AutismKB 2.0

Annotation Detail for PTGS1


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Basic Information Top
Gene Symbol:PTGS1 ( COX1,COX3,PCOX1,PGG/HS,PGHS-1,PGHS1,PHS1,PTGHS )
Gene Full Name: prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
Band: 9q33.2
Quick LinksEntrez ID:5742; OMIM: 176805; Uniprot ID:PGH1_HUMAN; ENSEMBL ID: ENSG00000095303; HGNC ID: 9604
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY66-374prostanoid biosynthesis
Pathway IDPathway Name
hsa00590Arachidonic acid metabolism
hsa01100Metabolic pathways
Pathway IDPathway Name
Hormone biosynthesis
Metabolism of lipids and lipoproteins
Biological oxidations
No data
No data
No data
Related Diseases/Disorders Top
No data
No data
Desease Name
colorectal cancer
CARDIOVASCULAR
colon polyps
CANCER
Cardiovascular Diseases
Hypertension/complications*
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C097240 15-deoxy-delta(12,14)-prostaglandin J2 PTGS1 protein promotes the reaction [lipopolysaccharide, Escherichia coli 0111 B4 results in increased abundance of 15-deoxy-delta(12,14)-prostaglandin J2]increases abundance|increases reaction 17439952
C400184 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased expression of PTGS1 mRNAincreases expression 16386258
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of PTGS1 mRNAincreases expression 19933214
C049584 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine PTGS1 protein results in increased metabolism of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridineincreases metabolic processing 11159734
C036990 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline PTGS1 protein results in increased metabolism of 2-amino-3,8-dimethylimidazo(4,5-f)quinoxalineincreases metabolic processing 11159734
C029216 2-amino-3-methylimidazo(4,5-f)quinoline PTGS1 protein results in increased metabolism of 2-amino-3-methylimidazo(4,5-f)quinolineincreases metabolic processing 11159734
C034047 2-cresol 2-cresol results in decreased activity of PTGS1 proteindecreases activity 15664436
C475568 3-aminobenzanthrone PTGS1 protein affects the metabolism of and results in increased activity of 3-aminobenzanthroneaffects metabolic processing|increases activity 15885895
C006757 4-biphenylamine PTGS1 protein results in increased metabolism of 4-biphenylamineincreases metabolic processing 11159734
C006757 4-biphenylamine PTGS1 protein results in increased metabolism of 4-biphenylamineincreases metabolic processing 11159734
C032538 4-cresol 4-cresol results in decreased activity of PTGS1 proteindecreases activity 15664436
C478738 4-(nitroxy)butanoic acid 4-acetylaminophenyl ester 4-(nitroxy)butanoic acid 4-acetylaminophenyl ester results in decreased expression of PTGS1 mRNAdecreases expression 16172162
C002202 4-oxoretinoic acid 4-oxoretinoic acid results in decreased expression of PTGS1 mRNAdecreases expression 15982314
C029728 4-phenylenediamine 4-phenylenediamine results in increased expression of PTGS1 mRNAincreases expression 18571826
C077580 7-(deoxyadenosin-N(6)-yl)aristolactam I PTGS1 protein results in increased activity of 7-(deoxyadenosin-N(6)-yl)aristolactam Iincreases activity 15386410
D000079 Acetaldehyde Acetaldehyde results in increased expression of PTGS1 mRNAincreases expression 17050345
D000082 Acetaminophen Acetaminophen results in decreased activity of PTGS1 protein alternative formdecreases activity 12242329
D000082 Acetaminophen Acetaminophen analog results in decreased activity of PTGS1 proteindecreases activity 16141368
D000082 Acetaminophen Acetaminophen results in decreased activity of PTGS1 proteindecreases activity 16141368
11113024
D000082 Acetaminophen Acetaminophen results in decreased activity of PTGS1 protein alternative formdecreases activity 15263079
D000082 Acetaminophen Acetaminophen results in decreased expression of PTGS1 mRNAdecreases expression 17175104
D000082 Acetaminophen Acetaminophen results in decreased expression of PTGS1 protein alternative formdecreases expression 16674937
D000082 Acetaminophen PTGS1 protein affects the susceptibility to Acetaminophenaffects response to substance 16674937
D000082 Acetaminophen PTGS1 protein alternative form affects the susceptibility to Acetaminophenaffects response to substance 16674937
D000082 Acetaminophen Acetaminophen affects the activity of PTGS1 proteinaffects activity 20024105
D000082 Acetaminophen Acetaminophen analog affects the activity of PTGS1 proteinaffects activity 20024105
D000082 Acetaminophen Acetaminophen results in decreased expression of PTGS1 mRNAdecreases expression 16172162
D000082 Acetaminophen Acetaminophen results in decreased activity of PTGS1 proteindecreases activity 17606472
C056165 acetovanillone acetovanillone inhibits the reaction [Streptozocin results in increased expression of PTGS1 protein]decreases reaction|increases expression 18414395
D012436 S-Adenosylmethionine S-Adenosylmethionine results in decreased expression of PTGS1 mRNAdecreases expression 18098314
C103303 alitretinoin alitretinoin results in decreased expression of PTGS1 mRNAdecreases expression 15982314
C523074 allylpyrocatechol allylpyrocatechol inhibits the reaction [Indomethacin results in decreased expression of PTGS1 protein]decreases expression|decreases reaction 18431645
C011512 alpha-naphthoflavone alpha-naphthoflavone results in increased expression of PTGS1 mRNAincreases expression 19403181
D000632 Aminopyrine Aminopyrine analog results in decreased activity of PTGS1 proteindecreases activity 16141368
D000632 Aminopyrine Aminopyrine results in decreased activity of PTGS1 proteindecreases activity 16141368
D000643 Ammonium Chloride Ammonium Chloride affects the expression of PTGS1 mRNAaffects expression 16483693
D000983 Antipyrine Antipyrine results in decreased activity of PTGS1 protein alternative formdecreases activity 12242329
D000983 Antipyrine Antipyrine analog results in decreased activity of PTGS1 proteindecreases activity 16141368
D000983 Antipyrine Antipyrine results in decreased activity of PTGS1 proteindecreases activity 16141368
D016718 Arachidonic Acid PTGS1 protein results in increased metabolism of Arachidonic Acidincreases metabolic processing 10718109
D016718 Arachidonic Acid PTGS1 protein alternative form results in increased metabolism of Arachidonic Acidincreases metabolic processing 16141368
D016718 Arachidonic Acid PTGS1 protein results in increased metabolism of Arachidonic Acidincreases metabolic processing 16141368
D016718 Arachidonic Acid [PTGS1 protein results in increased metabolism of Arachidonic Acid] which results in increased chemical synthesis of prostaglandin G2increases chemical synthesis|increases metabolic processing 7775455
D016718 Arachidonic Acid Arachidonic Acid results in increased activity of PTGS1 proteinincreases activity 11755111
D016718 Arachidonic Acid Ibuprofen analog inhibits the reaction [Arachidonic Acid results in increased activity of PTGS1 protein]decreases reaction|increases activity 11755111
D016718 Arachidonic Acid Indomethacin inhibits the reaction [Arachidonic Acid results in increased activity of PTGS1 protein]decreases reaction|increases activity 11755111
D016718 Arachidonic Acid Naproxen inhibits the reaction [Arachidonic Acid results in increased activity of PTGS1 protein]decreases reaction|increases activity 11755111
D016718 Arachidonic Acid PTGS1 protein affects the metabolism of Arachidonic Acidaffects metabolic processing 12902868
D001241 Aspirin Aspirin results in decreased activity of PTGS1 protein alternative formdecreases activity 12242329
D001241 Aspirin Aspirin analog results in decreased activity of PTGS1 proteindecreases activity 16141368
D001241 Aspirin Aspirin results in decreased activity of PTGS1 proteindecreases activity 15843042
16141368
D001241 Aspirin Aspirin results in decreased activity of PTGS1 proteindecreases activity 12242329
D001241 Aspirin Aspirin results in decreased activity of PTGS1 proteindecreases activity 18848576
D016589 Astemizole Astemizole results in decreased expression of PTGS1 mRNAdecreases expression 20221588
D001397 Azoxymethane Azoxymethane results in decreased expression of PTGS1 mRNAdecreases expression 17190766
C029876 benzidine PTGS1 protein results in increased metabolism of benzidineincreases metabolic processing 11159734
C029876 benzidine PTGS1 protein results in increased metabolism of benzidineincreases metabolic processing 11159734
C017228 benzo(a)pyrene 7,8-dihydrodiol PTGS1 protein results in increased metabolism of benzo(a)pyrene 7,8-dihydrodiolincreases metabolic processing 11159734
C017228 benzo(a)pyrene 7,8-dihydrodiol PTGS1 protein results in increased metabolism of benzo(a)pyrene 7,8-dihydrodiolincreases metabolic processing 11159734
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of PTGS1 mRNAincreases expression 19403181
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of PTGS1 mRNAincreases expression 20713471
C002791 bismuth tripotassium dicitrate bismuth tripotassium dicitrate results in decreased expression of PTGS1 mRNAdecreases expression 15912405
C006780 bisphenol A bisphenol A affects the expression of PTGS1 mRNAaffects expression 20170705
D019819 Budesonide Budesonide promotes the reaction [lipopolysaccharide, Escherichia coli 0111 B4 results in increased expression of PTGS1 mRNA]increases expression|increases reaction 15734790
D002034 Bumetanide Bumetanide results in increased expression of PTGS1 mRNAincreases expression 14504926
D002045 Bupivacaine Bupivacaine results in increased expression of PTGS1 mRNAincreases expression 18165598
D002084 Butylated Hydroxytoluene Butylated Hydroxytoluene results in increased expression of PTGS1 proteinincreases expression 11696405
D002084 Butylated Hydroxytoluene Butylated Hydroxytoluene analog results in decreased activity of PTGS1 proteindecreases activity 16690318
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased activity of PTGS1 proteinincreases activity 15604817
D020148 Butyric Acid Butyric Acid results in increased expression of PTGS1 mRNAincreases expression 17928716
D002118 Calcium Calcium affects the expression of PTGS1 mRNAaffects expression 15913539
C459604 candoxin candoxin results in decreased expression of PTGS1 mRNAdecreases expression 16309724
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of PTGS1 mRNAaffects expression 17484886
D017452 Receptors, IgG PTGS1 protein promotes the reaction [Receptors, IgG results in increased abundance of Reactive Oxygen Species]increases abundance|increases reaction 17982097
D017455 Receptors, IgE FR 122047 inhibits the reaction [PTGS1 protein promotes the reaction [Receptors, IgE results in increased abundance of Reactive Oxygen Species]]decreases reaction|increases abundance|increases reaction 17982097
D017455 Receptors, IgE PTGS1 protein promotes the reaction [Receptors, IgE results in increased abundance of Reactive Oxygen Species]increases abundance|increases reaction 17982097
C105934 celecoxib celecoxib analog results in decreased activity of PTGS1 proteindecreases activity 16141368
C105934 celecoxib celecoxib results in decreased activity of PTGS1 proteindecreases activity 16141368
C105934 celecoxib celecoxib results in decreased expression of PTGS1 mRNA alternative formdecreases expression 11375891
D003345 Corticosterone Corticosterone results in increased expression of PTGS1 mRNAincreases expression 15755911
D003345 Corticosterone Corticosterone results in increased expression of PTGS1 proteinincreases expression 15755911
C423222 cotylenin A cotylenin A results in increased expression of PTGS1 mRNAincreases expression 16129123
C017154 cyanidin cyanidin results in decreased activity of PTGS1 proteindecreases activity 10075763
C477734 delta-viniferin PTGS1 protein affects the chemical synthesis of delta-viniferinaffects chemical synthesis 15688382
D003907 Dexamethasone Dexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS1 protein]decreases reaction|increases expression 16880258
D003907 Dexamethasone DUSP1 gene mutant form inhibits the reaction [Dexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS1 protein]]decreases reaction|increases expression 16880258
D002945 Cisplatin PTGS1 protein affects the susceptibility to Cisplatinaffects response to substance 16217747
D004008 Diclofenac Diclofenac results in decreased activity of PTGS1 protein alternative formdecreases activity 12242329
D004008 Diclofenac Diclofenac analog results in decreased activity of PTGS1 proteindecreases activity 16141368
D004008 Diclofenac Diclofenac results in decreased activity of PTGS1 proteindecreases activity 16141368
D004008 Diclofenac Diclofenac results in decreased activity of PTGS1 proteindecreases activity 12242329
D004052 Diethylnitrosamine [Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of PTGS1 mRNAaffects cotreatment|decreases expression 18253720
D002117 Calcitriol Calcitriol results in increased expression of PTGS1 mRNAincreases expression 16129123
D004177 Dipyrone Dipyrone results in decreased activity of PTGS1 protein alternative formdecreases activity 12242329
D004177 Dipyrone Dipyrone results in decreased activity of PTGS1 proteindecreases activity 11852909
D004177 Dipyrone Dipyrone analog results in decreased activity of PTGS1 proteindecreases activity 16141368
D004177 Dipyrone Dipyrone results in decreased activity of PTGS1 proteindecreases activity 16141368
D004177 Dipyrone Dipyrone results in decreased activity of PTGS1 proteindecreases activity 12242329
D004317 Doxorubicin PPARA protein affects the reaction [PTGS1 protein inhibits the reaction [Doxorubicin results in increased cleavage of CASP3 protein]]affects reaction|decreases reaction|increases cleavage 17671096
D004317 Doxorubicin PTGS1 protein inhibits the reaction [Doxorubicin results in increased cleavage of CASP3 protein]decreases reaction|increases cleavage 17671096
C042986 ebselen ebselen results in decreased activity of PTGS1 proteindecreases activity 7590103
C091891 epsilon-viniferin PTGS1 protein affects the chemical synthesis of epsilon-viniferinaffects chemical synthesis 15688382
