AutismKB 2.0

Annotation Detail for PTGFRN


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Basic Information Top
Gene Symbol:PTGFRN ( CD315,CD9P-1,EWI-F,FLJ11001,FPRP,KIAA1436,SMAP-6 )
Gene Full Name: prostaglandin F2 receptor negative regulator
Band: 1p13.1
Quick LinksEntrez ID:5738; OMIM: 601204; Uniprot ID:FPRP_HUMAN; ENSEMBL ID: ENSG00000134247; HGNC ID: 9601
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of PTGFRN mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of PTGFRN mRNAaffects expression 17562736
D019386 Alendronate Alendronate affects the expression of PTGFRN mRNAaffects expression 16079270
D000643 Ammonium Chloride Ammonium Chloride affects the expression of PTGFRN mRNAaffects expression 16483693
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of PTGFRN mRNAaffects expression 17484886
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of PTGFRN mRNAaffects expression 16079270
D005419 Flavonoids Flavonoids results in increased expression of PTGFRN mRNAincreases expression 18035473
C010176 halofuginone halofuginone results in increased expression of PTGFRN mRNAincreases expression 17180598
C025589 ochratoxin A ochratoxin A results in increased expression of PTGFRN mRNAincreases expression 16251485
C006253 pirinixic acid pirinixic acid results in increased expression of PTGFRN mRNAincreases expression 18301758
D011794 Quercetin Quercetin results in increased expression of PTGFRN mRNAincreases expression 19729006
D020849 Raloxifene Raloxifene affects the expression of PTGFRN mRNAaffects expression 16079270
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.7118287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.1217505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.2318653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8314692618
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.6316434500
MESH:D000419 Albuminuria Raloxifene 4.7217308373 17451421
MESH:D000544 Alzheimer Disease Raloxifene 2.5615800139
MESH:D000743 Anemia, Hemolytic Quercetin 4.3517084956
MESH:D000799 Angioedema Acetaminophen 4.0210982225
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.6011256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7315885639
MESH:D001260 Ataxia Telangiectasia Quercetin 5.1315336622
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001327 Autoimmune Diseases Quercetin 4.5519761891
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.2619483382
MESH:D001930 Brain Injuries Raloxifene 4.6116580743
MESH:D001943 Breast Neoplasms ochratoxin A 2.2111921183
MESH:D001943 Breast Neoplasms Quercetin 2.2118628248
MESH:D001943 Breast Neoplasms Raloxifene 2.2117893378 17242785 17952589 16912660 17595753 15572757 17440819 15758505 17261762 15775269 17049068 16837676
MESH:D002105 Cadmium Poisoning Quercetin 5.7216962696
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.9216124888 15700767 18705752 16227642 16097048 15673190 10355542 15721981 3786805 16192424 16050911 16011737
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 6.7016705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.703084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 6.7018788625
MESH:D006528 Carcinoma, Hepatocellular Quercetin 6.7019519916 12508355
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 5.0917234771
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 4.1717572228
MESH:D006332 Cardiomegaly Quercetin 3.3719794523
MESH:D002318 Cardiovascular Diseases Raloxifene 3.5215775269
MESH:D002386 Cataract Acetaminophen 2.6410977129
MESH:D002779 Cholestasis Ethinyl Estradiol 8.0116105132 17333356 16919318 15861022 17681005 11677210 17110522
MESH:D002779 Cholestasis pirinixic acid 8.0119176532
MESH:D003072 Cognition Disorders Raloxifene 4.7615800139
MESH:D003110 Colonic Neoplasms Quercetin 2.4319440933 16640504 17148506 19056647 11134977 17191121 15741050
MESH:D015179 Colorectal Neoplasms Quercetin 2.1918852136 18095365
MESH:D019465 Craniofacial Abnormalities ochratoxin A 3.2120036863
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.1518551238
MESH:D003865 Depressive Disorder, Major Raloxifene 4.2617474826
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4718249437
