AutismKB 2.0

Annotation Detail for NDRG2


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Basic Information Top
Gene Symbol:NDRG2 ( DKFZp781G1938,FLJ25522,KIAA1248,SYLD )
Gene Full Name: NDRG family member 2
Band: 14q11.2
Quick LinksEntrez ID:57447; OMIM: 605272; Uniprot ID:NDRG2_HUMAN; ENSEMBL ID: ENSG00000165795; HGNC ID: 14460
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
200171Validated targets of C-MYC transcriptional repression
No data
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Related Diseases/Disorders Top
No data
Desease IDDesease Name
1740Alzheimer's disease
1934Cancer
No data
No data
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of NDRG2 mRNAaffects expression 17562736
D000082 Acetaminophen Acetaminophen results in decreased expression of NDRG2 proteindecreases expression 16538043
16538041
C068073 Am 580 Am 580 results in decreased expression of NDRG2 mRNAdecreases expression 16982809
D000638 Amiodarone Amiodarone affects the expression of NDRG2 mRNAaffects expression 19483382
D000638 Amiodarone Amiodarone results in decreased expression of NDRG2 proteindecreases expression 16538043
D000643 Ammonium Chloride Ammonium Chloride affects the expression of NDRG2 mRNAaffects expression 16483693
D000965 Antimony Antimony results in decreased expression of NDRG2 mRNAdecreases expression 17547211
D000966 Antimony Potassium Tartrate Antimony Potassium Tartrate results in decreased expression of NDRG2 mRNAdecreases expression 17547211
C015001 arsenite arsenite results in decreased expression of NDRG2 mRNAdecreases expression 18929588
C015001 arsenite TRP53 protein affects the reaction [arsenite results in decreased expression of NDRG2 mRNA]affects reaction|decreases expression 18929588
D001553 Benzbromarone Benzbromarone affects the expression of NDRG2 mRNAaffects expression 19483382
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of NDRG2 mRNAdecreases expression 20106945
C006780 bisphenol A bisphenol A affects the expression of NDRG2 mRNAaffects expression 20170705
C006780 bisphenol A bisphenol A results in increased expression of NDRG2 mRNAincreases expression 12075121
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of NDRG2 mRNAaffects expression 17484886
D002251 Carbon Tetrachloride Carbon Tetrachloride results in decreased expression of NDRG2 proteindecreases expression 16538043
D002994 Clofibrate Clofibrate affects the expression of NDRG2 mRNAaffects expression 19483382
D002995 Clofibric Acid Clofibric Acid affects the expression of NDRG2 mRNAaffects expression 17602206
D003345 Corticosterone Corticosterone results in increased expression of NDRG2 mRNAincreases expression 15755911
D016572 Cyclosporine Cyclosporine results in decreased expression of NDRG2 mRNAdecreases expression 20106945
D004052 Diethylnitrosamine Diethylnitrosamine results in decreased expression of NDRG2 mRNAdecreases expression 19638242
D004128 Dimethylnitrosamine Dimethylnitrosamine results in decreased expression of NDRG2 mRNAdecreases expression 17547211
D004958 Estradiol Estradiol results in decreased expression of NDRG2 mRNAdecreases expression 14664709
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of NDRG2 mRNAaffects expression 20170705
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of NDRG2 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of NDRG2 mRNAdecreases expression 16174780
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of NDRG2 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of NDRG2 mRNAaffects cotreatment|decreases expression 17942748
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of NDRG2 mRNAaffects expression 20170705
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of NDRG2 mRNAdecreases expression 17557909
16174780
17351261
17108234
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of NDRG2 mRNAincreases expression 12075121
D005001 Ethionine Ethionine affects the expression of NDRG2 mRNAaffects expression 19483382
D019833 Genistein Genistein results in increased expression of NDRG2 mRNAincreases expression 12075121
D008466 Mechlorethamine Mechlorethamine results in decreased expression of NDRG2 mRNAdecreases expression 17107856
C013598 methoxyacetic acid methoxyacetic acid results in increased expression of NDRG2 mRNAincreases expression 19471968
C013598 methoxyacetic acid methoxyacetic acid results in increased expression of NDRG2 proteinincreases expression 19471968
D009853 Omeprazole Omeprazole affects the expression of NDRG2 mRNAaffects expression 19483382
D010126 Ozone Ozone results in decreased expression of NDRG2 mRNAdecreases expression 12763052
C006253 pirinixic acid pirinixic acid results in increased expression of NDRG2 mRNAincreases expression 17426115