D004958 Estradiol [Progesterone co-treated with Estradiol] results in increased expression of PTGS1 mRNAaffects cotreatment|increases expression 17404688
C017296 estrone sulfate PTGS1 protein promotes the reaction [EGF protein promotes the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]]increases reaction|increases uptake 15238352
C017296 estrone sulfate PTGS1 protein promotes the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]increases reaction|increases uptake 15238352
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of PTGS1 mRNAaffects expression 20170705
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of PTGS1 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PTGS1 mRNAaffects cotreatment|increases expression 17942748
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of PTGS1 mRNAaffects expression 20170705
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of PTGS1 mRNAdecreases expression 17557909
D011345 Fenofibrate [Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of PTGS1 mRNAaffects cotreatment|decreases expression 18253720
D005419 Flavonoids Flavonoids results in increased expression of PTGS1 mRNAincreases expression 18035473
C014557 flunixin flunixin results in decreased activity of PTGS1 proteindecreases activity 12967936
D005475 Flupenthixol Flupenthixol results in decreased expression of PTGS1 proteindecreases expression 8897462
D005480 Flurbiprofen Flurbiprofen results in decreased activity of PTGS1 proteindecreases activity 18848576
C085131 FR 122047 FR 122047 inhibits the reaction [PTGS1 protein promotes the reaction [Receptors, IgE results in increased abundance of Reactive Oxygen Species]]decreases reaction|increases abundance|increases reaction 17982097
C085131 FR 122047 FR 122047 results in decreased activity of PTGS1 proteindecreases activity 17982097
D005665 Furosemide Furosemide affects the expression of PTGS1 mRNAaffects expression 11961000
D005665 Furosemide Furosemide affects the expression of PTGS1 proteinaffects expression 11961000
C056507 gemcitabine gemcitabine results in decreased expression of PTGS1 mRNAdecreases expression 17039268
D017313 Fenretinide Fenretinide results in decreased expression of PTGS1 mRNAdecreases expression 10697514
D006861 Hydrogen Peroxide Hydrogen Peroxide results in increased activity of PTGS1 proteinincreases activity 15604817
D007052 Ibuprofen Ibuprofen results in decreased activity of PTGS1 protein alternative formdecreases activity 12242329
D007052 Ibuprofen Ibuprofen analog results in decreased activity of PTGS1 proteindecreases activity 16141368
D007052 Ibuprofen Ibuprofen results in decreased activity of PTGS1 proteindecreases activity 17164136
18848576
16141368
D007052 Ibuprofen Ibuprofen results in decreased activity of PTGS1 proteindecreases activity 12242329
D007052 Ibuprofen Ibuprofen analog inhibits the reaction [Arachidonic Acid results in increased activity of PTGS1 protein]decreases reaction|increases activity 11755111
D007052 Ibuprofen Ibuprofen results in decreased expression of PTGS1 mRNAdecreases expression 10697514
D007213 Indomethacin Indomethacin results in decreased activity of PTGS1 protein alternative formdecreases activity 12242329
D007213 Indomethacin Indomethacin results in decreased activity of PTGS1 proteindecreases activity 11852909
D007213 Indomethacin Indomethacin analog results in decreased activity of PTGS1 proteindecreases activity 16141368
D007213 Indomethacin Indomethacin inhibits the reaction [PTGS1 protein results in increased chemical synthesis of Dinoprostone]decreases reaction|increases chemical synthesis 16354411
D007213 Indomethacin Indomethacin results in decreased activity of PTGS1 proteindecreases activity 16141368
D007213 Indomethacin Indomethacin results in decreased expression of PTGS1 proteindecreases expression 14736730
D007213 Indomethacin Indomethacin results in increased expression of PTGS1 proteinincreases expression 15482327
D007213 Indomethacin allylpyrocatechol inhibits the reaction [Indomethacin results in decreased expression of PTGS1 protein]decreases expression|decreases reaction 18431645
D007213 Indomethacin Indomethacin binds to PTGS1 proteinaffects binding 17243824
D007213 Indomethacin Indomethacin results in decreased activity of PTGS1 proteindecreases activity 11239499
12242329
D007213 Indomethacin Indomethacin results in decreased expression of PTGS1 proteindecreases expression 18431645
18237397
17977527
D007213 Indomethacin malabaricone B inhibits the reaction [Indomethacin results in decreased expression of PTGS1 protein]decreases expression|decreases reaction 17977527
D007213 Indomethacin malabaricone C inhibits the reaction [Indomethacin results in decreased expression of PTGS1 protein]decreases expression|decreases reaction 17977527
D007213 Indomethacin Plant Extracts inhibits the reaction [Indomethacin results in decreased expression of PTGS1 protein]decreases expression|decreases reaction 18237397
D007213 Indomethacin Indomethacin analog results in decreased activity of PTGS1 proteindecreases activity 16690318
D007213 Indomethacin Indomethacin inhibits the reaction [Arachidonic Acid results in increased activity of PTGS1 protein]decreases reaction|increases activity 11755111
D007213 Indomethacin Indomethacin results in decreased activity of PTGS1 proteindecreases activity 8985016
17397826
D007213 Indomethacin Indomethacin results in increased expression of PTGS1 mRNAincreases expression 18299717
D007213 Indomethacin rebamipide inhibits the reaction [Indomethacin results in increased expression of PTGS1 mRNA]decreases reaction|increases expression 18299717
D007213 Indomethacin Indomethacin results in decreased activity of PTGS1 proteindecreases activity 12606626
16391822
16343605
D020910 Ketorolac Ketorolac results in decreased activity of PTGS1 proteindecreases activity 17175104
D020910 Ketorolac Ketorolac results in decreased expression of PTGS1 mRNAdecreases expression 17175104
C440499 lipopolysaccharide, Escherichia coli 0111 B4 PTGS1 protein promotes the reaction [lipopolysaccharide, Escherichia coli 0111 B4 results in increased abundance of 15-deoxy-delta(12,14)-prostaglandin J2]increases abundance|increases reaction 17439952
C440499 lipopolysaccharide, Escherichia coli 0111 B4 Budesonide promotes the reaction [lipopolysaccharide, Escherichia coli 0111 B4 results in increased expression of PTGS1 mRNA]increases expression|increases reaction 15734790
D008070 Lipopolysaccharides Dexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS1 protein]decreases reaction|increases expression 16880258
D008070 Lipopolysaccharides DUSP1 gene mutant form inhibits the reaction [Dexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS1 protein]]decreases reaction|increases expression 16880258
D008070 Lipopolysaccharides Lipopolysaccharides results in increased expression of PTGS1 proteinincreases expression 16880258
D008070 Lipopolysaccharides PTGS1 protein promotes the reaction [[Zymosan co-treated with Lipopolysaccharides] results in increased metabolism of Prostaglandins]affects cotreatment|increases metabolic processing|increases reaction 16787386
D008070 Lipopolysaccharides PTGS1 protein promotes the reaction [[Zymosan co-treated with Lipopolysaccharides] results in increased metabolism of Prostaglandins analog]affects cotreatment|increases metabolic processing|increases reaction 16787386
C059451 lornoxicam lornoxicam results in decreased activity of PTGS1 proteindecreases activity 10450786
C071788 malabaricone B malabaricone B inhibits the reaction [Indomethacin results in decreased expression of PTGS1 protein]decreases expression|decreases reaction 17977527
C071787 malabaricone C malabaricone C inhibits the reaction [Indomethacin results in decreased expression of PTGS1 protein]decreases expression|decreases reaction 17977527
D008748 Methylcholanthrene Methylcholanthrene results in increased expression of PTGS1 mRNAincreases expression 20713471
D008753 Methylenebis(chloroaniline) PTGS1 protein results in increased metabolism of Methylenebis(chloroaniline)increases metabolic processing 11159734
D015735 Mifepristone Mifepristone results in decreased expression of PTGS1 mRNAdecreases expression 17584828
D009020 Morphine Morphine results in decreased expression of PTGS1 mRNAdecreases expression 15183518
D009151 Mustard Gas PTGS1 protein results in decreased susceptibility to Mustard Gasdecreases response to substance 15451306
C080955 N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in decreased activity of PTGS1 proteindecreases activity 15843042
15155531
D009288 Naproxen Naproxen results in decreased activity of PTGS1 proteindecreases activity 17164136
D009288 Naproxen Naproxen inhibits the reaction [Arachidonic Acid results in increased activity of PTGS1 protein]decreases reaction|increases activity 11755111
C012655 nimesulide nimesulide results in increased expression of PTGS1 proteinincreases expression 15482327
C007350 nitrofen nitrofen results in increased expression of PTGS1 mRNAincreases expression 12612200
C007350 nitrofen nitrofen results in increased expression of PTGS1 proteinincreases expression 12612200
C014707 nitrosobenzylmethylamine nitrosobenzylmethylamine results in increased expression of PTGS1 mRNAincreases expression 17616710
D010126 Ozone Ozone results in increased expression of PTGS1 mRNAincreases expression 19555225
C084656 paricalcitol [Phosphorus co-treated with paricalcitol] results in increased expression of PTGS1 mRNAaffects cotreatment|increases expression 17715259
D044262 Prostaglandin H2 [PTGS1 protein results in increased metabolism of prostaglandin G2] which results in increased chemical synthesis of Prostaglandin H2increases chemical synthesis|increases metabolic processing 7775455
D010615 Phenacetin Phenacetin results in decreased activity of PTGS1 protein alternative formdecreases activity 12242329
D010615 Phenacetin Phenacetin analog results in decreased activity of PTGS1 proteindecreases activity 16141368
D010615 Phenacetin Phenacetin results in decreased activity of PTGS1 proteindecreases activity 16141368
D010615 Phenacetin Phenacetin results in decreased activity of PTGS1 proteindecreases activity 17606472
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in decreased expression of PTGS1 mRNA]affects reaction|decreases expression 19482888
D010634 Phenobarbital Phenobarbital results in decreased expression of PTGS1 mRNAdecreases expression 19482888
D010656 Phenylephrine FBN1 protein affects the reaction [PTGS1 protein affects the susceptibility to Phenylephrine]affects reaction|affects response to substance 17641673
D010656 Phenylephrine PTGS1 protein affects the susceptibility to Phenylephrineaffects response to substance 17641673
C016658 phorbolol myristate acetate phorbolol myristate acetate results in decreased expression of PTGS1 mRNAdecreases expression 14508638
D010758 Phosphorus [Phosphorus co-treated with paricalcitol] results in increased expression of PTGS1 mRNAaffects cotreatment|increases expression 17715259
C006253 pirinixic acid pirinixic acid results in decreased expression of PTGS1 mRNAdecreases expression 18445702
D010894 Piroxicam Piroxicam results in decreased activity of PTGS1 proteindecreases activity 17606472
D010936 Plant Extracts Plant Extracts inhibits the reaction [Indomethacin results in decreased expression of PTGS1 protein]decreases expression|decreases reaction 18237397
D010972 Platelet Activating Factor Platelet Activating Factor results in increased expression of PTGS1 mRNAincreases expression 16386258
D011374 Progesterone [Progesterone co-treated with Estradiol] results in increased expression of PTGS1 mRNAaffects cotreatment|increases expression 17404688
D011374 Progesterone Progesterone results in increased expression of PTGS1 mRNAincreases expression 17404688
D015232 Dinoprostone PTGS1 protein results in increased chemical synthesis of Dinoprostoneincreases chemical synthesis 14508638
D015232 Dinoprostone PTGS1 protein results in increased chemical synthesis of Dinoprostoneincreases chemical synthesis 10718109
D015232 Dinoprostone Indomethacin inhibits the reaction [PTGS1 protein results in increased chemical synthesis of Dinoprostone]decreases reaction|increases chemical synthesis 16354411
D015232 Dinoprostone PTGS1 protein results in increased chemical synthesis of Dinoprostoneincreases chemical synthesis 16894348
D015232 Dinoprostone [SC 58560 results in decreased activity of PTGS1 protein] which results in decreased chemical synthesis of Dinoprostonedecreases activity|decreases chemical synthesis 10484518
D015232 Dinoprostone PTGS1 protein affects the chemical synthesis of Dinoprostoneaffects chemical synthesis 12902868
D015232 Dinoprostone PTGS1 protein results in increased chemical synthesis of Dinoprostoneincreases chemical synthesis 10231640
C038291 prostaglandin G2 [PTGS1 protein results in increased metabolism of Arachidonic Acid] which results in increased chemical synthesis of prostaglandin G2increases chemical synthesis|increases metabolic processing 7775455
C038291 prostaglandin G2 [PTGS1 protein results in increased metabolism of prostaglandin G2] which results in increased chemical synthesis of Prostaglandin H2increases chemical synthesis|increases metabolic processing 7775455
D011453 Prostaglandins PTGS1 protein promotes the reaction [[Zymosan co-treated with Lipopolysaccharides] results in increased metabolism of Prostaglandins]affects cotreatment|increases metabolic processing|increases reaction 16787386
D011453 Prostaglandins PTGS1 protein promotes the reaction [[Zymosan co-treated with Lipopolysaccharides] results in increased metabolism of Prostaglandins analog]affects cotreatment|increases metabolic processing|increases reaction 16787386
D011794 Quercetin Quercetin results in decreased activity of PTGS1 proteindecreases activity 15155531
D011794 Quercetin Quercetin results in decreased expression of PTGS1 mRNAdecreases expression 19056647
D017382 Reactive Oxygen Species FR 122047 inhibits the reaction [PTGS1 protein promotes the reaction [Receptors, IgE results in increased abundance of Reactive Oxygen Species]]decreases reaction|increases abundance|increases reaction 17982097
