AutismKB 2.0

Annotation Detail for SLC24A3


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:SLC24A3 ( NCKX3 )
Gene Full Name: solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
Band: 20p11.23
Quick LinksEntrez ID:57419; OMIM: 609839; Uniprot ID:NCKX3_HUMAN; ENSEMBL ID: ENSG00000185052; HGNC ID: 10977
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Transmembrane transport of small molecules
No data
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1781Rheumatoid arthritis
Desease Name
HEMATOLOGICAL
CHEMDEPENDENCY
smoking cessation
serum Matrix Metalloproteinase
Desease Name
Serum matrix metalloproteinase
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of SLC24A3 mRNAaffects expression 16483693
C006632 arsenic trioxide arsenic trioxide results in increased expression of SLC24A3 mRNAincreases expression 20458559
C015001 arsenite arsenite results in increased expression of SLC24A3 mRNAincreases expression 18929588
C015001 arsenite TRP53 protein affects the reaction [arsenite results in increased expression of SLC24A3 mRNA]affects reaction|increases expression 18929588
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of SLC24A3 mRNAdecreases expression 20064835
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of SLC24A3 mRNAaffects expression 17484886
D002251 Carbon Tetrachloride Carbon Tetrachloride results in decreased expression of SLC24A3 proteindecreases expression 17544377
D004041 Dietary Fats Dietary Fats results in decreased expression of SLC24A3 mRNAdecreases expression 18042831
D004958 Estradiol [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of SLC24A3 mRNAaffects cotreatment|decreases expression 19619570
D004958 Estradiol Estradiol results in decreased expression of SLC24A3 mRNAdecreases expression 19619570
C041786 palm oil palm oil results in decreased expression of SLC24A3 mRNAdecreases expression 18042831
C025299 polyphenols polyphenols results in decreased expression of SLC24A3 mRNAdecreases expression 16293270
D013749 Tetrachlorodibenzodioxin [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of SLC24A3 mRNAaffects cotreatment|decreases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of SLC24A3 mRNAdecreases expression 19619570
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0811752688 15322242 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.8018287403
MESH:D000230 Adenocarcinoma arsenic trioxide 7.2911798837 19825857
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 7.2920127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 7.2911473722
MESH:D000236 Adenoma Benzo(a)pyrene 2.746695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.6116835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1111748828
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2919183758
MESH:D001161 Arteriosclerosis Dietary Fats 4.1015238619
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 9.5416206674
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.5412125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8715746008
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.9420146248 17474063
MESH:D001943 Breast Neoplasms Dietary Fats 1.9420435547
MESH:D001943 Breast Neoplasms Estradiol 1.9417289903 12948864 18497071 17261762 17018787 14630087 19861407 16675129
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9420435547
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.5111589617
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.7016111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.9915721981 16011737 10355542 16124888 16192424 16097048 3786805 15673190 16050911 15700767 16227642 18705752
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9316835633
MESH:D003528 Carcinoma, Adenoid Cystic marker/mechanism 16762588
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 4.7316217749 15553829 14691202 15073043 11135700
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 4.7318788625
MESH:D006528 Carcinoma, Hepatocellular Estradiol 4.7316924424
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.1419014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.2812490120
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.0920419170
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4518670907 18850075 16120746
MESH:D002471 Cell Transformation, Neoplastic Estradiol 2.8818566989
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3116835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1616354765 12621046 8697196 15668235 15340226
MESH:D003110 Colonic Neoplasms arsenite 4.2115037631
MESH:D003110 Colonic Neoplasms polyphenols 4.2116293270
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2114669216 17141729
MESH:D023903 Coronary Restenosis arsenic trioxide 4.3812609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 2.5110525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5120055451 15322242 10048152
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.2815213294
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7017107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.5619279558
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 6.5415968718 10915739 6623471 7440962 6884620 16177239 17522070 7179309 4309450 19085960 3786805 16227642 9327722 2869522 3732212 15027814 15998439 21278145 7120509 10092053 19336974 11566570
MESH:D056486 Drug-Induced Liver Injury polyphenols 6.5419370779
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.5420420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8911462148
MESH:D050171 Dyslipidemias Dietary Fats 3.5718367378
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.5511000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.1716714409 15322242 18230668
MESH:D016889 Endometrial Neoplasms Estradiol 3.0918566989 11473722 19148513
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.189294722 10568697
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.5612903497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.5616530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1411564622
MESH:D005234 Fatty Liver arsenic trioxide 20.3115073043
MESH:D005234 Fatty Liver arsenite 20.3118296743
MESH:D005234 Fatty Liver Carbon Tetrachloride 20.3119224547 12795759 15959796 12631006 16239168 16045604 17595544 61145
MESH:D005234 Fatty Liver Dietary Fats 20.3119004024 18296743 17967931 19551842
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6711858732
MESH:D005355 Fibrosis arsenite 23.0918296743
MESH:D005355 Fibrosis Carbon Tetrachloride 23.0918705752
MESH:D005355 Fibrosis Dietary Fats 23.0918296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 23.0920067830
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.4616904648
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8610696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.7220471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.7210048152 11294989
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5111000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.7919110552 19900420
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.1116120746 15340226 12621046
MESH:D006558 Herpes Genitalis Estradiol 5.3015709030
