AutismKB 2.0

Annotation Detail for PTGER4


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Basic Information Top
Gene Symbol:PTGER4 ( EP4,EP4R,MGC126583 )
Gene Full Name: prostaglandin E receptor 4 (subtype EP4)
Band: 5p13.1
Quick LinksEntrez ID:5734; OMIM: 601586; Uniprot ID:PE2R4_HUMAN; ENSEMBL ID: ENSG00000171522; HGNC ID: 9596
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04080Neuroactive ligand-receptor interaction
Pathway IDPathway Name
Signaling by GPCR
No data
No data
No data
Related Diseases/Disorders Top
No data
No data
Desease Name
asthma asthma, aspirin-intolerant
multiple sclerosis
IMMUNE
Crohn's disease
Desease Name
Crohn's disease
Multiple sclerosis
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C034008 11-deoxyprostaglandin E1 11-deoxyprostaglandin E1 binds to and results in increased activity of PTGER4 proteinaffects binding|increases activity 11595431
C487890 4-(4-cyano-2-(2-(4-fluoronaphthalen-1-yl)propionylamino)phenyl)butyric acid 4-(4-cyano-2-(2-(4-fluoronaphthalen-1-yl)propionylamino)phenyl)butyric acid results in decreased activity of PTGER4 proteindecreases activity 15976003
D000643 Ammonium Chloride Ammonium Chloride affects the expression of PTGER4 mRNAaffects expression 16483693
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of PTGER4 mRNAaffects expression 20382639
C095105 bexarotene bexarotene results in decreased expression of PTGER4 mRNAdecreases expression 17849452
C006780 bisphenol A bisphenol A results in increased expression of PTGER4 mRNAincreases expression 20096755
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of PTGER4 mRNAaffects expression 17484886
D003993 Dibutyl Phthalate Dibutyl Phthalate results in decreased expression of PTGER4 mRNAdecreases expression 15620428
C036042 dicyclohexyl phthalate dicyclohexyl phthalate results in increased expression of PTGER4 mRNAincreases expression 15620428
D004051 Diethylhexyl Phthalate Diethylhexyl Phthalate results in decreased expression of PTGER4 mRNAdecreases expression 15620428
D002117 Calcitriol Calcitriol results in decreased expression of PTGER4 mRNAdecreases expression 16002434
D015064 16,16-Dimethylprostaglandin E2 16,16-Dimethylprostaglandin E2 binds to and results in increased activity of PTGER4 proteinaffects binding|increases activity 11595431
D004958 Estradiol [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of PTGER4 mRNAaffects cotreatment|increases expression 19619570
D004958 Estradiol Estradiol results in increased expression of PTGER4 mRNAincreases expression 19619570
19153601
D004958 Estradiol [Progesterone co-treated with Estradiol] results in increased expression of PTGER4 mRNAaffects cotreatment|increases expression 15829624
D004958 Estradiol [Progesterone co-treated with Estradiol] results in increased expression of PTGER4 proteinaffects cotreatment|increases expression 15829624
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of PTGER4 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of PTGER4 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PTGER4 mRNAaffects cotreatment|increases expression 17942748
D005665 Furosemide PTGER4 protein affects the reaction [Furosemide results in increased expression of REN mRNA]affects reaction|increases expression 15976003
D005665 Furosemide PTGER4 protein affects the reaction [Furosemide results in increased expression of REN protein]affects reaction|increases expression 15976003
C029424 hydrazine hydrazine results in decreased expression of PTGER4 mRNAdecreases expression 15282401
C475919 hydroxytamoxifen GPR30 protein affects the reaction [hydroxytamoxifen results in increased expression of PTGER4 mRNA]affects reaction|increases expression 19153601
C475919 hydroxytamoxifen hydroxytamoxifen results in increased expression of PTGER4 mRNAincreases expression 19153601
C119620 kenpaullone kenpaullone results in decreased expression of PTGER4 mRNAdecreases expression 17993264
D015741 Metribolone Metribolone results in increased expression of PTGER4 mRNAincreases expression 17010675
C528911 N-((4-(5,9-diethoxy-6-oxo-6,8-dihydro-7H-pyrrolo(3,4-g)quinolin-7-yl)-3-methylbenzyl)sulfonyl)-2-(2-methoxyphenyl)acetamide N-((4-(5,9-diethoxy-6-oxo-6,8-dihydro-7H-pyrrolo(3,4-g)quinolin-7-yl)-3-methylbenzyl)sulfonyl)-2-(2-methoxyphenyl)acetamide binds to and results in decreased activity of PTGER4 proteinaffects binding|decreases activity 18287210