D017382 Reactive Oxygen Species PTGS1 protein promotes the reaction [Receptors, IgE results in increased abundance of Reactive Oxygen Species]increases abundance|increases reaction 17982097
D017382 Reactive Oxygen Species PTGS1 protein promotes the reaction [Receptors, IgG results in increased abundance of Reactive Oxygen Species]increases abundance|increases reaction 17982097
C052785 rebamipide rebamipide inhibits the reaction [Indomethacin results in increased expression of PTGS1 mRNA]decreases reaction|increases expression 18299717
C052785 rebamipide rebamipide results in increased expression of PTGS1 mRNAincreases expression 18299717
C059514 resveratrol resveratrol results in decreased activity of PTGS1 proteindecreases activity 15155531
C059514 resveratrol resveratrol results in decreased activity of PTGS1 proteindecreases activity 8985016
D015474 Isotretinoin Isotretinoin results in decreased expression of PTGS1 mRNAdecreases expression 15982314
C488333 Ro 65-7199 Ro 65-7199 affects the expression of PTGS1 mRNAaffects expression 14610520
C488334 Ro 66-0074 Ro 66-0074 affects the expression of PTGS1 mRNAaffects expression 14610520
C116926 rofecoxib rofecoxib analog results in decreased activity of PTGS1 proteindecreases activity 16141368
C116926 rofecoxib rofecoxib results in decreased activity of PTGS1 proteindecreases activity 16141368
C116926 rofecoxib rofecoxib results in decreased expression of PTGS1 mRNAdecreases expression 17175104
C115461 SC 560 SC 560 results in decreased activity of PTGS1 proteindecreases activity 16894348
14633654
C115461 SC 560 SC 560 results in decreased activity of PTGS1 proteindecreases activity 15718289
C115461 SC 560 SC 560 results in decreased activity of PTGS1 proteindecreases activity 12163478
C115461 SC 560 SC 560 results in decreased activity of PTGS1 proteindecreases activity 15964185
16391822
11250881
15379866
16699067
C404729 SC 58560 SC 58560 results in decreased activity of PTGS1 proteindecreases activity 10484518
C404729 SC 58560 [SC 58560 results in decreased activity of PTGS1 protein] which results in decreased chemical synthesis of Dinoprostonedecreases activity|decreases chemical synthesis 10484518
C404729 SC 58560 SC 58560 results in decreased activity of PTGS1 proteindecreases activity 10484518
D012906 Smoke Smoke results in decreased expression of PTGS1 mRNAdecreases expression 17255567
D013311 Streptozocin acetovanillone inhibits the reaction [Streptozocin results in increased expression of PTGS1 protein]decreases reaction|increases expression 18414395
D013311 Streptozocin Streptozocin results in increased expression of PTGS1 proteinincreases expression 18414395
D013467 Sulindac Sulindac results in decreased expression of PTGS1 mRNA alternative formdecreases expression 11375891
D013467 Sulindac Sulindac results in increased expression of PTGS1 mRNAincreases expression 12586211
C025462 sulindac sulfide sulindac sulfide results in decreased activity of PTGS1 proteindecreases activity 11245490
C025463 sulindac sulfone sulindac sulfone results in decreased expression of PTGS1 mRNA alternative formdecreases expression 11375891
C073135 tepoxalin tepoxalin results in decreased activity of PTGS1 proteindecreases activity 7775455
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of PTGS1 mRNAincreases expression 19403181
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PTGS1 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of PTGS1 mRNAincreases expression 16611356
17035482
D014212 Tretinoin Tretinoin metabolite results in decreased expression of PTGS1 mRNAdecreases expression 15982314
D014212 Tretinoin Tretinoin results in increased expression of PTGS1 mRNAincreases expression 16129123
D014212 Tretinoin Tretinoin results in increased expression of PTGS1 proteinincreases expression 16894348
D014520 Urethane Urethane results in increased expression of PTGS1 mRNAincreases expression 11497255
D014520 Urethane Urethane results in increased expression of PTGS1 proteinincreases expression 11497255
D014520 Urethane Urethane results in decreased expression of PTGS1 mRNAdecreases expression 11211925
C401835 valerylsalicylate valerylsalicylate results in decreased activity of PTGS1 proteindecreases activity 15700047
D002762 Cholecalciferol Cholecalciferol results in increased expression of PTGS1 mRNAincreases expression 17170073
C104536 xanthohumol xanthohumol results in decreased activity of PTGS1 proteindecreases activity 17590382
D015054 Zymosan PTGS1 protein promotes the reaction [[Zymosan co-treated with Lipopolysaccharides] results in increased metabolism of Prostaglandins]affects cotreatment|increases metabolic processing|increases reaction 16787386
D015054 Zymosan PTGS1 protein promotes the reaction [[Zymosan co-treated with Lipopolysaccharides] results in increased metabolism of Prostaglandins analog]affects cotreatment|increases metabolic processing|increases reaction 16787386
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Sulindac 4.4914745880
MESH:D000014 Abnormalities, Drug-Induced Isotretinoin 8.7318769834
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 8.736195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.7311752688 14514962 15322242
MESH:D000015 Abnormalities, Multiple Isotretinoin 4.0718769834
MESH:D000138 Acidosis Ammonium Chloride 2.5818287403
MESH:D017486 Acneiform Eruptions Isotretinoin 5.2716232082
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 8.6717505938
MESH:D000152 Acne Vulgaris Isotretinoin 8.6718769834 16185265
MESH:D058186 Acute Kidney Injury Cisplatin 21.8715814532 17670903 12690470
MESH:D058186 Acute Kidney Injury Diclofenac 21.877897758
MESH:D058186 Acute Kidney Injury Ibuprofen 21.876375363
MESH:D058186 Acute Kidney Injury Naproxen 21.877897758
MESH:D058186 Acute Kidney Injury resveratrol 21.8716538975
MESH:D058186 Acute Kidney Injury Sulindac 21.877897758
MESH:D055371 Acute Lung Injury Lipopolysaccharides 5.9918653653 11850527
MESH:D055371 Acute Lung Injury pirinixic acid 5.9918653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 27.2620127859 20464547
MESH:D000230 Adenocarcinoma Cisplatin 27.2611798837 17638652
MESH:D000230 Adenocarcinoma Doxorubicin 27.2617418594
MESH:D000230 Adenocarcinoma Estradiol 27.2611473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 27.2614692618
MESH:D000230 Adenocarcinoma Fenretinide 27.2610697514
MESH:D000230 Adenocarcinoma Ibuprofen 27.2610697514
MESH:D000230 Adenocarcinoma Indomethacin 27.2616537180
MESH:D000230 Adenocarcinoma Methylenebis(chloroaniline) 27.26512554
MESH:D000230 Adenocarcinoma Sulindac 27.2611910360
MESH:D000230 Adenocarcinoma Urethane 27.2618316556
MESH:D002282 Adenocarcinoma, Bronchiolo-Alveolar Urethane 4.7015814487
MESH:D000236 Adenoma Benzo(a)pyrene 25.336695378
MESH:D000236 Adenoma Diethylnitrosamine 25.336695378 10737359
MESH:D000236 Adenoma Indomethacin 25.3311497255
MESH:D000236 Adenoma Methylcholanthrene 25.336695378 10545420
MESH:D000236 Adenoma Methylenebis(chloroaniline) 25.33512554
MESH:D000236 Adenoma resveratrol 25.3315688382
MESH:D000236 Adenoma Sulindac 25.3310223192
MESH:D000236 Adenoma Urethane 25.3311497255 10822126 10530776 6695378 17093202 16926031 17195641
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 16.8516434500 19061943 18056438 19052882 17162532 17620307
MESH:D018248 Adenoma, Liver Cell Phenobarbital 16.8517620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 16.8516434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 16.8516835633
MESH:D011125 Adenomatous Polyposis Coli celecoxib 20.8619003578 16215675
MESH:D011125 Adenomatous Polyposis Coli Dinoprostone 20.8617942926
MESH:D011125 Adenomatous Polyposis Coli Flurbiprofen 20.8610680582
MESH:D011125 Adenomatous Polyposis Coli Sulindac 20.8611874996 19003578 12394442 15623613 11535846 16460482 17611924
MESH:D011125 Adenomatous Polyposis Coli sulindac sulfone 20.8616150858
MESH:D000419 Albuminuria Doxorubicin 3.5921441931
MESH:D000505 Alopecia Tretinoin 2.7915955085
MESH:D016301 Alveolar Bone Loss Indomethacin 4.3617225004
MESH:D000544 Alzheimer Disease Ibuprofen 10.9818351690
MESH:D000544 Alzheimer Disease Indomethacin 10.9815579461 17627676
MESH:D000544 Alzheimer Disease Ozone 10.9815513908
MESH:D000544 Alzheimer Disease Plant Extracts 10.9816962711
MESH:D000544 Alzheimer Disease resveratrol 10.9816183991 16162502
MESH:D000544 Alzheimer Disease sulindac sulfide 10.9818759972
MESH:D000707 Anaphylaxis Ibuprofen 4.289532969
MESH:D000740 Anemia Phenacetin 9.992444515
MESH:D000740 Anemia Tetrachlorodibenzodioxin 9.9911748828
MESH:D000740 Anemia Zymosan 9.9918664788
MESH:D000741 Anemia, Aplastic marker/mechanism 18575777
MESH:D000743 Anemia, Hemolytic Phenacetin 7.621949026 17698508 17082564
MESH:D000743 Anemia, Hemolytic Quercetin 7.6217084956
MESH:D000799 Angioedema Acetaminophen 8.7010982225
MESH:D000799 Angioedema Astemizole 8.702883202
MESH:D001014 Aortic Aneurysm Dinoprostone 9.0610231640
MESH:D001014 Aortic Aneurysm Indomethacin 9.0610231640
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 14.5519183758
MESH:D017544 Aortic Aneurysm, Abdominal Dinoprostone 14.5510388637
MESH:D017544 Aortic Aneurysm, Abdominal Indomethacin 14.5510388637
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 3.2417460149
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 2.5011256880
MESH:D018771 Arthralgia Indomethacin 4.162160914
MESH:D001169 Arthritis, Experimental Dexamethasone 23.8317659584
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 23.8315885639
MESH:D001169 Arthritis, Experimental Plant Extracts 23.8314686799
MESH:D001169 Arthritis, Experimental resveratrol 23.8317115116
MESH:D001169 Arthritis, Experimental rofecoxib 23.8316690336
MESH:D001169 Arthritis, Experimental Tretinoin 23.8316412693
MESH:D001169 Arthritis, Experimental Zymosan 23.8316872482 15188379 17659584 15944321 15142272
MESH:D001172 Arthritis, Rheumatoid Indomethacin 5.2511248219
MESH:D001172 Arthritis, Rheumatoid Ozone 5.2515570426
MESH:D001172 Arthritis, Rheumatoid Tretinoin 5.2516292516
MESH:D001249 Asthma Acetaldehyde 10.159600491
MESH:D001249 Asthma Budesonide 10.1518489783 15136378 10893010 12113382 12604023 15572850 20004779
MESH:D001249 Asthma Mustard Gas 10.1510378619
MESH:D001249 Asthma Ozone 10.1517854713 16373670
MESH:D001249 Asthma Tretinoin 10.1516456186
MESH:D055963 Asthma, Aspirin-Induced Aspirin 3.8512372130 20485159
MESH:D001260 Ataxia Telangiectasia Quercetin 3.9915336622
MESH:D050197 Atherosclerosis Methylcholanthrene 4.7011922910
MESH:D050197 Atherosclerosis resveratrol 4.7016873680 17967414
MESH:D001321 Autistic Disorder Acetaminophen 2.2318445737
MESH:D001321 Autistic Disorder Arachidonic Acid 2.2318582451
MESH:D001321 Autistic Disorder S-Adenosylmethionine 2.2316917939 19056591
MESH:D001327 Autoimmune Diseases Cholecalciferol 7.8616142846
MESH:D001327 Autoimmune Diseases Quercetin 7.8619761891
MESH:D001471 Barrett Esophagus Tretinoin 3.4516935849
MESH:D001477 Bartter Syndrome Dinoprostone 9.4815976003
MESH:D001477 Bartter Syndrome Indomethacin 9.4810684365
MESH:D001768 Blister Mustard Gas 4.1719167455
MESH:D001778 Blood Coagulation Disorders pirinixic acid 10.0619483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 10.0612125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 10.0616206674 16197459
MESH:D001836 Body Weight Changes 2-cresol 9.0712820538
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 9.0715340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.0415746008
MESH:D019046 Bone Marrow Neoplasms Cisplatin 8.7314601052
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 8.7314601052
MESH:D001862 Bone Resorption bisphenol A 2.9711985600
MESH:D001913 Bowen's Disease Sulindac 4.3511207687
MESH:D001919 Bradycardia Phenylephrine 3.5615306635
MESH:D001929 Brain Edema Indomethacin 4.0211481608
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 4.3317868700
MESH:D001930 Brain Injuries Progesterone 3.2915665606 15845082 15380490
MESH:D002545 Brain Ischemia Ibuprofen 21.4515837124
MESH:D002545 Brain Ischemia Indomethacin 21.4512524144
MESH:D002545 Brain Ischemia Morphine 21.4519211983
MESH:D002545 Brain Ischemia Plant Extracts 21.4516041641
MESH:D002545 Brain Ischemia resveratrol 21.4517600658
MESH:D001932 Brain Neoplasms Aspirin 9.7715481559
MESH:D001932 Brain Neoplasms Doxorubicin 9.7717150277
MESH:D001932 Brain Neoplasms Fenretinide 9.7716187019
MESH:D001943 Breast Neoplasms 2-amino-3-methylimidazo(4,5-f)quinoline 22.9417474063
MESH:D001943 Breast Neoplasms 4-biphenylamine 22.9417671175
MESH:D001943 Breast Neoplasms alitretinoin 22.9416344269
MESH:D001943 Breast Neoplasms Aspirin 22.9415161893
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 22.9417474063 20146248
MESH:D001943 Breast Neoplasms bisphenol A 22.9417123778
MESH:D001943 Breast Neoplasms Calcitriol 22.9411237771
MESH:D001943 Breast Neoplasms Cisplatin 22.9419526202 18382427
MESH:D001943 Breast Neoplasms Diethylnitrosamine 22.9417474063
MESH:D001943 Breast Neoplasms Doxorubicin 22.9418234424 15567936 16264153 15993339 18628466 15668708 16096432 16826403 18695136 17426702 15939500 15136595 19526202 16322301 15994142 17369602 16595493 16115903 18382427 17983394 16935488 11325840 15634643 15692762
MESH:D001943 Breast Neoplasms Estradiol 22.9417289903 16675129 17261762 14630087 18497071 19861407 17018787 12948864
MESH:D001943 Breast Neoplasms estrone sulfate 22.9417261762
MESH:D001943 Breast Neoplasms Fenretinide 22.9416601279
MESH:D001943 Breast Neoplasms gemcitabine 22.9417039268 18382427
MESH:D001943 Breast Neoplasms Indomethacin 22.9417401462
MESH:D001943 Breast Neoplasms Methylcholanthrene 22.9417474063
MESH:D001943 Breast Neoplasms Methylenebis(chloroaniline) 22.94512554
MESH:D001943 Breast Neoplasms Progesterone 22.9416175315 15562024 17614352
MESH:D001943 Breast Neoplasms Quercetin 22.9418628248
MESH:D001943 Breast Neoplasms resveratrol 22.9416393696 17651959 17534123
MESH:D001943 Breast Neoplasms Sulindac 22.9416642371
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 22.9420435547