C006253 pirinixic acid pirinixic acid affects the expression of NDRG2 mRNAaffects expression 19483382
D011441 Propylthiouracil Propylthiouracil affects the expression of NDRG2 mRNAaffects expression 19483382
C089730 rosiglitazone rosiglitazone results in decreased expression of NDRG2 mRNAdecreases expression 16982809
D013629 Tamoxifen Tamoxifen affects the expression of NDRG2 mRNAaffects expression 17555576
C004648 testosterone enanthate testosterone enanthate affects the expression of NDRG2 mRNAaffects expression 17440010
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of NDRG2 mRNAaffects cotreatment|decreases expression 17942748
D013752 Tetracycline Tetracycline results in decreased expression of NDRG2 proteindecreases expression 16538043
D013853 Thioacetamide Thioacetamide affects the expression of NDRG2 mRNAaffects expression 19483382
C402769 tipifarnib tipifarnib results in decreased expression of NDRG2 mRNAdecreases expression 16403772
D014501 Uranium Uranium affects the expression of NDRG2 mRNAaffects expression 15672453
C005460 uranyl acetate uranyl acetate affects the expression of NDRG2 mRNAaffects expression 15672453
D014635 Valproic Acid Valproic Acid results in increased expression of NDRG2 mRNAincreases expression 19101580
D014810 Vitamin E Vitamin E results in increased expression of NDRG2 mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.1514745880
MESH:D000014 Abnormalities, Drug-Induced methoxyacetic acid 12.1112805644 15959878 3652986 1761404 1761407
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 12.1111752688 15322242 14514962
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 12.118875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.5819490988
MESH:D000138 Acidosis Ammonium Chloride 3.1718287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.5417505938
MESH:D055371 Acute Lung Injury pirinixic acid 2.7618653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 12.3320127859 20464547
MESH:D000230 Adenocarcinoma Dimethylnitrosamine 12.3316033868
MESH:D000230 Adenocarcinoma Estradiol 12.3311473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 12.3314692618
MESH:D000230 Adenocarcinoma Genistein 12.3311473722
MESH:D000236 Adenoma Benzo(a)pyrene 9.886695378
MESH:D000236 Adenoma Diethylnitrosamine 9.8810737359 6695378
MESH:D000236 Adenoma Dimethylnitrosamine 9.8819555203
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 14.9917162532 17620307 16434500 19061943 18056438 19052882
MESH:D018248 Adenoma, Liver Cell pirinixic acid 14.9916434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 14.9916835633
MESH:D000544 Alzheimer Disease Ozone 4.1515513908
MESH:D000544 Alzheimer Disease rosiglitazone 4.1519621015
MESH:D000550 Amblyopia Valproic Acid 4.8317688650
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.6111748828
MESH:D000799 Angioedema Acetaminophen 3.4410982225
MESH:D001008 Anxiety Disorders Valproic Acid 3.2617497229
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.6919183758
MESH:D001145 Arrhythmias, Cardiac Amiodarone 3.4618057881 18218290 20041841
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.0811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.4215885639
MESH:D001172 Arthritis, Rheumatoid Ozone 2.4615570426
MESH:D001249 Asthma Ozone 2.5117854713 16373670
MESH:D001281 Atrial Fibrillation Amiodarone 3.6119698954 18651412
MESH:D001321 Autistic Disorder Acetaminophen 1.8518445737
MESH:D001321 Autistic Disorder Valproic Acid 1.8518558336 19232924 18985861 18775368 17507914 17157402 18316065 18396377 20603192 19460635 15238991 16609825 17688650 18940202 18177632
MESH:D001714 Bipolar Disorder Valproic Acid 2.8720046352 17594078
MESH:D001778 Blood Coagulation Disorders Amiodarone 51.3019483382
MESH:D001778 Blood Coagulation Disorders Benzbromarone 51.3019483382
MESH:D001778 Blood Coagulation Disorders Clofibrate 51.3019483382
MESH:D001778 Blood Coagulation Disorders Ethionine 51.3019483382
MESH:D001778 Blood Coagulation Disorders Omeprazole 51.3019483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 51.3019483382
MESH:D001778 Blood Coagulation Disorders Propylthiouracil 51.3019483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 51.3012125929
MESH:D001778 Blood Coagulation Disorders Thioacetamide 51.3019483382
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.3915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 7.1715746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 7.178888407
MESH:D001862 Bone Resorption bisphenol A 3.5111985600
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 3.4717474063 20146248
MESH:D001943 Breast Neoplasms bisphenol A 3.4717123778