C528911 N-((4-(5,9-diethoxy-6-oxo-6,8-dihydro-7H-pyrrolo(3,4-g)quinolin-7-yl)-3-methylbenzyl)sulfonyl)-2-(2-methoxyphenyl)acetamide N-((4-(5,9-diethoxy-6-oxo-6,8-dihydro-7H-pyrrolo(3,4-g)quinolin-7-yl)-3-methylbenzyl)sulfonyl)-2-(2-methoxyphenyl)acetamide results in decreased expression of PTGER4 mRNAdecreases expression 18287210
C025256 nonylphenol nonylphenol results in decreased expression of PTGER4 mRNAdecreases expression 15620428
C461399 ONO-AE1-329 PTGER4 protein affects the reaction [ONO-AE1-329 inhibits the reaction [Zymosan results in increased expression of TNF mRNA]]affects reaction|decreases reaction|increases expression 11301049
C461399 ONO-AE1-329 PTGER4 protein affects the reaction [ONO-AE1-329 inhibits the reaction [Zymosan results in increased expression of TNF protein]]affects reaction|decreases reaction|increases expression 11301049
C461399 ONO-AE1-329 PTGER4 protein affects the reaction [ONO-AE1-329 promotes the reaction [Zymosan results in increased expression of IL10 mRNA]]affects reaction|increases expression|increases reaction 11301049
C461399 ONO-AE1-329 PTGER4 protein affects the reaction [ONO-AE1-329 promotes the reaction [Zymosan results in increased expression of IL10 protein]]affects reaction|increases expression|increases reaction 11301049
C461399 ONO-AE1-329 ONO-AE1-329 binds to and results in increased activity of PTGER4 proteinaffects binding|increases activity 11595431
D017239 Paclitaxel Paclitaxel results in decreased expression of PTGER4 mRNAdecreases expression 15585946
C006253 pirinixic acid pirinixic acid results in decreased expression of PTGER4 mRNAdecreases expression 17426115
C009042 pristane pristane results in increased expression of PTGER4 mRNAincreases expression 15075356
D011374 Progesterone [Progesterone co-treated with Estradiol] results in increased expression of PTGER4 mRNAaffects cotreatment|increases expression 15829624
D011374 Progesterone [Progesterone co-treated with Estradiol] results in increased expression of PTGER4 proteinaffects cotreatment|increases expression 15829624
D015232 Dinoprostone Dinoprostone binds to and results in decreased activity of PTGER4 proteinaffects binding|decreases activity 12009843
C017947 sodium arsenite sodium arsenite results in decreased expression of PTGER4 mRNAdecreases expression 16014739
D018038 Sodium Selenite Sodium Selenite results in increased expression of PTGER4 mRNAincreases expression 18175754
D013629 Tamoxifen Tamoxifen affects the expression of PTGER4 mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of PTGER4 mRNAaffects cotreatment|increases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of PTGER4 mRNAincreases expression 19619570
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PTGER4 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of PTGER4 mRNAincreases expression 17942748
C017963 vinyl carbamate vinyl carbamate results in decreased expression of PTGER4 mRNAdecreases expression 17849452
D015054 Zymosan PTGER4 protein affects the reaction [ONO-AE1-329 inhibits the reaction [Zymosan results in increased expression of TNF mRNA]]affects reaction|decreases reaction|increases expression 11301049
D015054 Zymosan PTGER4 protein affects the reaction [ONO-AE1-329 inhibits the reaction [Zymosan results in increased expression of TNF protein]]affects reaction|decreases reaction|increases expression 11301049
D015054 Zymosan PTGER4 protein affects the reaction [ONO-AE1-329 promotes the reaction [Zymosan results in increased expression of IL10 mRNA]]affects reaction|increases expression|increases reaction 11301049
D015054 Zymosan PTGER4 protein affects the reaction [ONO-AE1-329 promotes the reaction [Zymosan results in increased expression of IL10 protein]]affects reaction|increases expression|increases reaction 11301049
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.2214745880
MESH:D000014 Abnormalities, Drug-Induced Diethylhexyl Phthalate 7.636734493
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 7.6311752688 15322242 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.2318287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.6117505938