MESH:D001943 Breast Neoplasms Tretinoin 22.9416873071 16166294 16443354
MESH:D016535 Bronchial Hyperreactivity Ozone 2.8616777450 19059883 15516495 17626835 18315731 14754758 18417511
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 4.1715286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 3.9717687719 10378619
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 3.6016813970
MESH:D002056 Burns Indomethacin 3.7410459503
MESH:D002057 Burns, Chemical Plant Extracts 4.339625245
MESH:D002100 Cachexia Ibuprofen 15.4615141370
MESH:D002100 Cachexia Indomethacin 15.4615141370 15625704 11239499 16537180
MESH:D002100 Cachexia Ozone 15.4616183385
MESH:D002105 Cadmium Poisoning Quercetin 4.5416962696
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 3.4716111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 2.823786805 16227642 16192424 15721981 16011737 18705752 10355542 15700767 16050911 15673190 16124888 16097048
MESH:D002276 Carcinoid Tumor Doxorubicin 9.3616051944
MESH:D002276 Carcinoid Tumor Streptozocin 9.3616051944
MESH:D002277 Carcinoma Methylcholanthrene 9.4710545420
MESH:D002277 Carcinoma Methylenebis(chloroaniline) 9.47512554
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 9.4716835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.1516168501
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 29.803084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 29.8018788625
MESH:D006528 Carcinoma, Hepatocellular Cisplatin 29.8017982673
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 29.8019701751 20512989 16830150 20727157 20524982 16935385 16540662 17761372 17138121 16878318 16779866 18210153 18665156 18788625 20935162 18978308 16288022 17162532 10737359 16502159 19171122 20514400 17428255 19208518 20432363 19052882 18506893 18393292 17173139 19919837 20007298 19107877 18056438 16569478 19822196 10672840 11831363 20214788 3581430 20101231 19394651 16328049 19335982 17055752 18971187 19383236 19539802 18494052 20084675 3084413 16698587 17978847 21159647 19519916 16807293 16681979 18785209 19418558 18691550
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 29.8018059187 16234567 16023760 17876044
MESH:D006528 Carcinoma, Hepatocellular Estradiol 29.8016924424
MESH:D006528 Carcinoma, Hepatocellular Fenretinide 29.8017159502 16270382
MESH:D006528 Carcinoma, Hepatocellular Indomethacin 29.8016391822
MESH:D006528 Carcinoma, Hepatocellular nimesulide 29.8016391822
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 29.8020935162 6705139 17173139 20007298 1701930
MESH:D006528 Carcinoma, Hepatocellular Plant Extracts 29.8018834353
MESH:D006528 Carcinoma, Hepatocellular Quercetin 29.8019519916 12508355
MESH:D006528 Carcinoma, Hepatocellular resveratrol 29.8019321006 16227395
MESH:D006528 Carcinoma, Hepatocellular SC 560 29.8016391822
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 29.801917145
MESH:D002278 Carcinoma in Situ bisphenol A 4.0017123778
MESH:D018827 Carcinoma, Lewis Lung Indomethacin 8.1511053908
MESH:D018827 Carcinoma, Lewis Lung resveratrol 8.1516675471
MESH:D018276 Carcinoma, Medullary Indomethacin 4.3614736730 11352223 18791128
MESH:D002289 Carcinoma, Non-Small-Cell Lung Cisplatin 6.4212023789 16685392
MESH:D002289 Carcinoma, Non-Small-Cell Lung sulindac sulfide 6.4212391285
MESH:D002289 Carcinoma, Non-Small-Cell Lung sulindac sulfone 6.4218758305
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 3.9817234771
MESH:D002291 Carcinoma, Papillary Methylenebis(chloroaniline) 5.91722185
MESH:D002292 Carcinoma, Renal Cell celecoxib 7.5716369983
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 7.5716201981 1485588
MESH:D002292 Carcinoma, Renal Cell Indomethacin 7.5717341418
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 24.7420419170
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 24.7411237771
MESH:D002294 Carcinoma, Squamous Cell Cisplatin 24.746189445 17066447 18337622
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 24.746189445
MESH:D002294 Carcinoma, Squamous Cell Fenretinide 24.7416274795
MESH:D002294 Carcinoma, Squamous Cell Indomethacin 24.7415482327 12636206
MESH:D002294 Carcinoma, Squamous Cell Isotretinoin 24.7411237771
MESH:D002294 Carcinoma, Squamous Cell nimesulide 24.7415482327
MESH:D002294 Carcinoma, Squamous Cell resveratrol 24.7416227395
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 24.7416051514 16096774
MESH:D006332 Cardiomegaly Phenylephrine 10.9315728586 11754973 17124262 16170337 11179087 17287366
MESH:D006332 Cardiomegaly Plant Extracts 10.9317645561
MESH:D006332 Cardiomegaly Quercetin 10.9319794523
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 10.9318670907 16120746 18850075
MESH:D009202 Cardiomyopathies Doxorubicin 2.8116278810 17329180 17007740 16364871 16242529 17131338 16952015 16612575 18627295 15476868 16651473 17519947 17928571 16269455 15792986 16731534 17382496 16109756 17351982 15505089 17974986 17308081 15811867 16455267 17924179
MESH:D002310 Cardiomyopathy, Alcoholic Acetaldehyde 5.4710525098
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.4916243910 17334414
MESH:D002318 Cardiovascular Diseases 4-cresol 8.1720430946
MESH:D002318 Cardiovascular Diseases Hydrogen Peroxide 8.1716936243
MESH:D002318 Cardiovascular Diseases resveratrol 8.1715458977
MESH:D002386 Cataract Acetaminophen 4.9410977129
MESH:D002386 Cataract Tretinoin 4.9417460283
MESH:D002471 Cell Transformation, Neoplastic 4-biphenylamine 16.6915746073
MESH:D002471 Cell Transformation, Neoplastic Azoxymethane 16.6915705887 18075178
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 16.6921159647 7505956 17174075 2727394
MESH:D002471 Cell Transformation, Neoplastic Dinoprostone 16.6916192471
MESH:D002471 Cell Transformation, Neoplastic Estradiol 16.6918566989
MESH:D002471 Cell Transformation, Neoplastic Methylcholanthrene 16.6916192471
MESH:D002493 Central Nervous System Diseases Phenobarbital 3.284080065
MESH:D018290 Cervical Intraepithelial Neoplasia Fenretinide 9.7016154183
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 9.7016129372
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 6.4419052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 6.4416835633
MESH:D002764 Cholecystitis Indomethacin 4.1611181007
MESH:D002779 Cholestasis Ethinyl Estradiol 5.1115861022 16919318 17681005 17110522 16105132 11677210 17333356
MESH:D002779 Cholestasis pirinixic acid 5.1119176532
MESH:D002822 Choriocarcinoma Tretinoin 4.1516461808
MESH:D043171 Chromosomal Instability 4-biphenylamine 6.0017671175
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 6.7015668235 16354765 8697196 12621046 15340226
MESH:D002972 Cleft Palate Tretinoin 6.709407595
MESH:D002972 Cleft Palate Urethane 6.7012810352
MESH:D003092 Colitis resveratrol 6.4416474422
MESH:D003092 Colitis Tretinoin 6.4417035595
MESH:D003110 Colonic Neoplasms 2-amino-3-methylimidazo(4,5-f)quinoline 23.1516353153
MESH:D003110 Colonic Neoplasms Aspirin 23.1512411196
MESH:D003110 Colonic Neoplasms Azoxymethane 23.1516818512 12189186 14668109 16293270 15824018 19056647 15705887
MESH:D003110 Colonic Neoplasms celecoxib 23.1516004971
MESH:D003110 Colonic Neoplasms Dexamethasone 23.1515824018
MESH:D003110 Colonic Neoplasms Indomethacin 23.1511260862 15625704 15963497 15936596 15637740 15786552
MESH:D003110 Colonic Neoplasms Piroxicam 23.1515824018
MESH:D003110 Colonic Neoplasms Quercetin 23.1519056647 15741050 11134977 16640504 17191121 17148506 19440933
MESH:D003110 Colonic Neoplasms resveratrol 23.1516338953
MESH:D003110 Colonic Neoplasms rofecoxib 23.1512902858
MESH:D003110 Colonic Neoplasms Sulindac 23.1512902858 12458338
MESH:D015179 Colorectal Neoplasms 4-biphenylamine 19.7517671175
MESH:D015179 Colorectal Neoplasms Aspirin 19.7517047198
MESH:D015179 Colorectal Neoplasms Azoxymethane 19.7511076880 10416599
MESH:D015179 Colorectal Neoplasms celecoxib 19.7511197048 18349538
MESH:D015179 Colorectal Neoplasms Cisplatin 19.7515273666
MESH:D015179 Colorectal Neoplasms Doxorubicin 19.7518259882 18802399
MESH:D015179 Colorectal Neoplasms Fenretinide 19.7517273769
MESH:D015179 Colorectal Neoplasms Indomethacin 19.7511197048 17054584 18059344 12606626
MESH:D015179 Colorectal Neoplasms nimesulide 19.7518349538
MESH:D015179 Colorectal Neoplasms Quercetin 19.7518095365 18852136
MESH:D015179 Colorectal Neoplasms resveratrol 19.7516550006
MESH:D015179 Colorectal Neoplasms Sulindac 19.7510666051 11197048 18059344 11076880
MESH:D015179 Colorectal Neoplasms sulindac sulfone 19.7510666051 10416599 18059344 11197048
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.2017141729 14669216
MESH:D003327 Coronary Disease resveratrol 3.0316507316
MESH:D018352 Coronavirus Infections Indomethacin 4.7117302372
MESH:D019465 Craniofacial Abnormalities Dexamethasone 6.7117728286
MESH:D019465 Craniofacial Abnormalities Isotretinoin 6.7118769834 9879862
MESH:D019465 Craniofacial Abnormalities nitrofen 6.7111405365
MESH:D019465 Craniofacial Abnormalities Reactive Oxygen Species 6.7115736158
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 6.7120055451 10048152 15322242
MESH:D019465 Craniofacial Abnormalities Tretinoin 6.719125849 10589399 16925845 9664655 9211117 14991402 9142499 17551590 9224671 8800419
MESH:D017449 Dermatitis, Allergic Contact 4-phenylenediamine 4.6816533241 19470301 18759875 16823706 11298694 11906362
MESH:D017449 Dermatitis, Allergic Contact Dexamethasone 4.6812438553
MESH:D003876 Dermatitis, Atopic pirinixic acid 1.8518249437
MESH:D003877 Dermatitis, Contact 4-phenylenediamine 4.4211531941
MESH:D003920 Diabetes Mellitus Streptozocin 3.8716285004
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 9.2419496084
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 9.2416873680
MESH:D003921 Diabetes Mellitus, Experimental Streptozocin 9.2416684804 15831366 19960420 11260395 7637645 12083368 15862027 12093613 18603373 1374869 12644472 11055810 6379147 16286809 15298345 17874149 12446591 19586609 19496084 18715473 19298542 17442507 2177838 8740154
MESH:D003922 Diabetes Mellitus, Type 1 Streptozocin 3.2218603373
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.9620387270
MESH:D003924 Diabetes Mellitus, Type 2 Streptozocin 4.9619647726 19586609
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.9617107852
MESH:D058065 Diabetic Cardiomyopathies Streptozocin 4.7316025228
MESH:D003928 Diabetic Nephropathies Estradiol 14.4719279558
MESH:D003928 Diabetic Nephropathies Plant Extracts 14.4719706694
MESH:D003928 Diabetic Nephropathies resveratrol 14.4716286809
MESH:D003928 Diabetic Nephropathies Streptozocin 14.4719682444 19960420
MESH:D003929 Diabetic Neuropathies Progesterone 3.5217187935
MESH:D003930 Diabetic Retinopathy Streptozocin 9.1117662242
MESH:D003930 Diabetic Retinopathy Sulindac 9.1112861449 17621415
MESH:D003967 Diarrhea Dexamethasone 11.447237001
MESH:D003967 Diarrhea Dinoprostone 11.4411488427 7237001 10446763
MESH:D003967 Diarrhea Indomethacin 11.447907874 7237001
MESH:D003967 Diarrhea Morphine 11.442540324
MESH:D004244 Dizziness Astemizole 5.463105558
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 7.3517906064 12705907 16109766 11529661 11834606 11739529 15619225 10915739 11461765 19370779 16781746 12153990 19085960 12540782 15968718 10663392 12958197 16485898 17522070 10774834 16177239 18071297 19923254 11287661 16227642 17562736 19739265 14550746 12594235 18713872 14986274 11743745 19164858 16393943 16081117 12392966 14725611 19420014 11421492 2444490 19416960
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 7.357120509 2869522 15998439 15027814 19336974 4309450 3786805 6884620 3732212 10915739 16227642 7179309 19085960 21278145 11566570 9327722 6623471 15968718 7440962 10092053 16177239 17522070
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 7.3519107877
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 7.3517416283
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 7.3520420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.0919426721
MESH:D004362 Drug Toxicity Cisplatin 9.1819839026 12231392 15033597 12649298
MESH:D004362 Drug Toxicity Doxorubicin 9.1818602426
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 9.1811462148
MESH:D004374 Ductus Arteriosus, Patent Ibuprofen 9.9518450898 18446180 16133044
MESH:D004374 Ductus Arteriosus, Patent Indomethacin 9.9516133044 18446180 17190690 12774134 18043480 16326151
MESH:D004381 Duodenal Ulcer Indomethacin 3.2111535926 11991626 17329845 11595431 17351913 17202747 17151854 17045617 10671773 11595415 16699067
MESH:D050171 Dyslipidemias Fenofibrate 3.6516707586
MESH:D004417 Dyspnea Budesonide 7.7520016425
MESH:D004417 Dyspnea Furosemide 7.7516935035
MESH:D004421 Dystonia Phenobarbital 3.081851702
MESH:D004485 Eczema Dexamethasone 3.5112438553
MESH:D004487 Edema Arachidonic Acid 43.0015177302 9831321 7990266 9599246 11698051 16716910
MESH:D004487 Edema Aspirin 43.0017259670
MESH:D004487 Edema Dexamethasone 43.0019703484
MESH:D004487 Edema Diclofenac 43.0016273134
MESH:D004487 Edema Furosemide 43.0011834646
MESH:D004487 Edema Indomethacin 43.0016100529 8985016 7907874 10653021 19703484 8273558 7990266
MESH:D004487 Edema Mustard Gas 43.0011402378 11428647 9260866 11428631
MESH:D004487 Edema pirinixic acid 43.0012083418
MESH:D004487 Edema Piroxicam 43.007907874
MESH:D004487 Edema Plant Extracts 43.0012787963
MESH:D004487 Edema resveratrol 43.008985016
MESH:D004487 Edema Tetrachlorodibenzodioxin 43.0011000095 12711302
MESH:D004487 Edema Zymosan 43.007907874
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 8.6115322242 16714409 18230668
MESH:D004489 Edema, Cardiac Tretinoin 8.6118230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental 15-deoxy-delta(12,14)-prostaglandin J2 18.8916844232
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 18.8915138306
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 18.8912538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 18.8917692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 18.8917872969
MESH:D016889 Endometrial Neoplasms Doxorubicin 11.8217359293
MESH:D016889 Endometrial Neoplasms Estradiol 11.8211473722 18566989 19148513