MESH:D001943 Breast Neoplasms Diethylnitrosamine 3.4717474063
MESH:D001943 Breast Neoplasms Estradiol 3.4712948864 16675129 17289903 18497071 14630087 17261762 17018787 19861407
MESH:D001943 Breast Neoplasms Genistein 3.4716541309 17200150 16873071
MESH:D001943 Breast Neoplasms Tamoxifen 3.4717049068 16202921 15565566 18351453 18425577 19155303 15668708 19142967 21138602 11161223 20859285 19066611 16873071 19221464 19289846 18855134 19288272 19084267 19244106 20135344 17440819 20065188 19059307 19115204 19103187 17893378 20544844 18821012 16273361 18815881 19487384 19189210 19200415 18997820 21152245 18629630 17261762 19011961 19410462 19189212 20390343 16818667 18984771 17242785 20005174
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 3.4720435547
MESH:D016535 Bronchial Hyperreactivity Ozone 3.3717626835 18417511 16777450 18315731 15516495 14754758 19059883
MESH:D001991 Bronchitis Antimony 5.738768112
MESH:D002057 Burns, Chemical Mechlorethamine 5.839625245
MESH:D002100 Cachexia Ozone 4.3516183385
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.0716111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 8.6616050911 15721981 18705752 16227642 3786805 15673190 10355542 15700767 16097048 16011737 16192424 16124888
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 8.6616050911
MESH:D002277 Carcinoma Dimethylnitrosamine 7.3219555203
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.3216835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.1219066611
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 15.603084413
MESH:D006528 Carcinoma, Hepatocellular Benzbromarone 15.601701930
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 15.6018788625
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 15.6018494052 18788625 21159647 10737359 19171122 20214788 18785209 20727157 20084675 16935385 20935162 20512989 19519916 18210153 20524982 18393292 3581430 10672840 20432363 16569478 18978308 19052882 17978847 19418558 16681979 17055752 19383236 20514400 11831363 16328049 17428255 16502159 18691550 19701751 16698587 19539802 16779866 19919837 17138121 18665156 20101231 18971187 20007298 19208518 19822196 16878318 16288022 3084413 17173139 17761372 16540662 16807293 17162532 18056438 19335982 16830150 19107877 19394651 18506893
MESH:D006528 Carcinoma, Hepatocellular Estradiol 15.6016924424
MESH:D006528 Carcinoma, Hepatocellular Genistein 15.6016924424
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 15.6016924424
MESH:D006528 Carcinoma, Hepatocellular Thioacetamide 15.6017997003
MESH:D002278 Carcinoma in Situ bisphenol A 4.5917123778
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.3920419170
MESH:D002294 Carcinoma, Squamous Cell Dimethylnitrosamine 4.3916033868
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.2717572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.1518670907 18850075 16120746
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 5.8515710769 19225199
MESH:D002311 Cardiomyopathy, Dilated Antimony 5.8510334427
MESH:D002318 Cardiovascular Diseases Genistein 3.0316332659
MESH:D002341 Carotid Artery Thrombosis Amiodarone 4.6918974383
MESH:D002386 Cataract Acetaminophen 6.9010977129
MESH:D002386 Cataract Am 580 6.9017460283
MESH:D002471 Cell Transformation, Neoplastic Clofibrate 13.801399818
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 13.8012371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 13.8017174075 2727394 21159647 7505956
MESH:D002471 Cell Transformation, Neoplastic Estradiol 13.8018566989
MESH:D002637 Chest Pain Omeprazole 4.7115447763
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.5620734317
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 14.2119052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 14.2116835633
MESH:D018281 Cholangiocarcinoma Thioacetamide 14.2118291259
MESH:D002779 Cholestasis Cyclosporine 11.6519486331
MESH:D002779 Cholestasis Ethinyl Estradiol 11.6516105132 17110522 16919318 17681005 15861022 11677210 17333356
MESH:D002779 Cholestasis pirinixic acid 11.6519176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 1.9312621046 15668235 16354765 8697196 15340226
MESH:D003092 Colitis Am 580 4.5817035595
MESH:D003110 Colonic Neoplasms marker/mechanism 19050079
MESH:D003110 Colonic Neoplasms arsenite 3.7015037631
MESH:D003110 Colonic Neoplasms Genistein 3.7017182828
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.7317141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.4920055451 10048152 15322242
MESH:D019465 Craniofacial Abnormalities Valproic Acid 3.4916575769 8888407 17688650
MESH:D019465 Craniofacial Abnormalities Vitamin E 3.4919769572
MESH:D003711 Demyelinating Diseases Tamoxifen 3.9819031437