MESH:D019584 Hot Flashes Estradiol 4.0217088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.3116959395 18606429 8697196 15340226 16354765
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.7716899240
MESH:D006937 Hypercholesterolemia Dietary Fats 3.7621332399
MESH:D006949 Hyperlipidemias Dietary Fats 3.8021332399
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9618670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.3015338365
MESH:D007249 Inflammation Dietary Fats 8.8620412841
MESH:D007249 Inflammation polyphenols 8.8616366677
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.8612878042 12200463
MESH:D007333 Insulin Resistance Dietary Fats 7.7318457598 11836018
MESH:D007333 Insulin Resistance Estradiol 7.7316627594 16393666
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5116580747
MESH:D007674 Kidney Diseases Estradiol 2.6715618244
MESH:D007680 Kidney Neoplasms Estradiol 3.1215610895
MESH:D007938 Leukemia arsenic trioxide 2.9115070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.9717077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.5416972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.5514633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.9319077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1617050201 16968895 20471514 16467208 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.3216331271 12679006 17217047 15213294 15748426 12018890 19642359 16966277 9834237 16891316 19035177 19075265 16330433 11161223 17649720 19225113 17107899 15622746 12712474 17869043 17712046 15336539 16112521 16823087 11468182
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.5516882451
MESH:D008103 Liver Cirrhosis arsenite 11.6118296743
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 11.6116239168 17157831 17174718 11408273 21278145 11903743 17334410 16943688 16221502
MESH:D008103 Liver Cirrhosis Dietary Fats 11.6118296743
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 3.5314724832 17766677 17944888 17708605 16033810 15338365 18418968 12958196 17565644 17714472 17976157 12632512 15370692 18210741 17481882 17557913 18166357 12898905 18054572 16638106 16136751 17922224 18006644 18395914 16011737 17761835 12445418 13678700 18339082 16248980 15876570 16192424 18420326 18251166 17640975 12546737 12609069 18187930 18395095 15730626 12445421 12649538 17869086 18376398 16116963 15931870 18481824 18412020 15959796 15818738 12741479 15673190 20821823 17631135 16015684 17805973 18705752 12632514 15996030 12389079 18263696 18156304 18279442 18317297 18429990 18472332 17721639 15052691 10355542 14716496 15893842 15925388 11481614 17823541 18205269 15123356 14748882 15362042 18277467 14512876 16097048 15057751 12666154 12667390 14620537 17698563 14716833 17525996 17900296 12586293 18472094 16027843 15650968
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.5314716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.5312878042
MESH:D008107 Liver Diseases Carbon Tetrachloride 4.4517285989 16964402 15830285 16246199 15720792
MESH:D008107 Liver Diseases polyphenols 4.4516698588
MESH:D017093 Liver Failure Carbon Tetrachloride 4.3815123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.8516899240 14706259
MESH:D008113 Liver Neoplasms arsenic trioxide 11.1714682389
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 11.1721137059 20195826
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 11.1719294768
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 11.1716984957
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 10.4120377131
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 10.4112014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.4112151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.4815213294
MESH:D008175 Lung Neoplasms arsenic trioxide 5.0011798837 19825857
MESH:D008175 Lung Neoplasms arsenite 5.0016809336
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 5.0020135361 18816296 20064080 18569708 6695378 20464547 17053015 18520028 20869020
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 5.0019555203 11884234
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.6616891317 17203775 11408345 11807958
MESH:D020149 Manganese Poisoning Estradiol 4.7519453300
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3216381670
MESH:D009101 Multiple Myeloma arsenic trioxide 3.2219417148 19549372 11468182 14977855 15949261
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.9418349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.2316105982 16882451
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1612213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.4116810080
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.1616624393
MESH:D009369 Neoplasms Benzo(a)pyrene 2.2411141357
MESH:D009389 Neovascularization, Pathologic arsenite 10.9615738583
MESH:D009389 Neovascularization, Pathologic Estradiol 10.9617289903
MESH:D009421 Nervous System Malformations Estradiol 10.1411399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 10.1414600291
MESH:D009436 Neural Tube Defects arsenic trioxide 3.2210525206
MESH:D009765 Obesity Dietary Fats 2.3219632207 17217161 20518802 21332399 11836018 18674790 20132043 16723640 18457598
MESH:D010051 Ovarian Neoplasms arsenic trioxide 4.9819769630 16624393 12452020
MESH:D010051 Ovarian Neoplasms Estradiol 4.9819401270
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 2.5815580305
MESH:D010235 Paraganglioma arsenic trioxide 4.3519927285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5112520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7618163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.4311222880 11399792 11896295 11118676
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.0620887781
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.4919131511
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.4917292933
MESH:D011471 Prostatic Neoplasms Estradiol 2.4916740699
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0418990726
MESH:D012468 Salivary Gland Neoplasms marker/mechanism 16762588
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.1616646077
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.7219755658 10029692
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.7216192470
MESH:D013274 Stomach Neoplasms arsenic trioxide 2.4017007042
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.4020155912 2093021
MESH:D013705 Temporomandibular Joint Disorders polyphenols 5.5217997062
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1712697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 3.2219014326
MESH:D013978 Tibial Fractures Estradiol 4.9519048282
MESH:D016171 Torsades de Pointes arsenic trioxide 4.2015213294
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 5.2412845720 12973940 11780464 20435036
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.2417053015
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8612125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5115886252
MESH:D015430 Weight Gain Dietary Fats 3.8916723640
Pathway ID Pathway Name
REACT:15518 Transmembrane transport of small molecules
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved