AutismKB 2.0

Annotation Detail for CYP20A1


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Basic Information Top
Gene Symbol:CYP20A1 ( CYP-M,MGC22229 )
Gene Full Name: cytochrome P450, family 20, subfamily A, polypeptide 1
Band: 2q33.2
Quick LinksEntrez ID:57404; OMIM: NA; Uniprot ID:CP20A_HUMAN; ENSEMBL ID: ENSG00000119004; HGNC ID: 20576
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of CYP20A1 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of CYP20A1 mRNAaffects expression 21346803
D001151 Arsenic Arsenic results in decreased expression of CYP20A1 mRNAdecreases expression 19654921
D002251 Carbon Tetrachloride Carbon Tetrachloride results in decreased expression of CYP20A1 mRNAdecreases expression 17484886
D016572 Cyclosporine Cyclosporine results in increased expression of CYP20A1 mRNAincreases expression 20106945
D010634 Phenobarbital Phenobarbital results in increased expression of CYP20A1 mRNAincreases expression 19270015
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 3.906195326
MESH:D018248 Adenoma, Liver Cell Phenobarbital 4.4317620307
MESH:D018246 Adrenocortical Adenoma Arsenic 5.7317306315
MESH:D020261 Arsenic Poisoning Arsenic 2.9316835338 12569548 16251483 18414634
MESH:D050197 Atherosclerosis Arsenic 3.4212928151 19371607
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 4.2016124888 16050911 16097048 16192424 16011737 15673190 3786805 15721981 10355542 15700767 18705752 16227642
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.7517687452 15504454
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 9.3216705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 9.3216705839
MESH:D006528 Carcinoma, Hepatocellular Arsenic 9.3217306315 16507464
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 9.3218788625
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 9.326705139 17173139 20935162 20007298 1701930
MESH:D002294 Carcinoma, Squamous Cell Arsenic 2.7618922899 15504454 17687452
MESH:D002295 Carcinoma, Transitional Cell Arsenic 4.3818640142
MESH:D002318 Cardiovascular Diseases Arsenic 3.6619152805 17938729 15738583
MESH:D002340 Carotid Artery Diseases Arsenic 4.6018022660 16973168
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 7.276135515
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 7.2712371664
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.674080065
MESH:D002779 Cholestasis Cyclosporine 3.1419486331
MESH:D003490 Cyanosis 2,4-dinitrotoluene 12.3218551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 12.3218551238
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 6.6918551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 6.6921346803 18551238
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 6.6916227642 4309450 7440962 17522070 19336974 15968718 11566570 9327722 16177239 2869522 19085960 10915739 3732212 3786805 7179309 15027814 6884620 10092053 21278145 7120509 15998439 6623471
MESH:D004421 Dystonia Phenobarbital 4.361851702
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.533659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.393922381 11558140
MESH:D004827 Epilepsy Phenobarbital 3.0320417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.836401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.677750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.483659116
MESH:D005234 Fatty Liver Carbon Tetrachloride 8.8116239168 61145 12631006 17595544 15959796 19224547 12795759 16045604
MESH:D005234 Fatty Liver Cyclosporine 8.8119224547
MESH:D005355 Fibrosis Carbon Tetrachloride 10.0918705752
MESH:D005355 Fibrosis Cyclosporine 10.0912168785 12639820
MESH:D005534 Foot Diseases Arsenic 6.086392382
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.688708960
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.8815720958
MESH:D006505 Hepatitis Carbon Tetrachloride 3.9719110552 19900420
MESH:D006529 Hepatomegaly Phenobarbital 3.9016109766
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.9916899240
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.7617050553
MESH:D006973 Hypertension Arsenic 5.6316076760 11953799 9931084
MESH:D006973 Hypertension Cyclosporine 5.6310903974
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.5015338365
MESH:D006987 Hypesthesia Arsenic 6.0816093927
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.9615604871
MESH:D007642 Keratosis Arsenic 5.4512749816 16930632
MESH:D007674 Kidney Diseases Cyclosporine 2.5018776723 8314463 10903974
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 13.9716705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 13.9716705839
MESH:D007680 Kidney Neoplasms Cyclosporine 13.9712371664
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 3.7417339181
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 7.1516943688 16221502 17174718 16239168 21278145 17157831 11408273 11903743 17334410
MESH:D008103 Liver Cirrhosis Phenobarbital 7.1521047994
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 1.7515123356 17698563 15362042 14512876 17557913 18054572 18279442 15730626 18412020 18420326 10355542 15818738 18205269 16638106 12898905 17708605 16027843 17714472 18429990 14620537 18210741 17481882 17721639 12546737 17805973 15959796 12632514 18251166 18395914 17922224 15338365 17869086 15673190 18277467 18339082 12649538 16248980 18472094 18418968 12445418 12667390 17823541 16097048 16015684 17525996 18263696 12445421 16011737 17640975 16136751 12741479 17976157 20821823 12609069 11481614 18376398 15893842 18006644 15876570 12666154 15650968 15925388 15052691 17761835 17631135 14716833 16192424 12389079 12632512 14716496 16033810 15931870 17900296 18472332 12958196 18395095 14724832 14748882 15996030 15370692 15057751 18705752 16116963 17766677 17944888 18156304 18317297 18187930 17565644 18166357 18481824 12586293 13678700
MESH:D008107 Liver Diseases Arsenic 7.0011134558
MESH:D008107 Liver Diseases Carbon Tetrachloride 7.0016246199 16964402 17285989 15830285 15720792
MESH:D008107 Liver Diseases Phenobarbital 7.0019363144
MESH:D017093 Liver Failure Carbon Tetrachloride 4.5815123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.9914706259 16899240
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 11.587678174
MESH:D008113 Liver Neoplasms Arsenic 11.5816368122
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 11.5819294768
MESH:D008113 Liver Neoplasms Phenobarbital 11.588742319 19812893 15975961 19482888 19073162 21047994
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 10.946135515 2876784 2876786
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 10.9412014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 10.9417172636 2563599 1399818 18308698 6150874
MESH:D008175 Lung Neoplasms Arsenic 2.2117976673 19168569 17306315
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.3116801185
MESH:D017202 Myocardial Ischemia Arsenic 4.2415371236
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.9417484760
MESH:D009336 Necrosis 2,4-dinitrotoluene 11.9418551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 11.947678174 18551238
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.9617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.5718481113 19348381
MESH:D009436 Neural Tube Defects Arsenic 3.6416620997
MESH:D020078 Neurogenic Inflammation Arsenic 4.7317056641
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.9216049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.9216049721
MESH:D010018 Osteomalacia Phenobarbital 4.8317016548
MESH:D010051 Ovarian Neoplasms Arsenic 2.8217306315
MESH:D010190 Pancreatic Neoplasms Phenobarbital 2.5816965848
MESH:D010523 Peripheral Nervous System Diseases Arsenic 4.5616093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 5.456392382 16905509 15371236
MESH:D011230 Precancerous Conditions Cyclosporine 9.9412371664
MESH:D011230 Precancerous Conditions Phenobarbital 9.942563599
MESH:D011471 Prostatic Neoplasms Arsenic 3.5616140617
MESH:D011507 Proteinuria Arsenic 4.3521343184
MESH:D019310 Pseudolymphoma Phenobarbital 5.0212752131
MESH:D011565 Psoriasis Cyclosporine 2.3116882103
MESH:D012640 Seizures 2,4-dinitrotoluene 11.0418551238
MESH:D012640 Seizures 2,6-dinitrotoluene 11.0418551238
MESH:D012640 Seizures Phenobarbital 11.0411442880 16876388 3137016 4039156
MESH:D003294 Seizures, Febrile Phenobarbital 5.286407741
MESH:D012871 Skin Diseases Arsenic 2.8117050553 17453740 19834688 6392382 15952646 17548696 18709164 16702368 16353154 17938729 16759981
MESH:D012878 Skin Neoplasms Arsenic 3.1317050553 19538983 16251483 15504454 17976673 17029826
MESH:D013964 Thyroid Neoplasms Phenobarbital 3.291399818
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 8.9616049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.9616049721
MESH:D001749 Urinary Bladder Neoplasms Arsenic 8.9611144890 17306315 17976673 18640142 19322015 19429237 15987713
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 13.5810091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 13.5810091137
MESH:D014605 Uveitis Cyclosporine 4.501336536
MESH:D014652 Vascular Diseases Arsenic 5.2017056641
MESH:D014985 Xerophthalmia Cyclosporine 4.9617120751
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA134911420
    • No data
    Releated disease ID Related disease Name
    PA445742Stomach Neoplasms
    Releated drug ID Related drug Name
    PA449957ibuprofen
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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