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.2418249437
MESH:D003920 Diabetes Mellitus rosiglitazone 3.9717446233
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 9.3420387270
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 9.3416647724
MESH:D003924 Diabetes Mellitus, Type 2 rosiglitazone 9.3412642470
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 9.3417107852
MESH:D003928 Diabetic Nephropathies Estradiol 7.7419279558
MESH:D003928 Diabetic Nephropathies Tamoxifen 7.7419279558
MESH:D004283 Dog Diseases Antimony 5.2612019027
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 23.3311529661 17906064 2444490 15968718 18713872 19420014 12540782 14986274 12153990 11834606 11739529 14725611 18071297 16177239 11743745 11287661 16485898 16781746 14550746 16081117 10774834 11421492 17562736 16227642 19370779 12958197 19923254 17522070 11461765 19739265 12594235 15619225 16393943 16109766 10663392 19085960 19416960 12705907 19164858 10915739 12392966
MESH:D056486 Drug-Induced Liver Injury Amiodarone 23.3315265979 18218290
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 23.332869522 15998439 9327722 19336974 17522070 11566570 10092053 3786805 21278145 6623471 10915739 7120509 16177239 7440962 15968718 3732212 16227642 7179309 4309450 6884620 15027814 19085960
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 23.3319107877
MESH:D056486 Drug-Induced Liver Injury Dimethylnitrosamine 23.338172417
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 23.3320420201
MESH:D056486 Drug-Induced Liver Injury Tetracycline 23.3317522070
MESH:D056486 Drug-Induced Liver Injury Thioacetamide 23.3312963478
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 23.331733752 19641884
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.7019426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.4711462148
MESH:D004381 Duodenal Ulcer Omeprazole 3.9615991576 21218061 17151854 16613094
MESH:D050171 Dyslipidemias Clofibrate 3.7816707586
MESH:D004421 Dystonia Valproic Acid 3.691851702
MESH:C538011 Eales disease Vitamin E 4.309068938
MESH:D004487 Edema pirinixic acid 9.4612083418
MESH:D004487 Edema rosiglitazone 9.4612083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 9.4612711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.5018230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 7.7112538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 7.7119031437
MESH:D004714 Endometrial Hyperplasia Genistein 4.1916402032
MESH:D016889 Endometrial Neoplasms Estradiol 10.9511473722 18566989 19148513
MESH:D016889 Endometrial Neoplasms Genistein 10.9511473722
MESH:D016889 Endometrial Neoplasms Tamoxifen 10.9519155303 20544844 16202921 17893378
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.689294722 10568697
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 3.773659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 3.5216628512 3922381
MESH:D004827 Epilepsy Valproic Acid 2.7318234410 20417680
MESH:D004832 Epilepsy, Absence Valproic Acid 3.267562514 6254150 6426943
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 3.917750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 3.673659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.7116302075
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.2816530937
MESH:D004938 Esophageal Neoplasms Dimethylnitrosamine 4.2817016578
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.7211564622
MESH:D005218 Fat Necrosis Thioacetamide 5.3216456712
MESH:D005234 Fatty Liver Amiodarone 61.2214986274
MESH:D005234 Fatty Liver arsenite 61.2218296743
MESH:D005234 Fatty Liver Carbon Tetrachloride 61.2212631006 17595544 12795759 16239168 61145 16045604 19224547 15959796
MESH:D005234 Fatty Liver Clofibrate 61.2219224547
MESH:D005234 Fatty Liver Cyclosporine 61.2219224547
MESH:D005234 Fatty Liver Diethylnitrosamine 61.2221071580 20387270
MESH:D005234 Fatty Liver Ethinyl Estradiol 61.2215345470
MESH:D005234 Fatty Liver pirinixic acid 61.2220131406 19236843
MESH:D005234 Fatty Liver rosiglitazone 61.2219196556
MESH:D005234 Fatty Liver Tamoxifen 61.2214986274 19224547
MESH:D005234 Fatty Liver Tetracycline 61.2219224547 16917069
MESH:D005234 Fatty Liver Valproic Acid 61.2219224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 2.9916709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.0711858732
MESH:D005315 Fetal Diseases Valproic Acid 4.4816575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 3.768888407 18558336
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.1314745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 3.7919069698
MESH:D005355 Fibrosis arsenite 18.0018296743
MESH:D005355 Fibrosis Carbon Tetrachloride 18.0018705752