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 3.8219496084
MESH:D003928 Diabetic Nephropathies Raloxifene 4.0315920148 17451421 17308373
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 6.3618551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.3615619225 17906064 12392966 12540782 11421492 19739265 16393943 11287661 14986274 11461765 2444490 11743745 17562736 16177239 10663392 16109766 19370779 16781746 16485898 14725611 19420014 15968718 12594235 12705907 19164858 19085960 12153990 14550746 12958197 11739529 10774834 19416960 17522070 18071297 11834606 10915739 16227642 16081117 18713872 11529661 19923254
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 6.369327722 7179309 3786805 11566570 19085960 6884620 16177239 10092053 7120509 3732212 19336974 6623471 4309450 10915739 17522070 15998439 15968718 21278145 7440962 15027814 2869522 16227642
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.2719426721
MESH:D004487 Edema pirinixic acid 7.2512083418
MESH:D004487 Edema Raloxifene 7.2515860553
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.5412538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 9.5415845917
MESH:D005234 Fatty Liver Carbon Tetrachloride 19.7216045604 15959796 19224547 16239168 61145 12631006 12795759 17595544
MESH:D005234 Fatty Liver Ethinyl Estradiol 19.7215345470
MESH:D005234 Fatty Liver pirinixic acid 19.7220131406 19236843
MESH:D005234 Fatty Liver Raloxifene 19.7217473493
MESH:D005355 Fibrosis Carbon Tetrachloride 9.4118705752
MESH:D005355 Fibrosis Quercetin 9.4119474275
MESH:D005756 Gastritis Acetaminophen 3.8516983495
MESH:D005909 Glioblastoma Quercetin 3.4619804834
MESH:D005910 Glioma Quercetin 3.0917643826
MESH:D006331 Heart Diseases Raloxifene 3.6111110106
MESH:D006333 Heart Failure pirinixic acid 2.6020558911
MESH:D006505 Hepatitis Carbon Tetrachloride 3.7219900420 19110552
MESH:D006529 Hepatomegaly pirinixic acid 3.1319772884 16221962 19176532 18467677
MESH:D006930 Hyperalgesia Acetaminophen 8.4716870215
MESH:D006930 Hyperalgesia Alendronate 8.4716769263
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.6916899240
MESH:D006943 Hyperglycemia pirinixic acid 9.5920558911
MESH:D006943 Hyperglycemia Quercetin 9.5911834736 18262572
MESH:D006965 Hyperplasia halofuginone 5.3811874485
MESH:D006973 Hypertension Quercetin 5.7018356687
MESH:D006973 Hypertension Raloxifene 5.7017577099 15787275
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.2315338365
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9516945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.5812013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5617937319
MESH:D007249 Inflammation Flavonoids 2.7017296493
MESH:D007251 Influenza, Human Quercetin 4.6816624496
MESH:D007333 Insulin Resistance pirinixic acid 2.7016306350
MESH:D007627 Keloid Quercetin 5.0917086741
MESH:D007674 Kidney Diseases Acetaminophen 10.6412587719 15629191
MESH:D007674 Kidney Diseases ochratoxin A 10.6411409539
MESH:D007674 Kidney Diseases Quercetin 10.6416962696
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 8.2316705839
MESH:D007680 Kidney Neoplasms ochratoxin A 8.2316251485
MESH:D007889 Leiomyoma Raloxifene 4.6116973256
MESH:D007938 Leukemia Quercetin 3.2017468513
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 7.2416221502 16239168 11408273 17334410 17174718 11903743 16943688 17157831 21278145
MESH:D008103 Liver Cirrhosis halofuginone 7.2417180598
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 5.1212546737 17900296 17631135 16015684 17766677 17823541 18279442 12666154 12586293 18263696 14724832 15370692 18187930 14512876 17640975 15931870 12632512 15925388 18317297 12609069 18481824 18277467 18429990 18472094 12445421 15052691 16027843 15959796 17944888 16248980 17714472 14748882 17565644 16638106 13678700 14716496 15996030 18210741 17721639 18006644 15057751 14620537 20821823 17976157 12667390 16011737 15362042 18472332 17557913 14716833 16192424 17761835 15123356 17698563 18376398 16033810 18166357 15818738 18339082 12389079 15650968 17869086 12898905 18054572 18418968 17922224 18395914 17805973 11481614 17481882 18705752 16136751 12741479 15338365 15876570 16097048 16116963 18395095 18156304 12649538 10355542 15673190 12958196 12632514 18412020 18420326 18251166 17708605 18205269 12445418 15893842 15730626 17525996