MESH:D055371 Acute Lung Injury pirinixic acid 2.8218653653
MESH:D000230 Adenocarcinoma Estradiol 6.7311473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 6.7314692618
MESH:D000230 Adenocarcinoma vinyl carbamate 6.7316247444 17363558
MESH:D018248 Adenoma, Liver Cell pirinixic acid 15.6216434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 15.6216835633
MESH:D018248 Adenoma, Liver Cell vinyl carbamate 15.6212371669
MESH:D011125 Adenomatous Polyposis Coli Dinoprostone 4.7517942926
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.3715276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.5716712894 17306315
MESH:D000740 Anemia Tetrachlorodibenzodioxin 8.0611748828
MESH:D000740 Anemia Zymosan 8.0618664788
MESH:D001014 Aortic Aneurysm Dinoprostone 5.3010231640
MESH:D017544 Aortic Aneurysm, Abdominal Dinoprostone 5.3110388637
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.1511256880
MESH:D001169 Arthritis, Experimental marker/mechanism 18287210
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 11.5415885639
MESH:D001169 Arthritis, Experimental N-((4-(5,9-diethoxy-6-oxo-6,8-dihydro-7H-pyrrolo(3,4-g)quinolin-7-yl)-3-methylbenzyl)sulfonyl)-2-(2-methoxyphenyl)acetamide 11.5418287210
MESH:D001169 Arthritis, Experimental Zymosan 11.5416872482 15142272 15188379 17659584 15944321
MESH:D001477 Bartter Syndrome Dinoprostone 5.4215976003
MESH:D001778 Blood Coagulation Disorders pirinixic acid 7.8019483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 7.8012125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.4615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.5615746008
MESH:D001859 Bone Neoplasms Paclitaxel 4.2715867366
MESH:D001862 Bone Resorption bisphenol A 3.5711985600
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.0117868700
MESH:D001930 Brain Injuries Progesterone 3.9415845082 15665606 15380490
MESH:D001943 Breast Neoplasms bexarotene 4.4416344269 16818667
MESH:D001943 Breast Neoplasms bisphenol A 4.4417123778
MESH:D001943 Breast Neoplasms Calcitriol 4.4411237771
MESH:D001943 Breast Neoplasms Estradiol 4.4416675129 14630087 17289903 17261762 12948864 17018787 18497071 19861407
MESH:D001943 Breast Neoplasms Paclitaxel 4.4418223236 18323546 18234424 16115903 15136595 16273361 11325840 16244791
MESH:D001943 Breast Neoplasms Progesterone 4.4417614352 15562024 16175315
MESH:D001943 Breast Neoplasms Tamoxifen 4.4419410462 18821012 19011961 18984771 19487384 17242785 21138602 20005174 19221464 18629630 17049068 19200415 18815881 19059307 17893378 19288272 15668708 21152245 15565566 16818667 18351453 19103187 20544844 16273361 17440819 19244106 20135344 18425577 19189210 20390343 18855134 19289846 11161223 17261762 19189212 18997820 16873071 20065188 19084267 16202921 19155303 19142967 19115204 20859285 19066611
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 4.4420435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.1416111702
MESH:D002252 Carbon Tetrachloride Poisoning 16,16-Dimethylprostaglandin E2 9.653786805
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 9.6516124888 16227642 18705752 16192424 3786805 15700767 10355542 16050911 16011737 15721981 16097048 15673190
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.5516835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.1919066611
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 10.6418788625
MESH:D006528 Carcinoma, Hepatocellular Estradiol 10.6416924424
MESH:D006528 Carcinoma, Hepatocellular Paclitaxel 10.6416313753
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 10.6416507464 15276417 17306315
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 10.6416924424
MESH:D006528 Carcinoma, Hepatocellular vinyl carbamate 10.6412371669
MESH:D002278 Carcinoma in Situ bisphenol A 4.6617123778
MESH:D002289 Carcinoma, Non-Small-Cell Lung bexarotene 5.9016247446
MESH:D002289 Carcinoma, Non-Small-Cell Lung vinyl carbamate 5.9016247446
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 4.4711237771
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 4.4718572023
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.3317572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.1916120746 18670907 18850075