MESH:D005355 Fibrosis Cyclosporine 18.0012639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 18.0020067830
MESH:D005532 Foot Deformities, Congenital methoxyacetic acid 5.353652986
MESH:D005756 Gastritis Acetaminophen 3.2716983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.828708960
MESH:D005909 Glioblastoma Genistein 3.0016598420
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.1910696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 9.8520471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 9.8510048152 11294989
MESH:D006330 Heart Defects, Congenital Vitamin E 9.8516080930
MESH:D006333 Heart Failure pirinixic acid 2.2920558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.0315720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.9811000095
MESH:D006501 Hepatic Encephalopathy Thioacetamide 4.2217276928 18665440 15929193
MESH:D006505 Hepatitis Carbon Tetrachloride 8.2419900420 19110552
MESH:D006505 Hepatitis Thioacetamide 8.2416456712
MESH:D006529 Hepatomegaly Amiodarone 12.1915265979
MESH:D006529 Hepatomegaly pirinixic acid 12.1919176532 16221962 19772884 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 12.1912621046 15340226 16120746
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.5616490937 16863852
MESH:D006558 Herpes Genitalis Estradiol 4.6315709030
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 5.3417440010
MESH:D019584 Hot Flashes Estradiol 8.7117088409
MESH:D019584 Hot Flashes Vitamin E 8.7114716179
MESH:D006849 Hydrocephalus Valproic Acid 4.4717688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.6415340226 16959395 8697196 16354765 18606429
MESH:D006930 Hyperalgesia Acetaminophen 6.8616870215
MESH:D006930 Hyperalgesia rosiglitazone 6.8612083418
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.1416899240
MESH:D006937 Hypercholesterolemia Amiodarone 3.528137927 9751232
MESH:D006943 Hyperglycemia pirinixic acid 2.8420558911
MESH:D006973 Hypertension Cyclosporine 4.4110903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.4118850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.7015338365
MESH:D007021 Hypospadias Ethinyl Estradiol 3.4216569931 16945680
MESH:D007037 Hypothyroidism Amiodarone 10.3318020914 17991464
MESH:D007037 Hypothyroidism Propylthiouracil 10.3318031379 8137927
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.1012013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.2317937319
MESH:D007249 Inflammation Diethylnitrosamine 10.2218785209
MESH:D007249 Inflammation rosiglitazone 10.2212083418
MESH:D007249 Inflammation Tamoxifen 10.2219457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 10.2212200463 12878042
MESH:D007251 Influenza, Human Vitamin E 3.8116624496
MESH:D007333 Insulin Resistance bisphenol A 15.5316393666
MESH:D007333 Insulin Resistance Estradiol 15.5316627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 15.5316306350
MESH:D007333 Insulin Resistance rosiglitazone 15.5316306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 2.9816580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.0415604871
MESH:D007674 Kidney Diseases Acetaminophen 12.5012587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 12.508314463 18776723 10903974
MESH:D007674 Kidney Diseases Estradiol 12.5015618244
MESH:D007674 Kidney Diseases Vitamin E 12.5012488133
MESH:D007680 Kidney Neoplasms Cyclosporine 10.5312371664
MESH:D007680 Kidney Neoplasms Estradiol 10.5315610895
MESH:D007680 Kidney Neoplasms Tamoxifen 10.5318625569
MESH:D007896 Leishmaniasis Antimony 4.4812019027 21063981 21182181 15220340 10953559
MESH:D016773 Leishmaniasis, Cutaneous Antimony 7.9611475954 19141829 8889330
MESH:D016773 Leishmaniasis, Cutaneous Omeprazole 7.9619248655
MESH:D007897 Leishmaniasis, Mucocutaneous Antimony 5.0910651420 9643325 11370249 7854095 10881086
MESH:D007898 Leishmaniasis, Visceral Antimony 7.7411105143 7875148 7854095 7554475 8142506 20495762 1899875
MESH:D007898 Leishmaniasis, Visceral Antimony Potassium Tartrate 7.7412707265
MESH:D007938 Leukemia Genistein 2.8217468513 18980019
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.0816294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Antimony Potassium Tartrate 4.269834237
MESH:D017880 Limb Deformities, Congenital methoxyacetic acid 4.4615959878 12805644
MESH:D008064 Lipidoses Amiodarone 6.9815342952 17567588
MESH:D008064 Lipidoses Tamoxifen 6.9817567588 15342952
MESH:D008103 Liver Cirrhosis arsenite 9.7918296743
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 9.7916239168 11408273 16221502 16943688 17157831 17174718 17334410 11903743 21278145
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 9.7918522880 19638242 20032147 18665156 18407596
