AutismKB 2.0

Annotation Detail for SENP7


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Basic Information Top
Gene Symbol:SENP7 ( KIAA1707,MGC157730 )
Gene Full Name: SUMO1/sentrin specific peptidase 7
Band: 3q12.3
Quick LinksEntrez ID:57337; OMIM: 612846; Uniprot ID:SENP7_HUMAN; ENSEMBL ID: ENSG00000138468; HGNC ID: 30402
Relate to Another Database: SFARIGene; denovo-db
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of SENP7 mRNAdecreases expression 16788091
D000082 Acetaminophen Acetaminophen affects the expression of SENP7 mRNAaffects expression 17562736
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of SENP7 mRNAdecreases expression 20106945
D003010 Clorgyline Clorgyline results in increased expression of SENP7 mRNAincreases expression 19691856
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of SENP7 mRNAaffects binding|decreases expression|increases activity 19710929
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.5218653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0520127859 20464547
MESH:D000236 Adenoma Benzo(a)pyrene 2.846695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 4.0216434500
MESH:D000799 Angioedema Acetaminophen 4.4510982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.5619183758
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.5219483382
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.0017474063 20146248
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 1.403084413
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1320419170
MESH:D002386 Cataract Acetaminophen 2.7710977129
MESH:D002779 Cholestasis pirinixic acid 3.0819176532
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5618249437
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 1.6617562736 19420014 16781746 19739265 19370779 16485898 12540782 11287661 11529661 16081117 18713872 12958197 14725611 18071297 12153990 19923254 11743745 19164858 11739529 10915739 19416960 2444490 10663392 11421492 14550746 12392966 10774834 17906064 11461765 11834606 14986274 12594235 16227642 15619225 16177239 16109766 17522070 12705907 16393943 19085960 15968718
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.7119426721
MESH:D004487 Edema pirinixic acid 2.8512083418
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0716530937
MESH:D005234 Fatty Liver pirinixic acid 3.1420131406 19236843
MESH:D005756 Gastritis Acetaminophen 4.2916983495
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.8220471113
MESH:D006333 Heart Failure pirinixic acid 2.7320558911
MESH:D006529 Hepatomegaly pirinixic acid 3.4819772884 18467677 19176532 16221962
MESH:D006930 Hyperalgesia Acetaminophen 2.9916870215
MESH:D006943 Hyperglycemia pirinixic acid 3.5320558911
MESH:D007333 Insulin Resistance pirinixic acid 2.8516306350
MESH:D007674 Kidney Diseases Acetaminophen 2.3815629191 12587719
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3515474484
MESH:D008107 Liver Diseases Acetaminophen 1.6919014921 12969438 12587719 19784758 19460945 16611625 16610002 11587558
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5817185352 16871587
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 4.7321137059 20195826
MESH:D008113 Liver Neoplasms pirinixic acid 4.7320007298 15890375 16377806
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 1.576695378 17053015 18816296 18569708 20869020 20464547 20135361 18520028 20064080
MESH:D008546 Melanoma, Experimental Acetaminophen 4.0519513568
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.4616381670
MESH:D009135 Muscular Diseases pirinixic acid 3.9916239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2619151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.2216411023
MESH:D009369 Neoplasms Benzo(a)pyrene 5.3311141357
MESH:D009369 Neoplasms pirinixic acid 5.3317405874
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1818514411
MESH:D009765 Obesity pirinixic acid 1.8820558911
MESH:D010146 Pain Acetaminophen 2.6916870215
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.4817292933
MESH:D011471 Prostatic Neoplasms Clorgyline 3.4819691856
MESH:D015427 Reperfusion Injury pirinixic acid 2.5319058328
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.5119755658 10029692
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.562093021 20155912
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.2917053015
MESH:D014581 Urticaria Acetaminophen 3.3810982225
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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