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 14.2620889678
MESH:D002471 Cell Transformation, Neoplastic Dinoprostone 14.2616192471
MESH:D002471 Cell Transformation, Neoplastic Estradiol 14.2618566989
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 14.2619524636 20056578
MESH:D054506 Chloracne marker/mechanism 17101203
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.8916835633
MESH:D002779 Cholestasis Ethinyl Estradiol 6.9517333356 16919318 15861022 16105132 17110522 17681005 11677210
MESH:D002779 Cholestasis pirinixic acid 6.9519176532
MESH:D019457 Chromosome Breakage Sodium Selenite 4.4315894690
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 1.9712621046 16354765 15668235 8697196 15340226
MESH:D015179 Colorectal Neoplasms Paclitaxel 2.4418802399
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.7914669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2410048152 15322242 20055451
MESH:D003456 Cryptorchidism Dibutyl Phthalate 5.1416037377
MESH:D003711 Demyelinating Diseases Tamoxifen 4.0419031437
MESH:D003876 Dermatitis, Atopic Diethylhexyl Phthalate 6.4616882537
MESH:D003876 Dermatitis, Atopic pirinixic acid 6.4618249437
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.5116285004
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.5917107852
MESH:D003928 Diabetic Nephropathies Estradiol 7.9419279558
MESH:D003928 Diabetic Nephropathies Tamoxifen 7.9419279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.1717187935
MESH:D003967 Diarrhea Dinoprostone 4.257237001 11488427 10446763
MESH:D056486 Drug-Induced Liver Injury 16,16-Dimethylprostaglandin E2 8.233786805
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 8.2321278145 16227642 7179309 17522070 15027814 4309450 6884620 7440962 15998439 19085960 7120509 19336974 3786805 15968718 2869522 10915739 10092053 9327722 3732212 11566570 6623471 16177239
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 8.2315131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 8.2320420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.5211462148
MESH:D004381 Duodenal Ulcer 16,16-Dimethylprostaglandin E2 9.7611595431 10671773 11991626 16699067
MESH:D004381 Duodenal Ulcer ONO-AE1-329 9.7611991626 11595431
MESH:D004417 Dyspnea Furosemide 4.6116935035
MESH:D004487 Edema Furosemide 14.1411834646
MESH:D004487 Edema pirinixic acid 14.1412083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 14.1411000095 12711302
MESH:D004487 Edema Zymosan 14.147907874
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.5716714409 18230668 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 19.3815138306
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 19.3812538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 19.3817692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 19.3819031437
MESH:D016889 Endometrial Neoplasms Estradiol 6.6811473722 18566989 19148513
MESH:D016889 Endometrial Neoplasms Tamoxifen 6.6819155303 20544844 17893378 16202921
MESH:D004715 Endometriosis Progesterone 8.0016134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 8.0010568697 9294722
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.3720426865
MESH:D004938 Esophageal Neoplasms Paclitaxel 4.3716481741
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.7711564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 16.3616239168 19224547 12631006 17595544 15959796 12795759 16045604 61145
MESH:D005234 Fatty Liver Ethinyl Estradiol 16.3615345470
MESH:D005234 Fatty Liver pirinixic acid 16.3619236843 20131406
MESH:D005234 Fatty Liver Tamoxifen 16.3619224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.0416709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.1411858732
MESH:D005334 Fever Dinoprostone 4.6016997862 11852909
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.2014745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 3.8619069698
MESH:D005355 Fibrosis Carbon Tetrachloride 7.5418705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 7.5420067830
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.3516452187
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.2610696789
MESH:D034381 Hearing Loss Furosemide 4.5617868369