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 16.9815370692 15925388 12445418 15931870 14512876 15996030 18395914 18339082 17708605 17922224 12667390 16011737 15876570 15362042 16015684 18395095 16027843 16638106 18376398 18166357 12445421 15650968 18251166 18006644 16248980 10355542 17805973 17698563 17525996 17631135 17714472 12632512 12898905 17944888 15338365 12741479 17640975 12586293 18429990 17900296 18412020 17869086 18210741 15893842 18472332 18420326 18054572 11481614 17557913 20821823 17761835 18705752 18156304 13678700 15818738 18317297 14716496 18187930 14748882 14724832 15730626 18481824 12546737 17481882 12632514 17976157 17823541 12389079 12666154 16192424 15673190 16033810 18418968 12958196 18277467 15057751 18263696 18472094 14716833 18279442 17565644 16097048 14620537 18205269 15959796 12609069 15052691 16116963 17766677 15123356 12649538 17721639 16136751
MESH:D008106 Liver Cirrhosis, Experimental Dimethylnitrosamine 16.9815081153 15161499 14709902 15798949 15099470 15383259 18095165 17203207 15067225 16603200 18210741 16570917 15492853 15733078 17719030 15577212 15479170 15339415 15763062 18239293 17196135 15369754 17465448 17640959 15942678 14568256 16042886 18567088 17432682 15504291 15138612 15591649 17881167 14643895 17036385 15571005 15864749 18629640 17666798 17534399 14659978 12925901 15086199 16627068 17198567 15842777 16169303 16009107 18672772 14726149 18364076 17201889 17348192 18371158 18237412 15744066 16544323 16270385 15298665 17724770 18637143 15793283 12918455 15366600 15723089
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 16.9814716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Genistein 16.9817823541
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 16.9815474484
MESH:D008106 Liver Cirrhosis, Experimental rosiglitazone 16.9817347453 15980055
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 16.9818564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 16.9812878042
MESH:D008106 Liver Cirrhosis, Experimental Thioacetamide 16.9817292413 11682029 15158331 18416461 12085344 18395095 18031379 18263696 18458672 17127702 17355460 18606216 18615449 16097051 15095483 12679928 18380797 12175628 12891558 16489207 15316131 15362042 17629604 11481614 18295389 17050028 16343077 15465738 15474484 16511523 15716488 10677585 16248980 12531686 11172339 16098781 15288472 15334695 18032466 15075984 12557150 15288473 16126171 14739098 15078482
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 16.9816169303
MESH:D008107 Liver Diseases Acetaminophen 8.4319784758 11587558 19460945 19014921 12969438 16610002 12587719 16611625
MESH:D008107 Liver Diseases Carbon Tetrachloride 8.4316964402 15720792 15830285 16246199 17285989
MESH:D008107 Liver Diseases Diethylnitrosamine 8.4317034775
MESH:D008107 Liver Diseases Thioacetamide 8.4316337175 15158337 18374380
MESH:D017093 Liver Failure Carbon Tetrachloride 3.7815123358
MESH:D017114 Liver Failure, Acute Acetaminophen 20.4616871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 20.4616899240 14706259
MESH:D017114 Liver Failure, Acute Dimethylnitrosamine 20.4617457977
MESH:D017114 Liver Failure, Acute Thioacetamide 20.4615633222 12479984 17276928 15313186
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 23.1120195826 21137059
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 23.1119294768
MESH:D008113 Liver Neoplasms Clofibric Acid 23.1117602206
MESH:D008113 Liver Neoplasms Diethylnitrosamine 23.1119090486 19642983 15175105 21047994 19294768 19996281 18644402 20492335 19426721 18978307 20434301 19499222 18977376 19833225 18754104 19073162 19690152 2862719 19551842 20583210 18648771 20501860 20101389 12112319 19254457 20118626 2422723 19638242 19850985 21278145 19812893 19427195 16942905 15885732 12771043 21167192 21071580 20137499 19255062 9163691 20405173 20452335 10737359 19256749
MESH:D008113 Liver Neoplasms Dimethylnitrosamine 23.1115890375 3113478
MESH:D008113 Liver Neoplasms pirinixic acid 23.1116377806 20007298 15890375
MESH:D008113 Liver Neoplasms Tamoxifen 23.1116684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 23.1116984957
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 12.0812014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 12.0818253720 17854601 21159647 18775883 19519916 16267830 3124819 19539802 17942915 19009564 18093689 2563599 18079962 18544905 19004024 19126423 18308698 16842330 17174075 18282651 18164116 9362446
MESH:D008114 Liver Neoplasms, Experimental Dimethylnitrosamine 12.081848544 6150874 15603536
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 12.0812151625
MESH:D008133 Long QT Syndrome Amiodarone 3.2817391786 15350150 11989578
MESH:D008171 Lung Diseases Amiodarone 10.8512587719
