AutismKB 2.0

Annotation Detail for NDRG3


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Basic Information Top
Gene Symbol:NDRG3 ( FLJ13556 )
Gene Full Name: NDRG family member 3
Band: 20q11.23
Quick LinksEntrez ID:57446; OMIM: 605273; Uniprot ID:NDRG3_HUMAN; ENSEMBL ID: ENSG00000101079; HGNC ID: 14462
Relate to Another Database: SFARIGene; denovo-db
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of NDRG3 mRNAdecreases expression 16788091
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane affects the expression of NDRG3 mRNAaffects expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of NDRG3 mRNAaffects expression 17562736
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of NDRG3 mRNAdecreases expression 15336504
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of NDRG3 mRNAaffects expression 17484886
D016572 Cyclosporine Cyclosporine results in decreased expression of NDRG3 mRNAdecreases expression 20106945
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.923712494
MESH:D000799 Angioedema Acetaminophen 4.3610982225
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.5411289319 1440618
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 4.2016124888 15700767 16097048 18705752 16050911 15721981 16011737 16227642 10355542 15673190 16192424 3786805
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 4.747296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.743084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 4.7418788625
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.807296757
MESH:D002386 Cataract Acetaminophen 2.7510977129
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 7.277505956
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 7.2712371664
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 8.6519486331 9022650
MESH:D002779 Cholestasis Cyclosporine 8.6519486331
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.2112868966 2524372 18759878 14531868 8156756 8970840 11298694 11906362
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.842952479 3621924
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 6.639328219 18289764 6482804 6679447 18648102 7440962 11289319 18692083 1440618 16192314 9653073 9022650 8291058
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.6312594235 11834606 14550746 16081117 12392966 12958197 10663392 16109766 17562736 11421492 19370779 14986274 11461765 19739265 18713872 11287661 12153990 15619225 16393943 15968718 11529661 19085960 12540782 17906064 16485898 18071297 19164858 2444490 16781746 16177239 19420014 19923254 11739529 12705907 19416960 16227642 10774834 17522070 11743745 10915739 14725611
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 6.6319085960 6623471 2869522 11566570 6884620 3786805 16177239 15998439 10092053 17522070 10915739 7179309 7440962 15027814 21278145 15968718 16227642 19336974 4309450 3732212 9327722 7120509
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.6219426721
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.173581430
MESH:D005234 Fatty Liver Carbon Tetrachloride 8.8116045604 61145 17595544 19224547 16239168 12795759 15959796 12631006
MESH:D005234 Fatty Liver Cyclosporine 8.8119224547
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.546705139
MESH:D005355 Fibrosis Carbon Tetrachloride 10.0918705752
MESH:D005355 Fibrosis Cyclosporine 10.0912639820 12168785
MESH:D005756 Gastritis Acetaminophen 4.1916983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.688708960
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.397505956
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.8815720958
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 10.526705139
MESH:D006505 Hepatitis Carbon Tetrachloride 10.5219110552 19900420
MESH:D006930 Hyperalgesia Acetaminophen 2.9516870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.9916899240
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.3615034207
MESH:D006973 Hypertension Cyclosporine 2.1910903974
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.5015338365
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.549022650 8074119
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.9615604871
MESH:D007674 Kidney Diseases Acetaminophen 6.3412587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 6.348314463 18776723 10903974
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 8.176582329
MESH:D007680 Kidney Neoplasms Cyclosporine 8.1712371664
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.9617334410 16943688 16221502 11408273 17157831 11903743 21278145 17174718 16239168
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.389327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 1.7515362042 17525996 18279442 18412020 18339082 16248980 18187930 17708605 12609069 17805973 18317297 14620537 15052691 12958196 15123356 12546737 18481824 12667390 18166357 18156304 18205269 14748882 16097048 18006644 17766677 17823541 16638106 15673190 16027843 18054572 15931870 15370692 17565644 15730626 14716833 18277467 17922224 12389079 18263696 18376398 15996030 17640975 18705752 18395914 12632512 18210741 10355542 17481882 16192424 18472094 17631135 12649538 17944888 17869086 14724832 17761835 15959796 12445418 17721639 14512876 18395095 15876570 17900296 15338365 12741479 12898905 16011737 12666154 15650968 18418968 12586293 12632514 15893842 15925388 18420326 18472332 18429990 13678700 16116963 12445421 17976157 17714472 11481614 18251166 15057751 15818738 20821823 17557913 16033810 16136751 16015684 17698563 14716496
MESH:D008107 Liver Diseases Acetaminophen 4.1219784758 19460945 16611625 12587719 12969438 19014921 11587558 16610002
MESH:D008107 Liver Diseases Carbon Tetrachloride 4.1216964402 15830285 15720792 16246199 17285989
MESH:D017093 Liver Failure Carbon Tetrachloride 4.5815123358
MESH:D017114 Liver Failure, Acute Acetaminophen 10.4416871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 10.4416899240 14706259
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 2.3119294768
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 6.533712494 598648 1399818 6587162
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 6.5312014681 15583823
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9819513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.3116801185
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.573581430
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.9617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.5718481113 19348381
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.106679447
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1418514411
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.724026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.543988306
MESH:D010146 Pain Acetaminophen 2.6516870215
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.907296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.996228378
MESH:D011230 Precancerous Conditions Cyclosporine 3.5112371664
MESH:D011565 Psoriasis Cyclosporine 2.3116882103
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.613692021
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 2.818532709
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.126582329 6587162 1399818 3712494 7505956
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 2.378074119
MESH:D014581 Urticaria Acetaminophen 3.3310982225
MESH:D014605 Uveitis Cyclosporine 4.501336536
MESH:D014985 Xerophthalmia Cyclosporine 4.9617120751
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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