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.1611294989 10048152
MESH:D006333 Heart Failure Furosemide 6.6516011733 16845234 12660669
MESH:D006333 Heart Failure pirinixic acid 6.6520558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.0511000095
MESH:D006505 Hepatitis Carbon Tetrachloride 8.6319900420 19110552
MESH:D006505 Hepatitis Zymosan 8.6319110552
MESH:D006529 Hepatomegaly pirinixic acid 7.2116221962 19176532 18467677 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 7.2115340226 12621046 16120746
MESH:D006558 Herpes Genitalis Estradiol 4.7015709030
MESH:D006689 Hodgkin Disease sodium arsenite 2.8912676792
MESH:D019584 Hot Flashes Estradiol 3.4217088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.718697196 18606429 15340226 16354765 16959395
MESH:D006930 Hyperalgesia Dinoprostone 4.2816793879
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.2116899240
MESH:D006934 Hypercalcemia Furosemide 4.7817652376
MESH:D053565 Hypercalciuria Furosemide 5.3317652376
MESH:D006943 Hyperglycemia pirinixic acid 2.9020558911
MESH:D006962 Hyperparathyroidism, Secondary Furosemide 5.5415086907
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.7818850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.7715338365
MESH:D046110 Hypertension, Pregnancy-Induced Furosemide 4.9716612254
MESH:C537153 Hypomagnesemia primary Furosemide 5.3311041285
MESH:D007019 Hypoproteinemia Furosemide 5.5416096441
MESH:D007021 Hypospadias Ethinyl Estradiol 3.4916945680 16569931
MESH:D007022 Hypotension Furosemide 4.3211041285
MESH:D007024 Hypotension, Orthostatic Furosemide 5.0915811171
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.0815869954
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.1612013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 5.9217937319
MESH:D007248 Infertility, Male sodium arsenite 5.9212646999 15346721
MESH:D007249 Inflammation marker/mechanism 18287210
MESH:D007249 Inflammation Progesterone 10.5815869954
MESH:D007249 Inflammation Tamoxifen 10.5819457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 10.5812878042 12200463
MESH:D007249 Inflammation Zymosan 10.588014878 11289658
MESH:D007333 Insulin Resistance bisphenol A 15.9016393666
MESH:D007333 Insulin Resistance Estradiol 15.9016393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 15.9016306350
MESH:D007333 Insulin Resistance Sodium Selenite 15.9014714311
MESH:D043183 Irritable Bowel Syndrome Zymosan 5.5117553498
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.0516580747
MESH:D007674 Kidney Diseases Estradiol 9.1515618244
MESH:D007674 Kidney Diseases Furosemide 9.1511041285
MESH:D007674 Kidney Diseases sodium arsenite 9.1520008137
MESH:D007680 Kidney Neoplasms Estradiol 6.5215610895
MESH:D007680 Kidney Neoplasms Tamoxifen 6.5218625569
MESH:D008064 Lipidoses Tamoxifen 2.9315342952 17567588
MESH:D008080 Liposarcoma Paclitaxel 4.5217353645
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.6311408273 17157831 17174718 11903743 17334410 16239168 16943688 16221502 21278145
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 8.1514748882 15893842 16136751 10355542 16015684 15650968 12389079 15996030 17708605 12958196 14716496 14724832 17698563 14716833 12445418 12632514 14620537 12667390 18277467 15876570 12666154 18156304 14512876 18279442 15052691 17557913 16011737 16033810 15931870 18429990 17823541 12586293 15818738 18412020 18263696 18210741 18317297 12445421 15959796 12741479 18472094 11481614 17976157 17721639 17922224 20821823 18054572 16097048 18006644 17525996 18251166 15123356 18376398 15338365 12649538 16248980 15925388 15673190 17869086 17766677 18472332 17944888 16638106 18420326 17481882 17805973 15370692 15057751 17714472 18705752 17565644 12546737 17761835 18481824 16116963 18339082 18187930 12609069 18205269 15362042 18395095 18418968 17640975 18166357 12898905 12632512 16192424 17631135 16027843 18395914 15730626 13678700 17900296
MESH:D008106 Liver Cirrhosis, Experimental Dinoprostone 8.1515816358
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 8.1514659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 8.1515474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 8.1518564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 8.1512878042