MESH:D008171 Lung Diseases Ozone 10.858266340 19066396
MESH:D008171 Lung Diseases Vitamin E 10.8516863852
MESH:D017563 Lung Diseases, Interstitial Amiodarone 9.9318516814
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 9.9317228818
MESH:D055370 Lung Injury Ozone 3.4720417186
MESH:D008175 Lung Neoplasms arsenite 14.2616809336
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 14.2620064080 20464547 20869020 20135361 18816296 18569708 18520028 6695378 17053015
MESH:D008175 Lung Neoplasms Diethylnitrosamine 14.2620970405 6695378 20512841 21163286
MESH:D008175 Lung Neoplasms Dimethylnitrosamine 14.2616061637 11884234 19555203
MESH:D008175 Lung Neoplasms Ozone 14.267614698 8597069
MESH:D008175 Lung Neoplasms Tamoxifen 14.2618625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 14.2619555203 11884234
MESH:D008175 Lung Neoplasms tipifarnib 14.2616885199
MESH:D008175 Lung Neoplasms Vitamin E 14.2611062179
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.3719428831
MESH:D008325 Mammary Neoplasms, Experimental Corticosterone 20.2612807724
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 20.2616891317 17203775 11408345 11807958
MESH:D008325 Mammary Neoplasms, Experimental Genistein 20.2614578162 12929590
MESH:D008325 Mammary Neoplasms, Experimental rosiglitazone 20.2616827153
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 20.2619196723 11731420 16827153 14580682 19196722
MESH:D008325 Mammary Neoplasms, Experimental tipifarnib 20.2616648579
MESH:D020149 Manganese Poisoning Estradiol 11.3119453300
MESH:D020149 Manganese Poisoning Tamoxifen 11.3119453300
MESH:D008545 Melanoma Tamoxifen 1.8319393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.7915990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.1819513568
MESH:D024821 Metabolic Syndrome X rosiglitazone 4.0617261469
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.3916801185
MESH:D008679 Metaplasia Ozone 4.7010496685
MESH:D008881 Migraine Disorders Valproic Acid 2.9118803445 18765137
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 2.8916381670
MESH:D009135 Muscular Diseases pirinixic acid 3.1216239165
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 3.688888407
MESH:D009181 Mycoses Amiodarone 4.5017974566 12754197
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 2.9217596541
MESH:D009203 Myocardial Infarction Genistein 5.1017141266
MESH:D009203 Myocardial Infarction pirinixic acid 5.1019151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.7112213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 12.4316810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 12.4317141266
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 12.4316411023
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.179029167 3581430
MESH:D009362 Neoplasm Metastasis Tamoxifen 5.1719393235
MESH:D009364 Neoplasm Recurrence, Local marker/mechanism 19050079
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.3819410462
MESH:D009369 Neoplasms Benzo(a)pyrene 4.1511141357
MESH:D009369 Neoplasms pirinixic acid 4.1517405874
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.6019200415 19196722 19189210
MESH:D009389 Neovascularization, Pathologic arsenite 8.8415738583
MESH:D009389 Neovascularization, Pathologic Estradiol 8.8417289903
MESH:D009395 Nephritis, Interstitial Tetracycline 4.389884423
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.0417954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 2.9519348381 18481113
MESH:D009421 Nervous System Malformations bisphenol A 20.3711399458 16427766
MESH:D009421 Nervous System Malformations Estradiol 20.3716427766 11399458
MESH:D009421 Nervous System Malformations Genistein 20.3716427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 20.3714600291
MESH:D009436 Neural Tube Defects Valproic Acid 2.8716359493 8888407
MESH:D019636 Neurodegenerative Diseases Acetaminophen 7.1218514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 7.1220387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.7120387270
MESH:D052556 Niemann-Pick Disease, Type C Clofibrate 4.559802331
MESH:D009765 Obesity pirinixic acid 1.7120558911
MESH:D010024 Osteoporosis Genistein 3.0119401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 3.7216169203
MESH:D010049 Ovarian Diseases bisphenol A 4.5911985600
MESH:D010051 Ovarian Neoplasms Estradiol 4.4519401270
MESH:D010051 Ovarian Neoplasms Genistein 4.4519005980
MESH:D010146 Pain Acetaminophen 2.0916870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.2816540662
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.3211578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.8512520081
MESH:D010391 Pemphigoid, Bullous Tetracycline 5.0311026799
MESH:D010409 Penile Diseases Antimony 5.359643325