MESH:D016889 Endometrial Neoplasms Fenofibrate 11.8216569247
MESH:D016889 Endometrial Neoplasms Tretinoin 11.8216569247
MESH:D004715 Endometriosis celecoxib 40.4815652904
MESH:D004715 Endometriosis Ibuprofen 40.4815652904
MESH:D004715 Endometriosis Indomethacin 40.4815652904
MESH:D004715 Endometriosis Mifepristone 40.4816134523
MESH:D004715 Endometriosis Naproxen 40.4815652904
MESH:D004715 Endometriosis Progesterone 40.4816134523
MESH:D004715 Endometriosis rofecoxib 40.4815652904
MESH:D004715 Endometriosis Sulindac 40.4815652904
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 40.489294722 10568697
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 10.7218037988
MESH:D004719 Endomyocardial Fibrosis Plant Extracts 10.7215268973
MESH:D019446 Endotoxemia Ibuprofen 17.0911545620
MESH:D019446 Endotoxemia Indomethacin 17.0918509659
MESH:D019446 Endotoxemia lipopolysaccharide, Escherichia coli 0111 B4 17.0912954792
MESH:D019446 Endotoxemia Lipopolysaccharides 17.0915328337 15821434 17637181
MESH:D004751 Enteritis Indomethacin 3.7416328016 10567023 17763956
MESH:D020345 Enterocolitis, Necrotizing Indomethacin 9.1617980183
MESH:D020345 Enterocolitis, Necrotizing resveratrol 9.1617923197
MESH:D004802 Eosinophilia Astemizole 6.281355641
MESH:D004802 Eosinophilia Indomethacin 6.2811298111
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 3.143659116
MESH:D004828 Epilepsies, Partial Phenobarbital 2.8811558140 3922381
MESH:D004827 Epilepsy Phenobarbital 4.8720417680
MESH:D004827 Epilepsy Plant Extracts 4.8719439326 19700373
MESH:D004832 Epilepsy, Absence Phenobarbital 2.696401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 3.287750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 3.043659116
MESH:D004890 Erythema Mustard Gas 4.179357497
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.1116302075
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 12.1816530937
MESH:D004938 Esophageal Neoplasms Cisplatin 12.1816785472 16481741 15464296 17638652 15173087
MESH:D004938 Esophageal Neoplasms Indomethacin 12.1811005569
MESH:D004938 Esophageal Neoplasms nitrosobenzylmethylamine 12.1815878914 16805852 15547721 15623463 16510608 15150132 15264214 16704527 15547733
MESH:D004938 Esophageal Neoplasms Piroxicam 12.1815878914
MESH:D004938 Esophageal Neoplasms Sulindac 12.1812235107
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 6.1711564622
MESH:D005124 Eye Abnormalities Tretinoin 6.1716938888 9664655
MESH:D005128 Eye Diseases Ketorolac 6.0811084241
MESH:D005234 Fatty Liver Carbon Tetrachloride 15.2517595544 19224547 16239168 12631006 16045604 12795759 15959796 61145
MESH:D005234 Fatty Liver Diethylnitrosamine 15.2521071580 20387270
MESH:D005234 Fatty Liver Ethinyl Estradiol 15.2515345470
MESH:D005234 Fatty Liver pirinixic acid 15.2520131406 19236843
MESH:D005234 Fatty Liver Plant Extracts 15.2515975614
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 2.4911858732
MESH:D005334 Fever Arachidonic Acid 29.0211852909
MESH:D005334 Fever Dinoprostone 29.0216997862 11852909
MESH:D005334 Fever Dipyrone 29.0211852909
MESH:D005334 Fever Ibuprofen 29.0216997862
MESH:D005334 Fever Indomethacin 29.0210431976 11852909 17627676
MESH:D005334 Fever lipopolysaccharide, Escherichia coli 0111 B4 29.0216997862
MESH:D005334 Fever Lipopolysaccharides 29.0211852909 9205823
MESH:D018221 Fibromatosis, Abdominal Sulindac 4.4914745880
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 8.5219069698
MESH:D018222 Fibromatosis, Aggressive Sulindac 8.5219069698
MESH:D005354 Fibrosarcoma Indomethacin 8.8210962813
MESH:D005354 Fibrosarcoma Methylcholanthrene 8.8214633661 10962813
MESH:D005355 Fibrosis Carbon Tetrachloride 17.6918705752
MESH:D005355 Fibrosis Indomethacin 17.6917994277
MESH:D005355 Fibrosis Quercetin 17.6919474275
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 17.6920067830
MESH:D005355 Fibrosis Tretinoin 17.6917994277
MESH:D005499 Folliculitis Astemizole 10.071671328
MESH:D005499 Folliculitis Indomethacin 10.0711298111
MESH:D005739 Gas Poisoning Budesonide 4.9220016425
MESH:D005756 Gastritis Acetaminophen 7.8216983495
MESH:D005756 Gastritis Indomethacin 7.8215046732
MESH:D005764 Gastroesophageal Reflux Sulindac 4.0611910360
MESH:D005909 Glioblastoma Aspirin 18.3612870263
MESH:D005909 Glioblastoma Doxorubicin 18.3617150277
MESH:D005909 Glioblastoma Fenretinide 18.3616187019
MESH:D005909 Glioblastoma Indomethacin 18.3612870263
MESH:D005909 Glioblastoma Quercetin 18.3619804834
MESH:D005909 Glioblastoma Tretinoin 18.3617312396
MESH:D005910 Glioma Indomethacin 4.5518371953 16487511
MESH:D005910 Glioma Quercetin 4.5517643826
MESH:D005923 Glomerulosclerosis, Focal Segmental Indomethacin 3.4511849393
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 3.5810696789
MESH:D006073 Gout Indomethacin 4.3611248219
MESH:D006261 Headache Aspirin 3.9615240983
MESH:D006258 Head and Neck Neoplasms Cisplatin 16.3515102660 15464296
MESH:D006258 Head and Neck Neoplasms Doxorubicin 16.3515692506
MESH:D006258 Head and Neck Neoplasms Indomethacin 16.3515482327
MESH:D006258 Head and Neck Neoplasms nimesulide 16.3515482327
MESH:D006258 Head and Neck Neoplasms Tretinoin 16.3516096774
MESH:D034381 Hearing Loss Cisplatin 7.3819898482
MESH:D034381 Hearing Loss Furosemide 7.3817868369
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.1516084493
MESH:D006319 Hearing Loss, Sensorineural Cisplatin 3.5615464296
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 10.7520471113
MESH:D006330 Heart Defects, Congenital nitrofen 10.7516080930
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 10.7510048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 10.7514991402 9664655
MESH:D006331 Heart Diseases Doxorubicin 8.5916879835 17888722 18674790 12587719 18006777 16495754 16707910 16244371 14766674 16144979 16244372 16330681 17875725
MESH:D006331 Heart Diseases Streptozocin 8.5912093613
MESH:D006331 Heart Diseases Urethane 8.5916046796
MESH:D006333 Heart Failure Doxorubicin 11.1617481944
MESH:D006333 Heart Failure Furosemide 11.1616011733 12660669 16845234
MESH:D006333 Heart Failure pirinixic acid 11.1620558911
MESH:D006333 Heart Failure Plant Extracts 11.1618097624
MESH:D006394 Hemangiosarcoma Doxorubicin 6.8815692506
MESH:D006394 Hemangiosarcoma Methylenebis(chloroaniline) 6.88512554
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 3.5016366002
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.4311000095
MESH:D006501 Hepatic Encephalopathy Indomethacin 3.6615633222
MESH:D006505 Hepatitis Carbon Tetrachloride 6.5419110552 19900420
MESH:D006505 Hepatitis Zymosan 6.5419110552
MESH:D019698 Hepatitis C, Chronic Indomethacin 3.7315135802
MESH:D006521 Hepatitis, Chronic Diclofenac 4.6714986274
MESH:D006529 Hepatomegaly Phenobarbital 8.8716109766
MESH:D006529 Hepatomegaly pirinixic acid 8.8719176532 18467677 19772884 16221962
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.8712621046 15340226 16120746
MESH:D006548 Hernia, Diaphragmatic Dexamethasone 4.807520565
MESH:D006548 Hernia, Diaphragmatic nitrofen 4.807760232 9575882 15578192 12746050 12407540 18958481 11057544 10370017 15756563 17270546 15136996 11409163 10370016 9476886 15793718 18280291 12194112 12759764 16490937 10541330 12547725 10359170 11329586 7520565 18280292 17618886 11584395 12904592 8863223 15707848 10693666 9473106 11076806 11685700 9859898 15764645 12021965 16292651 12505043 7576705 11588001 11051153 16080930 9698600 15185205 10898222 15088113 10646786 16473863 10898224 17245593 16863852 16720372
MESH:D006558 Herpes Genitalis Estradiol 4.0215709030
MESH:D006561 Herpes Simplex Flupenthixol 11.161682908
MESH:D006561 Herpes Simplex Plant Extracts 11.1610715843
MESH:D006561 Herpes Simplex resveratrol 11.1616876885
MESH:D015658 HIV Infections Plant Extracts 3.0812878215
MESH:D006689 Hodgkin Disease Cisplatin 4.8416200630 16170182
MESH:D006689 Hodgkin Disease Doxorubicin 4.8417606976 18501091 15147373
MESH:D019584 Hot Flashes Estradiol 7.0217088409
MESH:D019584 Hot Flashes Plant Extracts 7.0217454163 16566672 14716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.0418606429 15340226 16959395 16354765 8697196
MESH:D012001 Hyperacusis Aspirin 4.7515240983
MESH:D006930 Hyperalgesia 4-(nitroxy)butanoic acid 4-acetylaminophenyl ester 15.8816870215
MESH:D006930 Hyperalgesia Acetaminophen 15.8816870215
MESH:D006930 Hyperalgesia Dinoprostone 15.8816793879
MESH:D006930 Hyperalgesia Indomethacin 15.8812727271
MESH:D006930 Hyperalgesia Tretinoin 15.8816870215
MESH:D034321 Hyperamylasemia Indomethacin 4.7117883296
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 3.5416899240
MESH:D006934 Hypercalcemia Furosemide 4.1617652376
MESH:D053565 Hypercalciuria Furosemide 4.6617652376
MESH:D006937 Hypercholesterolemia resveratrol 3.1117188708
MESH:D006940 Hyperemia Indomethacin 4.0212524144
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 3.6016778211
MESH:D006943 Hyperglycemia pirinixic acid 6.3120558911
MESH:D006943 Hyperglycemia Quercetin 6.3111834736 18262572
MESH:D020138 Hyperhomocysteinemia Plant Extracts 3.6016484555
MESH:D006949 Hyperlipidemias Indomethacin 10.3217546600
MESH:D006949 Hyperlipidemias Plant Extracts 10.3215975614 15268973
MESH:D006949 Hyperlipidemias resveratrol 10.3216873680
MESH:D006962 Hyperparathyroidism, Secondary Furosemide 4.8715086907
MESH:D006967 Hypersensitivity Butylated Hydroxytoluene 3.6417604070
MESH:D006973 Hypertension Dexamethasone 8.1417042910
MESH:D006973 Hypertension Phenylephrine 8.1412717712 8949925
MESH:D006973 Hypertension Quercetin 8.1418356687
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 8.1418850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.1215338365
MESH:D046110 Hypertension, Pregnancy-Induced Furosemide 4.3216612254
MESH:D006984 Hypertrophy Ibuprofen 7.9116672835
MESH:D006984 Hypertrophy Phenylephrine 7.9118502941 12791704
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 3.4117488730
MESH:C537153 Hypomagnesemia primary Furosemide 4.6611041285
MESH:D007019 Hypoproteinemia Furosemide 4.8716096441
MESH:D007021 Hypospadias Ethinyl Estradiol 2.8416569931 16945680
MESH:D007022 Hypotension Furosemide 3.7111041285
MESH:D007024 Hypotension, Orthostatic Furosemide 4.4115811171
MESH:D007077 Ileal Diseases Indomethacin 4.0218306037 10574470
MESH:D007079 Ileitis Indomethacin 4.3616133968 10651667 10647630
MESH:D007235 Infant, Premature, Diseases Ibuprofen 10.8616133044
MESH:D007235 Infant, Premature, Diseases Indomethacin 10.8616133044
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 8.2715869954
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 8.2717600658
MESH:D007247 Infertility, Female Ethinyl Estradiol 2.5412013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 1.7917937319
MESH:D007249 Inflammation Arachidonic Acid 56.8615177302 9831321 17371808
MESH:D007249 Inflammation Bupivacaine 56.8618165598
MESH:D007249 Inflammation Dexamethasone 56.8611099482 8960868
MESH:D007249 Inflammation Diclofenac 56.8616273134
MESH:D007249 Inflammation Diethylnitrosamine 56.8618785209
MESH:D007249 Inflammation Flavonoids 56.8617296493
MESH:D007249 Inflammation Flurbiprofen 56.8611099482
MESH:D007249 Inflammation Ibuprofen 56.863291741
MESH:D007249 Inflammation Indomethacin 56.8612568917 3291741 7812673
MESH:D007249 Inflammation Lipopolysaccharides 56.8612878042 17963957 17255318 9205823 17237260
MESH:D007249 Inflammation Mustard Gas 56.8617524151 9357497 8975870 11428631 9260866 11428647 11428620 16001271 11402378
MESH:D007249 Inflammation Naproxen 56.863291741
MESH:D007249 Inflammation nimesulide 56.8611438310
MESH:D007249 Inflammation Plant Extracts 56.8615997105 12787963 19332304 16366677
MESH:D007249 Inflammation Progesterone 56.8615869954
MESH:D007249 Inflammation resveratrol 56.8616366677
MESH:D007249 Inflammation Sulindac 56.863291741
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 56.8612200463 12878042
MESH:D007249 Inflammation Zymosan 56.868014878 11289658
MESH:D007251 Influenza, Human Quercetin 7.8716624496
MESH:D007251 Influenza, Human resveratrol 7.8716624496
MESH:D007333 Insulin Resistance bisphenol A 8.0716393666
MESH:D007333 Insulin Resistance Estradiol 8.0716393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 8.0716306350
MESH:D007410 Intestinal Diseases Indomethacin 15.6717994277 15831440 18236018 11686837 15610444 17329856 10210152 11855677 11713966
MESH:D007410 Intestinal Diseases rebamipide 15.6711686837
MESH:D007410 Intestinal Diseases rofecoxib 15.6715831440
MESH:D007410 Intestinal Diseases Tretinoin 15.6717994277
MESH:D007414 Intestinal Neoplasms Piroxicam 11.6310213222
MESH:D007414 Intestinal Neoplasms Plant Extracts 11.6312584176 12351151 12628509
MESH:D007414 Intestinal Neoplasms Sulindac 11.6312663524 12351151 12584176 10223192 12628509 10213222
MESH:D007417 Intestinal Polyps marker/mechanism 10753194
MESH:D007417 Intestinal Polyps rofecoxib 8.5511245490
MESH:D007417 Intestinal Polyps Sulindac 8.5512394442 11245490
MESH:D002532 Intracranial Aneurysm Reactive Oxygen Species 4.1219381132
MESH:D019586 Intracranial Hypertension Indomethacin 4.3615241188
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 3.7017255318
MESH:D043183 Irritable Bowel Syndrome Zymosan 4.8517553498
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 6.9216580747
MESH:D007569 Jaw Abnormalities Tretinoin 6.9215992940 17551590
MESH:D007579 Jejunal Diseases Indomethacin 4.0210574470 16133968 18306037
MESH:D007627 Keloid Quercetin 3.9817086741
MESH:D017492 Keratosis, Seborrheic alitretinoin 4.6516144296
MESH:D007673 Kidney Cortex Necrosis Cisplatin 4.1315464296
MESH:D007674 Kidney Diseases Acetaminophen 22.1315629191 12587719
MESH:D007674 Kidney Diseases Cisplatin 22.1319839026 12649298 12231392 18289764 15190930
MESH:D007674 Kidney Diseases Doxorubicin 22.1315369732 15699352 16775033
MESH:D007674 Kidney Diseases Estradiol 22.1315618244
MESH:D007674 Kidney Diseases Furosemide 22.1311041285
MESH:D007674 Kidney Diseases Indomethacin 22.1317190690
MESH:D007674 Kidney Diseases Quercetin 22.1316962696
MESH:D007674 Kidney Diseases Streptozocin 22.1312093613
MESH:D007676 Kidney Failure, Chronic Doxorubicin 7.1216707910