MESH:D008107 Liver Diseases Carbon Tetrachloride 4.2716964402 15830285 15720792 17285989 16246199
MESH:D008107 Liver Diseases Dinoprostone 4.2715816358
MESH:D017093 Liver Failure Carbon Tetrachloride 3.8515123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.4114706259 16899240
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 16.3019294768
MESH:D008113 Liver Neoplasms Diethylhexyl Phthalate 16.3011940454
MESH:D008113 Liver Neoplasms pirinixic acid 16.3020007298 15890375 16377806
MESH:D008113 Liver Neoplasms sodium arsenite 16.3015276417 16712894
MESH:D008113 Liver Neoplasms Tamoxifen 16.3016684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 16.3016984957
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 5.0915583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.0912151625
MESH:D008171 Lung Diseases sodium arsenite 2.9619095001
MESH:D008175 Lung Neoplasms bexarotene 6.1517849452
MESH:D008175 Lung Neoplasms sodium arsenite 6.1519931552 16712894 15276417 17306315 17077188
MESH:D008175 Lung Neoplasms Tamoxifen 6.1518625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 6.1519555203 11884234
MESH:D008175 Lung Neoplasms vinyl carbamate 6.1515824018 12117777 15172992 11195469 16885199 16247444 12438228 17163412 12765245 14755239 11134547 17363558 17361011
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 3.7614737004
MESH:D008228 Lymphoma, Non-Hodgkin Paclitaxel 3.8314749477
MESH:D016410 Lymphoma, T-Cell, Cutaneous bexarotene 4.8311161223
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.4419428831
MESH:D008325 Mammary Neoplasms, Experimental bexarotene 12.5819196722 15591091 19196723
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 12.5816891317 11807958 17203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 12.5817203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 12.5816827153 11731420 19196723 14580682 19196722
MESH:D020149 Manganese Poisoning Estradiol 11.5419453300
MESH:D020149 Manganese Poisoning Tamoxifen 11.5419453300
MESH:D008545 Melanoma Paclitaxel 4.8112025231 12040289 16342250
MESH:D008545 Melanoma sodium arsenite 4.8119082730 16487513
MESH:D008545 Melanoma Tamoxifen 4.8119393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.8615990972
MESH:D020326 Migraine without Aura Dinoprostone 4.9511304026
MESH:D009101 Multiple Myeloma Paclitaxel 3.4614749477
MESH:D009102 Multiple Organ Failure Zymosan 4.9118160304 12879239 12130978 10890648 10479408 15213630 15834315 15241586 15259001 17724436
MESH:D009135 Muscular Diseases pirinixic acid 3.1916239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.0119151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.7612213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 7.4316810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 7.4316411023
MESH:D009362 Neoplasm Metastasis Paclitaxel 5.5315867366
MESH:D009362 Neoplasm Metastasis Tamoxifen 5.5319393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4119410462
MESH:D009369 Neoplasms pirinixic acid 4.4017405874
MESH:D009369 Neoplasms sodium arsenite 4.4011559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.3520056578
MESH:D009376 Neoplasms, Hormone-Dependent bexarotene 9.8319196722
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 9.8319189210 19200415 19196722
MESH:D009389 Neovascularization, Pathologic Estradiol 3.4117289903
MESH:D009397 Nephrocalcinosis Furosemide 5.5415086907
MESH:D009421 Nervous System Malformations bisphenol A 14.5616427766 11399458
MESH:D009421 Nervous System Malformations Estradiol 14.5616427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 14.5614600291
MESH:D009436 Neural Tube Defects sodium arsenite 2.9312854658
MESH:D053206 Nocturnal Enuresis Furosemide 5.5417945291
MESH:D009765 Obesity pirinixic acid 1.7320558911
MESH:D010003 Osteoarthritis N-((4-(5,9-diethoxy-6-oxo-6,8-dihydro-7H-pyrrolo(3,4-g)quinolin-7-yl)-3-methylbenzyl)sulfonyl)-2-(2-methoxyphenyl)acetamide 5.4618287210
MESH:D010005 Osteoarthropathy, Secondary Hypertrophic Dinoprostone 6.1418500342
MESH:D010014 Osteolysis Paclitaxel 4.6515867366
MESH:D010049 Ovarian Diseases bisphenol A 4.6611985600
MESH:D010051 Ovarian Neoplasms Estradiol 10.4219401270
MESH:D010051 Ovarian Neoplasms Paclitaxel 10.4211161223