MESH:D008106 Liver Cirrhosis, Experimental halofuginone 5.1214739098 16489207 11172339 12175628 18458672
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 5.1215474484
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 5.1212741479
MESH:D008107 Liver Diseases Acetaminophen 3.9816611625 19784758 12969438 19014921 11587558 19460945 16610002 12587719
MESH:D008107 Liver Diseases Carbon Tetrachloride 3.9817285989 15830285 16246199 16964402 15720792
MESH:D017093 Liver Failure Carbon Tetrachloride 4.3015123358
MESH:D017114 Liver Failure, Acute Acetaminophen 9.7616871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 9.7616899240 14706259
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 7.6919294768
MESH:D008113 Liver Neoplasms pirinixic acid 7.6916377806 15890375 20007298
MESH:D008113 Liver Neoplasms Quercetin 7.6918980244
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 6.3312014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Quercetin 6.3319519916
MESH:D008175 Lung Neoplasms Quercetin 2.1916280456
MESH:D008325 Mammary Neoplasms, Experimental ochratoxin A 4.1411921183
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7119513568
MESH:D008850 Microphthalmos ochratoxin A 5.9220036863
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.7315863610
MESH:D009101 Multiple Myeloma Raloxifene 3.5116497877
MESH:D009135 Muscular Diseases pirinixic acid 3.6416239165
MESH:D009203 Myocardial Infarction pirinixic acid 5.8619151258
MESH:D009203 Myocardial Infarction Quercetin 5.8619595682
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.7216411023
MESH:D015428 Myocardial Reperfusion Injury Quercetin 8.7219207477
MESH:D009232 Myxoma Raloxifene 5.7316343187
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.0118551238
MESH:D009369 Neoplasms pirinixic acid 5.2217405874
MESH:D009369 Neoplasms Quercetin 5.2215185748
MESH:D009436 Neural Tube Defects ochratoxin A 4.5120036863
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9618514411
MESH:D020078 Neurogenic Inflammation Quercetin 4.4817929310
MESH:D009765 Obesity pirinixic acid 1.8420558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.5316049721 12819281
MESH:D010024 Osteoporosis Alendronate 8.0117882678
MESH:D010024 Osteoporosis Raloxifene 8.0117882678 19059307 15775268
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 10.5919495926
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 10.5915579764 17823083 15758505 17893378
MESH:D010051 Ovarian Neoplasms Quercetin 2.7619005980
MESH:D010146 Pain Acetaminophen 2.4816870215
MESH:D010190 Pancreatic Neoplasms Quercetin 2.8816965848
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8011578682
MESH:D011230 Precancerous Conditions Quercetin 4.0819056647
MESH:D011471 Prostatic Neoplasms Quercetin 3.5017292933 14715546
MESH:D011471 Prostatic Neoplasms Raloxifene 3.5015731164 16536755 16220300
MESH:D011537 Pruritus Ethinyl Estradiol 3.4715861022 16919318
MESH:D011693 Purpura Raloxifene 5.7315770314
MESH:D015427 Reperfusion Injury pirinixic acid 2.4319058328
MESH:D012554 Schistosomiasis japonica Quercetin 5.7216862918
MESH:D012640 Seizures 2,4-dinitrotoluene 2.6018551238
MESH:D012871 Skin Diseases halofuginone 3.5411874485
MESH:D013088 Spermatocele Ethinyl Estradiol 4.1216709447
MESH:D020521 Stroke Raloxifene 3.9116837676
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2515669648
MESH:D013978 Tibial Fractures Raloxifene 5.3819048282
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 8.6516049721
MESH:D001749 Urinary Bladder Neoplasms Quercetin 8.6516720314
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 8.6517572228
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.4710091137
MESH:D014581 Urticaria Acetaminophen 3.0910982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.4214692618
MESH:D054556 Venous Thromboembolism Raloxifene 5.3816837676
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6515869587 14671159
MESH:D014846 Vulvar Neoplasms Raloxifene 5.7316343187
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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