MESH:D007676 Kidney Failure, Chronic Hydrogen Peroxide 7.1216518626
MESH:D007680 Kidney Neoplasms Estradiol 2.1815610895
MESH:D007683 Kidney Tubular Necrosis, Acute Calcium 8.5616316344
MESH:D007683 Kidney Tubular Necrosis, Acute Cisplatin 8.5611231351
MESH:D016773 Leishmaniasis, Cutaneous Indomethacin 3.0812228301 11703811 10320625
MESH:D007938 Leukemia Quercetin 4.4217468513
MESH:D007938 Leukemia Tretinoin 4.4217143497
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 4.1516085563
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Indomethacin 3.1410785260 16572323 15631656
MESH:D007951 Leukemia, Myeloid Tretinoin 2.8019285840 16482212 16932348
MESH:D015470 Leukemia, Myeloid, Acute Indomethacin 3.0818360721
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 3.0817596541 19850784 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 5.3316087638
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 5.3319642359 16788101 17361223 16140955 17368321 17506722 16331271 17217047 19035177 19225113 16891316 17294898 9834237 17649720 15748426 16823087 17712046 19029980 17339181 17301526 19075265 12679006 17107899 16935935 16766008
MESH:D007964 Leukocytosis Indomethacin 4.3616537180
MESH:D007969 Leukomalacia, Periventricular Indomethacin 4.7117980183
MESH:D007970 Leukopenia Lipopolysaccharides 3.7115821434
MESH:D007972 Leukoplakia, Oral Fenretinide 5.0316707609
MESH:D017513 Lichen Nitidus Astemizole 5.462563723
MESH:D017880 Limb Deformities, Congenital Tretinoin 2.549224671
MESH:D008101 Liver Abscess, Amebic Indomethacin 4.7111479899
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 10.3816221502 16943688 21278145 11903743 17334410 17174718 11408273 16239168 17157831
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 10.3818522880 19638242 18665156 20032147 18407596
MESH:D008103 Liver Cirrhosis Phenobarbital 10.3821047994
MESH:D008103 Liver Cirrhosis Plant Extracts 10.3817157831
MESH:D008105 Liver Cirrhosis, Biliary Sulindac 3.5112468960
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 24.1812649538 16027843 17640975 17721639 12445421 18395914 18481824 18279442 18472094 12632514 18166357 10355542 16638106 16015684 15876570 15123356 17922224 18412020 20821823 18339082 15650968 17823541 18418968 14716496 11481614 18429990 17976157 17557913 18395095 18251166 16011737 12666154 17525996 15673190 12586293 18376398 17900296 15730626 18277467 15370692 15052691 15818738 12667390 12741479 14724832 12445418 18263696 17805973 17481882 14512876 16097048 14620537 18156304 17708605 18472332 17698563 18420326 15362042 15996030 18006644 16192424 18205269 12632512 16248980 17631135 17714472 12958196 18210741 16033810 15338365 17565644 12389079 18187930 18054572 17869086 12898905 13678700 12546737 16136751 15925388 16116963 17761835 18705752 15057751 12609069 18317297 17766677 17944888 15931870 14748882 15893842 15959796 14716833
MESH:D008106 Liver Cirrhosis, Experimental Dexamethasone 24.1816718785
MESH:D008106 Liver Cirrhosis, Experimental Dinoprostone 24.1815816358
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 24.1816595196 16439617
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 24.1814659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Fenofibrate 24.1815474484
MESH:D008106 Liver Cirrhosis, Experimental Indomethacin 24.1818194892
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 24.1812878042
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 24.1815474484
MESH:D008106 Liver Cirrhosis, Experimental Plant Extracts 24.1815479170
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 24.1812741479
MESH:D008106 Liver Cirrhosis, Experimental rofecoxib 24.1817565644
MESH:D008106 Liver Cirrhosis, Experimental S-Adenosylmethionine 24.1815983038
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 24.1812878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 24.1818397230 16248980
MESH:D008107 Liver Diseases Acetaminophen 24.6716611625 16610002 19460945 11587558 19014921 12587719 12969438 19784758
MESH:D008107 Liver Diseases Carbon Tetrachloride 24.6715830285 17285989 16246199 16964402 15720792
MESH:D008107 Liver Diseases Diclofenac 24.6714566034 16867024
MESH:D008107 Liver Diseases Diethylnitrosamine 24.6717034775
MESH:D008107 Liver Diseases Dinoprostone 24.6715816358
MESH:D008107 Liver Diseases Naproxen 24.6716867024
MESH:D008107 Liver Diseases nimesulide 24.6716867024
MESH:D008107 Liver Diseases Phenobarbital 24.6719363144
MESH:D008107 Liver Diseases Piroxicam 24.6716867024
MESH:D008107 Liver Diseases Plant Extracts 24.6717034775
MESH:D008107 Liver Diseases Sulindac 24.6716867024 14986274
MESH:D017093 Liver Failure Carbon Tetrachloride 3.2015123358
MESH:D017114 Liver Failure, Acute Acetaminophen 6.4716871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 6.4716899240 14706259
MESH:D008113 Liver Neoplasms 2-amino-3-methylimidazo(4,5-f)quinoline 39.8516353153
MESH:D008113 Liver Neoplasms 4-biphenylamine 39.8515761837
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 39.8520195826 21137059
MESH:D008113 Liver Neoplasms Butylated Hydroxytoluene 39.8518177683
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 39.8519294768
MESH:D008113 Liver Neoplasms Diethylnitrosamine 39.8512112319 19294768 21047994 20101389 19996281 19255062 20118626 20452335 19551842 18648771 19256749 21167192 19073162 19850985 19427195 15175105 19638242 18644402 19833225 15885732 20137499 19254457 9163691 18977376 16942905 20434301 2862719 18754104 21278145 19812893 19690152 19090486 19426721 20583210 19499222 20501860 10737359 20492335 21071580 2422723 20405173 19642983 12771043 18978307
MESH:D008113 Liver Neoplasms Fenofibrate 39.8518978307
MESH:D008113 Liver Neoplasms Methylenebis(chloroaniline) 39.85512554
MESH:D008113 Liver Neoplasms Phenobarbital 39.858742319 19482888 15975961 19073162 21047994 19812893
MESH:D008113 Liver Neoplasms pirinixic acid 39.8520007298 15890375 16377806
MESH:D008113 Liver Neoplasms Plant Extracts 39.8519168119
MESH:D008113 Liver Neoplasms Quercetin 39.8518980244
MESH:D008113 Liver Neoplasms resveratrol 39.8519073162 19321006 19812893 20405173
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 39.8516984957
MESH:D008113 Liver Neoplasms Urethane 39.8516391232 17093202 17559639
MESH:D008114 Liver Neoplasms, Experimental 4-biphenylamine 28.0911376689
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 28.0912014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 28.0917174075 18079962 9362446 16842330 2563599 16267830 3124819 19009564 19126423 18544905 18253720 18308698 19519916 19539802 18093689 21159647 18282651 18775883 17942915 17854601 18164116 19004024
MESH:D008114 Liver Neoplasms, Experimental Dipyrone 28.096150874
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 28.0916842330 17085340
MESH:D008114 Liver Neoplasms, Experimental Fenofibrate 28.0918775883 18253720
MESH:D008114 Liver Neoplasms, Experimental Methylcholanthrene 28.091399818 598648
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 28.0918308698 6150874 17172636 1399818 2563599
MESH:D008114 Liver Neoplasms, Experimental Quercetin 28.0919519916
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 28.0912151625
MESH:D008133 Long QT Syndrome Astemizole 3.8011989578 18472280
MESH:D008171 Lung Diseases Mustard Gas 8.2518702808 18161513
MESH:D008171 Lung Diseases nitrofen 8.2517245593 9859898 9614859 16863852
MESH:D008171 Lung Diseases Ozone 8.258266340 19066396
MESH:D055370 Lung Injury Lipopolysaccharides 6.0721114838
MESH:D055370 Lung Injury Ozone 6.0720417186
MESH:D008175 Lung Neoplasms 2-amino-3-methylimidazo(4,5-f)quinoline 51.1816353153
MESH:D008175 Lung Neoplasms 4-biphenylamine 51.1817671175
MESH:D008175 Lung Neoplasms Acetaldehyde 51.1817372256
MESH:D008175 Lung Neoplasms alitretinoin 51.1816413115
MESH:D008175 Lung Neoplasms Azoxymethane 51.1815824018
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 51.1820135361 20464547 18569708 18520028 20064080 18816296 6695378 17053015 20869020
MESH:D008175 Lung Neoplasms Budesonide 51.1817163412 12117777 16885199
MESH:D008175 Lung Neoplasms Butylated Hydroxytoluene 51.1819359593 11246140 11696405 18597497 19925653 16337739 15390079
MESH:D008175 Lung Neoplasms Cisplatin 51.1817225452 11798837 6189445
MESH:D008175 Lung Neoplasms Dexamethasone 51.1811195469 15824018
MESH:D008175 Lung Neoplasms Diethylnitrosamine 51.1821163286 20970405 20512841 6695378
MESH:D008175 Lung Neoplasms Doxorubicin 51.186189445 17418594
MESH:D008175 Lung Neoplasms Indomethacin 51.1811497255 11053908 16537180
MESH:D008175 Lung Neoplasms Isotretinoin 51.1815899809
MESH:D008175 Lung Neoplasms Methylcholanthrene 51.1820512841 15390079 9230183 1399818 11893704 20970405 7750092 16337739 21163286 16271038 17909032 10545420 6695378
MESH:D008175 Lung Neoplasms Methylenebis(chloroaniline) 51.18512554
MESH:D008175 Lung Neoplasms Mustard Gas 51.183148597 8781369
MESH:D008175 Lung Neoplasms Ozone 51.187614698 8597069
MESH:D008175 Lung Neoplasms Piroxicam 51.1811195469 15824018
MESH:D008175 Lung Neoplasms Plant Extracts 51.1820869020
MESH:D008175 Lung Neoplasms Quercetin 51.1816280456
MESH:D008175 Lung Neoplasms Smoke 51.1811091918
MESH:D008175 Lung Neoplasms Sulindac 51.1815713900 19359593
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 51.1811884234 19555203
MESH:D008175 Lung Neoplasms Urethane 51.187750092 16007126 10822126 11246140 10779650 11497255 11807781 17093202 11992545 17195641 15902970 12117781 11893704 16788158 17255336 10530776 12957351 15136453 15166089 10997738 16289808 11323394 12765245 16926031 6695378 14587096 16337739 11062179 16204055 11552296 11544531 11074608 12466968 11307925 16391232
MESH:D008223 Lymphoma Doxorubicin 2.7116098063
MESH:D016393 Lymphoma, B-Cell resveratrol 3.3817088997
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 6.0817654614
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 6.0814749477
MESH:D016399 Lymphoma, T-Cell Doxorubicin 3.6015621674
MESH:D008288 Malaria Astemizole 3.9916816845
MESH:D015674 Mammary Neoplasms, Animal resveratrol 3.2715688416
MESH:D008325 Mammary Neoplasms, Experimental Butylated Hydroxytoluene 24.491500032
MESH:D008325 Mammary Neoplasms, Experimental celecoxib 24.4919196722 12104042
MESH:D008325 Mammary Neoplasms, Experimental Corticosterone 24.4912807724
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 24.4915458769
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 24.4917203775 11408345 11807958 16891317
MESH:D008325 Mammary Neoplasms, Experimental Fenretinide 24.4910697514
MESH:D008325 Mammary Neoplasms, Experimental Ibuprofen 24.4910697514
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 24.4911408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 24.498985016 11606380
MESH:D020149 Manganese Poisoning Estradiol 3.4819453300
MESH:D008527 Medulloblastoma Tretinoin 2.2717453147
MESH:D008545 Melanoma Cisplatin 15.2816432458 18176117 18505091 12883367 17023156 16809738 16248763 12393984 17761969 18332650 12374674 11135225 15577323
MESH:D008545 Melanoma Doxorubicin 15.2816827129
MESH:D008545 Melanoma Fenretinide 15.2816270382
MESH:D008545 Melanoma Isotretinoin 15.2817237267
MESH:D008545 Melanoma N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide 15.2816487513
MESH:D008545 Melanoma Reactive Oxygen Species 15.2817992120
MESH:D008545 Melanoma resveratrol 15.2817992120
MESH:D008545 Melanoma Sulindac 15.2816642371
MESH:D008545 Melanoma Tretinoin 15.2816752155
MESH:D018328 Melanoma, Amelanotic Cisplatin 3.7915990972
MESH:D008546 Melanoma, Experimental Acetaminophen 2.6019513568
MESH:D008591 Meningomyelocele Tretinoin 3.4516940565
MESH:D001523 Mental Disorders Flupenthixol 4.9216856516
MESH:D008654 Mesothelioma Cisplatin 4.6817638057
MESH:D008654 Mesothelioma Doxorubicin 4.6817638057
MESH:D008659 Metabolic Diseases resveratrol 3.4717112576
MESH:D008679 Metaplasia Ozone 4.1010496685
MESH:D008708 Methemoglobinemia 4-biphenylamine 7.1112030840
MESH:D008708 Methemoglobinemia Phenacetin 7.111949026 3537620 4834387 16296465
MESH:D008881 Migraine Disorders Aspirin 8.4715240983
MESH:D008881 Migraine Disorders Indomethacin 8.4711903285
MESH:D008881 Migraine Disorders Naproxen 8.4718803445
MESH:D020326 Migraine without Aura Dinoprostone 4.3211304026
MESH:D028361 Mitochondrial Diseases Doxorubicin 3.5915792986
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 9.8216381670
MESH:D009062 Mouth Neoplasms Fenretinide 9.8216274795
MESH:D009062 Mouth Neoplasms Indomethacin 9.8212636206
MESH:D052016 Mucositis Doxorubicin 3.8017415656
MESH:D009101 Multiple Myeloma celecoxib 7.9216123214
MESH:D009101 Multiple Myeloma Dexamethasone 7.9216118317 15867202 15744524
MESH:D009101 Multiple Myeloma resveratrol 7.9217049120 16267019 16490592 17935668 17164350 14749477
MESH:D009102 Multiple Organ Failure Zymosan 4.2910890648 15241586 15213630 18160304 12879239 12130978 10479408 15259001 15834315 17724436
MESH:D009134 Muscular Atrophy, Spinal resveratrol 3.8817962980
MESH:D009135 Muscular Diseases pirinixic acid 2.5416239165
MESH:D009190 Myelodysplastic Syndromes Dexamethasone 5.299809623
MESH:D009190 Myelodysplastic Syndromes Tretinoin 5.2917596541
MESH:D009203 Myocardial Infarction Aspirin 12.0512692751
MESH:D009203 Myocardial Infarction Doxorubicin 12.0519429709 15857846
MESH:D009203 Myocardial Infarction pirinixic acid 12.0519151258
MESH:D009203 Myocardial Infarction Quercetin 12.0519595682
MESH:D009203 Myocardial Infarction resveratrol 12.0517188708 16317513 16525036 17015251 17125593 16456233
MESH:D017202 Myocardial Ischemia resveratrol 6.2517125593 17015251
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 6.2512213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 9.4916810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 9.4916411023
MESH:D015428 Myocardial Reperfusion Injury Quercetin 9.4919207477
MESH:D009205 Myocarditis resveratrol 3.7717322642
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 3.4917484760
MESH:D009325 Nausea Aspirin 4.2115240983
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 6.483581430 9029167
MESH:D009362 Neoplasm Metastasis Doxorubicin 6.4818259882
MESH:D009362 Neoplasm Metastasis Indomethacin 6.4811053908 11239499 16537180