MESH:D010493 Pericarditis Antimony 5.7220465667
MESH:D010538 Peritonitis Ozone 3.7516369182
MESH:D011014 Pneumonia Ozone 4.0018007984 18929643 18381685
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.1818163543
MESH:D011230 Precancerous Conditions Cyclosporine 7.8512371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 7.852563599
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 13.9610548101
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 13.9611896295 11222880 11399792 11118676
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 13.9620603192
MESH:D017096 Prion Diseases Tetracycline 5.0210903871
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 9.3820887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 9.3820887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 1.8717292933
MESH:D011471 Prostatic Neoplasms bisphenol A 1.8716740699
MESH:D011471 Prostatic Neoplasms Estradiol 1.8716740699
MESH:D011471 Prostatic Neoplasms Genistein 1.8715256057 16925846 15378649
MESH:D011471 Prostatic Neoplasms Tamoxifen 1.8715067354
MESH:D011471 Prostatic Neoplasms Vitamin E 1.8715084515
MESH:D011537 Pruritus Ethinyl Estradiol 2.9216919318 15861022
MESH:D019310 Pseudolymphoma Valproic Acid 4.1411422049 12752131
MESH:D011565 Psoriasis Cyclosporine 2.0816882103
MESH:D011629 Puberty, Precocious bisphenol A 4.3910548101
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.7012490602 11597910 12832656
MESH:D015427 Reperfusion Injury pirinixic acid 2.1919058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.4618990726
MESH:D012208 Rhabdomyosarcoma Valproic Acid 3.8119155313
MESH:D012559 Schizophrenia Valproic Acid 2.0115737665 19110320
MESH:D012640 Seizures Valproic Acid 2.4811738929 1511512 17978042 14763951 16876388 15475178 3137016 11044598
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 4.6918724381
MESH:D012871 Skin Diseases Vitamin E 2.3318709164
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 4.8319755658 10029692
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 4.8316192470
MESH:D013088 Spermatocele Ethinyl Estradiol 10.2216709447
MESH:D013088 Spermatocele Tamoxifen 10.2216709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.6419457130
MESH:D016135 Spinal Dysraphism Valproic Acid 3.4819490988
MESH:D013158 Splenic Diseases Dimethylnitrosamine 4.8712587719
MESH:D013226 Status Epilepticus Valproic Acid 4.1412833885
MESH:D013272 Stomach Diseases Omeprazole 4.2218545984
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 3.172093021 20155912
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 3.1718456281
MESH:D013274 Stomach Neoplasms Dimethylnitrosamine 3.1716033868
MESH:D013276 Stomach Ulcer Amiodarone 6.4318087811
MESH:D013276 Stomach Ulcer Omeprazole 6.4318237397 17977527 15991576 11906479 10750652 16755016
MESH:D020521 Stroke Vitamin E 3.2116517955
MESH:D019966 Substance-Related Disorders bisphenol A 3.5916684133 16045194
MESH:D013576 Syndactyly methoxyacetic acid 5.261761407 1761404
MESH:D013610 Tachycardia Amiodarone 3.9211238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 3.8219225199
MESH:D013733 Testicular Diseases methoxyacetic acid 4.9418486176 6499806
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.2611994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.8215669648
MESH:D013959 Thyroid Diseases Amiodarone 10.7119731979
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 10.7112697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 6.427505956
MESH:D013964 Thyroid Neoplasms Propylthiouracil 6.4215710170
MESH:D013971 Thyrotoxicosis Amiodarone 4.4719584973 18020914
MESH:D013978 Tibial Fractures Estradiol 4.2819048282
MESH:D016171 Torsades de Pointes Amiodarone 3.8011989578 17467628
MESH:D014178 Translocation, Genetic Valproic Acid 4.8317262798
MESH:D014352 Trypanosomiasis Antimony 5.5315220340
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.133119515
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 4.4517053015
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 4.4516712894 8653321 17572228
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.268888407
MESH:D014581 Urticaria Acetaminophen 2.6210982225
MESH:D014591 Uterine Diseases bisphenol A 4.6114652134
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 2.9314692618
MESH:D014605 Uveitis Cyclosporine 3.581336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.1912125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.1914671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.8515886252
MESH:D014985 Xerophthalmia Cyclosporine 4.0417120751
No data
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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