MESH:D010051 Ovarian Neoplasms Progesterone 10.4216525653 17393432
MESH:D010051 Ovarian Neoplasms sodium arsenite 10.4215276417 17306315
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.3911578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.9212520081
MESH:D010538 Peritonitis Zymosan 4.5714761945 15979727 18760300 19641140 18557954 18977430 11985352 17371808 15259001 17826846 19088179
MESH:D010954 Plasmacytoma pristane 6.9615087411
MESH:D011141 Polyuria Furosemide 5.3317945291
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.2518163543
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 8.4210548101
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 8.4211118676 11222880 11896295 11399792
MESH:D011470 Prostatic Hyperplasia Calcitriol 4.4515572423
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 9.5820887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 9.5820887781
MESH:D011471 Prostatic Neoplasms bisphenol A 2.0516740699
MESH:D011471 Prostatic Neoplasms Calcitriol 2.0518247401 15754350 16289102 12479363 16644109
MESH:D011471 Prostatic Neoplasms Estradiol 2.0516740699
MESH:D011471 Prostatic Neoplasms Paclitaxel 2.0516729912 17136230 17172428 16356831
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.0516039940
MESH:D011471 Prostatic Neoplasms Sodium Selenite 2.0518760546
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.0515067354
MESH:D011537 Pruritus Ethinyl Estradiol 2.9915861022 16919318
MESH:D011629 Puberty, Precocious bisphenol A 4.4610548101
MESH:D015427 Reperfusion Injury Furosemide 6.2616526316
MESH:D015427 Reperfusion Injury pirinixic acid 6.2619058328
MESH:D012128 Respiratory Distress Syndrome, Adult Furosemide 4.3215912074 16096441 12394941
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.5318990726
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.7418045962
MESH:D018805 Sepsis Zymosan 4.3811441115
MESH:D012878 Skin Neoplasms sodium arsenite 5.0718572023 19524636
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.0716192470
MESH:D013088 Spermatocele Ethinyl Estradiol 10.4616709447
MESH:D013088 Spermatocele Tamoxifen 10.4616709447
MESH:D013119 Spinal Cord Injuries Progesterone 9.7916503802 15862959
MESH:D013119 Spinal Cord Injuries Tamoxifen 9.7919457130
MESH:D016135 Spinal Dysraphism sodium arsenite 3.5512854658
MESH:D013274 Stomach Neoplasms Furosemide 2.9817052386
MESH:D013274 Stomach Neoplasms Paclitaxel 2.9818506536 18396642
MESH:D013276 Stomach Ulcer 16,16-Dimethylprostaglandin E2 4.9411595431
MESH:D019966 Substance-Related Disorders bisphenol A 3.6616045194 16684133
MESH:D024801 Tauopathies Paclitaxel 4.4916930453
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.3211994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.8815669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.5712697716
MESH:D013978 Tibial Fractures Estradiol 4.3519048282
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 4.6816712894 11723127 17306315 16452187
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 4.6816712894 17572228 8653321
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 3.4911813266
MESH:D014591 Uterine Diseases bisphenol A 4.6814652134
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 2.9914692618
MESH:D014605 Uveitis Zymosan 5.0711006244
MESH:D014652 Vascular Diseases sodium arsenite 4.1017056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.2612125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.2514671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.9215886252
Pathway ID Pathway Name
KEGG:04080 Neuroactive ligand-receptor interaction
REACT:14797 Signaling by GPCR
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA289
    • Releated gene ID Related gene Name
    PA289PTGER4
    Releated disease ID Related disease Name
    PA443756Colonic Neoplasms
    Releated drug ID Related drug Name
    PA449345dinoprostone
    PA449479epoprostenol
    PA164712740Epoxides
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00917 agonist Dinoprostone Oxytocics;Prostaglandins
    DB00929 agonist Misoprostol Anti-Ulcer Agents;Oxytocics;Abortifacient Agents, Nonsteroidal;Abortifacient Agents;Prostaglandins
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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