MESH:D009369 Neoplasms alitretinoin 20.7316946489
MESH:D009369 Neoplasms Benzo(a)pyrene 20.7311141357
MESH:D009369 Neoplasms Cisplatin 20.7316773208
MESH:D009369 Neoplasms Fenretinide 20.7315958647 17353921
MESH:D009369 Neoplasms pirinixic acid 20.7317405874
MESH:D009369 Neoplasms Piroxicam 20.7316684565
MESH:D009369 Neoplasms Quercetin 20.7315185748
MESH:D009369 Neoplasms Tretinoin 20.7316946489 16594593
MESH:D009369 Neoplasms Urethane 20.7315625555
MESH:D009374 Neoplasms, Experimental Indomethacin 9.9715625704 10663608
MESH:D009374 Neoplasms, Experimental resveratrol 9.978985016
MESH:D009374 Neoplasms, Experimental Urethane 9.9715582191
MESH:D009376 Neoplasms, Hormone-Dependent celecoxib 4.4319196722
MESH:D009389 Neovascularization, Pathologic Estradiol 2.7617289903
MESH:D009395 Nephritis, Interstitial Cisplatin 7.6015464296
MESH:D009395 Nephritis, Interstitial Ibuprofen 7.606375363
MESH:D009397 Nephrocalcinosis Furosemide 4.8715086907
MESH:D009401 Nephrosis Doxorubicin 3.8016636307 16899518
MESH:D009404 Nephrotic Syndrome Doxorubicin 3.1416889571 15640375
MESH:D009410 Nerve Degeneration Ibuprofen 3.5910961664
MESH:D009421 Nervous System Malformations bisphenol A 15.7511399458 16427766
MESH:D009421 Nervous System Malformations Estradiol 15.7511399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 15.7514600291
MESH:D009421 Nervous System Malformations Tretinoin 15.759125849
MESH:D009436 Neural Tube Defects Tretinoin 2.349142499
MESH:D019954 Neurobehavioral Manifestations Plant Extracts 4.2117168769
MESH:D009447 Neuroblastoma Cisplatin 7.938761367
MESH:D009447 Neuroblastoma Doxorubicin 7.9315555623
MESH:D009447 Neuroblastoma Isotretinoin 7.9317368321
MESH:D019636 Neurodegenerative Diseases Acetaminophen 17.4818514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 17.4820387270
MESH:D019636 Neurodegenerative Diseases Indomethacin 17.4812349958
MESH:D019636 Neurodegenerative Diseases resveratrol 17.4817652729
MESH:D019636 Neurodegenerative Diseases Sulindac 17.4817266991 16850258
MESH:D017599 Neuroectodermal Tumors Cisplatin 3.718761367
MESH:D020078 Neurogenic Inflammation Quercetin 7.6217929310
MESH:D020078 Neurogenic Inflammation resveratrol 7.6217929310
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.1120387270
MESH:D009472 Neuronal Ceroid-Lipofuscinoses Fenretinide 4.6916303764
MESH:D009503 Neutropenia Mustard Gas 3.0616761898 7688884
MESH:D053206 Nocturnal Enuresis Furosemide 4.8717945291
MESH:D009759 Nystagmus, Pathologic Astemizole 5.466135121
MESH:D009765 Obesity pirinixic acid 3.4820558911
MESH:D009765 Obesity Plant Extracts 3.4820132043 19056576
MESH:D007752 Obstetric Labor, Premature Indomethacin 4.166374098
MESH:D010003 Osteoarthritis Aspirin 16.077009135
MESH:D010003 Osteoarthritis Diclofenac 16.0718287210
MESH:D010003 Osteoarthritis Ibuprofen 16.077009135
MESH:D010003 Osteoarthritis Indomethacin 16.077009135
MESH:D010003 Osteoarthritis rofecoxib 16.0716690336
MESH:D010005 Osteoarthropathy, Secondary Hypertrophic Dinoprostone 5.4718500342
MESH:D010018 Osteomalacia Phenobarbital 3.3817016548
MESH:D010024 Osteoporosis Calcium 3.1017882678
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 7.1319495926
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 7.1317513867
MESH:D012516 Osteosarcoma Doxorubicin 3.2815930896
MESH:D010049 Ovarian Diseases bisphenol A 4.0011985600
MESH:D010051 Ovarian Neoplasms Cisplatin 18.986897625 19769630 15464296 17225452
MESH:D010051 Ovarian Neoplasms Estradiol 18.9819401270
MESH:D010051 Ovarian Neoplasms Fenretinide 18.9816133793
MESH:D010051 Ovarian Neoplasms Mifepristone 18.9816525653
MESH:D010051 Ovarian Neoplasms Progesterone 18.9817393432 16525653
MESH:D010051 Ovarian Neoplasms Quercetin 18.9819005980
MESH:D010051 Ovarian Neoplasms Tretinoin 18.9816936753
MESH:D010051 Ovarian Neoplasms Urethane 18.9816391232
MESH:D010146 Pain 4-(nitroxy)butanoic acid 4-acetylaminophenyl ester 34.8416870215
MESH:D010146 Pain Acetaminophen 34.8416870215
MESH:D010146 Pain Aspirin 34.846363464 6995502
MESH:D010146 Pain Diclofenac 34.8413679232
MESH:D010146 Pain Ibuprofen 34.843291741
MESH:D010146 Pain Indomethacin 34.8417627676 3291741 13679232 17440234
MESH:D010146 Pain Morphine 34.8415215642 18699797 6776300 15275824 16273134 20225289
MESH:D010146 Pain Naproxen 34.843291741
MESH:D010146 Pain nimesulide 34.8411438310
MESH:D010146 Pain Sulindac 34.843291741
MESH:D010146 Pain Tretinoin 34.8416870215
MESH:D010149 Pain, Postoperative Bupivacaine 18.6918165598
MESH:D010149 Pain, Postoperative Ibuprofen 18.6916678543
MESH:D010149 Pain, Postoperative Indomethacin 18.6918702446 12538197
MESH:D010149 Pain, Postoperative rofecoxib 18.6918165598 16678543
MESH:D010190 Pancreatic Neoplasms Cisplatin 31.3319003803
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 31.3316540662
MESH:D010190 Pancreatic Neoplasms Fenretinide 31.3315580305
MESH:D010190 Pancreatic Neoplasms gemcitabine 31.3318383843 18992248 11504793 17440100 16929163
MESH:D010190 Pancreatic Neoplasms Ibuprofen 31.3312384795
MESH:D010190 Pancreatic Neoplasms N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide 31.3311504793
MESH:D010190 Pancreatic Neoplasms Phenobarbital 31.3316965848
MESH:D010190 Pancreatic Neoplasms Quercetin 31.3316965848
MESH:D010190 Pancreatic Neoplasms Reactive Oxygen Species 31.3315580305
MESH:D010190 Pancreatic Neoplasms Sulindac 31.3311504793 16820089
MESH:D010190 Pancreatic Neoplasms Tretinoin 31.3315976015
MESH:D010195 Pancreatitis Indomethacin 3.0315028970 17883296
MESH:D016584 Panic Disorder Ethinyl Estradiol 2.7611578682
MESH:D010212 Papilloma Hydrogen Peroxide 6.5112065085
MESH:D010212 Papilloma Plant Extracts 6.5116517061 15173996
MESH:D010257 Paraneoplastic Syndromes Indomethacin 4.7116537180
MESH:D020734 Parkinsonian Disorders Indomethacin 3.2412349958
MESH:D051302 Paroxysmal Hemicrania Indomethacin 4.7111903285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.2412520081
MESH:D010437 Peptic Ulcer Indomethacin 4.1611148446
MESH:D010438 Peptic Ulcer Hemorrhage Aspirin 4.5511156591
MESH:D010518 Periodontitis Indomethacin 3.9117225004
MESH:D010523 Peripheral Nervous System Diseases Cisplatin 3.3715464296
MESH:D010538 Peritonitis Ozone 7.2216369182
MESH:D010538 Peritonitis Zymosan 7.2218977430 15979727 18557954 17371808 17826846 11985352 19641140 14761945 15259001 18760300 19088179
MESH:D020795 Photophobia Aspirin 4.7515240983
MESH:D003557 Phyllodes Tumor Doxorubicin 4.1517983394
MESH:D010911 Pituitary Neoplasms Urethane 4.4416391232
MESH:D010997 Pleural Neoplasms Cisplatin 10.6017638057
MESH:D010997 Pleural Neoplasms Doxorubicin 10.6017638057
MESH:D011014 Pneumonia Butylated Hydroxytoluene 13.0011893704
MESH:D011014 Pneumonia Lipopolysaccharides 13.0012224865 11605937
MESH:D011014 Pneumonia Ozone 13.0018007984 18929643 18381685
MESH:D011041 Poisoning Mustard Gas 2.9015727166
MESH:D011141 Polyuria Furosemide 4.6617945291
MESH:D017499 Porokeratosis alitretinoin 4.9916144296
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 2.6118163543
MESH:D011230 Precancerous Conditions Azoxymethane 14.9414668109 19056647 12458338
MESH:D011230 Precancerous Conditions Diethylnitrosamine 14.942563599
MESH:D011230 Precancerous Conditions Phenobarbital 14.942563599
MESH:D011230 Precancerous Conditions Quercetin 14.9419056647
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Dexamethasone 2.8921297632
MESH:D047928 Premature Birth Indomethacin 4.1517000239
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 15.3210548101
MESH:D011297 Prenatal Exposure Delayed Effects Isotretinoin 15.3218769834
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 15.3216679765
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 15.3211222880 11896295 11118676 11399792
MESH:D011470 Prostatic Hyperplasia Calcitriol 3.7915572423
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 7.5420887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 7.5420887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 5.0217292933
MESH:D011471 Prostatic Neoplasms bisphenol A 5.0216740699
MESH:D011471 Prostatic Neoplasms Calcitriol 5.0215754350 16289102 16644109 12479363 18247401
MESH:D011471 Prostatic Neoplasms celecoxib 5.0215570007 17908994
MESH:D011471 Prostatic Neoplasms Cholecalciferol 5.0217024972
MESH:D011471 Prostatic Neoplasms Doxorubicin 5.0218437689 16729912 15749863 15897917 16888761 16868541
MESH:D011471 Prostatic Neoplasms Estradiol 5.0216740699
MESH:D011471 Prostatic Neoplasms Fenretinide 5.0217024972
MESH:D011471 Prostatic Neoplasms Flurbiprofen 5.0217409433
MESH:D011471 Prostatic Neoplasms Ibuprofen 5.0217409433
MESH:D011471 Prostatic Neoplasms Plant Extracts 5.0214666653 17804756
MESH:D011471 Prostatic Neoplasms Quercetin 5.0214715546 17292933
MESH:D011471 Prostatic Neoplasms resveratrol 5.0215767336 17675339 17718901 17804756 17636462 16731767
MESH:D011471 Prostatic Neoplasms sulindac sulfone 5.0215570007 17908994
MESH:D011507 Proteinuria Ibuprofen 10.286375363
MESH:D011507 Proteinuria Indomethacin 10.2811849393
MESH:D011507 Proteinuria Tretinoin 10.2816636307
MESH:D011537 Pruritus Ethinyl Estradiol 6.2815861022 16919318
MESH:D011537 Pruritus Mustard Gas 6.2818058305
MESH:D019310 Pseudolymphoma Phenobarbital 3.4912752131
MESH:D011596 Psychomotor Disorders Isotretinoin 4.9318769834
MESH:D011625 Pterygium Tretinoin 3.8016723453
MESH:D011629 Puberty, Precocious bisphenol A 3.8010548101
MESH:D011658 Pulmonary Fibrosis Mustard Gas 2.4510334151 17894541 17620002 17266442 17720292
MESH:D051437 Renal Insufficiency Cisplatin 7.1815464296
MESH:D051437 Renal Insufficiency Doxorubicin 7.1817922066
MESH:D051436 Renal Insufficiency, Chronic resveratrol 4.5716325855
MESH:D015427 Reperfusion Injury Furosemide 10.6716526316
MESH:D015427 Reperfusion Injury Morphine 10.6719211983
MESH:D015427 Reperfusion Injury pirinixic acid 10.6719058328
MESH:D015427 Reperfusion Injury resveratrol 10.6715827377 16314181 17058453 16317513 17520802
MESH:D012128 Respiratory Distress Syndrome, Adult Dexamethasone 6.4811700416 18379247
MESH:D012128 Respiratory Distress Syndrome, Adult Furosemide 6.4815912074 16096441 12394941
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.0010835634
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 2.8918990726
MESH:D012162 Retinal Degeneration Fenretinide 3.6116303925
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.1716283617 16116481
MESH:D012220 Rhinitis Acetaldehyde 6.4517050345
MESH:D012220 Rhinitis Aspirin 6.4512372130
MESH:D012221 Rhinitis, Allergic, Perennial Astemizole 4.4310822083
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.3918045962
MESH:D012509 Sarcoma Doxorubicin 3.1115625365 17710206 18313854 17203757 16767912 15675481
MESH:D012512 Sarcoma, Ewing's Cisplatin 7.3114601052
MESH:D012512 Sarcoma, Ewing's Doxorubicin 7.3114601052 16326096
MESH:D012514 Sarcoma, Kaposi Doxorubicin 3.8017846226
MESH:D012554 Schistosomiasis japonica Quercetin 4.5416862918
MESH:D012640 Seizures Phenobarbital 2.033137016 16876388 11442880 4039156
MESH:D003294 Seizures, Febrile Phenobarbital 3.836407741
MESH:D018805 Sepsis Zymosan 3.8011441115
MESH:D012852 Sinusitis Phenylephrine 3.727327846
MESH:D012851 Sinus Thrombosis, Intracranial Aspirin 4.2912269725
MESH:D012871 Skin Diseases Mustard Gas 2.3612880345 15451306 16961503
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 28.9919755658 10029692
MESH:D012878 Skin Neoplasms Doxorubicin 28.9915692506
MESH:D012878 Skin Neoplasms Fenretinide 28.9916467112
MESH:D012878 Skin Neoplasms Hydrogen Peroxide 28.9912065085
MESH:D012878 Skin Neoplasms Plant Extracts 28.9915173996 16517061
MESH:D012878 Skin Neoplasms resveratrol 28.9915837718 8985016
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 28.998532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 28.9916192470
MESH:D012878 Skin Neoplasms Tretinoin 28.9916467112
MESH:D012878 Skin Neoplasms Urethane 28.9911807781
MESH:D012892 Sleep Deprivation marker/mechanism 16343605
MESH:D055752 Small Cell Lung Carcinoma Cisplatin 4.3315464296
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 3.6017203757 15625365 16767912
MESH:D013088 Spermatocele Ethinyl Estradiol 2.9416709447
MESH:D013119 Spinal Cord Injuries Progesterone 3.3015862959 16503802
MESH:D013272 Stomach Diseases Dexamethasone 11.5815472012
MESH:D013272 Stomach Diseases Indomethacin 11.5818545984 15038085 10486359 16113693 10192188 17160473 16280098 17207306 16184426 15472012 17638125 10215738 18209964
MESH:D013272 Stomach Diseases rebamipide 11.5816184426
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 10.882093021 20155912
MESH:D013274 Stomach Neoplasms celecoxib 10.8815609394
MESH:D013274 Stomach Neoplasms Cisplatin 10.8818396642 15958060 17522103
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 10.8818456281
MESH:D013274 Stomach Neoplasms Furosemide 10.8817052386
MESH:D013274 Stomach Neoplasms Indomethacin 10.8815609394
MESH:D013274 Stomach Neoplasms nitrosobenzylmethylamine 10.8817575124 12958204
MESH:D013274 Stomach Neoplasms rebamipide 10.8815993841
MESH:D013274 Stomach Neoplasms Tretinoin 10.8817261132
MESH:D013276 Stomach Ulcer allylpyrocatechol 20.4018431645
MESH:D013276 Stomach Ulcer Dexamethasone 20.4015138204
MESH:D013276 Stomach Ulcer Indomethacin 20.4010878458 18237397 17895592 11729361 16631530 14567935 15138204 18726076 15104355 12500499 18431645 18299717 18193104 17654042 16934674 12787963 11906479 18087811 17918041 17135157 17627676 11145282 17657623 12498302 16755016 16150113 11595431 16169175 17977527 16252198 10423059 18543354 12077510 11595415 16397915 18181030 1323529 10750652 18209962 15255614 12467913 11523592
MESH:D013276 Stomach Ulcer malabaricone B 20.4017977527
MESH:D013276 Stomach Ulcer malabaricone C 20.4017977527
MESH:D013276 Stomach Ulcer Piroxicam 20.4015309881
MESH:D013276 Stomach Ulcer Plant Extracts 20.4018237397 12787963 15255614 18193104 17135157
MESH:D020521 Stroke Aspirin 3.5616403987
OMIM:601367 STROKE, ISCHEMIC resveratrol 3.5916321402
MESH:D019966 Substance-Related Disorders bisphenol A 3.0116045194 16684133
MESH:D013436 Sulfhemoglobinemia Phenacetin 5.55978859
