17217161 19632207 21332399 16723640 20132043 18457598 18674790
MESH:D009784 Occupational Diseases 4-amino-2,6-dinitrotoluene 3.8414694615
MESH:D010003 Osteoarthritis Ibuprofen 12.087009135
MESH:D010003 Osteoarthritis N-((4-(5,9-diethoxy-6-oxo-6,8-dihydro-7H-pyrrolo(3,4-g)quinolin-7-yl)-3-methylbenzyl)sulfonyl)-2-(2-methoxyphenyl)acetamide 12.0818287210
MESH:D010003 Osteoarthritis rofecoxib 12.0816690336
MESH:D010005 Osteoarthropathy, Secondary Hypertrophic Dinoprostone 6.1718500342
MESH:D010024 Osteoporosis Calcium 10.9517882678
MESH:D010024 Osteoporosis Genistein 10.9519401787
MESH:D010024 Osteoporosis Raloxifene 10.9517882678 15775268 19059307
MESH:D015663 Osteoporosis, Postmenopausal Genistein 9.2416169203
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 9.2417823083 15758505 17893378 15579764
MESH:D010049 Ovarian Diseases bisphenol A 4.6911985600
MESH:D010051 Ovarian Neoplasms Estradiol 7.3319401270
MESH:D010051 Ovarian Neoplasms Genistein 7.3319005980
MESH:D010051 Ovarian Neoplasms Tretinoin 7.3316936753
MESH:D010146 Pain Ibuprofen 6.373291741
MESH:D010146 Pain Tretinoin 6.3716870215
MESH:D010149 Pain, Postoperative Ibuprofen 10.7416678543
MESH:D010149 Pain, Postoperative rofecoxib 10.7418165598 16678543
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 8.1016540662
MESH:D010190 Pancreatic Neoplasms Ibuprofen 8.1012384795
MESH:D010190 Pancreatic Neoplasms Tretinoin 8.1015976015
MESH:D010300 Parkinson Disease Paraquat 5.3616510128 16140633 15451049 12911755 11445065 11124998 11181820 15824117
MESH:D010300 Parkinson Disease Polychlorinated Biphenyls 5.3616702228
MESH:D010302 Parkinson Disease, Secondary Paraquat 4.1416190885
MESH:D010523 Peripheral Nervous System Diseases Acrylamide 4.8311510240
MESH:D010954 Plasmacytoma pristane 6.9915087411
MESH:D011014 Pneumonia Paraquat 4.1612504350
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.312563599
MESH:D011248 Pregnancy Complications 2,4-Dichlorophenoxyacetic Acid 5.442087686
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 3.6610548101
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 9.6720887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 9.6720887781
MESH:D011471 Prostatic Neoplasms bisphenol A 2.3916740699
MESH:D011471 Prostatic Neoplasms Cholecalciferol 2.3917024972
MESH:D011471 Prostatic Neoplasms Estradiol 2.3916740699
MESH:D011471 Prostatic Neoplasms Genistein 2.3915378649 15256057 16925846
MESH:D011471 Prostatic Neoplasms Ibuprofen 2.3917409433
MESH:D011471 Prostatic Neoplasms Polychlorinated Biphenyls 2.3915721890
MESH:D011471 Prostatic Neoplasms Raloxifene 2.3916220300 16536755 15731164
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.3915067354
MESH:D011507 Proteinuria Ibuprofen 8.606375363
MESH:D011507 Proteinuria Tretinoin 8.6016636307
MESH:D011625 Pterygium Tretinoin 4.5016723453
MESH:D011629 Puberty, Precocious bisphenol A 4.4910548101
MESH:D011658 Pulmonary Fibrosis Paraquat 2.8016324872 17997886
MESH:D011693 Purpura Raloxifene 5.2515770314
MESH:D012128 Respiratory Distress Syndrome, Adult Paraquat 3.6411700416
MESH:D012135 Respiratory Sounds Paraquat 3.7711874814
MESH:D012162 Retinal Degeneration Paraquat 3.6516458197
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.8316116481 16283617
MESH:D012878 Skin Neoplasms Tretinoin 2.4716467112
MESH:D013088 Spermatocele Tamoxifen 3.9916709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.7419457130
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 2.3418456281
MESH:D013274 Stomach Neoplasms Tretinoin 2.3417261132
MESH:D013276 Stomach Ulcer 16,16-Dimethylprostaglandin E2 4.9711595431
MESH:D020521 Stroke Raloxifene 3.5916837676
MESH:D019966 Substance-Related Disorders bisphenol A 3.6916045194 16684133
MESH:D013733 Testicular Diseases Acrylamide 4.9315864552
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 6.447505956
MESH:D013964 Thyroid Neoplasms Tretinoin 6.4416026305 17045167
MESH:D013978 Tibial Fractures Estradiol 12.7119048282
MESH:D013978 Tibial Fractures Raloxifene 12.7119048282
MESH:D014062 Tongue Neoplasms Tretinoin 3.5316051514
MESH:D014376 Tuberculosis Tretinoin 3.0516040207
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 4.8417572228
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 4.848653321 17572228 16712894
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.4216129372
MESH:D014591 Uterine Diseases bisphenol A 4.7114652134
MESH:D014604 Uveal Neoplasms Tretinoin 4.3116752155
MESH:D020301 Vasospasm, Intracranial Ibuprofen 4.8919057314
MESH:D054556 Venous Thromboembolism Raloxifene 4.9116837676
MESH:D014820 Vitiligo Tretinoin 3.7816761959
MESH:D014846 Vulvar Neoplasms Raloxifene 5.2516343187
MESH:D015430 Weight Gain Dietary Fats 3.4916723640
MESH:D009396 Wilms Tumor Tretinoin 3.7216287080
Pathway ID Pathway Name
KEGG:04020 Calcium signaling pathway
KEGG:04080 Neuroactive ligand-receptor interaction
REACT:14797 Signaling by GPCR
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA288
    • No data
    Releated disease ID Related disease Name
    PA443803Cough
    PA444987Multiple Sclerosis
    Releated drug ID Related drug Name
    PA449345dinoprostone
    PA449479epoprostenol
    PA164712740Epoxides
    PA164712308Ace Inhibitors, Plain
    PA450037interferon beta-1a
    PA450039interferon beta-1b
    PA451999interferons
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00905 agonist Bimatoprost Antihypertensive Agents;Antiglaucomic Agents
    DB00917 agonist Dinoprostone Oxytocics;Prostaglandins
    DB00929 agonist Misoprostol Anti-Ulcer Agents;Oxytocics;Abortifacient Agents, Nonsteroidal;Abortifacient Agents;Prostaglandins
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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