MESH:D013705 Temporomandibular Joint Disorders Plant Extracts 4.4717997062
MESH:D013736 Testicular Neoplasms Cisplatin 3.7015464296 17225452
MESH:D013921 Thrombocytopenia Lipopolysaccharides 3.2815821434
MESH:D019851 Thrombophilia Ethinyl Estradiol 2.6911994571
MESH:D013927 Thrombosis Aspirin 6.3317672075
MESH:D013927 Thrombosis Ethinyl Estradiol 6.3315669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 2.9012697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 14.047505956
MESH:D013964 Thyroid Neoplasms Doxorubicin 14.0416010429 17909728
MESH:D013964 Thyroid Neoplasms Indomethacin 14.0414736730 18791128 11352223
MESH:D013964 Thyroid Neoplasms Phenobarbital 14.041399818
MESH:D013964 Thyroid Neoplasms Tretinoin 14.0416026305 17045167
MESH:D013978 Tibial Fractures Estradiol 3.6819048282
MESH:D014062 Tongue Neoplasms resveratrol 6.9716227395
MESH:D014062 Tongue Neoplasms Tretinoin 6.9716051514
MESH:D016171 Torsades de Pointes Astemizole 4.239583453 8256756
MESH:D014202 Tremor 2-cresol 5.3812820538
MESH:D014376 Tuberculosis Tretinoin 2.5216040207
MESH:D014456 Ulcer Indomethacin 3.9117380554 10574470
MESH:D001749 Urinary Bladder Neoplasms 4-biphenylamine 22.4717671175 11144890 6654951 12376482
MESH:D001749 Urinary Bladder Neoplasms benzidine 22.4711144890 12500666 16003747
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 22.4717053015
MESH:D001749 Urinary Bladder Neoplasms Cisplatin 22.4712973940 17225452 15464296
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 22.4717653716
MESH:D001749 Urinary Bladder Neoplasms Fenretinide 22.4716720286
MESH:D001749 Urinary Bladder Neoplasms Methylenebis(chloroaniline) 22.4715929884 3189344 722185
MESH:D001749 Urinary Bladder Neoplasms Phenacetin 22.4711144890
MESH:D001749 Urinary Bladder Neoplasms Quercetin 22.4716720314
MESH:D014581 Urticaria Acetaminophen 17.9310982225
MESH:D014581 Urticaria Aspirin 17.9310982225 20485159
MESH:D014581 Urticaria Astemizole 17.932568013 1976298 2147912 2565098 2883202 3080510 2859714 3134034 1683191 3097109 2568189 2885854
MESH:D014581 Urticaria nimesulide 17.9310982225
MESH:D014581 Urticaria Piroxicam 17.9310982225
MESH:D002583 Uterine Cervical Neoplasms Cisplatin 15.4816803524
MESH:D002583 Uterine Cervical Neoplasms Fenretinide 15.4816154183
MESH:D002583 Uterine Cervical Neoplasms resveratrol 15.4817473185
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 15.4816129372
MESH:D014591 Uterine Diseases bisphenol A 4.0014652134
MESH:D014594 Uterine Neoplasms celecoxib 20.1518645019
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 20.1514692618
MESH:D014594 Uterine Neoplasms resveratrol 20.1517044934
MESH:D014594 Uterine Neoplasms Sulindac 20.1518645019
MESH:D014594 Uterine Neoplasms sulindac sulfide 20.1518645019
MESH:D014604 Uveal Neoplasms Tretinoin 3.6016752155
MESH:D014605 Uveitis Dexamethasone 8.961336536
MESH:D014605 Uveitis Zymosan 8.9611006244
MESH:D014625 Vaginal Neoplasms Cisplatin 3.6415577323
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 3.5812125929
MESH:D019043 Vascular Neoplasms Urethane 4.9010620525
MESH:D020301 Vasospasm, Intracranial Ibuprofen 4.2119057314
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 2.6314671159 15869587
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 11.6917678736 16364871 17638931 17334414
MESH:D018487 Ventricular Dysfunction, Left Plant Extracts 11.6918097624
MESH:D018487 Ventricular Dysfunction, Left resveratrol 11.6917488730
MESH:D020257 Ventricular Remodeling Plant Extracts 4.3318097624
MESH:D014717 Vertigo Astemizole 5.463105558
MESH:D014820 Vitiligo Tretinoin 3.1116761959
MESH:D014839 Vomiting Cisplatin 8.2111897121
MESH:D014839 Vomiting Indomethacin 8.2111897121
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.2415886252
MESH:D009396 Wilms Tumor Tretinoin 3.1016287080
MESH:D014947 Wounds and Injuries Plant Extracts 3.4220213670 19894650
Pathway ID Pathway Name
KEGG:00590 Arachidonic acid metabolism
REACT:13433 Biological oxidations
REACT:15314 Hormone biosynthesis
KEGG:01100 Metabolic pathways
REACT:22258 Metabolism of lipids and lipoproteins
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA24346
    • No data
    Releated disease ID Related disease Name
    PA443624Carcinoma, Renal Cell
    PA444682Kidney Diseases
    PA446021Vascular Diseases
    PA445204Ovarian Neoplasms
    PA443635Cardiovascular Diseases
    PA443797Coronary Disease
    Releated drug ID Related drug Name
    PA164749376interferon alfacon-1
    PA450373mephenytoin
    PA450911phenobarbital
    PA450947phenytoin
    PA164744924trimethadione
    PA448497aspirin
    PA449345dinoprostone
    PA449479epoprostenol
    PA164712740Epoxides
    PA448015acetaminophen
    PA449982indomethacin
    PA452363prostaglandins
    PA448871celecoxib
    PA448497aspirin
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00154 inhibitor gamma-Homolinolenic acid Dietary supplement;Micronutrient
    DB00159 antagonist Icosapent Dietary supplement;Micronutrient
    DB00244 inhibitor Mesalazine
    DB00316 antagonist Zydone Analgesics, Non-Narcotic;Antipyretics
    DB00328 inhibitor Indomethacin Anti-inflammatory Agents;Cyclooxygenase Inhibitors;Tocolytic Agents;Cardiovascular Agents;Nonsteroidal Anti-inflammatory Agents (NSAIAs);Gout Suppressants
    DB00350 agonist Minoxidil Antihypertensive Agents;Vasodilator Agents
    DB00461 inhibitor Nabumetone Antineoplastic Agents
    DB00465 inhibitor Ketorolac Cyclooxygenase Inhibitors
    DB00469 inhibitor Tenoxicam Cyclooxygenase Inhibitors
    DB00500 inhibitor Tolmetin Cyclooxygenase Inhibitors
    DB00554 antagonist Piroxicam Cyclooxygenase Inhibitors
    DB00573 antagonist Fenoprofen Cyclooxygenase Inhibitors;Propionic acid derivatives
    DB00586 antagonist Diclofenac Cyclooxygenase Inhibitors;Nonsteroidal Anti-inflammatory Agents (NSAIAs)
    DB00605 inhibitor Sulindac Antineoplastic Agents;Anti-inflammatory Agents;Cyclooxygenase Inhibitors;Analgesics;Analgesics, Non-Narcotic;Antipyretics;Nonsteroidal Anti-inflammatory Agents (NSAIAs)
    DB00711 antagonist Filaribits Plus 180/136mg Chewable Tablet Lipoxygenase Inhibitors;Anthelmintics;Filaricides
    DB00712 antagonist Flurbiprofen Anti-inflammatory Agents;Cyclooxygenase Inhibitors;Analgesics;Analgesics, Non-Narcotic;Antipyretics;Nonsteroidal Anti-inflammatory Agents (NSAIAs)
    DB00749 inhibitor Etodolac Anti-inflammatory Agents;Cyclooxygenase Inhibitors;Analgesics;Analgesics, Non-Narcotic;Antipyretics;Nonsteroidal Anti-inflammatory Agents (NSAIAs)
    DB00784 inhibitor Mefenamic acid Cyclooxygenase Inhibitors
    DB00788 inhibitor Naproxen Cyclooxygenase Inhibitors;Gout Suppressants
    DB00795 inhibitor Sulfasalazine Antirheumatic Agents;Anti-Infective Agents;Sulfonamides;Gastrointestinal Agents
    DB00812 antagonist Phenylone Plus Tab Anti-inflammatory Agents;Nonsteroidal Anti-inflammatory Agents (NSAIAs)
    DB00814 antagonist Meloxicam Antineoplastic Agents;Cyclooxygenase Inhibitors;Antiemetics;Analgesics;Growth Inhibitors;Nonsteroidal Anti-inflammatory Agents (NSAIAs)
    DB00821 antagonist Carprofen Photosensitizing Agents
    DB00861 inhibitor Diflunisal Anti-inflammatory Agents;Cyclooxygenase Inhibitors;Analgesics;Analgesics, Non-Narcotic;Antipyretics;Nonsteroidal Anti-inflammatory Agents (NSAIAs)
    DB00870 antagonist Suprofen Cyclooxygenase Inhibitors
    DB00936 antagonist Mobilat Anti-Infective Agents;Keratolytic Agents;Antifungal Agents
    DB00939 antagonist Meclofenamic acid Cyclooxygenase Inhibitors
    DB00945 antagonist Extra Strength Aspirin Backache Anticoagulants;Cyclooxygenase Inhibitors;Platelet Aggregation Inhibitors;Fibrinolytic Agents;Salicylates
    DB00963 inhibitor Bromfenac Analgesics
    DB00991 inhibitor Oxaprozin Anti-inflammatory Agents;Nonsteroidal Anti-inflammatory Agents (NSAIAs)
    DB01009 inhibitor Ketoprofen Anti-inflammatory Agents;Cyclooxygenase Inhibitors;Analgesics;Analgesics, Non-Narcotic;Antipyretics;Nonsteroidal Anti-inflammatory Agents (NSAIAs)
    DB01014 antagonist Balsalazide Anti-Ulcer Agents;Gastrointestinal Agents
    DB01050 - Vicoprofen® Anti-inflammatory Agents;Cyclooxygenase Inhibitors;Analgesics;Analgesics, Non-Narcotic;Antipyretics;Nonsteroidal Anti-inflammatory Agents (NSAIAs)
    DB01283 antagonist Lumiracoxib Cyclooxygenase Inhibitors;Cyclooxygenase 2 Inhibitors
    DB01294 antagonist Watkins Settelz Antidiarrheals
    DB01397 antagonist Magnesium salicylate
    DB01398 antagonist Salicylate-sodium Nonsteroidal Anti-inflammatory Agents (NSAIAs);Salicylates
    DB01399 antagonist Salsalate
    DB01401 antagonist Trisalicylate-choline
    DB01419 antagonist Antrafenine
    DB01435 antagonist Formule L2
    DB01600 antagonist Tiaprofenic acid
    DB01837 - O-Acetylserine
    DB01892 inhibitor Hyperforin
    DB02047 - 2-(1,1'-Biphenyl-4-Yl)Propanoic Acid
    DB02110 - Protoporphyrin Ix Containing Co
    DB02198 - 2-Bromoacetyl Group
    DB02266 - Flufenamic Acid Anti-inflammatory Agents
    DB02379 - Beta-D-Glucose Sweetening Agents
    DB02687 - Beta-D-Mannose
    DB02709 inhibitor Resveratrol Antioxidants;Platelet Aggregation Inhibitors;Enzyme Inhibitors;Anticarcinogenic Agents;Antineoplastic Agents, Phytogenic;Antimutagenic Agents
    DB02773 - (3-Chloro-4-Propoxy-Phenyl)-Acetic Acid
    DB02944 - Alpha-D-Mannose
    DB03014 - Heme
    DB03122 - B-Octylglucoside Detergents
    DB03667 - Acetic Acid Salicyloyl-Amino-Ester
    DB03752 - P-(2'-Iodo-5'-Thenoyl)Hydrotropic Acid
    DB03753 - Flurbiprofen Methyl Ester
    DB03783 - Phenacetin Analgesics;Analgesics, Non-Narcotic
    DB04557 - Arachidonic Acid
    DB04817 - Dipyrone
    DB06725 antagonist Lornoxicam Analgesics;Nonsteroidal Anti-inflammatory Agents (NSAIAs)
    DB06802 antagonist Nepafenac Nonsteroidal Anti-inflammatory Agents (NSAIAs);Prodrugs;Anti-inflammatory Agents, Locally Applied
    DB07981 - 2-[1-(4-CHLOROBENZOYL)-5-METHOXY-2-METHYL-1H-INDOL-3-YL]-N-[(1R)-1-(HYDROXYMETHYL)PROPYL]ACETAMIDE
    DB07983 - 1-(4-IODOBENZOYL)-5-METHOXY-2-METHYL INDOLE-3-ACETIC ACID
    DB07984 - 2-[1-(4-CHLOROBENZOYL)-5-METHOXY-2-METHYL-1H-INDOL-3-YL]-N-[(1S)-1-(HYDROXYMETHYL)PROPYL]ACETAMIDE
    Drugbank ID Action Drug Name Description
    DB00188 substrate Bortezomib Antineoplastic Agents;Protease Inhibitors
    DB00214 substrate Torasemide Antihypertensive Agents;Diuretics
    DB00216 substrate Eletriptan Vasoconstrictor Agents;Anti-inflammatory Agents;Anti-migraine Agents;Selective Serotonin Agonists;Serotonin Agonists
    DB00250 substrate Dapsone Anti-Infective Agents;Anti-Infectives;Anti-inflammatory Agents;Antimalarials;Folic Acid Antagonists;Leprostatic Agents;Antimycobacterials
    DB00313 substrate Valproic Acid Anticonvulsants;Enzyme Inhibitors;Antimanic Agents;GABA Agents
    DB00327 substrate Hydromorphone Narcotics;Analgesics, Opioid
    DB00402 substrate Eszopiclone Hypnotics and Sedatives
    DB00412 substrate Avandaryl Hypoglycemic Agents;Vasodilator Agents;Fibrinolytic Agents;Thazolidinediones
    DB00425 substrate Zolpidem GABA Agonists;Hypnotics and Sedatives
    DB00470 substrate Dronabinol Antiemetics;Analgesics;Analgesics, Non-Narcotic;Psychotropic Drugs;Hallucinogens
    DB00471 substrate Montelukast Anti-Asthmatic Agents;Antiarrhythmic Agents;Leukotriene Antagonists
    DB00533 substrate Rofecoxib Cyclooxygenase Inhibitors;Cyclooxygenase 2 Inhibitors
    DB00540 substrate Nortriptyline Antidepressants;Adrenergic Uptake Inhibitors;Antidepressive Agents, Tricyclic;Norepinephrine-Reuptake Inhibitors
    DB00549 substrate Zafirlukast Anti-Asthmatic Agents;Leukotriene Antagonists
    DB00580 substrate Valdecoxib Anti-inflammatory Agents;Cyclooxygenase Inhibitors;Nonsteroidal Anti-inflammatory Agents (NSAIAs)
    DB00582 substrate Voriconazole Antifungals;Antifungal Agents
    DB00586 substrate Diclofenac Cyclooxygenase Inhibitors;Nonsteroidal Anti-inflammatory Agents (NSAIAs)
    DB00619 substrate Imatinib Antineoplastic Agents;Protein Kinase Inhibitors
    DB00672 substrate Chlorpropamide Hypoglycemic Agents;Sulfonylureas
    DB00731 substrate Nateglinide Hypoglycemic Agents;Meglitinides
    DB00744 substrate Zileuton Lipoxygenase Inhibitors;Leukotriene Antagonists
    DB00796 substrate Atacand Plus Antihypertensive Agents;Angiotensin II Receptor Antagonists;Angiotensin II Type 1 Receptor Blockers
    DB00829 substrate Diazepam Anti-anxiety Agents;Hypnotics and Sedatives;Antiemetics;Anticonvulsants;Adjuvants, Anesthesia;GABA Modulators;Anesthetics, Intravenous;Muscle Relaxants, Central
    DB00843 substrate Donepezil Parasympathomimetics;Cholinesterase Inhibitors;Nootropic Agents
    DB00857 substrate Terbinafine Antifungals;Enzyme Inhibitors;Antifungal Agents;Trypanocidal Agents;Allylamines
    DB01015 substrate Sulfamethoxazole and Trimethoprim Tablets Anti-Infective Agents;Anti-Infectives;Sulfonamides
    DB01029 substrate Avalide 300/12.5 mg Antihypertensive Agents;Angiotensin II Receptor Antagonists;Angiotensin II Type 1 Receptor Blockers
    DB01041 substrate Thalidomide Immunosuppressive Agents;Leprostatic Agents;Teratogens;Angiogenesis Inhibitors
    DB01075 substrate Suppress Cough Syr W.Cod.Diphen.Hcl Amm.Chl. Hypnotics and Sedatives;Antiemetics;Antiparkinson Agents;Antidyskinetics;Antipruritics;Anesthetics;Anti-Allergic Agents;Histamine H1 Antagonists;Anesthetics, Local;Antitussives;Ethanolamine Derivatives
    DB01132 substrate ActoplusMet Hypoglycemic Agents;Thazolidinediones
    DB01136 substrate Carvedilol Antihypertensive Agents;Adrenergic Agents;Adrenergic beta-Antagonists;Vasodilator Agents;Adrenergic alpha-Antagonists
    DB01181 substrate Ifosfamide Antineoplastic Agents;Immunosuppressive Agents;Antineoplastic Agents, Alkylating
    DB01198 substrate Zopiclone Hypnotics and Sedatives
    DB01221 substrate Ketamine Analgesics;General Anesthetics;Excitatory Amino Acid Antagonists;Anesthetics, Dissociative
    DB01355 substrate Hexobarbital Hypnotics and Sedatives;GABA Modulators;Barbiturates;Adjuvants
    DB05109 substrate Trabectedin Antineoplastic Agents, Alkylating
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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